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  1. We examined the efficacy and toxicity of proton beam therapy (PBT) for treating advanced cholangiocarcinoma.

    Authors: Chiyoko Makita, Tatsuya Nakamura, Akinori Takada, Kanako Takayama, Motohisa Suzuki, Yojiro Ishikawa, Yusuke Azami, Takahiro Kato, Iwao Tsukiyama, Yasuhiro Kikuchi, Masato Hareyama, Masao Murakami, Nobukazu Fuwa, Masaharu Hata and Tomio Inoue
    Citation: Radiation Oncology 2014 9:26
  2. In this study we determined if treatment combining radiation therapy (RT) with intracerebral (i.c.) administration of carboplatin to F98 glioma bearing rats could improve survival over that previously reported...

    Authors: Weilian Yang, Rolf F Barth, Tianyao Huo, Robin J Nakkula, Michael Weldon, Nilendu Gupta, Lawrence Agius and John C Grecula
    Citation: Radiation Oncology 2014 9:25
  3. The optimal management of high-risk prostate cancer remains uncertain. In this study we assessed the safety and efficacy of a novel multimodal treatment paradigm for high-risk prostate cancer.

    Authors: Andrea Guttilla, Roberto Bortolus, Gianluca Giannarini, Pirus Ghadjar, Fabio Zattoni, Michele Gnech, Vito Palumbo, Francesca Valent, Antonio Garbeglio and Filiberto Zattoni
    Citation: Radiation Oncology 2014 9:24
  4. Hypo-fractionated external beam radiotherapy with narrow CTV-PTV margins is increasingly applied for prostate cancer. This demands a precise target definition and knowledge on target location and extension dur...

    Authors: Adalsteinn Gunnlaugsson, Elisabeth Kjellén, Oskar Hagberg, Camilla Thellenberg-Karlsson, Anders Widmark and Per Nilsson
    Citation: Radiation Oncology 2014 9:22
  5. Maximisation of the ratio of normal tissue preservation and tumour cell reduction is the main concept of radiotherapy alone or combined with chemo-, immuno- or biologically targeted therapy. The foremost param...

    Authors: Kristian Unger
    Citation: Radiation Oncology 2014 9:21
  6. To determine the impact of body-mass factors (BMF) before radiotherapy and changes during radiotherapy on the magnitude of setup displacement in patients with head and neck cancer (HNC).

    Authors: Yo-Liang Lai, Shih-Neng Yang, Ji-An Liang, Yao-Ching Wang, Chun-Yen Yu, Ching-Hsiung Su and Shang-Wen Chen
    Citation: Radiation Oncology 2014 9:19
  7. To report technical features, early outcome and toxicity of stereotactic body radiation therapy (SBRT) treatments with volumetric modulated arc therapy (RapidArc) for patients with hepatocellular carcinoma (HCC).

    Authors: Po-Ming Wang, Wei-Chung Hsu, Na-Na Chung, Feng-Ling Chang, Chin-Jyh Jang, Antonella Fogliata, Marta Scorsetti and Luca Cozzi
    Citation: Radiation Oncology 2014 9:18
  8. MRI-only radiotherapy will eliminate the systematic registration errors introduced when transferring MRI information to the CT. However, challenges concerning the missing information on electron density, neces...

    Authors: Marie E Korsholm, Line W Waring and Jens M Edmund
    Citation: Radiation Oncology 2014 9:16
  9. Radiation-induced alterations in posttranslational histone modifications (PTMs) may affect the cellular response to radiation damage in the DNA. If not reverted appropriately, altered PTM patterns may cause lo...

    Authors: Belinda Maroschik, Anne Gürtler, Anne Krämer, Ute Rößler, Maria Gomolka, Sabine Hornhardt, Simone Mörtl and Anna A Friedl
    Citation: Radiation Oncology 2014 9:15
  10. The aim of this study was to quantify the variation in doses to organs at risk (ipsilateral lung and heart) and the clinical target volume (CTV) in the presence of breast implants. In this retrospective cohort...

    Authors: Annelie Liljegren, Dmytro Unukovych, Giovanna Gagliardi, Judith Bjöhle, Marie Wickman, Hemming Johansson and Kerstin Sandelin
    Citation: Radiation Oncology 2014 9:14
  11. To report the outcomes of patients treated with combined iodine-125 (I-125) brachytherapy and external beam radiotherapy (EBRT) for high-risk prostate cancer.

