Table 4 Overview of prior stereotactic radiosurgery results for the reirradiation of recurrent head and neck carcinoma.
Study | Patients (#) | SRS median total dose/fx | Follow-up median, range (months) | Tumor size median, range (cc) | Prior irradiation Dose, median, range (Gy) | Toxicity | Complete Response Rate | Overall survival |
|---|---|---|---|---|---|---|---|---|
Voynov et al. [13] | 22 | 24/1-8 | 19, 11-40* | 19.1, 2.5-140.3 | 97.8, 70.1-190.3 (BED10) | No Grade 4+ | - | 22% at 2-yrs |
Heron et al. [15] | 25 | 25-44/5 | NS | 44.8, 4.2-217 | 66-69.2 | No Grade 3+ | 8.6% | 18% at 1-yr |
Roh et al. [14] | 36 | 30/3-5 | 17.3 | 22.6, 0.2-114.9 | 70.2, 39.6-134.4 | No Grade 4+ 36% Grade 3 | 42.9% | 52.1% at 1-yr, 30.9% at 2-yrs |
Rwigema et al. [23] | 85 | 35/1-5 | 6, 1.3-39 | 25.1, 2.5-162 | 70, 32-170.7 | No Grade 4+ 4.7% Grade 3 | 34% | 48% at 1-yr, 16% at 2-yrs |
Sulman et al. [31] | 78§ | IMRT 60 Gy | 25, 0-81 | 64.1, 2.9-425.4 | 60, 16-75 | 20% severe Including 1% Grade 5 | - | 58% at 2-yrs |
Siddiqui et al. [25] | 44§†| 13-18/1 or 36-48/5-8 | 6.8, 1.5-48 | 15.5, 1.7-155‡ | 63.5, 50.4-74‡ | 6.7% Grade 3‡ 9% Grade 4‡ | 31% | 38.1% at 1-yr 14.3% at 2-yrs |
Unger et al. [24] | 65 | 30/2-5 | 16* | 75, 7-276 | 67, 32-120 | 11% Grade 4+ | 54% | 41% at 2-yrs |
Current Study | 22 (14 N-, 8 N+) | 33.7/2-5 | 24, 4-39 | 24.5, 3.4-74.4 | 40-65 | No Grade 4+ 22.7% Grade 3 | 45.4% (N- 64.3%, N+ 12.5%) | N- 78.6% at 2-yrs N+ 12.5% at 2-yrs |