Skip to main content

Table 2 Univariate and multivariate analyses of factors associated with survival in a cohort of 84 unresectable stage III non-small-cell lung cancer patients

From: FDG uptake correlates with recurrence and survival after treatment of unresectable stage III non-small cell lung cancer with high-dose proton therapy and chemotherapy

Variable

LRFS

DMFS

PFS

OS

 

HR 95% CI

p

HR 95% CI

p

HR 95%CI

p

HR 95%CI

p

Univariate analyses

        

Age (< 70 vs ≥ 70 years)

0.837,0.425-1.652

0.609

0.820,0.417-1.615

0.566

0.792,0.402-1.560

0.500

0.902,0.456-1.783

0.766

Gender (female vs male)

1.238,0.606-2.532

0.558

1.283,0.628-2.623

0.495

1.253,0.612-2.564

0.538

1.107,0.538-2.275

0.782

KPS (< 90 vs ≥ 90)

0.479,0.245-0.938

0.032

0.496,0.253-0.971

0.041

0.509,0.260-0.996

0.049

0.424,0.216-0.831

0.012

Smoking history(Yes vs No)

0.249,0.034-1.822

0.171

0.236,0.032-1.726

0.155

0.260,0.036-1.902

0.185

0.249,0.034-1.822

0.171

Histology (SCCvs Adeno)

0.593,0.287-1.223

0.157

0.556,0.270-1.147

0.112

0.538,0.261-1.111

0.094

0.637,0.309-1.313

0.222

GTV, cm3 (<96.6 vs ≥ 96.6)

1.664,0.817-3.309

0.163

1.718,0.855-3.453

0.129

1.734,0.863-3.483

0.122

1.764,0.866-3.592

0.118

Lung V20 (26.2 < vs ≥26.2)

1.057,0.544-2.053

0.871

0.967,0.497-1.881

0.921

1.002,0.515-1.947

0.996

1.005,0.517-1.955

0.989

MLD (1797.1 < vs ≥1797.1)

1.489,0.744-2.979

0.260

1.522,0.767-3.018

0.229

1.528,0.771-3.031

0.225

1.489,0.744-2.979

0.260

SUV1 (< 14.2 vs ≥ 14.2)

3.029,1.426-6.432

0.004

3.204,1.504-6.827

0.003

3.269,1.529-6.992

0.002

2.670,1.251-5.699

0.011

SUV2 (< 3.6 vs ≥ 3.6)

3.823,1.646-8.881

0.002

3.998,1.718-9.229

0.001

3.877,1.666-9.021

0.002

3.297,1.414-7.686

0.006

ΔSUV (< 9.4 vs ≥ 9.4)

1.372,0.649-2.899

0.407

1.575,0.745-3.332

0.235

1.721,0.812-3.646

0.156

1.366,0.646-2.889

0.414

ΔSUV/SUV1 (< 0.68 vs ≥ 0.68)

0.652,0.308-1.381

0.264

0.714,0.337-1.511

0.378

0.767,0.363-1.623

0.488

0.807,0.377-1.726

0.580

Multivariate analyses

        

KPS (< 90 vs ≥ 90)

0.409,0.188-0.893

0.025

0.419,0.189-0.929

0.032

0.413,0.187-0.912

0.029

0.291,0.130-0.651

0.003

SUV1 (< 14.2 vs ≥ 14.2)

2.304,0.994-5.337

0.052

2.576,1.098-6.041

0.030

2.620,1.115-6.158

0.027

2.347,1.006-5.474

0.048

SUV2 (< 3.6 vs ≥ 3.6)

2.947,1.213-7.161

0.017

2.892,1.195-7.001

0.019

2.792,1.155-6.750

0.023

2.620,1.083-6.342

0.033

  1. Abbreviations: LRFS = local recurrence free survival; DMFS = distant metastasis free survival; PFS = progress free survival; OS = overall survival; HR = hazard ration; CI = confidence interval; KPS = Karnofsky Performance Status; SCC = squamous cell carcinoma; Adeno = adenocarcinoma; GTV = gross tumor volume; MLD = mean lung dose; SUV = standardized uptake values.