Figure 11
From: Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
Balancing promotion and inhibition of cell proliferation in the downregulated networks. A) Although 1 gene (GHRH) involved in cell proliferation is downregulated in the third network, we observed downregulation of at least 4 key genes (ELF1, MTA3, RUNX1, and TYMS) related to tumor suppressor function. B) The fourth downregulated network with a significant score of 18 has TNF as the nodal molecule and downregulation of at least 2 genes (APOBEC3B, CHSY3) are known to promote carcinogenesis.