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  1. Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deox...

    Authors: Malene Martini Clausen, Anders Elias Hansen, Michael Lundemann, Christian Hollensen, Tobias Pommer, Per Munck af Rosenschöld, Annemarie Thuri Kristensen, Andreas Kjær, Fintan J McEvoy and Svend Aage Engelholm
    Citation: Radiation Oncology 2014 9:228
  2. To evaluate patient selection criteria, methodology, safety and clinical outcomes of stereotactic body radiotherapy (SBRT) for treatment of vertebral metastases.

    Authors: Matthias Guckenberger, Frederick Mantel, Peter C Gerszten, John C Flickinger, Arjun Sahgal, Daniel Létourneau, Inga S Grills, Maha Jawad, Daniel K Fahim, John H Shin, Brian Winey, Jason Sheehan and Ron Kersh
    Citation: Radiation Oncology 2014 9:226
  3. To compare the dosimetric differences among fixed field intensity-modulated radiation therapy (IMRT), single-arc volumetric-modulated arc therapy (SA-VMAT) and double-arc volumetric-modulated arc therapy (DA-V...

    Authors: Jun Shang, Wei Kong, Yan-yang Wang, Zhe Ding, Gang Yan and Hong Zhe
    Citation: Radiation Oncology 2014 9:219
  4. Yomo and Hayashi reported results of stereotactic radiosurgery alone for brainmetastases from small cell lung cancer. This strategy aims to avoid theneurocognitive effects of whole-brain radiation therapy. How...

    Authors: Eric Ojerholm, Michelle Alonso-Basanta and Charles B Simone II
    Citation: Radiation Oncology 2014 9:218
  5. To evaluate efficacy and toxicity of hypofractionated intensity-modulated simultaneous integrated boost (IMRT-SIB) and image-guided (IGRT) radiotherapy in the treatment of high-risk prostate cancer patients.

    Authors: Maurizio Valeriani, Alessia Carnevale, Mattia Falchetto Osti, Vitaliana DE Sanctis, Linda Agolli and Riccardo Maurizi Enrici
    Citation: Radiation Oncology 2014 9:214
  6. Gated Volumetric Modulated Arc Therapy (VMAT) is an emerging radiation therapy modality for treatment of tumors affected by respiratory motion. However, gating significantly prolongs the treatment time, as del...

    Authors: Benjamin Fahimian, Junqing Wu, Huanmei Wu, Sarah Geneser and Lei Xing
    Citation: Radiation Oncology 2014 9:209
  7. To retrospectively review the efficacy and organ preservation experience for muscle-invasive bladder cancer by trimodality therapy at our institution.

    Authors: Cheng-Yen Lee, Kai-Lin Yang, Hui-Ling Ko, Rong-Yau Huang, Pei-Pin Tsai, Ming-Tsun Chen, Yi-Chia Lin, Thomas I-Sheng Hwang, Guang-Dar Juang and Kwan-Hwa Chi
    Citation: Radiation Oncology 2014 9:213
  8. The role of prophylactic cranial irradiation (PCI) on small cell lung cancer (SCLC) has been established based on the two-stage system of limited versus extensive disease and the treatment modality of chemorad...

    Authors: Hui Zhu, Yongmin Bi, Anqin Han, Jingyu Luo, Minghuan Li, Fang Shi, Li Kong and Jinming Yu
    Citation: Radiation Oncology 2014 9:216
  9. Addition of whole-brain irradiation (WBI) to radiosurgery for treatment of few cerebral metastases is controversial. This study aimed to create an instrument that estimates the probability of developing new ce...

    Authors: Stefan Huttenlocher, Liesa Dziggel, Dagmar Hornung, Oliver Blanck, Steven E Schild and Dirk Rades
    Citation: Radiation Oncology 2014 9:215
  10. Lung cancer continues to be one of the most prevalent malignancies worldwide and is the leading cause of death in both men and women. Presently, local control rates are quite poor. Improvements in imaging and ...