    Authors: Toshio Ohashi, Atsunori Yorozu, Shiro Saito, Tetsuo Momma, Toru Nishiyama, Shoji Yamashita, Yutaka Shiraishi and Naoyuki Shigematsu
    Citation: Radiation Oncology 2014 9:13
  12. The purpose of this clinical study is to investigate the clinical feasibility and safety of a shuttle-based MR-linac connection to provide MR-guided radiotherapy.

    Authors: Tilman Bostel, Nils H Nicolay, Jörg G Grossmann, Angela Mohr, Stefan Delorme, Gernot Echner, Peter Häring, Jürgen Debus and Florian Sterzing
    Citation: Radiation Oncology 2014 9:12
  13. To evaluate use of breath-hold CTs and implanted fiducials for definition of the internal target volume (ITV) margin for upper abdominal stereotactic body radiation therapy (SBRT). To study the statistics of i...

    Authors: Wensha Yang, Benedick A Fraass, Robert Reznik, Nicholas Nissen, Simon Lo, Laith H Jamil, Kapil Gupta, Howard Sandler and Richard Tuli
    Citation: Radiation Oncology 2014 9:11
  14. Stereotactic Ablative RadioTherapy (SABR) of lung tumors/metastases has been shown to be an effective treatment modality with low toxicity. Outcome and toxicity were retrospectively evaluated in a unique singl...

    Authors: Judit Boda-Heggemann, Anian Frauenfeld, Christel Weiss, Anna Simeonova, Christian Neumaier, Kerstin Siebenlist, Ulrike Attenberger, Claus Peter Heußel, Frank Schneider, Frederik Wenz and Frank Lohr
    Citation: Radiation Oncology 2014 9:10
  15. In patients with highly advanced gastric cancer, the recurrence rate remains high and the prognosis disappointing. We previously reported a phase I study of a neoadjuvant chemoradiotherapy of S-1 plus weekly c...

    Authors: Satoru Matsuda, Tsunehiro Takahashi, Junichi Fukada, Kazumasa Fukuda, Hirofumi Kawakubo, Yoshiro Saikawa, Osamu Kawaguchi, Hiroya Takeuchi, Naoyuki Shigematsu and Yuko Kitagawa
    Citation: Radiation Oncology 2014 9:9

    The Erratum to this article has been published in Radiation Oncology 2014 9:140

  16. The overall treatment time of stereotactic body radiotherapy (SBRT) for non-small-cell lung cancer is usually 3 to over 10 days. If it is longer than 7 days, tumor volume expansion during SBRT may jeopardize t...

    Authors: Kotoha Tatekawa, Hiromitsu Iwata, Takatsune Kawaguchi, Satoshi Ishikura, Fumiya Baba, Shinya Otsuka, Akifumi Miyakawa, Maho Iwana and Yuta Shibamoto
    Citation: Radiation Oncology 2014 9:8
  17. The N1 definition of 2010 UICC/AJCC staging system for nasopharyngeal carcinoma (NPC) covers quite a large range of nodal pattern. The objective of this research is to investigate prognostic value of lymph nod...

    Authors: Qi Shi, Chunying Shen, Lin Kong, Xiaoshen Wang, Jianhui Ding, Yunsheng Gao, Tingting Xu and Chaosu Hu
    Citation: Radiation Oncology 2014 9:7
  18. Recurrent malignant gliomas (RMGs) are very difficult to control, and no standard treatments have been established for them. We performed boron neutron capture therapy (BNCT) for patients with RMG. BNCT enable...

    Authors: Shin-Ichi Miyatake, Shinji Kawabata, Ryo Hiramatsu, Motomasa Furuse, Toshihiko Kuroiwa and Minoru Suzuki
    Citation: Radiation Oncology 2014 9:6
  19. To recommend the optimal plan parameter set of grid size and angular increment for dose calculations in treatment planning for lung stereotactic body radiation therapy (SBRT) using dynamic conformal arc therap...

    Authors: Ji-Yeon Park, Siyong Kim, Hae-Jin Park, Jeong-Woo Lee, Yeon-Sil Kim and Tae-Suk Suh
    Citation: Radiation Oncology 2014 9:5
  20. Innovative strategies in cancer radiotherapy are stimulated by the growing knowledge on cellular and molecular tumor biology, tumor pathophysiology, and tumor microenvironment. In terms of tumor diagnostics an...

