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  1. Stereotactic radiosurgery (SRS) has been recognized as a first-line treatment option for small to moderate sized vestibular schwannoma (VS). Our aim is to evaluate the impact of SRS doses and other patient and...

    Authors: Ekin Ermiş, Lukas Anschuetz, Dominic Leiser, Robert Poel, Andreas Raabe, Peter Manser, Daniel M. Aebersold, Marco Caversaccio, Georgios Mantokoudis, Janine Abu-Isa, Franca Wagner and Evelyn Herrmann
    Citation: Radiation Oncology 2021 16:61
  2. This prospective phase I/II trial assessed feasibility and efficacy of dose-escalated definitive chemoradiation after induction chemotherapy in locally advanced esophageal cancer. Primary study endpoint was lo...

    Authors: C. Pöttgen, E. Gkika, M. Stahl, J. Abu Jawad, T. Gauler, S. Kasper, T. Trarbach, K. Herrmann, N. Lehmann, K.-H. Jöckel, H. Lax and M. Stuschke
    Citation: Radiation Oncology 2021 16:59
  3. To explore whether a highly refined dose volume histograms (DVH) prediction model can improve the accuracy and reliability of knowledge-based volumetric modulated arc therapy (VMAT) planning for cervical cancer.

    Authors: Mingli Wang, Huikuan Gu, Jiang Hu, Jian Liang, Sisi Xu and Zhenyu Qi
    Citation: Radiation Oncology 2021 16:58
  4. To analyze the pattern of failure in relation to pre-treatment [18F] FDG-PET/CT uptake in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive radio-chemotherapy (RT-CHT).

    Authors: C. Pisani, L. Vigna, F. Mastroleo, G. Loi, V. Amisano, L. Masini, L. Deantonio, P. Aluffi Valletti, G. Sacchetti and M. Krengli
    Citation: Radiation Oncology 2021 16:57
  5. Whole brain radiation (WBRT) may lead to acute xerostomia and dry eye from incidental parotid and lacrimal exposure, respectively. We performed a prospective observational study to assess the incidence/severit...

    Authors: Panayiotis Mavroidis, Kevin A. Pearlstein, Dominic H. Moon, Victoria Xu, Trevor J. Royce, Ashley A. Weiner, Colette J. Shen, Lawrence B. Marks, Bhishamjit S. Chera, Shiva K. Das and Kyle Wang
    Citation: Radiation Oncology 2021 16:56
  6. The current status of German residency training in the field of radiation oncology is provided and compared to programmes in other countries. In particular, we present the DEGRO-Academy within the internationa...

    Authors: Marcel Büttner, Nils Cordes, Tobias Gauer, Daniel Habermehl, Gunther Klautke, Oliver Micke, Matthias Mäurer, Jan Sokoll, Esther Gera Cornelia Troost, Hans Christiansen and Maximilian Niyazi
    Citation: Radiation Oncology 2021 16:55
  7. Systematic pelvic lymphadenectomy or whole pelvic irradiation is recommended for the patients with stage IB1 cervical cancer. However, the precise pattern of lymphatic tumor spread in cervical cancer is unknow...

    Authors: Jing Cai, Xiaoqi He, Hongbo Wang, Weihong Dong, Yuan Zhang, Jing Zhao, Kay C. Willborn, Bangxing Huang, Zehua Wang and Ping Jiang
    Citation: Radiation Oncology 2021 16:54
  8. Variation in target positioning represents a challenge to set-up reproducibility and reliability of dose delivery with stereotactic body radiation therapy (SBRT) for pancreatic adenocarcinoma (PDAC). While on-...

    Authors: Colin S. Hill, Sarah Han-Oh, Zhi Cheng, Ken Kang-Hsin Wang, Jeffrey J. Meyer, Joseph M. Herman and Amol K. Narang
    Citation: Radiation Oncology 2021 16:53
  9. Patients with lung cancer and interstitial lung disease treated with radiotherapy are at risk of developing radiation pneumonitis. However, the association between interstitial lung abnormalities (ILAs) and ra...

