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  1. Hypofractionation is increasingly being applied in radiotherapy for prostate cancer, requiring higher accuracy of daily treatment deliveries than in conventional image-guided radiotherapy (IGRT). Different ada...

    Authors: Miriam Eckl, Gustavo R. Sarria, Sandra Springer, Marvin Willam, Arne M. Ruder, Volker Steil, Michael Ehmann, Frederik Wenz and Jens Fleckenstein
    Citation: Radiation Oncology 2021 16:145
  2. To use cone-beam computed tomography (CBCT) imaging to determine the impacts of patient characteristics on the magnitude of geometric setup errors and obtain patient-specific planning target volume (PTV) margi...

    Authors: Jurui Luo, Zhihai Yin, Zhen Zhang, Xiaomao Guo, Xiaoli Yu and Juanqi Wang
    Citation: Radiation Oncology 2021 16:143
  3. Quality assurance (QA) of treatment plans in clinical trials improves protocol compliance and patient outcomes. Retrospective use of knowledge-based-planning (KBP) in clinical trials has demonstrated improved ...

    Authors: Nicholas Hardcastle, Olivia Cook, Xenia Ray, Alisha Moore, Kevin L. Moore, David Pryor, Alana Rossi, Farshad Foroudi, Tomas Kron and Shankar Siva
    Citation: Radiation Oncology 2021 16:142
  4. Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of majo...

    Authors: Minli Niu, Stephanie E. Combs, Annett Linge, Mechthild Krause, Michael Baumann, Fabian Lohaus, Nadja Ebert, Ingeborg Tinhofer, Volker Budach, Jens von der Grün, Franz Rödel, Anca-Ligia Grosu and Gabriele Multhoff
    Citation: Radiation Oncology 2021 16:141
  5. The risk for radiation necrosis is lower in fractionated stereotactic radiotherapy (SRT) than in conventional radiotherapy, and 13-fraction SRT is our method of choice for the treatment of brain metastases ≥ a...

    Authors: Megumi Uto, Kengo Ogura, Tomohiro Katagiri, Keiichi Takehana and Takashi Mizowaki
    Citation: Radiation Oncology 2021 16:140
  6. Mega-voltage fan-beam Computed Tomography (MV-FBCT) holds potential in accurate determination of relative electron density (RED) and proton stopping power ratio (SPR) but is not widely available.

    Authors: Hao Gong, Shengzhen Tao, Justin D. Gagneur, Wei Liu, Jiajian Shen, Cynthia H. McCollough, Yanle Hu and Shuai Leng
    Citation: Radiation Oncology 2021 16:139
  7. The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide ...

    Authors: Qing-Qing Xu, Yan-Zhen Lai, Zi-Lu Huang, Zi-Yi Zeng, Ya-Ni Zhang, Rui-Yao Ou, Wen-Min Wu, Lei Chen and Li-Xia Lu
    Citation: Radiation Oncology 2021 16:138
  8. Epidermal Growth Factor Receptor is often overexpressed in advanced prostate carcinoma. In-vitro-studies in prostate carcinoma cell line DU145 have demonstrated increased sensibility to radiation after cetuxim...

    Authors: Raik Schneider, Günther Gademann, Hans-Joachim Ochel, Karsten Neumann, Burkhard Jandrig, Peter Hass, Mathias Walke, Martin Schostak, Thomas Brunner and Frank Christoph
    Citation: Radiation Oncology 2021 16:137
  9. Online adaptive radiotherapy has the potential to reduce toxicity for patients treated for rectal cancer because smaller planning target volumes (PTV) margins around the entire clinical target volume (CTV) are...

    Authors: Rianne de Jong, Jorrit Visser, Niek van Wieringen, Jan Wiersma, Debby Geijsen and Arjan Bel
    Citation: Radiation Oncology 2021 16:136
  10. This study aimed to (1) develop a fully residual deep convolutional neural network (CNN)-based segmentation software for computed tomography image segmentation of the male pelvic region and (2) demonstrate its...

    Authors: Hideaki Hirashima, Mitsuhiro Nakamura, Pascal Baillehache, Yusuke Fujimoto, Shota Nakagawa, Yusuke Saruya, Tatsumasa Kabasawa and Takashi Mizowaki
    Citation: Radiation Oncology 2021 16:135
  11. Both patient-specific dose recalculation and γ passing rate analysis are important for the quality assurance (QA) of intensity modulated radiotherapy (IMRT) plans. The aim of this study was to analyse the corr...