    Authors: Arya Amini, Norman Yeh, Laurie E Gaspar, Brian Kavanagh and Sana D Karam
    Citation: Radiation Oncology 2014 9:210
  11. The transcription factor hypoxia-inducible factor-1 (HIF-1) pathway plays an important role in tumor response to cytotoxic treatments. We investigated the effects of a novel small molecule inhibitor of mitocho...

    Authors: Linda Helbig, Lydia Koi, Kerstin Brüchner, Kristin Gurtner, Holger Hess-Stumpp, Kerstin Unterschemmann, Michael Baumann, Daniel Zips and Ala Yaromina
    Citation: Radiation Oncology 2014 9:207
  12. Radiation induced bystander effects are an important component of the overall response of cells to irradiation and are associated with human health risks. The mechanism responsible includes intra-cellular and ...

    Authors: Shanaz A Ghandhi, Brian Ponnaiya, Sunil K Panigrahi, Kevin M Hopkins, Qingping Cui, Tom K Hei, Sally A Amundson and Howard B Lieberman
    Citation: Radiation Oncology 2014 9:206
  13. Novel irradiation techniques are continuously introduced in radiotherapy to optimize the accuracy, the security and the clinical outcome of treatments. These changes could raise the question of discontinuity i...

    Authors: Abdulhamid Chaikh, Jean-Yves Giraud, Emmanuel Perrin, Jean-Pierre Bresciani and Jacques Balosso
    Citation: Radiation Oncology 2014 9:205
  14. To compare conventional lateral photon-electron, fixed-beam intensity modulated radiation therapy (IMRT), coplanar and non-coplanar RapidArc for the treatment of a diffuse sebaceous gland carcinoma of the scalp.

    Authors: Jiang Hu, WeiWei Xiao, ZhiChun He, DeHua Kang, ALong Chen and ZhenYu Qi
    Citation: Radiation Oncology 2014 9:204
  15. There are already numerous reports about high local control rates in patients with craniopharyngioma but there are only few studies with follow up times of more than 10 years. This study is an analysis of long...

    Authors: Semi B Harrabi, Sebastian Adeberg, Thomas Welzel, Stefan Rieken, Daniel Habermehl, Jürgen Debus and Stephanie E Combs
    Citation: Radiation Oncology 2014 9:203
  16. Intensity modulated proton therapy (IMPT) plans are normally generated utilizing multiple field optimization (MFO) techniques. Similar to photon based IMRT, MFO allows for the utilization of a simultaneous int...

    Authors: Xiaorong Ronald Zhu, Falk Poenisch, Heng Li, Xiaodong Zhang, Narayan Sahoo, Richard Y Wu, Xiaoqiang Li, Andrew K Lee, Eric L Chang, Seungtaek Choi, Thomas Pugh, Steven J Frank, Michael T Gillin, Anita Mahajan and David R Grosshans
    Citation: Radiation Oncology 2014 9:202
  17. Standard treatment strategies for embryonal central nervous system (CNS) tumors have not yet been established. We treated these tumors using an original chemoradiation therapy protocol; the clinical outcomes a...

    Authors: Kazumasa Odagiri, Motoko Omura, Masaharu Hata, Noriko Aida, Tetsu Niwa, Hiroaki Goto, Susumu Ito, Masanori Adachi, Haruyasu Yoshida, Hiroko Yuki and Tomio Inoue
    Citation: Radiation Oncology 2014 9:201
  18. Prostate volume can affect whether patients qualify for brachytherapy (desired size ≥20 mL and ≤60 mL) and/or active surveillance (desired PSA density ≤0.15 for very low risk disease). This study examines vari...

    Authors: Yonina R Murciano-Goroff, Luciant D Wolfsberger, Arti Parekh, Fiona M Fennessy, Kemal Tuncali, Peter F Orio III, Thomas R Niedermayr, W Warren Suh, Phillip M Devlin, Clare Mary C Tempany, Emily H Neubauer Sugar, Desmond A O’Farrell, Graeme Steele, Michael O’Leary, Ivan Buzurovic, Antonio L Damato…
    Citation: Radiation Oncology 2014 9:200
  19. To evaluate feasibility and outcome of our institutional SIB-IMRT schedule in patients with anal cancer and to selectively review the literature on different SIB-IMRT schedules.

