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Table 1 MP470-induced tumor growth delay in U87 xenografts

From: The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells

Treatment Group

No. of Mice Per Group

Tumor Growth Period, days*

Absolute Growth Delay†

Normalized Growth Delay‡

Enhancement Factor**

Control

8

9.7 ± 1.01

   

MP470

8

8.6 ± 1.1

0 ± 1.1

  

Radiation

8

15.8 ± 2.3

6.1 ± 2.3

  

MP470 + Radiation

8

27.4 ± 2.8

17.7 ± 2.8

17.7 ± 2.8

2.9

  1. * Time for subcutaneous tumors to grow from 200 mm3 to 1500 mm3 (see text).
  2. † No. of days for tumors in the radiation-only and the MP470 + radiation groups to reach 1,500 mm3 minus no. of days for tumors in the control group to reach the same size.
  3. ‡ No. of days for tumors in the MP470 + radiation group to reach 1,500 mm3 minus no. of days for tumors in the MP470-only group to reach the same size.
  4. ** Normalized growth delay for MP470 + radiation group divided by absolute growth delay for the radiation-only group.
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Radiation Oncology

ISSN: 1748-717X

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