    Authors: Zhengwen Shen, Xia Tan, Shi Li, Xiumei Tian, Huanli Luo, Ying Wang and Fu Jin
    Citation: Radiation Oncology 2021 16:134
  12. The aim of this study was to evaluate and compare the performance of intensity modulated radiation therapy (IMRT) plans, planned for low-field strength magnetic resonance (MR) guided linear accelerator (linac)...

    Authors: Vanessa Da Silva Mendes, Lukas Nierer, Minglun Li, Stefanie Corradini, Michael Reiner, Florian Kamp, Maximilian Niyazi, Christopher Kurz, Guillaume Landry and Claus Belka
    Citation: Radiation Oncology 2021 16:133
  13. Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a currently widely used strategy for locally advanced esophageal cancer (EC). However, the conventional imaging methods have certain deficiencies in ...

    Authors: Xin Xu, Zhi-Yong Sun, Hua-Wei Wu, Chen-Peng Zhang, Bin Hu, Ling Rong, Hai-Yan Chen, Hua-Ying Xie, Yu-Ming Wang, Hai-Ping Lin, Yong-Rui Bai, Qing Ye and Xiu-Mei Ma
    Citation: Radiation Oncology 2021 16:132
  14. Symptomatic radiation pneumonitis (RP) may be a serious complication after thoracic radiation therapy (RT) for non-small cell lung cancer (NSCLC). This prospective observational study sought to evaluate the ut...

    Authors: Weronika Maria Szejniuk, Martin Skovmos Nielsen, Zsuzsanna Takács-Szabó, Jacek Pawlowski, Sahar Sulaiman Al-Saadi, Panagiotis Maidas, Martin Bøgsted, Tine McCulloch, Jens Brøndum Frøkjær, Ursula Gerda Falkmer and Oluf Dimitri Røe
    Citation: Radiation Oncology 2021 16:131
  15. Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which...

    Authors: Szu Ching Khoo, Syed Nabil, Azizah Ahmad Fauzi, Siti Salmiah Mohd Yunus, Wei Cheong Ngeow and Roszalina Ramli
    Citation: Radiation Oncology 2021 16:130
  16. Pathological complete response (pathCR) in rectal cancer is beneficial, as up to 75% of patients do not experience regrowth of the primary tumour, but it is poorly understood. We hypothesised that the changes ...

    Authors: Joanne D. Stockton, Louise Tee, Celina Whalley, Jonathan James, Mark Dilworth, Rachel Wheat, Thomas Nieto, Ian Geh, João D. Barros-Silva and Andrew D. Beggs
    Citation: Radiation Oncology 2021 16:129
  17. To map anatomic patterns of para-aortic lymph node (PALN) recurrence in cervical cancer patients and validate currently available guidelines on PA clinical target volumes (CTV).

    Authors: Bong Kyung Bae, Shin-Hyung Park, Shin Young Jeong, Gun Oh Chong, Mi Young Kim and Jae-Chul Kim
    Citation: Radiation Oncology 2021 16:128
  18. We read with great interest the recent review, entitled “Current status and recent advances in resection cavity irradiation of brain metastases”. It is a comprehensive summary of currently available techniques...

    Authors: Gustavo R. Sarria, Christopher P. Cifarelli, Henning Kahl and Frank A. Giordano
    Citation: Radiation Oncology 2021 16:127

    The original article was published in Radiation Oncology 2021 16:73

  19. Historically, IBD has been thought to increase the underlying risk of radiation related toxicity in the treatment of prostate cancer. In the modern era, contemporary radiation planning and delivery may mitigat...

    Authors: Jonathan W. Lischalk, Seth Blacksburg, Christopher Mendez, Michael Repka, Astrid Sanchez, Todd Carpenter, Matthew Witten, Jules E. Garbus, Andrew Evans, Sean P. Collins, Aaron Katz and Jonathan Haas
    Citation: Radiation Oncology 2021 16:126
  20. The aim of this work was to investigate the outcome of metastasis-directed radiotherapy (MDT) in prostate cancer patients with bone metastases following current ESTRO/EORTC subclassifications for oligometastat...

