IMRT using simultaneously integrated boost (SIB) in head and neck cancer patients

Radiation Oncology

Table 2 Characteristics on 21 patients (18 %) with loco-regional failure (LRF) are listed; patients with isolated distant failure (DF) are not included in this list. Mean time to failure (TTF) was 5 – 6 months in recurred patients; in 8 individuals (1/3) tumor persistence was observed.

Number	Diagnosis	TNM	LRF	DF	Outcome	TTF (m)	GTV PT (cc)	GTV LN (cc)	PTV1 (cc)	%PTV <95	%PTV < 93%
1	OC	T4N2c	LRR		AD	4	15	3	127	9	5
2	OC	T4N2c	LRR		DOD	10	75	27	253	6	3
3	OC	T1N2b	LR	distant	DOD	3	na	6.5	74	5	2
4	OC	T3N2c	LR		DOD	15	23	1	144	14	9
5	OC	T2N1	LR		AD	4	45	2	124	5	2
6	OC	Recurrence	LRR		AD	0	71	6	117	25	17
7	OC	T2N0	Persistence		AD	0	13	0	64	0	0
8	OC	T2N2c	Persistence		AD	0	16	2.4	82	50	7
9	OC	T4N1	Persistence		DOD	0	206	5	270	4	1
10	oro	T4N2b	LR	distant	AD	13	100	2	255	8	4
11	oro	T4N2c	NR	distant	DOD	3	34	15	179	8	4
12	oro	T4N0	Persistence		DOD	0	57	0	188	5	2
13	oro	T3N2b	Persistence	distant	AD	0	97	5	393	14	5
14	oro	T3N2a	Persistence		AD	0	31	4.3	198	35	25
15	oro	T4N2b	LRR		AD	8	41	5	178	15	10
16	Sinus	T4N0	Persistence		DOD	10	75	0	75	8	5
17	Sinus	Recurrence	Persistence	distant	AD	0	56	20	89	27	11
18	Sinus	T4N2b	LRR		DOD	15	141	17	176	11	5
19	Glottic	Recurrence	NR	distant	DOD	13	9	118	8	3	3
20	Supragl	T4N2c	LRR	distant	AD	6	79	18	353	7	2
21	Hypoph	T3N2c	NR		ANED *	9	22	30	210	15	7
Mean						5.4	63.0	8.5	174.6	13.3	6.1
Range						0 – 21	9 – 206	0 – 99	64 – 353	0 – 50	0 – 25

LRF loco-regional failure; DF distant failure; LC local recurrence; LRR loco-regional recurrence; NR nodal recurrence; TTF time to failure; GTVPT primary gross tumor volume, GTV LN lymph node gross tumor volume; PTV1 planning target volume 1 (boost).

ISSN: 1748-717X