    Authors: Haruki Kobayashi, Kazushige Wakuda, Tateaki Naito, Nobuaki Mamesaya, Shota Omori, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Yasuhiro Gon and Toshiaki Takahashi
    Citation: Radiation Oncology 2021 16:52
  10. Several radiotherapeutic approaches for patients with oligotopic malignant liver lesions unfit for surgical resection exist. The most advanced competitive techniques are high-dose-rate (HDR) brachytherapy, Cyb...

    Authors: Peter Wust, Marcus Beck, Robert Dabrowski, Oliver Neumann, Sebastian Zschaeck, David Kaul, Dominik P. Modest, Carmen Stromberger, Bernhard Gebauer and Pirus Ghadjar
    Citation: Radiation Oncology 2021 16:51
  11. Due to improved imaging sensitivity, the term “oligometastatic” prostate cancer disease is diagnosed more often, leading to an increasing interest in metastasis-directed therapy (MDT). There are two types of r...

    Authors: Paul Rogowski, Mack Roach III, Nina-Sophie Schmidt-Hegemann, Christian Trapp, Rieke von Bestenbostel, Run Shi, Alexander Buchner, Christian Stief, Claus Belka and Minglun Li
    Citation: Radiation Oncology 2021 16:50
  12. This study aimed to quantify errors by using a cine electronic portal imaging device (cine EPID) during deep inspiration breath-hold (DIBH) for left-sided breast cancer and to estimate the planning target volu...

    Authors: Yuka Ono, Michio Yoshimura, Tomohiro Ono, Takahiro Fujimoto, Yuki Miyabe, Yukinori Matsuo and Takashi Mizowaki
    Citation: Radiation Oncology 2021 16:49
  13. Patients with metastatic HER2/neu-positive (HER2/neu +) breast cancer (BC) often experience treatment resistance, disease recurrences and metastases. Thus, new approaches for improving the treatment of HER2/ne...

    Authors: Wende Li, Sen Li, Ivy X. Chen, Yujiao Liu, Rakesh R. Ramjiawan, Chi-Ho Leung, Leo E. Gerweck, Dai Fukumura, Jay S. Loeffler, Rakesh K. Jain, Dan G. Duda and Peigen Huang
    Citation: Radiation Oncology 2021 16:48
  14. The purpose of this study was to assess whether thoracic radiotherapy (TRT) combined with chemotherapy (CHT) showed promising anti-tumour activity in extensive-stage small cell lung cancer (ES-SCLC), to explor...

    Authors: Jinmin Han, Chengrui Fu and Baosheng Li
    Citation: Radiation Oncology 2021 16:47
  15. The value of O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET)-radiomics in the outcome assessment of patients with recurrent glioblastoma (rGBM) has not been evaluated until now. The...

    Authors: Montserrat Carles, Ilinca Popp, Michael Maximilian Starke, Michael Mix, Horst Urbach, Tanja Schimek-Jasch, Franziska Eckert, Maximilian Niyazi, Dimos Baltas and Anca L. Grosu
    Citation: Radiation Oncology 2021 16:46
  16. To compare linac-based mono-isocentric radiosurgery with Brainlab Elements Multiple Brain Mets (MBM) SRS and the Gamma Knife using a specific statistical method and to analyze the dosimetric impact of the targ...

    Authors: Michel Chea, Karen Fezzani, Julian Jacob, Marguerite Cuttat, Mathilde Croisé, Jean-Marc Simon, Loïc Feuvret, Charles-Ambroise Valery, Philippe Maingon, Mohamed-Amine Benadjaoud and Catherine Jenny
    Citation: Radiation Oncology 2021 16:45
  17. In breast cancer patients receiving radiotherapy (RT), accurate target delineation and reduction of radiation doses to the nearby normal organs is important. However, manual clinical target volume (CTV) and or...

    Authors: Seung Yeun Chung, Jee Suk Chang, Min Seo Choi, Yongjin Chang, Byong Su Choi, Jaehee Chun, Ki Chang Keum, Jin Sung Kim and Yong Bae Kim
    Citation: Radiation Oncology 2021 16:44
  18. To evaluate the effect of prophylactic irradiation of internal mammary lymph nodes in breast cancer patients.

