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  1. Parameter optimization in the process of inverse treatment planning for intensity modulated radiation therapy (IMRT) is mainly conducted by human planners in order to create a plan with the desired dose distri...

    Authors: Florian Stieler, Hui Yan, Frank Lohr, Frederik Wenz and Fang-Fang Yin

    Citation: Radiation Oncology 2009 4:39

    Content type: Research

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  2. The purpose of this study was to determine the dosimetric effect of on-line position correction for bladder tumor irradiation and to find methods to predict and handle this effect.

    Authors: Dominique C van Rooijen, Jeroen B van de Kamer, René Pool, Maarten CCM Hulshof, Caro CE Koning and Arjan Bel

    Citation: Radiation Oncology 2009 4:38

    Content type: Research

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  3. While IMRT is widely used in treating complex oncological cases in adults, it is not commonly used in pediatric radiation oncology for a variety of reasons. This report evaluates our 9 year experience using st...

    Authors: Florian Sterzing, Eva M Stoiber, Simeon Nill, Harald Bauer, Peter Huber, Jürgen Debus and Marc W Münter

    Citation: Radiation Oncology 2009 4:37

    Content type: Methodology

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  4. The aim of the study was to evaluate self-assessed bowel toxicity after radiotherapy (RT) for prostate cancer. In contrast to rectal bleeding, information concerning irritative symptoms (rectal urgency, pain) ...

    Authors: Michael Pinkawa, Marc D Piroth, Karin Fischedick, Sandra Nussen, Jens Klotz, Richard Holy and Michael J Eble

    Citation: Radiation Oncology 2009 4:36

    Content type: Research

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  5. When combined with adequate tumoricidal doses, accurate target volume delineation remains to be the one of the most important predictive factors for radiotherapy (RT) success in locally advanced or medically i...

    Authors: Berrin Pehlivan, Erkan Topkan, Cem Onal, Gul Nihal Nursal, Oznur Yuksel, Yemliha Dolek, Melek Nur Yavuz and Ali Aydin Yavuz

    Citation: Radiation Oncology 2009 4:35

    Content type: Research

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  6. A study was performed comparing volumetric modulated arcs (RA) and intensity modulation (with photons, IMRT, or protons, IMPT) radiation therapy (RT) for patients with recurrent prostate cancer after RT.

    Authors: Damien C Weber, Hui Wang, Luca Cozzi, Giovanna Dipasquale, Haleem G Khan, Osman Ratib, Michel Rouzaud, Hansjoerg Vees, Habib Zaidi and Raymond Miralbell

    Citation: Radiation Oncology 2009 4:34

    Content type: Research

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  7. In head and neck cancer, bilateral neck irradiation is the standard approach for many tumor locations and stages. Increasing knowledge on the pattern of nodal invasion leads to more precise targeting and norma...

    Authors: Laura Cerezo, Margarita Martín, Mario López, Alicia Marín and Alberto Gómez

    Citation: Radiation Oncology 2009 4:33

    Content type: Research

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  8. To retrospectively evaluate the results after a regimen of surgery, IORT (intraoperative radiotherapy), and EBRT (external beam radiotherapy) for soft-tissue sarcomas

    Authors: Marcus Niewald, Jochen Fleckenstein, Norbert Licht, Caroline Bleuzen and Christian Ruebe

    Citation: Radiation Oncology 2009 4:32

    Content type: Research

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  9. The DNA double-strand break (DSB) is the primary lethal lesion after therapeutic radiation. Thus, the development of assays to detect and to quantitate these lesions could have broad preclinical and clinical i...

    Authors: Dane Avondoglio, Tamalee Scott, Whoon Jong Kil, Mary Sproull, Philip J Tofilon and Kevin Camphausen

    Citation: Radiation Oncology 2009 4:31

    Content type: Research

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  10. Oxygen molecule modulates tumour response to radiotherapy. Higher radiation doses are required under hypoxic conditions to induce cell death. Hypoxia may inhibit the non-homologous end-joining DNA repair throu...

    Authors: Pedro C Lara, Marta Lloret, Bernardino Clavo, Rosa M Apolinario, Luis Alberto Henríquez-Hernández, Elisa Bordón, Fausto Fontes and Agustín Rey

    Citation: Radiation Oncology 2009 4:29

    Content type: Short report

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  11. Conformal external radiotherapy aims to improve tumor control by boosting tumor dose, reducing morbidity and sparing healthy tissues. To meet this objective careful visualization of the tumor and adjacent area...

