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  1. To compare linac-based mono-isocentric radiosurgery with Brainlab Elements Multiple Brain Mets (MBM) SRS and the Gamma Knife using a specific statistical method and to analyze the dosimetric impact of the targ...

    Authors: Michel Chea, Karen Fezzani, Julian Jacob, Marguerite Cuttat, Mathilde Croisé, Jean-Marc Simon, Loïc Feuvret, Charles-Ambroise Valery, Philippe Maingon, Mohamed-Amine Benadjaoud and Catherine Jenny
    Citation: Radiation Oncology 2021 16:45
  2. In breast cancer patients receiving radiotherapy (RT), accurate target delineation and reduction of radiation doses to the nearby normal organs is important. However, manual clinical target volume (CTV) and or...

    Authors: Seung Yeun Chung, Jee Suk Chang, Min Seo Choi, Yongjin Chang, Byong Su Choi, Jaehee Chun, Ki Chang Keum, Jin Sung Kim and Yong Bae Kim
    Citation: Radiation Oncology 2021 16:44
  3. To evaluate the effect of prophylactic irradiation of internal mammary lymph nodes in breast cancer patients.

    Authors: Sicong Jia, Zhikun Liu, Jun Zhang, Chenguang Zhao, Longyu Zhu, Jie Kong, Huina Han, Yuguang Shang, Dongxing Shen and Xuejuan Duan
    Citation: Radiation Oncology 2021 16:42
  4. The exact rate and relevant risk factors of radiation pneumonitis (RP) for non-small-cell cancer (NSCLC) patients treated with the combination of epidermal growth factor receptor-tyrosine kinase inhibitors (EG...

    Authors: Wenxiao Jia, Qianqian Gao, Min Wang, Ji Li, Wang Jing, Jinming Yu and Hui Zhu
    Citation: Radiation Oncology 2021 16:41
  5. Frequency and risk profile of radiation necrosis (RN) in patients with glioma undergoing either upfront stereotactic brachytherapy (SBT) and additional salvage external beam radiotherapy (EBRT) after tumor rec...

    Authors: Indrawati Hadi, Daniel Reitz, Raphael Bodensohn, Olarn Roengvoraphoj, Stefanie Lietke, Maximilian Niyazi, Jörg-Christian Tonn, Claus Belka, Niklas Thon and Silke Birgit Nachbichler
    Citation: Radiation Oncology 2021 16:40
  6. Stereotactic body radiation therapy (SBRT) is an established therapy for medically inoperable early-stage non-small cell lung cancer (NSCLC). Many elderly patients are medically inoperable owing to comorbiditi...

    Authors: Kenta Watanabe, Kuniaki Katsui, Soichiro Sugiyama, Kotaro Yoshio, Masahiro Kuroda, Takao Hiraki, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa
    Citation: Radiation Oncology 2021 16:39
  7. Primary tracheal adenoid cystic carcinoma (TACC) is rare and originates from the minor salivary gland. Biologically, TACC results in delayed presentation, and the therapeutic effects of multimodal treatment di...

    Authors: Juntao Ran, Guofeng Qu, Xiaohua Chen and Da Zhao
    Citation: Radiation Oncology 2021 16:38
  8. The benefit of MR-only workflow compared to current CT-based workflow for prostate radiotherapy is reduction of systematic errors in the radiotherapy chain by 2–3 mm. Nowadays, MRI is used for target delineati...

    Authors: Karin Goudschaal, F. Beeksma, M. Boon, M. Bijveld, J. Visser, K. Hinnen and Z. van Kesteren
    Citation: Radiation Oncology 2021 16:37
  9. Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO...

    Authors: Giuseppe Minniti, Maximilian Niyazi, Filippo Alongi, Piera Navarria and Claus Belka
    Citation: Radiation Oncology 2021 16:36
  10. The Halcyon is a new machine from the Varian company. The purpose of this study was to evaluate the dosimetry of the Halcyon in treatment of bilateral breast cancer with volumetric modulated arc therapy.