    Authors: Clemens C Cyran, Philipp M Paprottka, Michel Eisenblätter, Dirk A Clevert, Carsten Rist, Konstantin Nikolaou, Kirsten Lauber, Frederik Wenz, Daniel Hausmann, Maximilian F Reiser, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2014 9:3
  21. The increase in relative biological effectiveness (RBE) of proton beams at the distal edge of the spread out Bragg peak (SOBP) is a well-known phenomenon that is difficult to quantify accurately in vivo. For purp...

    Authors: Jeffrey C Buchsbaum, Mark W McDonald, Peter AS Johnstone, Ted Hoene, Marc Mendonca, Chee-Wei Cheng, Indra J Das, Kevin P McMullen and Mark R Wolanski
    Citation: Radiation Oncology 2014 9:2
  22. Stereotactic Body Radiotherapy (SBRT) has excellent control rates for low- and intermediate-risk prostate carcinoma.The role of SBRT for high-risk disease remains less studied. We present long-term results on ...

    Authors: Alan Katz and Josephine Kang
    Citation: Radiation Oncology 2014 9:1
  23. The aim of this trial was to investigate neurological outcome after emergency RT in MSCC of NSCLC patients with acute neurological deficit.

    Authors: Harald Rief, Rita C Heinhold, Lina C Petersen, Stefan Rieken, Thomas Bruckner, Arash Moghaddam-Alvandi, Jürgen Debus and Florian Sterzing
    Citation: Radiation Oncology 2013 8:297
  24. Circulating microRNAs (miRNAs) are easily accessible and have already proven to be useful as prognostic markers in cancer patients. However, their origin and function in the circulation is still under discussi...

    Authors: Isolde Summerer, Maximilian Niyazi, Kristian Unger, Adriana Pitea, Verena Zangen, Julia Hess, Michael J Atkinson, Claus Belka, Simone Moertl and Horst Zitzelsberger
    Citation: Radiation Oncology 2013 8:296

    The Erratum to this article has been published in Radiation Oncology 2015 10:102

  25. To investigate the feasibility of contouring the planning risk organ volume (PRV) for the heart, and to determine the probability of evaluating radiation dose to the heart using kilovoltage-cone beam computed ...

    Authors: Chengxin Liu, Guanzhong Gong, Chen Guo, Tonghai Liu, Jie Lu, Hong Zhao, Wei Dong and Yong Yin
    Citation: Radiation Oncology 2013 8:295
  26. A standard treatment for unresectable advanced-stage intrahepatic cholangiocarcinoma (IHCC) has not yet been established. Although neoadjuvant concurrent chemoradiotherapy (CCRT) and liver transplantation are ...

    Authors: Young-Il Kim, Joong-Won Park, Bo Hyun Kim, Sang Myung Woo, Tae Hyun Kim, Young Hwan Koh, Woo Jin Lee and Chang-Min Kim
    Citation: Radiation Oncology 2013 8:292
  27. Lung radiation injury is a critical complication of radiotherapy (RT) for thoracic esophageal carcinoma (EC). Therefore, the goal of this study was to investigate the feasibility and dosimetric effects of redu...

    Authors: Guanzhong Gong, Ruozheng Wang, Yujie Guo, Deyin Zhai, Tonghai Liu, Jie Lu, Jinhu Chen, Chengxin Liu and Yong Yin
    Citation: Radiation Oncology 2013 8:291
  28. For treatment of the entire cranium using passive scattering proton therapy (PSPT) compensators are often employed in order to reduce lens and cochlear exposure. We sought to assess the advantages and conseque...

    Authors: Jeffrey Dinh, Joshua Stoker, Rola H Georges, Narayan Sahoo, X Ronald Zhu, Smruti Rath, Anita Mahajan and David R Grosshans
    Citation: Radiation Oncology 2013 8:289
  29. The purpose of the study is to evaluate the long-term clinical outcome through biochemical no evidence of disease (bNED) rates among men with low to intermediate risk prostate cancer treated with two different...

    Authors: Haim Matzkin, Juza Chen, Larissa German and Nicola J Mabjeesh
    Citation: Radiation Oncology 2013 8:288
  30. Re-irradiation is a reasonable second treatment option for patients with recurrent malignant glioma (MG) after previous radio(chemo)therapy. However, only limited data is available allowing for a precise selec...

    Authors: Maximilian Niyazi, Ivan Karin, Matthias Söhn, Silke B Nachbichler, Peter Lang, Claus Belka and Ute Ganswindt
    Citation: Radiation Oncology 2013 8:287
  31. Meta-analysis of randomized trials has shown that postoperative radiotherapy (PORT) had a detrimental effect on overall survival (OS) in patients with resected N1 non–small cell lung cancer (NSCLC). Conversely...

