Figure 4From: The use of caspase inhibitors in pulsed-field gel electrophoresis may improve the estimation of radiation-induced DNA repair and apoptosisCaspase inhibitors blocked apoptosis induced by agarose encapsulation. Representative PFGE from A431 and NP18 cell lines are depicted. Spontaneous DNA fragmentation induced exclusively by incubation in unirradiated cell-plugs (black bars) was inhibited (grey bars) by zvad-fmk (100 μM). *P = 0.016; **P = 0.083 (Mann-Whitney test, 4 independent experiments). No significant differences were found between the A431 and N18 cell lines.Back to article page