    Authors: Chiang J Tyng, Rubens Chojniak, Paula NV Pinto, Marcelle A Borba, Almir GV Bitencourt, Ricardo C Fogaroli, Douglas G Castro and Paulo E Novaes

    Citation: Radiation Oncology 2009 4:28

    Content type: Research

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  12. A study was performed comparing dosimetric characteristics of volumetric modulated arcs (RapidArc, RA) and fixed field intensity modulated therapy (IMRT) on patients with bilateral breast carcinoma.

    Authors: Giorgia Nicolini, Alessandro Clivio, Antonella Fogliata, Eugenio Vanetti and Luca Cozzi

    Citation: Radiation Oncology 2009 4:27

    Content type: Methodology

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  13. To evaluate the impact of external beam radiation therapy (XRT) on weekly ultrasound determined post-void residual (PVR) urine volumes in patients with prostate cancer.

    Authors: Peter F Orio III, Gregory S Merrick, Zachariah A Allen, Wayne M Butler, Kent E Wallner, Brian S Kurko and Robert W Galbreath

    Citation: Radiation Oncology 2009 4:26

    Content type: Research

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  14. DCQ (2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide), a synthetic quinoxaline 1,4-dioxide, enhances the cytotoxic effect of ionizing radiation (IR) in vivo and in vitro. We sought to clarify whether incre...

    Authors: Joelle Haykal, Fady Geara, Makhluf J Haddadin, Colin A Smith and Hala Gali-Muhtasib

    Citation: Radiation Oncology 2009 4:25

    Content type: Research

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  15. Despite broad advances in multimodal treatment of locally advanced breast cancer (LABC), 30 to 40% of patients develop loco-regional relapse. The aim of this study was to analyze in a retrospective manner the ...

    Authors: Alberto Alvarado-Miranda, Oscar Arrieta, Carlos Gamboa-Vignolle, David Saavedra-Perez, Rafael Morales-Barrera, Enrique Bargallo-Rocha, Juan Zinser-Sierra, Victor Perez-Sanchez, Teresa Ramirez-Ugalde and Fernando Lara-Medina

    Citation: Radiation Oncology 2009 4:24

    Content type: Research

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  16. Over-expression of cyclooxygenase-2 (COX-2) enzyme has been reported in nasopharyngeal carcinoma (NPC). However, the prognostic significance of this has yet to be conclusively determined. Thus, from our random...

    Authors: Susan Li Er Loong, Jacqueline Siok Gek Hwang, Hui Hua Li, Joseph Tien Seng Wee, Swee Peng Yap, Melvin Lee Kiang Chua, Kam Weng Fong and Terence Wee Kiat Tan

    Citation: Radiation Oncology 2009 4:23

    Content type: Research

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  17. To assess the impact of two multileaf collimator (MLC) systems (2.5 and 5 mm leaf widths) on three-dimensional conformal radiotherapy, intensity-modulated radiotherapy, and dynamic conformal arc techniques for...

    Authors: James A Tanyi, Paige A Summers, Charles L McCracken, Yiyi Chen, Li-Chung Ku and Martin Fuss

    Citation: Radiation Oncology 2009 4:22

    Content type: Research

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  18. survivors of non-Hodgkin's lymphoma (NHL) are well known to be at an increased risk of second malignancies. In this study, we evaluated the incidence and clinical features of head and neck cancer (HNC) occurri...

    Authors: Kazuma Toda, Hitoshi Shibuya, Keiji Hayashi and Fumio Ayukawa

    Citation: Radiation Oncology 2009 4:21

    Content type: Research

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  19. Extracranial metastases from brain meningiomas is a rare, but well-documented entity. Metastases occur mostly in the lungs, pleura and liver, but may also affect lymph nodes and bones. We report here on a pati...

    Authors: Mirna Abboud, George Haddad, Mireille Kattar, Ibrahim Aburiziq and Fady B Geara

    Citation: Radiation Oncology 2009 4:20

    Content type: Short report

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  20. To evaluate the dosimetric differences between Superposition/Convolution (SC) and Monte Carlo (MC) calculated dose distributions for simultaneous integrated boost (SIB) prostate cancer intensity modulated radi...

    Authors: Nesrin Dogan, Ivaylo Mihaylov, Yan Wu, Paul J Keall, Jeffrey V Siebers and Michael P Hagan

    Citation: Radiation Oncology 2009 4:18

    Content type: Research

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  21. Breast cancer patients show a wide variation in normal tissue reactions after radiotherapy. The individual sensitivity to x-rays limits the efficiency of the therapy. Prediction of individual sensitivity to ra...