    Authors: Chengcheng Fan, Shugeng Gao, Zhouguang Hui, Jun Liang, Jima Lv, Xiaozhen Wang, Jie He and Luhua Wang
    Citation: Radiation Oncology 2013 8:286
  32. Clinically localized prostate cancer may be treated by different approaches of radiation therapy. The aim of this study was to report the results of disease control and toxicity in patients with clinically loc...

    Authors: Rafael Gadia, Élton T Leite, Flavia G Gabrielli, Gustavo N Marta, Fernando F Arruda, Carlos V Abreu, Samir A Hanna, Cecilia K Haddad, João F Silva, Heloisa A Carvalho and Bernardo Garicochea
    Citation: Radiation Oncology 2013 8:285
  33. To create an arc therapy plan, certain current general calculation algorithms such as pencil-beam calculation (PBC) are based on discretizing the continuous arc into multiple fields to simulate an arc. The iPl...

    Authors: Jin Ho Song, Hun-Joo Shin, Chul Seung Kay, Soo-Min Chae and Seok Hyun Son
    Citation: Radiation Oncology 2013 8:284
  34. Image-guidance maximizes the therapeutic index of brain irradiation by decreasing setup uncertainty. As dose-volume data emerge defining the tolerance of critical normal structures responsible for neuroendocri...

    Authors: Lisa BE Shields, James M Coons, Catherine Dedich, Maria Ragains, Kristi Scalf, Todd W Vitaz and Aaron C Spalding
    Citation: Radiation Oncology 2013 8:283
  35. To analyze our experience with intraoperative electron radiation therapy (IOERT) followed by moderate doses of external beam radiation therapy (EBRT) in patients with locally recurrent renal cell carcinoma.

    Authors: Gregor Habl, Matthias Uhl, Frank Hensley, Sascha Pahernik, Juergen Debus and Falk Röder
    Citation: Radiation Oncology 2013 8:282
  36. Boron neutron capture therapy (BNCT) is a selective radiotherapy that is dependent on the accumulation of 10B compound in tumors. Low-intensity ultrasound produces a transient pore on cell membranes, sonoporation...

    Authors: Naofumi Yamatomo, Takaki Iwagami, Itsuro Kato, Shin-Ichiro Masunaga, Yoshinori Sakurai, Soichi Iwai, Mitsuhiro Nakazawa, Koji Ono and Yoshiaki Yura
    Citation: Radiation Oncology 2013 8:280
  37. To investigate the anatomic and dosimetric variations of volumetric modulated arc therapy (VMAT) in the treatment of nasopharyngeal cancer (NPC) patients based on weekly cone beam CT (CBCT).

    Authors: Xiance Jin, Weigang Hu, Haijiao Shang, Ce Han, Jinling Yi, Yongqiang Zhou and Congying Xie
    Citation: Radiation Oncology 2013 8:279
  38. To compare the accuracy of different imaging modalities, alone and in combination in predicting findings at surgery after preoperative chemoradiation for locally advanced rectal cancer.

    Authors: Ram Dickman, Yulia Kundel, Rachel Levy-Drummer, Ofer Purim, Nir Wasserberg, Eyal Fenig, Aaron Sulkes and Baruch Brenner
    Citation: Radiation Oncology 2013 8:278
  39. To investigate the feasibility and benefits of a modified adaptive radiotherapy (ART) by replanning in the initial CT (iCT) with new contours from a repeat CT (rCT) based on CT-CT image fusion for nasopharynge...

    Authors: Xiance Jin, Ce Han, Yongqiang Zhou, Jinling Yi, Huawei Yan and Congying Xie
    Citation: Radiation Oncology 2013 8:277
  40. Evaluation of dose escalated salvage radiotherapy (SRT) in patients after radical prostatectomy (RP) who had never received antihormonal therapy. To investigate prognostic factors of the outcome of SRT and to ...

    Authors: Mohamed Shelan, Yasser Abo-Madyan, Grit Welzel, Christian Bolenz, Julia Kosakowski, Nadim Behnam, Frederik Wenz and Frank Lohr
    Citation: Radiation Oncology 2013 8:276
  41. The RSSearchâ„¢ Registry is a multi-institutional, observational, ongoing registry established to standardize data collection from patients treated with stereotactic radiosurgery (SRS) and/or stereotactic body r...

    Authors: Joanne N Davis, Clinton Medbery III, Sanjeev Sharma, Adnan Danish and Anand Mahadevan
    Citation: Radiation Oncology 2013 8:275

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