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  1. Metastasis directed treatment (MDT) is increasingly performed with the attempt to improve outcome in non-small cell lung cancer (NSCLC) patients receiving targeted- or immunotherapy (TT/IT). This study aimed t...

    Authors: Stephanie G. C. Kroeze, Jana Schaule, Corinna Fritz, David Kaul, Oliver Blanck, Klaus H. Kahl, Falk Roeder, Shankar Siva, Joost J. C. Verhoeff, Sonja Adebahr, Markus M. Schymalla, Markus Glatzer, Marcella Szuecs, Michael Geier, Georgios Skazikis, Irina Sackerer…

    Citation: Radiation Oncology 2021 16:4

    Content type: Research

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  2. Particle radiotherapy has increasingly gained acceptance for locally advanced pancreatic cancers owing to superior tumor conformity and dosimetry compared to conventional photon radiotherapy. However, the clos...

    Authors: Dongha Lee, Shohei Komatsu, Kazuki Terashima, Hirochika Toyama, Yoshiro Matsuo, Daiki Takahashi, Masaki Suga, Naoko Nishimura, Kentaro Tai, Masahiro Kido, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki and Takumi Fukumoto

    Citation: Radiation Oncology 2021 16:3

    Content type: Research

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  3. The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of ...

    Authors: Yasuo Kosugi, Terufumi Kawamoto, Masaki Oshima, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Naoto Shikama and Keisuke Sasai

    Citation: Radiation Oncology 2021 16:2

    Content type: Research

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  4. To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose–volume histogram (DVH) parameters.

    Authors: Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-ichi Nibu and Ryohei Sasaki

    Citation: Radiation Oncology 2021 16:1

    Content type: Research

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  5. Current guidelines for the treatment of anaplastic astrocytoma (AA) recommend maximal safe resection followed by radiotherapy and chemotherapy. Despite this multimodal treatment approach, patients have a limit...

    Authors: Helena C. W. Wahner, Malte Träger, Katja Bender, Leonille Schweizer, Julia Onken, Carolin Senger, Felix Ehret, Volker Budach and David Kaul

    Citation: Radiation Oncology 2020 15:282

    Content type: Research

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  6. Current studies about percutaneous endoscopic gastrostomy (PEG) tube placement report equivalent patient outcomes with prophylactic PEG tubes (pPEGs) versus common nutritional support. Unreported was if omitti...

    Authors: Beat Bojaxhiu, Binaya K. Shrestha, Pascal Luterbacher, Olgun Elicin, Mohamed Shelan, Andrew J. S. Macpherson, Benjamin Heimgartner, Roland Giger, Daniel M. Aebersold and Kathrin Zaugg

    Citation: Radiation Oncology 2020 15:281

    Content type: Research

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jana Schaule, Stephanie G. C. Kroeze, Oliver Blanck, Susanne Stera, Klaus H. Kahl, Falk Roeder, Stephanie E. Combs, David Kaul, An Claes, Markus M. Schymalla, Sonja Adebahr, Franziska Eckert, Fabian Lohaus, Nasrin Abbasi-Senger, Guido Henke, Marcella Szuecs…

    Citation: Radiation Oncology 2020 15:280

    Content type: Correction

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    The original article was published in Radiation Oncology 2020 15:135

  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alfredo Conti, Carolin Senger, Güliz Acker, Anne Kluge, Antonio Pontoriero, Alberto Cacciola, Stefano Pergolizzi, Antonino Germanò, Harun Badakhshi, Markus Kufeld, Franziska Meinert, Phuong Nguyen, Franziska Loebel, Peter Vajkoczy, Volker Budach and David Kaul

    Citation: Radiation Oncology 2020 15:279

    Content type: Correction

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    The original article was published in Radiation Oncology 2019 14:201

  9. Patients with locally advanced oropharynx squamous cell carcinoma have suboptimal outcomes with standard chemoradiation. Here, we evaluated toxicity and oncologic outcomes of dose escalation using radiosurgica...

    Authors: Prashant Vempati, Aditya N. Halthore, Sewit Teckie, Zaker Rana, Emile Gogineni, Jeffrey Antone, Honglai Zhang, Mihaela Marrero, Kristin Beadle, Douglas K. Frank, Mohamed Aziz, Doru Paul and Maged Ghaly

    Citation: Radiation Oncology 2020 15:278

    Content type: Research

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  10. We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) ...