    Authors: Paul Rogowski, Christian Trapp, Rieke von Bestenbostel, Nina-Sophie Schmidt-Hegemann, Run Shi, Harun Ilhan, Alexander Kretschmer, Christian Stief, Ute Ganswindt, Claus Belka and Minglun Li
    Citation: Radiation Oncology 2021 16:125
  21. Any Monte Carlo simulation of dose delivery using medical accelerator-generated megavolt photon beams begins by simulating electrons of the primary electron beam interacting with a target. Because the electron...

    Authors: Zbisław Tabor, Damian Kabat and Michael P. R. Waligórski
    Citation: Radiation Oncology 2021 16:124

    The Correction to this article has been published in Radiation Oncology 2022 17:44

  22. Adjuvant hysterectomy following chemoradiation for bulky, early stage cervical cancer has been shown to decrease local relapse rate. The objective of this study is to compare complications and recurrences betw...

    Authors: Heather Miller, Koji Matsuo, Lynda D. Roman, Annie A. Yessaian, Huyen Q. Pham, Marianne Hom, Antonio Castaneda, Anthony Pham, Omar Ragab, Laila Muderspach, Marcia Ciccone and Laurie L. Brunette
    Citation: Radiation Oncology 2021 16:123

    The Correction to this article has been published in Radiation Oncology 2021 16:162

  23. We evaluated the efficiency and toxicity of stereotactic hypofractionated boost in combination with conventionally fractionated radiotherapy in the treatment of advanced floor of the mouth cancer.

    Authors: Tomáš Blažek, Zuzana Zděblová Čermáková, Lukáš Knybel, Pavel Hurník, Jan Štembírek, Kamila Resová, Tereza Paračková, Martin Formánek, Jakub Cvek and Renata Soumarová
    Citation: Radiation Oncology 2021 16:122
  24. Screening and management of venous thromboembolism (VTE) after surgery is important in preventing sublethal VTE. However, the risk factors for VTE during interstitial brachytherapy (ISBT) remain unknown, and a...

    Authors: Keiko Nemoto Murofushi, Tetsuya Tomita, Kayoko Ohnishi, Kei Nakai, Azusa Akiyama, Tsukasa Saida, Toshiyuki Okumura, Katsuyuki Karasawa, Toyomi Satoh and Hideyuki Sakurai
    Citation: Radiation Oncology 2021 16:121
  25. To establish regression models of physical and equivalent dose in 2 Gy per fraction (EQD2) plan parameters of two kinds of hybrid planning for stage III NSCLC.

    Authors: Hao Wang, Yongkang Zhou, Wutian Gan, Hua Chen, Ying Huang, Yanhua Duan, Aihui Feng, Yan Shao, Hengle Gu, Qing Kong and Zhiyong Xu
    Citation: Radiation Oncology 2021 16:119
  26. Cranial nerve (CN) palsy due to cancer involvement has been considered as an unfavorable prognostic factor for patients with nasopharyngeal carcinoma (NPC). We assessed the role of IMRT based treatment on the ...

    Authors: Jian Zang, Yan Li, Shanquan Luo, Jianhua Wang, Bingxin Hou, Min Yao, Lina Zhao and Mei Shi
    Citation: Radiation Oncology 2021 16:118
  27. The purpose of this study is to comprehensively evaluate the suitability of Gafchromic EBT3 and EBT-XD film for dosimetric quality assurance in 0.35 T MR-guided radiotherapy.

    Authors: Ilma Xhaferllari, Joshua P. Kim, Ruchira Liyanage, Chang Liu, Dongsu Du, Anthony Doemer, Indrin J. Chetty and Ning Wen
    Citation: Radiation Oncology 2021 16:117
  28. Atypical meningiomas exhibit a high tendency for tumor recurrence even after multimodal therapy. Information regarding recurrence patterns after additive radiotherapy is scarce but could improve radiotherapy p...

