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Table 2 Pooled-average volumes irradiated (%) of IMRT and 3D-CRT in different risk organs and the publication bias

From: Dosimetric comparison of intensity modulated radiotherapy and three-dimensional conformal radiotherapy in patients with gynecologic malignancies: a systematic review and meta-analysis

Organs

Irradiated dose, Gy

No. of studies

No. of cases

Pooled volume irradiated, % (95% CI)

Egger’s p- value

Begg’s p- value

Studies trimmed

Adjusted volume irradiated, %

p- value⋆

IMRT*

3D-CRT+

IMRT*

3D-CRT+

IMRT*

3D-CRT+

IMRT*

3D-CRT+

IMRT*

3D-CRT+

Rectum

10

7

93

93.10

96.80

0.015

0.211

1.000

0.881

4

N/A

87.70

N/A

0.308

(83.80-97.30)

(90.00-99.00)

20

7

93

87.80

97.50

0.303

0.406

0.327

0.624

N/A

N/A

N/A

N/A

0.077

(73.70-94.90)

(90.50-99.40)

25

5

76

90.00

97.40

0.045

0.142

0.368

0.652

3

N/A

86.00

N/A

0.101

(79.90-95.30)

(89.30-99.40)

30

7

93

68.00

94.40

0.108

0.437

0.086

0.807

N/A

N/A

N/A

N/A

0.004

(56.60-77.50)

(86.20-96.80)

35

4

66

61.80

88.80

0.100

0.071

0.071

0.051

2

N/A

55.00

N/A

0.040

(48.80-73.30)

(74.70-95.50)

40

7

93

48.10

85.40

0.030

0.052

0.174

0.308

N/A

3

N/A

80.10

0.002

(26.90-70.10)

(74.40-92.20)

45

8

111

31.30

70.80

0.462

0.001

0.368

0.024

N/A

3

N/A

62.10

0.006

(13.20-57.70)

(59.60-80.00)

Small bowel

5

5

102

97.20

96.70

0.001

0.271

0.076

1.000

1

N/A

96.70

N/A

0.831

(90.90-99.20)

(89.50-99.00)

10

8

129

88.60

90.00

0.004

0.020

0.226

0.009

4

3

82.50

86.20

0.795

(79.00-94.20)

(81.30-95.00)

15

6

112

85.90

86.10

0.011

0.001

0.060

0.060

2

1

80.30

83.80

0.985

(74.40-92.70)

(75.00-92.80)

20

8

129

72.30

78.20

0.637

0.001

0.711

0.009

N/A

3

N/A

71.80

0.319

(63.70-83.70)

(66.90-86.50)

25

6

112

62.20

73.90

0.036

0.114

1.000

0.060

3

N/A

77.40

N/A

0.431

(44.00-77.50)

(49.10-89.30)

30

8

129

43.70

54.80

0.133

0.062

0.216

0.108

N/A

N/A

N/A

N/A

0.186

(35.00-52.80)

(34.30-73.80)

35

5

102

36.60

50.60

0.076

0.002

0.050

0.027

N/A

0

N/A

60.80

0.137

(27.70-46.60)

(27.50-73.40)

40

8

129

24.70

42.50

0.049

0.005

0.266

0.035

3

2

28.10

58.10

0.043

(17.30-34.10)

(24.00-63.40)

45

9

147

18.60

35.90

0.008

0.000

0.076

0.001

4

4

20.70

55.80

0.012

(12.60-26.70)

(21.90-52.80)

Bladder

10

6

80

95.50

96.00

0.334

0.001

0.851

0.133

N/A

2

N/A

96.60

0.871

(86.40-98.60)

(88.40-98.70)

20

6

80

88.90

96.00

0.151

0.001

0.707

0.133

N/A

2

N/A

96.60

0.169

(73.20-95.90)

(88.40-98.70)

25

4

63

90.90

96.60

0.015

 

0.089

0.497

2

N/A

86.00

N/A

0.258

(76.60-96.80)

(87.30-99.10)

30

6

80

81.20

94.60

0.227

0.153

0.133

0.260

N/A

N/A

N/A

N/A

0.079

(61.60-92.10)

(83.80-98.40)

35

3

53

80.60

89.70

0.936

0.029

1.000

0.296

N/A

2

N/A

85.00

0.396

(57.70-92.70)

(70.70-96.90)

40

6

80

53.60

76.70

0.260

0.176

0.133

0.133

N/A

N/A

N/A

N/A

0.090

(33.30-72.80)

(59.10-88.30)

45

7

98

50.10

79.30

0.059

0.005

0.071

0.133

N/A

2

N/A

64.70

0.062

(31.70-68.50)

(54.10-92.60)

Bone marrow

5

5

91/143

95.20

97.90

0.833

0.112

1.000

0.807

N/A

N/A

N/A

N/A

0.501

(86.10-98.40)

(83.60-99.80)

10

6

101/153

87.30

95.50

0.138

0.276

0.230

0.133

N/A

N/A

N/A

N/A

0.129

(73.20-93.60)

(86.00-98.60)

15

5

94/146

74.10

90.80

0.005

0.039

0.624

0.086

3

1

68.30

90.50

0.191

(61.10-83.90)

(80.60-95.90)

20

6

101/153

67.40

68.50

0.165

0.005

0.368

0.707

N/A

3

N/A

63.40

0.301

(47.50-82.50)

(55.40-79.30)

25

4

61/113

62.30

83.40

0.319

0.097

1.000

0.089

N/A

N/A

N/A

N/A

0.061

(45.20-76.80)

(66.50-92.70)

30

5

68/120

47.10

59.40

0.170

0.004

0.060

0.027

N/A

1

N/A

61.20

0.261

(32.50-62.20)

(44.00-73.50)

35

3

51/103

36.80

51.70

0.065

0.074

0.296

1.000

N/A

N/A

N/A

N/A

0.307

(19.90-57.80)

(32.60-70.40)

40

5

68/120

29.70

40.20

0.859

0.187

1.000

0.462

N/A

N/A

N/A

N/A

0.327

(17.50-45.70)

(26.50-55.70)

45

4

61/113

12.80

31.00

0.070

0.099

0.308

0.089

N/A

N/A

N/A

N/A

0.068

(5.00-28.90)

(18.00-47.90)

  1. * intensity modulated radiotherapy; + three-dimensional conformal radiotherapy; ⋆p- value for comparison difference of pooled volume irradiated between IMRT and 3D-CRT.
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