    Authors: Liwen Zhang, Weiwei Wang, Jiyi Hu, Jiade Lu and Lin Kong

    Citation: Radiation Oncology 2020 15:277

    Content type: Research

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  11. Local hypofractionated stereotactic radiotherapy (HFSRT) of the resection cavity is emerging as the standard of care in the treatment of patients with a limited number of brain metastases as it warrants less n...

    Authors: Sophia Scharl, Kerstin A. Kessel, Christian Diehl, Jens Gempt, Bernhard Meyer, Claus Zimmer, Christoph Straube and Stephanie E. Combs

    Citation: Radiation Oncology 2020 15:276

    Content type: Research

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  12. This long-term retrospective analysis aimed to investigate the outcome and toxicity profile of stereotactic brachytherapy (SBT) in selected low-grade gliomas WHO grade II (LGGII) in a large patient series.

    Authors: Juliana Watson, Alexander Romagna, Hendrik Ballhausen, Maximilian Niyazi, Stefanie Lietke, Sebastian Siller, Claus Belka, Niklas Thon and Silke Birgit Nachbichler

    Citation: Radiation Oncology 2020 15:275

    Content type: Research

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  13. Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been ...

    Authors: Daniel Rueß, Vera Weyer, Juman Tutunji, Stefan Grau, Martin Kocher, Mauritius Hoevels, Harald Treuer, Christian Baues and Maximilian I. Ruge

    Citation: Radiation Oncology 2020 15:274

    Content type: Research

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  14. An O-ring gantry-type linear accelerator (LINAC) with a 6-MV flattening filter-free (FFF) photon beam, Halcyon, includes a reference beam that contains representative information such as the percent depth dose...

    Authors: Min-Geon Choi, Martin Law, Do-Kun Yoon, Mikoto Tamura, Kenji Matsumoto, Masakazu Otsuka, Moo-Sub Kim, Shih-Kien Djeng, Hajime Monzen and Tae Suk Suh

    Citation: Radiation Oncology 2020 15:273

    Content type: Research

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  15. Deep learning-based delineation of organs-at-risk for radiotherapy purposes has been investigated to reduce the time-intensiveness and inter-/intra-observer variability associated with manual delineation. We s...

    Authors: Ward van Rooij, Max Dahele, Hanne Nijhuis, Berend J. Slotman and Wilko F. Verbakel

    Citation: Radiation Oncology 2020 15:272

    Content type: Research

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  16. To investigate predictors of cognitive decline after whole brain radiotherapy (WBRT) for brain metastases.

    Authors: Matthew Chan, David Ferguson, Elaine Ni Mhurchu, Ren Yuan, Lovedeep Gondara, Michael McKenzie, Robert Olson, Brian Thiessen, Nafisha Lalani, Roy Ma and Alan Nichol

    Citation: Radiation Oncology 2020 15:271

    Content type: Research

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  17. To recommend a cranial border for level IIb in delineating clinical target volumes (CTV) for nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy and to help reach a consensus on ...

    Authors: Lijun Wang, Shengfu Huang, Lanfang Zhang, Xia He and Yatian Liu

    Citation: Radiation Oncology 2020 15:270

    Content type: Research

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  18. Whole-brain radiotherapy is a primary treatment for brain tumors and brain metastasis, but it also induces long-term undesired effects. Since cognitive impairment can occur, research on the etiology of seconda...

    Authors: Javier Franco-Pérez, Sergio Montes, Josué Sánchez-Hernández and Paola Ballesteros-Zebadúa

    Citation: Radiation Oncology 2020 15:269

    Content type: Research

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Franziska Eckert, Kerstin Clasen, Carina Kelbsch, Felix Tonagel, Benjamin Bender, Ghazaleh Tabatabai, Daniel Zips, Daniela Thorwarth, Bettina Frey, Gerd Becker, Helmut Wilhelm and Frank Paulsen

    Citation: Radiation Oncology 2020 15:268

    Content type: Correction

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    The original article was published in Radiation Oncology 2019 14:240

  20. Metastatic epidural spinal cord compression (MESCC) is a devastating complication of advanced malignancy, which can result in neurologic complications and significant deterioration in overall function and qual...