    Authors: Stefan Janssen, Christoph Glanzmann, Peter Bauerfeind, Sonja Stieb, Gabriela Studer, Michelle Brown and Oliver Riesterer
    Citation: Radiation Oncology 2014 9:199
  20. An observational multi-institutional study has been conducted aimed to evaluate the inter-observer variability in clinical target volume (CTV) delineation among different radiation oncologists in radiotherapy ...

    Authors: Luciana Caravatta, Gabriella Macchia, Gian Carlo Mattiucci, Aldo Sainato, Nunzia LV Cernusco, Giovanna Mantello, Monica Di Tommaso, Marianna Trignani, Antonino De Paoli, Gianni Boz, Maria L Friso, Vincenzo Fusco, Marta Di Nicola, Alessio G Morganti and Domenico Genovesi
    Citation: Radiation Oncology 2014 9:198
  21. In this study, dosimetric aspects of TSEI consisting of a 4 MeV beam with no spoiler were investigated in comparison to a nominal 6 MeV beam with spoiler, and the potential for clinical applications was evalua...

    Authors: So-Yeon Park, Beom Seok Ahn, Jong Min Park, Sung-Joon Ye, Il han Kim and Jung-in Kim
    Citation: Radiation Oncology 2014 9:197
  22. To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned.

    Authors: Joep Stroom, Sandra Vieira, Dalila Mateus, Carlo Greco, Antonella Fogliata, Giorgia Nicolini, Alessandro Clivio, Eugenio Vanetti and Luca Cozzi
    Citation: Radiation Oncology 2014 9:196
  23. Since lymph nodes volumes are generally four times the volume of the primary PTV, the advantage of using tight margins around the primary PTV is not clear. Therefore treatment margins of T2-T4 laryngeal carcin...

    Authors: Cornelia AJM Vugts, Chris HJ Terhaard, Marielle EP Philippens, Frank A Pameijer, Nicolien Kasperts and Cornelis PJ Raaijmakers
    Citation: Radiation Oncology 2014 9:195
  24. The aim of this retrospective study was to evaluate the stability of spinal metastases in gynecologic cancer patients (pts) on the basis of a validated scoring system after radiotherapy (RT), to define prognos...

    Authors: Robert Foerster, Daniel Habermehl, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Thomas Welzel, Juergen Debus and Harald Rief
    Citation: Radiation Oncology 2014 9:194
  25. To compare dosimetric parameters of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer with regard to the coverage of p...

    Authors: Yuri Jeong, Sang-wook Lee, Jungwon Kwak, Ilsung Cho, Sang Min Yoon, Jong Hoon Kim, Jin-hong Park, Eun Kyung Choi, Si Yeol Song, Young Seok Kim, Su Ssan Kim, Ji Hyeon Joo and Seung Do Ahn
    Citation: Radiation Oncology 2014 9:193
  26. To report our experience with increased dose intensity-modulated radiation and concurrent systemic chemotherapy as definitive treatment of locally advanced esophageal cancer.

    Authors: Falk Roeder, Nils H Nicolay, Tam Nguyen, Ladan Saleh-Ebrahimi, Vasilis Askoxylakis, Tilman Bostel, Felix Zwicker, Juergen Debus, Carmen Timke and Peter E Huber
    Citation: Radiation Oncology 2014 9:191
  27. Stage III unresectable non-small cell lung cancer (NSCLC) is preferably treated with concurrent schedules of chemoradiotherapy, but none is clearly superior Gemcitabine is a radiosensitizing cytotoxic drug tha...

    Authors: Gerald SMA Kerner, Leon FA van Dullemen, Erwin M Wiegman, Joachim Widder, Edwin Blokzijl, Ellen M Driever, John WG van Putten, Jeroen JW Liesker, Tineke EJ Renkema, Remge M Pieterman, Marc JF Mertens, Thijo JN Hiltermann and Harry JM Groen
    Citation: Radiation Oncology 2014 9:190
  28. To evaluate the feasibility and educational value of high-fidelity, interprofessional team-based simulation in radiation oncology.