    Authors: Sicong Jia, Zhikun Liu, Jun Zhang, Chenguang Zhao, Longyu Zhu, Jie Kong, Huina Han, Yuguang Shang, Dongxing Shen and Xuejuan Duan
    Citation: Radiation Oncology 2021 16:42
  19. The exact rate and relevant risk factors of radiation pneumonitis (RP) for non-small-cell cancer (NSCLC) patients treated with the combination of epidermal growth factor receptor-tyrosine kinase inhibitors (EG...

    Authors: Wenxiao Jia, Qianqian Gao, Min Wang, Ji Li, Wang Jing, Jinming Yu and Hui Zhu
    Citation: Radiation Oncology 2021 16:41
  20. Frequency and risk profile of radiation necrosis (RN) in patients with glioma undergoing either upfront stereotactic brachytherapy (SBT) and additional salvage external beam radiotherapy (EBRT) after tumor rec...

    Authors: Indrawati Hadi, Daniel Reitz, Raphael Bodensohn, Olarn Roengvoraphoj, Stefanie Lietke, Maximilian Niyazi, Jörg-Christian Tonn, Claus Belka, Niklas Thon and Silke Birgit Nachbichler
    Citation: Radiation Oncology 2021 16:40
  21. Stereotactic body radiation therapy (SBRT) is an established therapy for medically inoperable early-stage non-small cell lung cancer (NSCLC). Many elderly patients are medically inoperable owing to comorbiditi...

    Authors: Kenta Watanabe, Kuniaki Katsui, Soichiro Sugiyama, Kotaro Yoshio, Masahiro Kuroda, Takao Hiraki, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa
    Citation: Radiation Oncology 2021 16:39
  22. Primary tracheal adenoid cystic carcinoma (TACC) is rare and originates from the minor salivary gland. Biologically, TACC results in delayed presentation, and the therapeutic effects of multimodal treatment di...

    Authors: Juntao Ran, Guofeng Qu, Xiaohua Chen and Da Zhao
    Citation: Radiation Oncology 2021 16:38
  23. The benefit of MR-only workflow compared to current CT-based workflow for prostate radiotherapy is reduction of systematic errors in the radiotherapy chain by 2–3 mm. Nowadays, MRI is used for target delineati...

    Authors: Karin Goudschaal, F. Beeksma, M. Boon, M. Bijveld, J. Visser, K. Hinnen and Z. van Kesteren
    Citation: Radiation Oncology 2021 16:37
  24. Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO...

    Authors: Giuseppe Minniti, Maximilian Niyazi, Filippo Alongi, Piera Navarria and Claus Belka
    Citation: Radiation Oncology 2021 16:36
  25. The Halcyon is a new machine from the Varian company. The purpose of this study was to evaluate the dosimetry of the Halcyon in treatment of bilateral breast cancer with volumetric modulated arc therapy.

    Authors: Tao Sun, Xiutong Lin, Guifang Zhang, Qingtao Qiu, Chengqiang Li and Yong Yin
    Citation: Radiation Oncology 2021 16:35
  26. The impact of adjuvant radiotherapy (RT) on atypical meningioma (AM) underwent a gross total resection (GTR) remains unclear, showing conflicting results from various studies. The objective of this study was t...

    Authors: Se-Woong Chun, Kyung Min Kim, Min-Sung Kim, Ho Kang, Yun-Sik Dho, Youngbeom Seo, Jin Wook Kim, Yong Hwy Kim and Chul-Kee Park
    Citation: Radiation Oncology 2021 16:34
  27. Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor...

    Authors: Somayeh Sadat Mehrnia, Bijan Hashemi, Seyed Javad Mowla, Maryam Nikkhah and Azim Arbabi
    Citation: Radiation Oncology 2021 16:33
  28. Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate can...

