Variable | LRFS | DMFS | PFS | OS | ||||
---|---|---|---|---|---|---|---|---|
HR 95% CI | p | HR 95% CI | p | HR 95%CI | p | HR 95%CI | p | |
Univariate analyses | ||||||||
Age (< 70 vs ≥ 70 years) | 0.837,0.425-1.652 | 0.609 | 0.820,0.417-1.615 | 0.566 | 0.792,0.402-1.560 | 0.500 | 0.902,0.456-1.783 | 0.766 |
Gender (female vs male) | 1.238,0.606-2.532 | 0.558 | 1.283,0.628-2.623 | 0.495 | 1.253,0.612-2.564 | 0.538 | 1.107,0.538-2.275 | 0.782 |
KPS (< 90 vs ≥ 90) | 0.479,0.245-0.938 | 0.032 | 0.496,0.253-0.971 | 0.041 | 0.509,0.260-0.996 | 0.049 | 0.424,0.216-0.831 | 0.012 |
Smoking history(Yes vs No) | 0.249,0.034-1.822 | 0.171 | 0.236,0.032-1.726 | 0.155 | 0.260,0.036-1.902 | 0.185 | 0.249,0.034-1.822 | 0.171 |
Histology (SCCvs Adeno) | 0.593,0.287-1.223 | 0.157 | 0.556,0.270-1.147 | 0.112 | 0.538,0.261-1.111 | 0.094 | 0.637,0.309-1.313 | 0.222 |
GTV, cm3 (<96.6 vs ≥ 96.6) | 1.664,0.817-3.309 | 0.163 | 1.718,0.855-3.453 | 0.129 | 1.734,0.863-3.483 | 0.122 | 1.764,0.866-3.592 | 0.118 |
Lung V20 (26.2 < vs ≥26.2) | 1.057,0.544-2.053 | 0.871 | 0.967,0.497-1.881 | 0.921 | 1.002,0.515-1.947 | 0.996 | 1.005,0.517-1.955 | 0.989 |
MLD (1797.1 < vs ≥1797.1) | 1.489,0.744-2.979 | 0.260 | 1.522,0.767-3.018 | 0.229 | 1.528,0.771-3.031 | 0.225 | 1.489,0.744-2.979 | 0.260 |
SUV1 (< 14.2 vs ≥ 14.2) | 3.029,1.426-6.432 | 0.004 | 3.204,1.504-6.827 | 0.003 | 3.269,1.529-6.992 | 0.002 | 2.670,1.251-5.699 | 0.011 |
SUV2 (< 3.6 vs ≥ 3.6) | 3.823,1.646-8.881 | 0.002 | 3.998,1.718-9.229 | 0.001 | 3.877,1.666-9.021 | 0.002 | 3.297,1.414-7.686 | 0.006 |
ΔSUV (< 9.4 vs ≥ 9.4) | 1.372,0.649-2.899 | 0.407 | 1.575,0.745-3.332 | 0.235 | 1.721,0.812-3.646 | 0.156 | 1.366,0.646-2.889 | 0.414 |
ΔSUV/SUV1 (< 0.68 vs ≥ 0.68) | 0.652,0.308-1.381 | 0.264 | 0.714,0.337-1.511 | 0.378 | 0.767,0.363-1.623 | 0.488 | 0.807,0.377-1.726 | 0.580 |
Multivariate analyses | ||||||||
KPS (< 90 vs ≥ 90) | 0.409,0.188-0.893 | 0.025 | 0.419,0.189-0.929 | 0.032 | 0.413,0.187-0.912 | 0.029 | 0.291,0.130-0.651 | 0.003 |
SUV1 (< 14.2 vs ≥ 14.2) | 2.304,0.994-5.337 | 0.052 | 2.576,1.098-6.041 | 0.030 | 2.620,1.115-6.158 | 0.027 | 2.347,1.006-5.474 | 0.048 |
SUV2 (< 3.6 vs ≥ 3.6) | 2.947,1.213-7.161 | 0.017 | 2.892,1.195-7.001 | 0.019 | 2.792,1.155-6.750 | 0.023 | 2.620,1.083-6.342 | 0.033 |