Prognostic indices for brain metastases – usefulness and challenges

Radiation Oncology

Table 2 Median values of reported patients' characteristics in each of the studies, empty fields indicate missing information

Score	Performance status	Age	Extracranial metastases	Controlled primary	Steroid treatment	Number of BM	Volume of BM	Interval to BM
RPA¹¹ n = 1,200	KPS 70	55–59 yrs. range	38%	60%		2
Rotterdam³⁶ n = 1,292	ECOG 1	59 yrs.			mean 15 mg dexamethasone per day	2		8.5 mo.
SIR³⁷ n = 65	KPS 80	61 yrs.				2	3.3 cc
BSBM⁴³ n = 110		57 yrs.				2	9 cc
GPA⁴⁴ n = 1,960	KPS 80	60 yrs.	36%	67%		2	5–13 cc
Rades et al.⁴⁵ n = 1,085	KPS 70	60 yrs.	64%					8 mo.

BM: brain metastases, RPA: recursive partitioning analysis, KPS: Karnofsky performance score, SIR: score index for radiosurgery, BSBM: basic score for brain metastases, GPA: graded prognostic assessment, ECOG: Eastern Cooperative Oncology Group

ISSN: 1748-717X