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Table 2 Association of SNPs with erythema for all patients as well as for the subgroups of patients with breast volume < or >750 cm³

From: Association of single nucleotide polymorphisms in the genes ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with risk of severe erythema after breast conserving radiotherapy

   

all patients

 

patients with breast volume <750 cm³

 

patients with breast volume ≥750 cm³

   

(n = 83)

 

(n = 48)

 

(n = 35)

Gene (codon)

Genotype

aa

n (%)

G0/1a

G2/3a

ORb

95% CIc

Pd

aa

n (%)

G0/1a

G2/3a

ORb

95% CIc

Pd

aa

n (%)

G0/1a

G2/3a

ORb

95% CIc

Pd

ATM

GG

 

63 (76)

28

35

1

   

36 (75)

20

16

1

   

27 (77)

8

19

1

0.19 – 5.68

 

(1853)

GA

 

18 (22)

9

9

1.18

0.45 – 3.25

0.826

 

11 (23)

6

5

1.43

0.38 – 5.67

0.573

 

7 (20)

3

4

0.92

0.04 – 32.21

1.000

 

AA

 

2 (2)

0

2

1.38

0.20 – 10.59

  

1 (2)

0

1

2.05

0.15 – 32.15

  

1 (3)

0

1

0.84

  

GSTP1

AA

 

37 (45)

19

18

1

   

21 (44)

12

9

1

   

16 (46)

7

9

1

  

(105)

AG

 

38 (45)

12

26

1.01

0.49 – 2.09

1.000

 

21 (44)

10

11

0.98

0.39 – 2.44

1.000

 

17 (48)

2

15

1.25

0.32 – 5.29

0.772

 

GG

 

8 (10)

6

2

1.02

0.24 – 4.35

  

6 (12)

4

2

0.96

0.15 – 5.97

  

2 (6)

2

0

1.56

0.10 – 28.03

 

TGFB1

CC

 

29 (35)

14

15

1

   

18 (38)

13

5

1

   

11 (31)

1

10

1

  

(pos-509)

CT

 

40 (48)

18

22

1.26

0.65 – 2.50

0.530

 

24 (50)

12

12

3.10

1.11 –10.21

0.028

 

16 (46)

6

10

0.36

0.10 – 1.14

0.083

 

TT

 

14 (17)

5

9

1.59

0.42 – 6.24

  

6 (12)

1

5

9.58

1.23 – 104.30

  

8 (23)

4

4

0.13

0.01 – 1.29

 

XPD e

GG

 

34 (42)

19

15

1

   

20 (43)

12

8

1

   

14 (40)

7

7

1

  

(751)

GT

 

38 (46)

14

24

1.85

0.90 – 4.00

0.098

 

20 (43)

10

10

1.42

0.59 – 3.59

0.420

 

18 (51)

4

14

3.95

0.91 – 22.75

0.046

 

TT

 

10 (12)

3

7

3.44

0.81 – 16.01

  

7 (14)

3

4

2.03

0.34 – 12.89

  

3 (9)

0

3

15.62

0.84 – 517.40

 

XRCC1

GG

 

36 (43)

17

19

1

   

25 (52)

14

11

1

   

11 (31)

3

8

1

  

(399)

GA

 

33 (40)

13

20

1.02

0.54 – 1.93

1.000

 

17 (35)

9

8

1.13

0.46 – 2.76

0.840

 

16 (46)

4

12

0.62

0.20 – 1.84

0.464

 

AA

 

14 (17)

7

7

1.04

0.29 – 3.73

  

6 (12)

3

3

1.27

0.21 – 7.63

  

8 (23)

4

4

0.39

0.04 – 3.39

 
  1. a Patients with erythema of grade 0 or 1 and grade 2 or 3.
  2. b Odds ratio per allele.
  3. c 95% confidence interval.
  4. d Two-sided p-value from the Cochran-Armitage trend test.
  5. e Failure to genotype one patient.