    Authors: Meredith Giuliani, Caitlin Gillan, Olive Wong, Nicole Harnett, Emily Milne, Doug Moseley, Robert Thompson, Pamela Catton and Jean-Pierre Bissonnette
    Citation: Radiation Oncology 2014 9:189
  29. Neoadjuvant chemoradiotherapy (nCRT) combined with surgery has been implemented as a standard treatment strategy in locally advanced rectal cancer (LARC). However, there is a wide spectrum of response to nCRT....

    Authors: Xiangjiao Meng, Zhaoqin Huang, Renben Wang, Yuhong Jiao, Huijuan Li, Xiaoqing Xu, Rui Feng, Kunli Zhu, Shumei Jiang, Hongjiang Yan and Jinming Yu
    Citation: Radiation Oncology 2014 9:188
  30. Locoregional tumor failure (LRF) after definitive chemoradiation for patients with stage III NSCLC remains unacceptably high. This analysis sought to further define where LRF occurs relative to radiation dose ...

    Authors: Raj S Rajpara, Eduard Schreibmann, Tim Fox, Liza J Stapleford, Jonathan J Beitler, Walter J Curran and Kristin A Higgins
    Citation: Radiation Oncology 2014 9:187
  31. There is a trend towards hypofractionated stereotactic radiotherapy (RT) in prostate cancer to apply high single doses in a few fractions. Using the Cyberknife® robotic system multiple non-coplanar fields are ...

    Authors: Marcin Sumila, Andreas Mack, Uwe Schneider, Fabrizio Storelli, Jürgen Curschmann and Günther Gruber
    Citation: Radiation Oncology 2014 9:186
  32. The principal aim of this study was to evaluate the feasibility of incorporating four-dimensional (4D)-computed tomography (CT)-based functional information into treatment planning and to evaluate the potentia...

    Authors: Ruihao Wang, Shuxu Zhang, Hui Yu, Shengqu Lin, Guoqian Zhang, Rijie Tang and Bin Qi
    Citation: Radiation Oncology 2014 9:184
  33. A study was undertaken to analyze the efficacy and feasibility of particle beam radiation therapy (PBRT) using carbon ions and protons for the treatment of patients with oligometastatic lung tumors.

    Authors: Nor Shazrina Sulaiman, Osamu Fujii, Yusuke Demizu, Kazuki Terashima, Yasue Niwa, Takashi Akagi, Takashi Daimon, Masao Murakami, Ryohei Sasaki and Nobukazu Fuwa
    Citation: Radiation Oncology 2014 9:183
  34. To determine the optimal threshold of 18 F-fluorodexyglucose (18 F-FDG) positron emission tomography CT (PET/CT) images that generates the best volumetric match to internal gross target volume (IGTV) based on fou...

    Authors: Yi-Li Duan, Jian-Bin Li, Ying-Jie Zhang, Wei Wang, Feng-Xiang Li, Xiao-Rong Sun, Yan-Luan Guo and Dong-Ping Shang
    Citation: Radiation Oncology 2014 9:182
  35. The eradication of large, established tumors by active immunotherapy is a major challenge because of the numerous cancer evasion mechanisms that exist. This study aimed to establish a novel combination therapy...

    Authors: Mariola Fotin-Mleczek, Kai Zanzinger, Regina Heidenreich, Christina Lorenz, Aleksandra Kowalczyk, Karl-Josef Kallen and Stephan M Huber
    Citation: Radiation Oncology 2014 9:180
  36. This research paper presents a valid treatment strategy for recurrent glioblastoma multiforme (GBM) using hypofractionated stereotactic radiotherapy by intensity modulated radiation therapy (HS-IMRT) planned w...

    Authors: Kazuhiro Miwa, Masayuki Matsuo, Shin-ichi Ogawa, Jun Shinoda, Kazutoshi Yokoyama, Jitsuhiro Yamada, Hirohito Yano and Toru Iwama
    Citation: Radiation Oncology 2014 9:181
  37. B cell translocation gene 1 (BTG1) has long been recognized as a tumor suppressor gene. Recent reports demonstrated that BTG1 plays an important role in progression of cell cycle and is involved in cellular respo...