    Authors: Tao Sun, Xiutong Lin, Guifang Zhang, Qingtao Qiu, Chengqiang Li and Yong Yin
    Citation: Radiation Oncology 2021 16:35
  11. The impact of adjuvant radiotherapy (RT) on atypical meningioma (AM) underwent a gross total resection (GTR) remains unclear, showing conflicting results from various studies. The objective of this study was t...

    Authors: Se-Woong Chun, Kyung Min Kim, Min-Sung Kim, Ho Kang, Yun-Sik Dho, Youngbeom Seo, Jin Wook Kim, Yong Hwy Kim and Chul-Kee Park
    Citation: Radiation Oncology 2021 16:34
  12. Gold nanoparticles (GNPs) have been used to sensitize cancer cells and enhance the absorbed dose delivered to such cells. Active targeting can provide specific effect and higher uptake of the GNPs in the tumor...

    Authors: Somayeh Sadat Mehrnia, Bijan Hashemi, Seyed Javad Mowla, Maryam Nikkhah and Azim Arbabi
    Citation: Radiation Oncology 2021 16:33
  13. Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate can...

    Authors: Lindsay S. Rowe, Stephanie Harmon, Adam Horn, Uma Shankavaram, Soumyajit Roy, Holly Ning, Liza Lindenberg, Esther Mena, Deborah E. Citrin, Peter Choyke and Baris Turkbey
    Citation: Radiation Oncology 2021 16:32
  14. The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is...

    Authors: Cecilia Jiang, Troy J. Kleber, Jeffrey M. Switchenko and Mohammad K. Khan
    Citation: Radiation Oncology 2021 16:31
  15. Radiation-induced brain injury is a common concern for survivors of adult and pediatric brain cancer. Pre-clinically, rodent models are the standard approach to evaluate mechanisms of injury and test new thera...

    Authors: Ilektra Athanasiadi, Whitney D. Perez, Jeannie M. Plantenga, Yava Jones-Hall and Carlos J. Perez-Torres
    Citation: Radiation Oncology 2021 16:30
  16. To evaluate the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy (WART) in women with ovarian clear cell cancer (OCCC) referred to an academi...

    Authors: Mark J. Stevens, Simon West, Gregory Gard, Christopher Renaud, David Nevell, Stephanie Roderick and Andrew Le
    Citation: Radiation Oncology 2021 16:29
  17. Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus is a current pandemic. We initiated a program of systematic SARS-CoV-2 polymerase chain reaction (PCR) testing in all asymptomatic patients re...

    Authors: Roshan S. Prabhu, Reshika Dhakal, Amy S. Hicks, James McBride, Alicia L. Patrick, Christopher D. Corso, Tomain Murphy, Melissa Thonen, Edward H. Lipford, Derek Raghavan and Stuart H. Burri
    Citation: Radiation Oncology 2021 16:28
  18. Future radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices...

    Authors: Stefanie Corradini, Maximilian Niyazi, Dirk Verellen, Vincenzo Valentini, Seán Walsh, Anca-L. Grosu, Kirsten Lauber, Amato Giaccia, Kristian Unger, Jürgen Debus, Bradley R. Pieters, Matthias Guckenberger, Suresh Senan, Wilfried Budach, Roland Rad, Julia Mayerle…
    Citation: Radiation Oncology 2021 16:27
  19. Segmentation is a crucial step in treatment planning that directly impacts dose distribution and optimization. The aim of this study was to evaluate the inter-individual variability of common cranial organs at...

    Authors: Guillaume Vogin, Liza Hettal, Clarisse Bartau, Juliette Thariat, Marie-Virginie Claeys, Guillaume Peyraga, Paul Retif, Ulrike Schick, Delphine Antoni, Zsuzsa Bodgal, Frederic Dhermain and Loic Feuvret
    Citation: Radiation Oncology 2021 16:26
  20. This meta-analysis evaluated the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer after breast-conserving surgery.