    Authors: Elysia K. Donovan, Jeffrey Greenspoon, Kara L. Schnarr, Timothy J. Whelan, James R. Wright, Crystal Hann, Anthony Whitton, Tom Chow, Sameer Parpia and Anand Swaminath

    Citation: Radiation Oncology 2020 15:267

    Content type: Study protocol

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  21. Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patt...

    Authors: Lucas Basler, Robert Poel, Christina Schröder, Alessandra Bolsi, Antony Lomax, Stephanie Tanadini-Lang, Matthias Guckenberger and Damien C. Weber

    Citation: Radiation Oncology 2020 15:266

    Content type: Research

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  22. Our institute initiated carbon ion radiotherapy research for patients with stage I breast cancer in April 2013. The purpose of this article is to evaluate the treatment outcome of cases treated outside clinica...

    Authors: Kumiko Karasawa, Tokuhiko Omatsu, Shintaro Shiba, Daisuke Irie, Masaru Wakatsuki and Shigekazu Fukuda

    Citation: Radiation Oncology 2020 15:265

    Content type: Research

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  23. It is important to understand how elderly patients with locally advanced pancreatic carcinoma (LAPC) should be treated, since the number of elderly cancer patients will increase. However, the optimal treatment...

    Authors: Takahiro Iwai, Michio Yoshimura, Ryo Ashida, Yoko Goto, Takahiro Kishi, Satoshi Itasaka, Keiko Shibuya, Masashi Kanai, Toshihiko Masui, Akihisa Fukuda, Hiroyoshi Isoda, Masahiro Hiraoka and Takashi Mizowaki

    Citation: Radiation Oncology 2020 15:264

    Content type: Research

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  24. The spine represents the site which is most frequently affected by bone metastases in patients with systemic cancer. Of all local treatment options, combined kyphoplasty and intraoperative radiotherapy (Kypho-...

    Authors: Frederic Bludau, Laura Winter, Grit Welzel, Udo Obertacke, Frank Schneider, Frederik Wenz, Arne Mathias Ruder and Frank A. Giordano

    Citation: Radiation Oncology 2020 15:263

    Content type: Short report

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  25. Transoral surgery (TOS), particularly transoral robotic surgery (TORS) has become the preferred modality in the United States for the treatment of early stage oropharyngeal cancer, largely due to assumptions o...

    Authors: Eric J. Di Gravio, Pencilla Lang, Hugh Andrew Jinwook Kim, Tricia Chinnery, Neil Mundi, S. Danielle MacNeil, Adrian Mendez, John Yoo, Kevin Fung, Joe S. Mymryk, John W. Barrett, Nancy Read, Varagur Venkatesan, Sara Kuruvilla, Lucas C. Mendez, Eric Winquist…

    Citation: Radiation Oncology 2020 15:261

    Content type: Research

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  26. The gross tumor volume (GTV) could be an independent prognostic factor for unresectable locally advanced non-small cell lung cancer (LANSCLC). We aimed to develop and validate a novel integrated GTV-TNM strati...

    Authors: Nai-Bin Chen, Qi-Wen Li, Zheng-Fei Zhu, Yi-Ming Wang, Zhangkai J. Cheng, Zhou-Guang Hui, Su-Ping Guo, Hao-Qiang He, Bin Wang, Xiao-Yan Huang, Ji-Bin Li, Jin-Yu Guo, Nan Hu, Xin-Lei Ai, Yin Zhou, Da-Quan Wang…

    Citation: Radiation Oncology 2020 15:260

    Content type: Research

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  27. There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different typ...

    Authors: Daniela Delago, Olivia Knittelfelder, Gabriele Jakse, Katarzyna Lukasiak, Sabine Reinisch, Wilfried Renner, Heidi Stranzl-Lawatsch, Richard Partl and Tanja Langsenlehner

    Citation: Radiation Oncology 2020 15:259

    Content type: Research

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  28. This study investigates daily breast geometry and delivered dose to prone-positioned patients undergoing tangential whole breast radiation therapy (WBRT) on an O-ring linear accelerator with 6X flattening filt...

    Authors: Suk W. Yoon, Neil K. Taunk, Gary M. Freedman, Emily Hubley, Shannon O’Reilly, Boon- Keng K. Teo, Shibu Anamalayil, Lei Dong, Christopher Kennedy, Wei Zou, James M. Metz and Taoran Li

    Citation: Radiation Oncology 2020 15:258

    Content type: Research

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  29. To assess the effects of various treatment planning parameters to identify the optimal gap distance for precise two-segment total body irradiation (TBI) using helical tomotherapy (HT) with fixed jaw mode.

