Trial | Period | n | Hypofraction schedule | SIB | Mastectomy | Regional nodes | IMRT/ IGRT | Chemo-therapy | Outcome |
---|---|---|---|---|---|---|---|---|---|
Hôpital Necker (*)[32] | 1982- | 230 | 5.75 Gy x 4 F/ 17 | No | Yes | ? | NS | Yes | = |
1984 | days | ||||||||
Royal Marsden Hospital[33] | 1986- | 1410 | 3 Gy x 13 F/ 5 | No | No | Yes | NS | No | More local relapses |
1998 | weeks | ||||||||
Royal Marsden Hospital | Â | Â | 3.3 Gy x 13 F/ 5 | No | No | Yes | NS | No | = |
weeks | |||||||||
Ontario[18] | 1993- | 1234 | 2.66 Gy x 16 F/ 3 | No | No | No | NS | Yes | = |
1996 | weeks | ||||||||
UK Start A[19] | 1998- | 2236 | 3 Gy x 13 F/ 5 | No | Yes | Yes | NS | Yes | More local relapses |
2002 | weeks | ||||||||
UK Start A | Â | Â | 3.2 Gy x 13 F/ 5 | No | Yes | Yes | NS | Yes | = |
weeks | |||||||||
Lahore[34] | 1998- | 300 | 5.4 Gy x 5 F/ 1 | No | Yes | Yes | NS | Yes | = |
2004 | week | ||||||||
Lahore | Â | Â | 3.5 Gy x 10 F/ 2 | No | Yes | Yes | NS | Yes | = |
weeks | |||||||||
Lahore | Â | Â | 2.66 Gy x 15 F/ 3 | No | Yes | Yes | NS | Yes | Control arm |
weeks | |||||||||
UK Start B[20] | 1999- | 2215 | 2.67 Gy x 15 F/ 3 | No | Yes | Yes | NS | Yes | = |
2001 | weeks | ||||||||
Egypt NCI[35] | 2002- | 30 | 2.66 Gy x 16 F/ 3 | No | No | No | NS | No | Boost in conventional arm |
2003 | weeks | ||||||||
UK FAST[36] | 2004- | 915 | 5.7 Gy x 5 F/ 5 | ? | No | No | Yes | No | = |
2007 | weeks | ||||||||
UK FAST | Â | Â | 6 Gy x 5 F/ 5 | ? | No | No | Yes | No | More breast toxicity |
weeks | |||||||||
DBCG 2009 RT Hypo[37] | 2009- | 1500** | 2.67 Gy x 15 F/ 3 | No | No | No | Yes | Yes | On-going |
weeks | |||||||||
UK IMPORT HIGH | 2009- | 840** | 2.4 Gy [SIB 3.2 Gy] | Yes | No | ? | Yes | ? | On-going |
x 15 F/ | |||||||||
UK IMPORT HIGH | Â | Â | 2.4 Gy [SIB 3.53 Gy] | Yes | No | ? | Yes | ? | Â |
x 15 F/ | |||||||||
UZ Brussel | 2007- | 122 | 2.8 Gy [SIB 3.4 Gy] | Yes | Yes | Yes | Yes | Yes | Closed for inclusion; FU on-going |
[this study] | x 15 F/ 3 weeks |