    Authors: Xiaoyong Xiang, Zhen Ding, Lingling Feng and Ning Li
    Citation: Radiation Oncology 2021 16:24
  21. Radiation therapy and chemoradiation therapy play a major role in the definitive management of esophageal cancer. Survival in esophageal cancer patients is still relatively poor, mostly due to high rates of lo...

    Authors: J. Ristau, M. Thiel, S. Katayama, I. Schlampp, K. Lang, M. F. Häfner, K. Herfarth, J. Debus and S. A. Koerber
    Citation: Radiation Oncology 2021 16:23
  22. For meningiomas, complete resection is recommended as first-line treatment while stereotactic radiosurgery (SRS) is established for meningiomas of smaller size considered inoperable. If the patient´s medical c...

    Authors: Maximilian I. Ruge, Juman Tutunji, Daniel Rueß, Eren Celik, Christian Baues, Harald Treuer, Martin Kocher and Stefan Grau
    Citation: Radiation Oncology 2021 16:22
  23. Most previous studies focused on the minimum interval between surgery and radiotherapy in spinal metastases, leaving the maximum interval under-investigated. However, in real world, limited radiotherapist and ...

    Authors: Yining Gong, Hongqing Zhuang, Shan Chong, Qianyu Shi, Feng Wei, Zhongjun Liu, Hanqiang Ouyang, Xiaoguang Liu and Liang Jiang
    Citation: Radiation Oncology 2021 16:21
  24. Proton therapy is a promising advancement in radiation oncology especially in terms of reducing normal tissue toxicity, although it is currently expensive and of limited availability. Here we estimated the ind...

    Authors: N. Patrik Brodin, Rafi Kabarriti, Clyde B. Schechter, Mark Pankuch, Vinai Gondi, Shalom Kalnicki, Madhur K. Garg and Wolfgang A. Tomé
    Citation: Radiation Oncology 2021 16:19
  25. To investigate maximum tolerated dose (MTD) of axitinib, a selective vascular endothelial growth factor receptor 1–3 inhibitor, in combination with radiotherapy (RT) for advanced hepatocellular carcinoma (HCC).

    Authors: Kai-Lin Yang, Mau-Shin Chi, Hui-Ling Ko, Yi-Ying Huang, Su-Chen Huang, Yu-Min Lin and Kwan-Hwa Chi
    Citation: Radiation Oncology 2021 16:18
  26. Patients with locally advanced rectal cancer generally have different response rates to preoperative neoadjuvant chemo-radiotherapy. This study investigated the value of the apparent diffusion coefficient (ADC...

    Authors: Mengjing Zhao, Lihao Zhao, Han Yang, Yuxia Duan and Gang Li
    Citation: Radiation Oncology 2021 16:17
  27. The watch-and-wait strategy offers a non-invasive therapeutic alternative for rectal cancer patients who have achieved a clinical complete response (cCR) after chemoradiotherapy. This study aimed to investigat...

    Authors: Qiao-xuan Wang, Rong Zhang, Wei-wei Xiao, Shu Zhang, Ming-biao Wei, Yong-heng Li, Hui Chang, Wei-hao Xie, Li-ren Li, Pei-rong Ding, Gong Chen, Zhi-fan Zeng, Wei-hu Wang, Xiang-bo Wan and Yuan-hong Gao
    Citation: Radiation Oncology 2021 16:16
  28. Stereotactic body radiotherapy (SBRT) is an emerging modality for hepatocellular carcinoma (HCC). However, there is scant information about its safety and effectiveness in the neoadjuvant setting prior to live...

    Authors: Ying-Fu Wang, Yang-Hong Dai, Chun-Shu Lin, Hao-Chih Chang, Po-Chien Shen, Jen-Fu Yang, Chih-Weim Hsiang, Cheng-Hsiang Lo and Wen-Yen Huang
    Citation: Radiation Oncology 2021 16:15
  29. Radiotherapy of gastric mucosa-associated lymphoid tissue (MALT) lymphoma should be delivered to the entire stomach with planning target volume (PTV) that accounts for variations in stomach volume, respiratory...