    Authors: Elgin Hoffmann, Kerstin Clasen, Bettina Frey, Jakob Ehlers, Felix Behling, Marco Skardelly, Benjamin Bender, Jens Schittenhelm, Matthias Reimold, Ghazaleh Tabatabai, Daniel Zips, Franziska Eckert and Frank Paulsen
    Citation: Radiation Oncology 2021 16:116
  29. 125I seed implantation has been found to show good therapeutic effects on tumors. Recent studies showed that three-dimensional (3D) print template-assisted 125I seed implantation can optimize radiation dose distr...

    Authors: Enli Chen, Yuwei Zhang, Hongtao Zhang, Chenfei Jia, Yansong Liang and Juan Wang
    Citation: Radiation Oncology 2021 16:115
  30. Advances in imaging, biomaterials and precision radiotherapy provide new opportunities to salvage locally recurrent prostate cancer (PC). This study evaluates the efficacy and safety of re-irradiation using st...

    Authors: Ron Lewin, Uri Amit, Menachem Laufer, Raanan Berger, Zohar Dotan, Liran Domachevsky, Tima Davidson, Orith Portnoy, Lev Tsvang, Maoz Ben-Ayun, Ilana Weiss and Zvi Symon
    Citation: Radiation Oncology 2021 16:114
  31. The hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and the location relative to the glioblastoma.

    Authors: Clara Le Fèvre, Xue Cheng, Marie-Pierre Loit, Audrey Keller, Hélène Cebula, Delphine Antoni, Alicia Thiery, Jean-Marc Constans, François Proust and Georges Noel
    Citation: Radiation Oncology 2021 16:112
  32. Daily anatomical deviations may distort the dose distribution in carbon ion radiotherapy (CIRT), which may cause treatment failure. Therefore, this study aimed to perform re-planning to maintain the dose cover...

    Authors: Yang Li, Yoshiki Kubota, Masahiko Okamoto, Shintaro Shiba, Shohei Okazaki, Toshiaki Matsui, Mutsumi Tashiro, Takashi Nakano and Tatsuya Ohno
    Citation: Radiation Oncology 2021 16:111
  33. To investigate the potential role of a novel spatially fractionated radiation therapy (SFRT) method where heterogeneous dose patterns are created in target areas with virtual rods, straight or curving, of vari...

    Authors: Luca Cozzi, Sushil Beriwal, Esa Kuusela, Supriya Chopra, Hester Burger, Nanette Joubert, Antonella Fogliata, Jai Prakash Agarwal and Pat Kupelian
    Citation: Radiation Oncology 2021 16:110
  34. The present study aimed to propose a new foetal shielding device for pregnant cancer patients to reduce the foetal dose associated with treatment techniques using multiple gantry angles, such as intensity-modu...

    Authors: Seonghee Kang, Kyeong-Hyeon Kim, Sang-Won Kang, Dong-Seok Shin, Seungwan Lee and Jin-Beom Chung
    Citation: Radiation Oncology 2021 16:109
  35. The purpose of this study is to develop a clinical application program that automatically calculates the effect for secondary cancer risk (SCR) of individual patient. The program was designed based on accurate...

    Authors: Dong-Jin Kang, Young-Joo Shin, Seonghoon Jeong, Jae-Yong Jung, Hakjae Lee and Boram Lee
    Citation: Radiation Oncology 2021 16:108
  36. The efficacy of a hydrogel spacer in stereotactic body radiotherapy (SBRT) has not been clarified. We evaluated the safety and efficacy of SBRT in combination with a hydrogel spacer for prostate cancer.

    Authors: Mami Ogita, Hideomi Yamashita, Yuki Nozawa, Sho Ozaki, Subaru Sawayanagi, Takeshi Ohta and Keiichi Nakagawa
    Citation: Radiation Oncology 2021 16:107
  37. The purpose of this study is to evaluate inter- and intra-fraction organ motion as well as to quantify clinical target volume (CTV) to planning target volume (PTV) margins to be adopted in the stereotactic tre...

    Authors: Annarita Perillo, Valeria Landoni, Alessia Farneti and Giuseppe Sanguineti
    Citation: Radiation Oncology 2021 16:106
  38. To examine treatment patterns, oncological outcomes and toxicity rates in elderly patients receiving radiotherapy for cutaneous squamous cell carcinoma (cSCC) of the head-and-neck region.