    Authors: Lindsay S. Rowe, Stephanie Harmon, Adam Horn, Uma Shankavaram, Soumyajit Roy, Holly Ning, Liza Lindenberg, Esther Mena, Deborah E. Citrin, Peter Choyke and Baris Turkbey
    Citation: Radiation Oncology 2021 16:32
  29. The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is...

    Authors: Cecilia Jiang, Troy J. Kleber, Jeffrey M. Switchenko and Mohammad K. Khan
    Citation: Radiation Oncology 2021 16:31
  30. Radiation-induced brain injury is a common concern for survivors of adult and pediatric brain cancer. Pre-clinically, rodent models are the standard approach to evaluate mechanisms of injury and test new thera...

    Authors: Ilektra Athanasiadi, Whitney D. Perez, Jeannie M. Plantenga, Yava Jones-Hall and Carlos J. Perez-Torres
    Citation: Radiation Oncology 2021 16:30
  31. To evaluate the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy (WART) in women with ovarian clear cell cancer (OCCC) referred to an academi...

    Authors: Mark J. Stevens, Simon West, Gregory Gard, Christopher Renaud, David Nevell, Stephanie Roderick and Andrew Le
    Citation: Radiation Oncology 2021 16:29
  32. Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus is a current pandemic. We initiated a program of systematic SARS-CoV-2 polymerase chain reaction (PCR) testing in all asymptomatic patients re...

    Authors: Roshan S. Prabhu, Reshika Dhakal, Amy S. Hicks, James McBride, Alicia L. Patrick, Christopher D. Corso, Tomain Murphy, Melissa Thonen, Edward H. Lipford, Derek Raghavan and Stuart H. Burri
    Citation: Radiation Oncology 2021 16:28
  33. Future radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices...

    Authors: Stefanie Corradini, Maximilian Niyazi, Dirk Verellen, Vincenzo Valentini, Seán Walsh, Anca-L. Grosu, Kirsten Lauber, Amato Giaccia, Kristian Unger, Jürgen Debus, Bradley R. Pieters, Matthias Guckenberger, Suresh Senan, Wilfried Budach, Roland Rad, Julia Mayerle…
    Citation: Radiation Oncology 2021 16:27
  34. Segmentation is a crucial step in treatment planning that directly impacts dose distribution and optimization. The aim of this study was to evaluate the inter-individual variability of common cranial organs at...

    Authors: Guillaume Vogin, Liza Hettal, Clarisse Bartau, Juliette Thariat, Marie-Virginie Claeys, Guillaume Peyraga, Paul Retif, Ulrike Schick, Delphine Antoni, Zsuzsa Bodgal, Frederic Dhermain and Loic Feuvret
    Citation: Radiation Oncology 2021 16:26
  35. This meta-analysis evaluated the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer after breast-conserving surgery.

    Authors: Xiaoyong Xiang, Zhen Ding, Lingling Feng and Ning Li
    Citation: Radiation Oncology 2021 16:24
  36. Radiation therapy and chemoradiation therapy play a major role in the definitive management of esophageal cancer. Survival in esophageal cancer patients is still relatively poor, mostly due to high rates of lo...

    Authors: J. Ristau, M. Thiel, S. Katayama, I. Schlampp, K. Lang, M. F. Häfner, K. Herfarth, J. Debus and S. A. Koerber
    Citation: Radiation Oncology 2021 16:23
  37. For meningiomas, complete resection is recommended as first-line treatment while stereotactic radiosurgery (SRS) is established for meningiomas of smaller size considered inoperable. If the patient´s medical c...

    Authors: Maximilian I. Ruge, Juman Tutunji, Daniel Rueß, Eren Celik, Christian Baues, Harald Treuer, Martin Kocher and Stefan Grau
    Citation: Radiation Oncology 2021 16:22
  38. Most previous studies focused on the minimum interval between surgery and radiotherapy in spinal metastases, leaving the maximum interval under-investigated. However, in real world, limited radiotherapist and ...