    Authors: Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Yumiko Kono, Yasuhiro Doi, Yoshiyuki Fukugawa, Takahiro Watakabe, Tadashi Matsumoto, Yudai Kai, Masato Maruyama and Natsuo Oya
    Citation: Radiation Oncology 2021 16:14
  30. Surface-guided radiation therapy can be used to continuously monitor a patient’s surface motions during radiotherapy by a non-irradiating, noninvasive optical surface imaging technique. In this study, machine ...

    Authors: Guangyu Wang, Zhibin Li, Guangjun Li, Guyu Dai, Qing Xiao, Long Bai, Yisong He, Yaxin Liu and Sen Bai
    Citation: Radiation Oncology 2021 16:13
  31. Whole brain radiotherapy (WBRT) can impair patients’ cognitive function. Hippocampal avoidance during WBRT can potentially prevent this side effect. However, manually delineating the target area is time-consum...

    Authors: Kaicheng Pan, Lei Zhao, Song Gu, Yi Tang, Jiahao Wang, Wen Yu, Lucheng Zhu, Qi Feng, Ruipeng Su, Zhiyong Xu, Xiadong Li, Zhongxiang Ding, Xiaolong Fu, Shenglin Ma, Jun Yan, Shigong Kang…
    Citation: Radiation Oncology 2021 16:12
  32. Stereotactic ablative radiation therapy (SABR) is effective in treating inoperable stage I non-small cell lung cancer (NSCLC), but imaging assessment of response after SABR is difficult. This prospective study...

    Authors: Dae-Myoung Yang, David A. Palma, Keith Kwan, Alexander V. Louie, Richard Malthaner, Dalilah Fortin, George B. Rodrigues, Brian P. Yaremko, Joanna Laba, Stewart Gaede, Andrew Warner, Richard Inculet and Ting-Yim Lee
    Citation: Radiation Oncology 2021 16:11
  33. An ever-growing body of evidence has linked the gut microbiome with both the effectiveness and the toxicity of cancer therapies. Radiotherapy is an effective way to treat tumors, although large variations exis...

    Authors: Jing Liu, Chao Liu and Jinbo Yue
    Citation: Radiation Oncology 2021 16:9
  34. This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for the treatment outcomes of patients with oesophageal squamous cell carcino...

    Authors: Chengbing Zeng, Tiantian Zhai, Jianzhou Chen, Longjia Guo, Baotian Huang, Hong Guo, Guozhi Liu, Tingting Zhuang, Weitong Liu, Ting Luo, Yanxuan Wu, Guobo Peng, Derui Li and Chuangzhen Chen
    Citation: Radiation Oncology 2021 16:8
  35. In a palliative situation like metastatic spinal cord compression (MSCC), overall treatment time of radiotherapy should be as short as possible. This study compared 5 × 5 Gy in 1 week to 10 × 3 Gy in 2 weeks i...

    Authors: Dirk Rades, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Darejan Lomidze, Raquel Ciervide, Niels H. Hollaender and Steven E. Schild
    Citation: Radiation Oncology 2021 16:7
  36. To investigate the potential benefit of cytoreductive radiotherapy (cRT) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving abiraterone.

    Authors: Yang Liu, Wen Long, Zitong Zhang, Lixin Mai, Sijuan Huang, Boji Liu, Wufei Cao, Jianhua Wu, Fangjian Zhou, Yonghong Li and Liru He
    Citation: Radiation Oncology 2021 16:5
  37. Metastasis directed treatment (MDT) is increasingly performed with the attempt to improve outcome in non-small cell lung cancer (NSCLC) patients receiving targeted- or immunotherapy (TT/IT). This study aimed t...