    Authors: HaiYang Wang, JunQi Liu, YiFei Pi, Qi Liu, Yang Mi, XiangXiang Yang, YueXin Guo and RuiTai Fan

    Citation: Radiation Oncology 2020 15:257

    Content type: Methodology

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  30. This study aimed to contrast four different irradiation methods for pediatric medulloblastoma tumors in a dosimetric comparison regarding planning target volume (PTV) coverage and sparing of organs at risk (OA...

    Authors: Gerhard Pollul, Tilman Bostel, Sascha Grossmann, Sati Akbaba, Heiko Karle, Marcus Stockinger and Heinz Schmidberger

    Citation: Radiation Oncology 2020 15:256

    Content type: Research

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  31. Recent advances in radiotherapy techniques have allowed ablative doses to be safely delivered to inoperable liver tumors. In this setting, proton beam radiotherapy (PBT) provides the means to escalate radiatio...

    Authors: Jacob S. Parzen, William Hartsell, John Chang, Smith Apisarnthanarax, Jason Molitoris, Michael Durci, Henry Tsai, James Urbanic, Jonathan Ashman, Carlos Vargas, Craig Stevens and Peyman Kabolizadeh

    Citation: Radiation Oncology 2020 15:255

    Content type: Research

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  32. Radiotherapy (RT) is a highly effective anti-cancer therapy delivered to around 50–60% of patients. It is part of therapy for around 40% of cancer patients who are cured of their disease. Until recently, the f...

    Authors: Madyson Colton, Eleanor J. Cheadle, Jamie Honeychurch and Tim M. Illidge

    Citation: Radiation Oncology 2020 15:254

    Content type: Review

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  33. The ESCALOX trial was designed as a multicenter, randomized prospective dose escalation study for head and neck cancer. Therefore, feasibility of treatment planning via different treatment planning systems (TP...

    Authors: Steffi U. Pigorsch, Severin Kampfer, Markus Oechsner, Michael C. Mayinger, Petra Mozes, Michal Devecka, Kerstin K. Kessel, Stephanie E. Combs and Jan J. Wilkens

    Citation: Radiation Oncology 2020 15:253

    Content type: Research

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  34. We read the article entitled “Patterns of brain metastasis immediately before prophylactic cranial irradiation (PCI): implications for PCI optimization in limited-stage small cell lung cancer” with great inter...

    Authors: Lukas Käsmann, Chukwuka Eze, Julian Taugner and Farkhad Manapov

    Citation: Radiation Oncology 2020 15:252

    Content type: Letter to the Editor

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  35. Whole-brain radiotherapy (WBRT) remains an important treatment for over 200,000 cancer patients in the United States annually. Hippocampal-avoidant WBRT (HA-WBRT) reduces neurocognitive toxicity compared to st...

    Authors: Christine H. Feng, Mariel Cornell, Kevin L. Moore, Roshan Karunamuni and Tyler M. Seibert

    Citation: Radiation Oncology 2020 15:251

    Content type: Research

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  36. Radiation therapy to upper abdominal sites is technically challenging due to motion of tumors and surrounding organs resulting from normal respiration. Breath-hold, using an Active Breathing Coordinator is one...

    Authors: Briana Farrugia, Richard Khor, Farshad Foroudi, Michael Chao, Kellie Knight and Caroline Wright

    Citation: Radiation Oncology 2020 15:250

    Content type: Study protocol

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  37. To develop and validate a nomogram model to predict complete response (CR) after concurrent chemoradiotherapy (CCRT) in esophageal squamous cell carcinoma (ESCC) patients using pretreatment CT radiomic features.

    Authors: He-San Luo, Shao-Fu Huang, Hong-Yao Xu, Xu-Yuan Li, Sheng-Xi Wu and De-Hua Wu

    Citation: Radiation Oncology 2020 15:249

    Content type: Research

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  38. The clonogenic assay is a versatile and frequently used tool to quantify reproductive cell survival in vitro. Current state-of-the-art analysis relies on plating efficiency-based calculations which assume a li...