    Authors: Luis Alberto Henríquez Hernández, Pedro Carlos Lara, Beatriz Pinar, Elisa Bordón, Carlos Rodríguez Gallego, Cristina Bilbao, Leandro Fernández Pérez and Amílcar Flores Morales

    Citation: Radiation Oncology 2009 4:17

    Content type: Short report

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  22. The purpose of this study was to analyze the radiotherapy (RT) quality assurance (QA) assessment in Japan Clinical Oncology Group (JCOG) 0202, which was the first trial that required on-going RT QA review in t...

    Authors: Naoko Sanuki-Fujimoto, Satoshi Ishikura, Kazushige Hayakawa, Kaoru Kubota, Yutaka Nishiwaki and Tomohide Tamura

    Citation: Radiation Oncology 2009 4:16

    Content type: Research

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  23. In stereotactic body radiotherapy (SBRT) for lung tumors, reducing tumor movement is necessary. In this study, we evaluated changes in tumor movement and percutaneous oxygen saturation (SpO2) levels, and prelimin...

    Authors: Fumiya Baba, Yuta Shibamoto, Natsuo Tomita, Chisa Ikeya-Hashizume, Kyota Oda, Shiho Ayakawa, Hiroyuki Ogino and Chikao Sugie

    Citation: Radiation Oncology 2009 4:15

    Content type: Research

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  24. To evaluate the impact of four different rectum contouring techniques and rectal toxicities in patients with treated with 3D conformal radiotherapy (3DCRT).

    Authors: Cem Onal, Erkan Topkan, Esma Efe, Melek Yavuz, Serhat Sonmez and Aydin Yavuz

    Citation: Radiation Oncology 2009 4:14

    Content type: Research

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  25. To evaluate the benefit of an on-line correction protocol based on implanted markers and weekly portal imaging in external beam radiotherapy of prostate cancer. To compare the use of bony anatomy versus implan...

    Authors: Reinhold Graf, Peter Wust, Volker Budach and Dirk Boehmer

    Citation: Radiation Oncology 2009 4:13

    Content type: Research

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  26. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concurrent chemo-radiotherapy is a valuable method for adjuvant treatment of breast c...

    Authors: Nabil Ismaili, Nawfel Mellas, Ouafae Masbah, Sanaa Elmajjaoui, Samia Arifi, Imane Bekkouch, Samir Ahid, Zakaria Bazid, Mohammed Adnane Tazi, Abdelouahed Erraki, Omar El Mesbahi, Noureddine Benjaafar, Brahim El Khalil El Gueddari, Mohammed Ismaili, Said Afqir and Hassan Errihani

    Citation: Radiation Oncology 2009 4:12

    Content type: Research

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  27. This retrospective study was done to better understand the conditions for which stereotactic radiosurgery (SRS) for glioblastoma may be efficacious.

    Authors: Tithi Biswas, Paul Okunieff, Michael C Schell, Therese Smudzin, Webster H Pilcher, Robert S Bakos, G Edward Vates, Kevin A Walter, Andrew Wensel, David N Korones and Michael T Milano

    Citation: Radiation Oncology 2009 4:11

    Content type: Research

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  28. The reproducibility of patient setup for radiotherapy is based on various methods including external markers, X-rays with planar or computerized image acquisition, and, more recently, surface matching imaging....

    Authors: Marco Krengli, Simone Gaiano, Eleonora Mones, Andrea Ballarè, Debora Beldì, Cesare Bolchini and Gianfranco Loi

    Citation: Radiation Oncology 2009 4:9

    Content type: Research

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  29. The Script Concordance test (SCT) is a reliable and valid tool to evaluate clinical reasoning in complex situations where experts' opinions may be divided. Scores reflect the degree of concordance between the ...

    Authors: Carole Lambert, Robert Gagnon, David Nguyen and Bernard Charlin

    Citation: Radiation Oncology 2009 4:7

    Content type: Research

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  30. Ongoing changes in cancer care cause an increase in the complexity of cases which is characterized by modern treatment techniques and a higher demand for patient information about the underlying disease and th...

    Authors: Susanne Sehlen, Dirk Vordermark, Christof Schäfer, Peter Herschbach, Anja Bayerl, Steffi Pigorsch, Jutta Rittweger, Claudia Dormin, Tobias Bölling, Hans Joachim Wypior, Franz Zehentmayr, Wolfgang Schulze and Hans Geinitz

    Citation: Radiation Oncology 2009 4:6

    Content type: Short report

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  31. Controversy still exists regarding the long-term outcome of patients whose uninvolved lymph node stations are not prophylactically irradiated for non-small cell lung cancer (NSCLC) treated with definitive radi...