    Authors: Stephanie G. C. Kroeze, Jana Schaule, Corinna Fritz, David Kaul, Oliver Blanck, Klaus H. Kahl, Falk Roeder, Shankar Siva, Joost J. C. Verhoeff, Sonja Adebahr, Markus M. Schymalla, Markus Glatzer, Marcella Szuecs, Michael Geier, Georgios Skazikis, Irina Sackerer…
    Citation: Radiation Oncology 2021 16:4
  38. Particle radiotherapy has increasingly gained acceptance for locally advanced pancreatic cancers owing to superior tumor conformity and dosimetry compared to conventional photon radiotherapy. However, the clos...

    Authors: Dongha Lee, Shohei Komatsu, Kazuki Terashima, Hirochika Toyama, Yoshiro Matsuo, Daiki Takahashi, Masaki Suga, Naoko Nishimura, Kentaro Tai, Masahiro Kido, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki and Takumi Fukumoto
    Citation: Radiation Oncology 2021 16:3
  39. The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of ...

    Authors: Yasuo Kosugi, Terufumi Kawamoto, Masaki Oshima, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Naoto Shikama and Keisuke Sasai
    Citation: Radiation Oncology 2021 16:2
  40. To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose–volume histogram (DVH) parameters.

    Authors: Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-ichi Nibu and Ryohei Sasaki
    Citation: Radiation Oncology 2021 16:1
  41. Current guidelines for the treatment of anaplastic astrocytoma (AA) recommend maximal safe resection followed by radiotherapy and chemotherapy. Despite this multimodal treatment approach, patients have a limit...

    Authors: Helena C. W. Wahner, Malte Träger, Katja Bender, Leonille Schweizer, Julia Onken, Carolin Senger, Felix Ehret, Volker Budach and David Kaul
    Citation: Radiation Oncology 2020 15:282
  42. Current studies about percutaneous endoscopic gastrostomy (PEG) tube placement report equivalent patient outcomes with prophylactic PEG tubes (pPEGs) versus common nutritional support. Unreported was if omitti...

    Authors: Beat Bojaxhiu, Binaya K. Shrestha, Pascal Luterbacher, Olgun Elicin, Mohamed Shelan, Andrew J. S. Macpherson, Benjamin Heimgartner, Roland Giger, Daniel M. Aebersold and Kathrin Zaugg
    Citation: Radiation Oncology 2020 15:281
  43. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jana Schaule, Stephanie G. C. Kroeze, Oliver Blanck, Susanne Stera, Klaus H. Kahl, Falk Roeder, Stephanie E. Combs, David Kaul, An Claes, Markus M. Schymalla, Sonja Adebahr, Franziska Eckert, Fabian Lohaus, Nasrin Abbasi-Senger, Guido Henke, Marcella Szuecs…
    Citation: Radiation Oncology 2020 15:280

    The original article was published in Radiation Oncology 2020 15:135

  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alfredo Conti, Carolin Senger, Güliz Acker, Anne Kluge, Antonio Pontoriero, Alberto Cacciola, Stefano Pergolizzi, Antonino Germanò, Harun Badakhshi, Markus Kufeld, Franziska Meinert, Phuong Nguyen, Franziska Loebel, Peter Vajkoczy, Volker Budach and David Kaul
    Citation: Radiation Oncology 2020 15:279

    The original article was published in Radiation Oncology 2019 14:201

  45. Patients with locally advanced oropharynx squamous cell carcinoma have suboptimal outcomes with standard chemoradiation. Here, we evaluated toxicity and oncologic outcomes of dose escalation using radiosurgica...

    Authors: Prashant Vempati, Aditya N. Halthore, Sewit Teckie, Zaker Rana, Emile Gogineni, Jeffrey Antone, Honglai Zhang, Mihaela Marrero, Kristin Beadle, Douglas K. Frank, Mohamed Aziz, Doru Paul and Maged Ghaly
    Citation: Radiation Oncology 2020 15:278

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