    Authors: Yining Gong, Hongqing Zhuang, Shan Chong, Qianyu Shi, Feng Wei, Zhongjun Liu, Hanqiang Ouyang, Xiaoguang Liu and Liang Jiang
    Citation: Radiation Oncology 2021 16:21
  39. Proton therapy is a promising advancement in radiation oncology especially in terms of reducing normal tissue toxicity, although it is currently expensive and of limited availability. Here we estimated the ind...

    Authors: N. Patrik Brodin, Rafi Kabarriti, Clyde B. Schechter, Mark Pankuch, Vinai Gondi, Shalom Kalnicki, Madhur K. Garg and Wolfgang A. Tomé
    Citation: Radiation Oncology 2021 16:19
  40. To investigate maximum tolerated dose (MTD) of axitinib, a selective vascular endothelial growth factor receptor 1–3 inhibitor, in combination with radiotherapy (RT) for advanced hepatocellular carcinoma (HCC).

    Authors: Kai-Lin Yang, Mau-Shin Chi, Hui-Ling Ko, Yi-Ying Huang, Su-Chen Huang, Yu-Min Lin and Kwan-Hwa Chi
    Citation: Radiation Oncology 2021 16:18
  41. Patients with locally advanced rectal cancer generally have different response rates to preoperative neoadjuvant chemo-radiotherapy. This study investigated the value of the apparent diffusion coefficient (ADC...

    Authors: Mengjing Zhao, Lihao Zhao, Han Yang, Yuxia Duan and Gang Li
    Citation: Radiation Oncology 2021 16:17
  42. The watch-and-wait strategy offers a non-invasive therapeutic alternative for rectal cancer patients who have achieved a clinical complete response (cCR) after chemoradiotherapy. This study aimed to investigat...

    Authors: Qiao-xuan Wang, Rong Zhang, Wei-wei Xiao, Shu Zhang, Ming-biao Wei, Yong-heng Li, Hui Chang, Wei-hao Xie, Li-ren Li, Pei-rong Ding, Gong Chen, Zhi-fan Zeng, Wei-hu Wang, Xiang-bo Wan and Yuan-hong Gao
    Citation: Radiation Oncology 2021 16:16
  43. Stereotactic body radiotherapy (SBRT) is an emerging modality for hepatocellular carcinoma (HCC). However, there is scant information about its safety and effectiveness in the neoadjuvant setting prior to live...

    Authors: Ying-Fu Wang, Yang-Hong Dai, Chun-Shu Lin, Hao-Chih Chang, Po-Chien Shen, Jen-Fu Yang, Chih-Weim Hsiang, Cheng-Hsiang Lo and Wen-Yen Huang
    Citation: Radiation Oncology 2021 16:15
  44. Radiotherapy of gastric mucosa-associated lymphoid tissue (MALT) lymphoma should be delivered to the entire stomach with planning target volume (PTV) that accounts for variations in stomach volume, respiratory...

    Authors: Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Yumiko Kono, Yasuhiro Doi, Yoshiyuki Fukugawa, Takahiro Watakabe, Tadashi Matsumoto, Yudai Kai, Masato Maruyama and Natsuo Oya
    Citation: Radiation Oncology 2021 16:14
  45. Surface-guided radiation therapy can be used to continuously monitor a patient’s surface motions during radiotherapy by a non-irradiating, noninvasive optical surface imaging technique. In this study, machine ...

    Authors: Guangyu Wang, Zhibin Li, Guangjun Li, Guyu Dai, Qing Xiao, Long Bai, Yisong He, Yaxin Liu and Sen Bai
    Citation: Radiation Oncology 2021 16:13
  46. Whole brain radiotherapy (WBRT) can impair patients’ cognitive function. Hippocampal avoidance during WBRT can potentially prevent this side effect. However, manually delineating the target area is time-consum...

    Authors: Kaicheng Pan, Lei Zhao, Song Gu, Yi Tang, Jiahao Wang, Wen Yu, Lucheng Zhu, Qi Feng, Ruipeng Su, Zhiyong Xu, Xiadong Li, Zhongxiang Ding, Xiaolong Fu, Shenglin Ma, Jun Yan, Shigong Kang…
    Citation: Radiation Oncology 2021 16:12

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