Table 3 Summary of results on main published studies on the radiosurgery of skull base meningiomas

From: Radiotherapy and radiosurgery for benign skull base meningiomas

authors	patients	type	S + RS %	RS %	tumor volume median (ml)	median dose Gy	follow-up median (months)	local control %	volume reduction (%)	neurological improvement	Toxicity %
valentino et al., 1993	72	LINAC	53	47	NA	NA	44	93	69	50	6.7
Hudgins et al., 1996	100*	GK	91	9	14	15	NA	91	47	8	12
Kurita et al., 1997	18	GK	83	17	NA	17	34.8	87.5 at 5 years	35	NA	49.9
Chang et al., 1998	24	GK	66	34	6.8	17.7	45.6	100	37	42	33
Pan et al., 1998	63	GK	54	46	NA	NA	21	91	74	37.5	7.5
Morita et al., 1999	88	GK	55	45	8.1	16	35	95 at 5 years	70	NA	14.8
Shafron et al., 1999	50	LINAC	46	54	10	12.7	23	100	44	NA	3
Liscak et al., (1999)	67	GK	36	64	7.8	12	19	100	52	35.8	3.8
Aichholzer et al., 2000	46*	GK	67	33	NA	15.9	48	97.5	52	33	13.2
Roche et al., 2000	80	GK	37	63	4.7	14	30.5	92.8 at 5 years	31	43	5
Villavicencio et al., 2001	56	LINAC	64	36	6	15	26	95	44	34	9
Kobayashi et al., 2001	87	GK	56	44	NA	14	30°	89 at 7 years	23	48	13.8
Shin et al., 2001	40	GK	66	34	4.3	18	40	82.3 a 10 years	37	20	22.5
Stafford et al., 2001	190*	GK	59	41	8.2	16	47	93 at 5 years	56	8	13
Spiegelmann et al., 2002	42	LINAC	26	74	8.4	14	36	97.5 at 7 years	60	22	22.4
Nicolato et al., 2002	111	GK	49	51	10	14.8	48.2	96 at 5 years	63	66	8
Lee et al., 2002	155	GK	46	54	6.5	15	35	93 at 5 and 10 years	34	29	6.7
Lo et al., 2002	35	LINAC	60	40	6.8	14	38	92.7 at 3 years	37.5	NA	6
Eustachio et al., 2002)	121	GK	49	51	6.8	13	82	97.8	60	44	6.7
Torres et al., 2003	77*	LINAC	65	35	12.7	15.6	40.6	92.1	35	35	5
DiBiase et al., 2004	162	GK	38	62	4.5	14	54	86.2 at 5 years	28	NA	8.3
Deinsberger et al., 2004	37	LINAC	22	78	5.9	14.6	66	97.2	32	NA	5.6
Pollock et al., 2005	49	GK	0	100	10.2	16	58	85 at 3 and 80 at 7 years	59	26	20
Kreil et al., 2005	200	GK	50.5	49.5	6.5	12	95	98.5 at 5 and 97 at 10 years	56.5	41	4.5
Zachenhofer et al., 2006	36	GK	70	30	NA	17	103	94	53	36	5
Kollova et al., 2007	368	GK	30	70	4.4	12.5	60	98 at 5 years	69	62	15.9
Hasewaga et al., 2007	115	GK	57	43	14	13	62	87 at 5 and 73 at 10 years	51	46	12
Feigl et al., 2007	214	GK	43	57	6.5°	13.6°	24°	86.3 at 4 years	74	19	6.7
Davidson et al., 2007	36	GK	100	0	4.1	16	81	100 at 5 and 94.7 at 10 years	14	44	3
Kondziolka et al., 2008	972*	GK	49	51	7.4*	14°	48°	87 at 10 and 15 years	42	35	7.7
Iway et al., 2008	108	GK	NA	NA	8.1	12	86.1	93 at 5 and 83 at 10 years	46	21	6
Han et al., 2008	98	GK	36	64	6.3°	12.7	77°	90 at 5 years	44	45	16
Takanashi et al., 2009	101	GK	24	76	7.1	13.2	52°	97%	44	45	0
Ganz et al., 2009	97	GK	NA	NA	15.9°	12°	53°	100% at 2 years	31	NA	3

*series include skull base and intracranial meningiomas;
°mean

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