    Authors: Nikko Brix, Daniel Samaga, Roman Hennel, Katharina Gehr, Horst Zitzelsberger and Kirsten Lauber

    Citation: Radiation Oncology 2020 15:248

    Content type: Research

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  39. Expression of PD-L1 is the most investigated predictor of benefit from immune checkpoint blockade in advanced NSCLC but little is known about the association of PD-L1 expression and clinicopathological paramet...

    Authors: Martina Vrankar, Izidor Kern and Karmen Stanic

    Citation: Radiation Oncology 2020 15:247

    Content type: Research

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  40. Radiation pneumonitis (RP) could be a lethal complication of lung cancer treatment. No reliable predictors of RP severity have been recognized. This prospective pilot study was performed to identify early pred...

    Authors: Samantha Aso, Arturo Navarro-Martin, Richard Castillo, Susana Padrones, Edward Castillo, Ana Montes, José Ignacio Martínez, Noelia Cubero, Rosa López, Laura Rodríguez, Ramon Palmero, Federico Manresa, Thomas Guerrero and María Molina

    Citation: Radiation Oncology 2020 15:246

    Content type: Research

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  41. Stereotactic radiation therapy (SRT) and immune checkpoint inhibitors (ICI) may act synergistically to improve treatment outcomes but may also increase the risk of symptomatic radiation necrosis (RN). The obje...

    Authors: Emily S. Kowalski, Jill S. Remick, Kai Sun, Gregory S. Alexander, Rahul Khairnar, Emily Morse, Hua-Ren Cherng, Lars J. Berg, Yannick Poirier, Narottam Lamichhane, Stewart Becker, Shifeng Chen, Jason K. Molitoris, Young Kwok, William F. Regine and Mark V. Mishra

    Citation: Radiation Oncology 2020 15:245

    Content type: Short report

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  42. There is no standard treatment for locoregional recurrent (LR) esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy (RT) previously. This retrospective study aimed to examine the effica...

    Authors: Kaikai Zhao, Youjiao Si, Liangchao Sun, Xiangjiao Meng and Jinming Yu

    Citation: Radiation Oncology 2020 15:243

    Content type: Research

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  43. To evaluate the applicability and estimate the radiobiological parameters of linear-quadratic Poisson tumour control probability (TCP) model for primary prostate cancer patients for two relevant target structu...

    Authors: Ilias Sachpazidis, Panayiotis Mavroidis, Constantinos Zamboglou, Christina Marie Klein, Anca-Ligia Grosu and Dimos Baltas

    Citation: Radiation Oncology 2020 15:242

    Content type: Research

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  44. Methods for the non-invasive quantification of changes in bladder wall thickness as potential predictors of radiation cystitis in pre-clinical research would be desirable. The use of ultrasound for this aim se...

    Authors: Antonello E. Spinelli, Andrea Bresolin, Stefania Zuppone, Laura Perani, Giuseppe Fallara, Nadia Di Muzio, Riccardo Vago, Claudio Fiorino and Cesare Cozzarini

    Citation: Radiation Oncology 2020 15:240

    Content type: Research

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  45. To evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) and determine dosimetric and clinical consequences.

    Authors: David J. Byun, Daniel J. Gorovets, Lauren M. Jacobs, Laura Happersett, Pengpeng Zhang, Xin Pei, Sarah Burleson, Zhigang Zhang, Margie Hunt, Sean McBride, Marisa A. Kollmeier and Michael J. Zelefsky

    Citation: Radiation Oncology 2020 15:239

    Content type: Research

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  46. Lung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 s...

    Authors: Qing Jin, Cunzhi Lin, Xinhong Zhu, Yiwei Cao, Caihong Guo and Lijun Wang

    Citation: Radiation Oncology 2020 15:238

    Content type: Research

    Published on:

  47. There is no ideal detector-phantom combination to perform patient specific quality assurance (PSQA) for Total Marrow (TMI) and Lymphoid (TMLI) Irradiation plan. In this study, 3D dose reconstruction using mega...

    Authors: Rajesh Thiyagarajan, Dayananda Shamurailatpam Sharma, Suryakant Kaushik, Mayur Sawant, K. Ganapathy, N. Arunai Nambi Raj, Srinivas Chilukuri, Sham C. Sundar, Kartikeswar Ch. Patro, Arjunan Manikandan, M. P. Noufal, Rangasamy Sivaraman, Jose Easow and Rakesh Jalali

    Citation: Radiation Oncology 2020 15:236

    Content type: Research

    Published on:

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