    Authors: Erik P Sulman, Ritsuko Komaki, Ann H Klopp, James D Cox and Joe Y Chang

    Citation: Radiation Oncology 2009 4:5

    Content type: Research

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  32. To determine the optimal approach to delineating patient-specific internal gross target volumes (IGTV) from four-dimensional (4-D) computed tomography (CT) image data sets used in the planning of radiation tre...

    Authors: Muthuveni Ezhil, Sastry Vedam, Peter Balter, Bum Choi, Dragan Mirkovic, George Starkschall and Joe Y Chang

    Citation: Radiation Oncology 2009 4:4

    Content type: Research

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  33. This study evaluated the dosimetric impact of various treatment techniques as well as collimator leaf width (2.5 vs 5 mm) for three groups of tumors – spine tumors, brain tumors abutting the brainstem, and liv...

    Authors: Q Jackie Wu, Zhiheng Wang, John P Kirkpatrick, Zheng Chang, Jeffrey J Meyer, Mei Lu, Calvin Huntzinger and Fang-Fang Yin

    Citation: Radiation Oncology 2009 4:3

    Content type: Research

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  34. A phase III multi-centre randomised trial (ROSEL) has been initiated to establish the role of stereotactic radiotherapy in patients with operable stage IA lung cancer. Due to rapid changes in radiotherapy tech...

    Authors: Coen W Hurkmans, Johan P Cuijpers, Frank J Lagerwaard, Joachim Widder, Uulke A van der Heide, Danny Schuring and Suresh Senan

    Citation: Radiation Oncology 2009 4:1

    Content type: Study protocol

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  35. To compare morphological gross tumor volumes (GTVs), defined as pre- and postoperative gadolinium enhancement on T1-weighted magnetic resonance imaging to biological tumor volumes (BTVs), defined by the uptake of...

    Authors: Damien C Weber, Thomas Zilli, Franz Buchegger, Nathalie Casanova, Guy Haller, Michel Rouzaud, Philippe Nouet, Giovanna Dipasquale, Osman Ratib, Habib Zaidi, Hansjorg Vees and Raymond Miralbell

    Citation: Radiation Oncology 2008 3:44

    Content type: Research

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  36. Radiation therapy is generally contraindicated for cancer patients with collagen vascular diseases (CVD) such as scleroderma due to an increased risk of fibrosis. The tight skin (TSK) mouse has skin which, in ...

    Authors: Sanath Kumar, Andrew Kolozsvary, Robert Kohl, Mei Lu, Stephen Brown and Jae Ho Kim

    Citation: Radiation Oncology 2008 3:40

    Content type: Research

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  37. To assess the radiation dose delivered to the heart and ipsilateral lung during accelerated partial breast brachytherapy using a MammoSite™ applicator and compare to those produced by whole breast external bea...

    Authors: Alexandra J Stewart, Desmond A O'Farrell, Robert A Cormack, Jorgen L Hansen, Atif J Khan, Subhakar Mutyala and Phillip M Devlin

    Citation: Radiation Oncology 2008 3:39

    Content type: Research

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  38. Image-guidance systems allow accurate interfractional repositioning of IMRT treatments, however, these may require up to 15 minutes. Therefore intrafraction motion might have an impact on treatment precision. ...

    Authors: Judit Boda-Heggemann, Frederick Marc Köhler, Hansjörg Wertz, Michael Ehmann, Brigitte Hermann, Nadja Riesenacker, Beate Küpper, Frank Lohr and Frederik Wenz

    Citation: Radiation Oncology 2008 3:37

    Content type: Research

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  39. To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking.

    Authors: Pirus Ghadjar, Jacqueline Vock, Daniel Vetterli, Peter Manser, Roland Bigler, Jan Tille, Axel Madlung, Frank Behrensmeier, Roberto Mini and Daniel M Aebersold

    Citation: Radiation Oncology 2008 3:35

    Content type: Research

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  40. Intrafractional motion results in local over- and under-dosage in particle therapy with a scanned beam. Scanned beam delivery offers the possibility to compensate target motion by tracking with the treatment b...

    Authors: Sven Oliver Grözinger, Christoph Bert, Thomas Haberer, Gerhard Kraft and Eike Rietzel

    Citation: Radiation Oncology 2008 3:34

    Content type: Research

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