    Authors: Erik Haehl, Alexander Rühle, Rabea Klink, Tobias Kalckreuth, Tanja Sprave, Eleni Gkika, Constantinos Zamboglou, Frank Meiß, Anca-Ligia Grosu and Nils H. Nicolay
    Citation: Radiation Oncology 2021 16:105
  39. The recent implementation of MR-Linacs has highlighted theranostic opportunities of contrast agents in both imaging and radiotherapy. There is a lack of data exploring the potential of superparamagnetic iron o...

    Authors: Emily Russell, Victoria Dunne, Ben Russell, Hibaaq Mohamud, Mihaela Ghita, Stephen J. McMahon, Karl T. Butterworth, Giuseppe Schettino, Conor K. McGarry and Kevin M. Prise
    Citation: Radiation Oncology 2021 16:104
  40. The main objective of this study was to evaluate the cumulative incidence of cause-specific mortality and other causes of mortality for patients with olfactory neuroblastoma (ONB). The secondary aim was to mod...

    Authors: Lipin Liu, Qiuzi Zhong, Ting Zhao, Dazhi Chen, Yonggang Xu and Gaofeng Li
    Citation: Radiation Oncology 2021 16:103
  41. To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring ...

    Authors: Xiao Chang, Wei Deng, Xin Wang, Zongmei Zhou, Jun Yang, Wenling Guo, Miaoling Liu, Xiaolu Qi, Ling Li, Kaixian Zhang, Min Zhang, Yonggang Shi, Ke Liu, Yidian Zhao, Huitao Wang, Zhilong Yu…
    Citation: Radiation Oncology 2021 16:102
  42. We recently described the validation of deep learning-based auto-segmented contour (DC) models for organs at risk (OAR) and clinical target volumes (CTV). In this study, we evaluate the performance of implemen...

    Authors: Jordan Wong, Vicky Huang, Derek Wells, Joshua Giambattista, Jonathan Giambattista, Carter Kolbeck, Karl Otto, Elantholi P. Saibishkumar and Abraham Alexander
    Citation: Radiation Oncology 2021 16:101
  43. Local recurrence (LR) is clinical challenge in the treatment of esophageal squamous cell carcinoma (ESCC). The current study aimed to determine the optimal re-irradiation dose for local recurrent esophageal sq...

    Authors: Xun Wu, Xingsheng Hu, Junru Chen and Lang He
    Citation: Radiation Oncology 2021 16:100
  44. Centrally located lung tumors present treatment challenges given their proximity to mediastinal structures including the central airway, esophagus, major vessels, and heart. Therapeutic options can be limited ...

    Authors: Stephanie M. Yoon, Robert Suh, Fereidoun Abtin, Drew Moghanaki, Scott Genshaft, Mitchell Kamrava, Alexandra Drakaki, Sandy Liu, Puja Venkat, Alan Lee and Albert J. Chang
    Citation: Radiation Oncology 2021 16:99
  45. Brachial plexopathy is a potentially serious complication from stereotactic body radiation therapy (SBRT) that has not been widely studied. Therefore, we compared datasets from two different institutions and g...

    Authors: Irina Kapitanova, Sharmi Biswas, Sabrina Divekar, Eric J. Kemmerer, Robert A. Rostock, Kenneth M. Forster, Rachel J. Grimm, Carla J. Scofield, Jimm Grimm, Bahman Emami and Anand Mahadevan
    Citation: Radiation Oncology 2021 16:98
  46. In this study, we performed a consecutive macropathologic analysis to assess microscopic extension (ME) in high-grade glioma (HGG) to determine appropriate clinical target volume (CTV) margins for radiotherapy.

    Authors: Shulun Nie, Yufang Zhu, Jia Yang, Tao Xin, Song Xue, Xianbin Zhang, Jujie Sun, Dianbin Mu, Yongsheng Gao, Zhaoqiu Chen, Xingchen Ding, Jinming Yu and Man Hu
    Citation: Radiation Oncology 2021 16:97
  47. We investigated the geometric and dosimetric impact of three-dimensional (3D) generative adversarial network (GAN)-based metal artifact reduction (MAR) algorithms on volumetric-modulated arc therapy (VMAT) and...

    Authors: Mitsuhiro Nakamura, Megumi Nakao, Keiho Imanishi, Hideaki Hirashima and Yusuke Tsuruta
    Citation: Radiation Oncology 2021 16:96

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