    Authors: Xin Wu, Nan Ding, Wentao Hu, Jinpeng He, Shuai Xu, Hailong Pei, Junrui Hua, Guangming Zhou and Jufang Wang
    Citation: Radiation Oncology 2014 9:179
  38. In a previous study we demonstrated that, based on 11C/18 F-choline positron emission tomography-computerized-tomography as a diagnostic tool, salvage lymph node dissection (LND) plus adjuvant radiotherapy (ART) ...

    Authors: Cordula A Jilg, Anja Leifert, Daniel Schnell, Simon Kirste, Natalia Volegova-Neher, Daniel Schlager, Gesche Wieser, Karl Henne, Wolfgang Schultze-Seemann, Anca-L Grosu and Hans Christian Rischke
    Citation: Radiation Oncology 2014 9:178
  39. The aim of the present analysis was to assess the feasibility, toxicity, and the tumor control of reirradiation as a salvage treatment for progressive pediatric non-pontine high-grade gliomas (HGG).

    Authors: Klaus Müller, Heike Scheithauer, Sophie Pietschmann, Marion Hoffmann, Jochen Rössler, Norbert Graf, Brigitta G Baumert, Hans Christiansen, Rolf-Dieter Kortmann, Christof M Kramm and André O von Bueren
    Citation: Radiation Oncology 2014 9:177
  40. To analyse the frequency of re-planning and its variability dependent on the IGRT correction strategy and on the modification of the dosimetric criteria for re-planning for the spinal cord in head and neck IG-...

    Authors: Markus Stoll, Kristina Giske, Jürgen Debus, Rolf Bendl and Eva Maria Stoiber
    Citation: Radiation Oncology 2014 9:175
  41. The accurate definition of organs at risk (OARs) is required to fully exploit the benefits of intensity-modulated radiotherapy (IMRT) for head and neck cancer. However, manual delineation is time-consuming and...

    Authors: David Thomson, Chris Boylan, Tom Liptrot, Adam Aitkenhead, Lip Lee, Beng Yap, Andrew Sykes, Carl Rowbottom and Nicholas Slevin
    Citation: Radiation Oncology 2014 9:173
  42. The rate of radiation pneumonitis (RP) for patients receiving chemoradiotherapy has been various across studies. Whether it is related to different chemotherapy schedules used in combination with radiation the...

    Authors: Jun Dang, Guang Li, Shuang Zang, Shuo Zhang and Lei Yao
    Citation: Radiation Oncology 2014 9:172
  43. Prostate-specific antigen (PSA) nadir + 2 ng/mL, also known as the Phoenix definition, is the definition most commonly used to establish biochemical failure (BF) after external beam radiotherapy for prostate canc...

    Authors: Kamran A Ahmed, Brian J Davis, Lance A Mynderse, Jeffrey M Slezak, Eric J Bergstralh, Torrence M Wilson and C Richard Choo
    Citation: Radiation Oncology 2014 9:171
  44. To report the dosimetric results and impact of volumetric arc therapy (VMAT) on temporary alopecia and hair-loss related quality of life (QOL) in whole brain radiotherapy (WBRT).

    Authors: Annemieke De Puysseleyr, Joris Van De Velde, Bruno Speleers, Tom Vercauteren, Anneleen Goedgebeur, Tom Van Hoof, Tom Boterberg, Wilfried De Neve, Carlos De Wagter and Piet Ost
    Citation: Radiation Oncology 2014 9:170
  45. To explore the effects of computed tomography (CT) image characteristics and B-spline knot spacing (BKS) on the spatial accuracy of a B-spline deformable image registration (DIR) in the head-and-neck geometry.

    Authors: Charlotte L Brouwer, Roel GJ Kierkels, Aart A van ’t Veld, Nanna M Sijtsema and Harm Meertens
    Citation: Radiation Oncology 2014 9:169

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