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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO...

    Authors: Giuseppe Minniti, Maximilian Niyazi, Filippo Alongi, Piera Navarria and Claus Belka
    Citation: Radiation Oncology 2021 16:36
    Content type: Review Published on:

  2. The impact of adjuvant radiotherapy (RT) on atypical meningioma (AM) underwent a gross total resection (GTR) remains unclear, showing conflicting results from various studies. The objective of this study was t...

    Authors: Se-Woong Chun, Kyung Min Kim, Min-Sung Kim, Ho Kang, Yun-Sik Dho, Youngbeom Seo, Jin Wook Kim, Yong Hwy Kim and Chul-Kee Park
    Citation: Radiation Oncology 2021 16:34
    Content type: Review Published on:

  3. Prostate Membrane Specific Antigen (PSMA) positron emission tomography (PET) and multiparametric MRI (mpMRI) have shown high accuracy in identifying recurrent lesions after definitive treatment in prostate can...

    Authors: Lindsay S. Rowe, Stephanie Harmon, Adam Horn, Uma Shankavaram, Soumyajit Roy, Holly Ning, Liza Lindenberg, Esther Mena, Deborah E. Citrin, Peter Choyke and Baris Turkbey
    Citation: Radiation Oncology 2021 16:32
    Content type: Research Published on:

  4. The management of melanoma with brain metastases (MBM) is increasingly complex, especially given recent improvements in targeted agents, immunotherapy, and radiotherapy. Whole brain radiation therapy (WBRT) is...

    Authors: Cecilia Jiang, Troy J. Kleber, Jeffrey M. Switchenko and Mohammad K. Khan
    Citation: Radiation Oncology 2021 16:31
    Content type: Research Published on:

  5. To evaluate the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy (WART) in women with ovarian clear cell cancer (OCCC) referred to an academi...

    Authors: Mark J. Stevens, Simon West, Gregory Gard, Christopher Renaud, David Nevell, Stephanie Roderick and Andrew Le
    Citation: Radiation Oncology 2021 16:29
    Content type: Research Published on:

  6. Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus is a current pandemic. We initiated a program of systematic SARS-CoV-2 polymerase chain reaction (PCR) testing in all asymptomatic patients re...

    Authors: Roshan S. Prabhu, Reshika Dhakal, Amy S. Hicks, James McBride, Alicia L. Patrick, Christopher D. Corso, Tomain Murphy, Melissa Thonen, Edward H. Lipford, Derek Raghavan and Stuart H. Burri
    Citation: Radiation Oncology 2021 16:28
    Content type: Research Published on:

  7. Future radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices...

    Authors: Stefanie Corradini, Maximilian Niyazi, Dirk Verellen, Vincenzo Valentini, Seán Walsh, Anca-L. Grosu, Kirsten Lauber, Amato Giaccia, Kristian Unger, Jürgen Debus, Bradley R. Pieters, Matthias Guckenberger, Suresh Senan, Wilfried Budach, Roland Rad, Julia Mayerle…
    Citation: Radiation Oncology 2021 16:27
    Content type: Review Published on:

  8. Segmentation is a crucial step in treatment planning that directly impacts dose distribution and optimization. The aim of this study was to evaluate the inter-individual variability of common cranial organs at...

    Authors: Guillaume Vogin, Liza Hettal, Clarisse Bartau, Juliette Thariat, Marie-Virginie Claeys, Guillaume Peyraga, Paul Retif, Ulrike Schick, Delphine Antoni, Zsuzsa Bodgal, Frederic Dhermain and Loic Feuvret
    Citation: Radiation Oncology 2021 16:26
    Content type: Research Published on:

  10. This meta-analysis evaluated the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer after breast-conserving surgery.

    Authors: Xiaoyong Xiang, Zhen Ding, Lingling Feng and Ning Li
    Citation: Radiation Oncology 2021 16:24
    Content type: Review Published on:

  11. Radiation therapy and chemoradiation therapy play a major role in the definitive management of esophageal cancer. Survival in esophageal cancer patients is still relatively poor, mostly due to high rates of lo...

    Authors: J. Ristau, M. Thiel, S. Katayama, I. Schlampp, K. Lang, M. F. Häfner, K. Herfarth, J. Debus and S. A. Koerber
    Citation: Radiation Oncology 2021 16:23
    Content type: Research Published on:

  12. For meningiomas, complete resection is recommended as first-line treatment while stereotactic radiosurgery (SRS) is established for meningiomas of smaller size considered inoperable. If the patient´s medical c...

    Authors: Maximilian I. Ruge, Juman Tutunji, Daniel Rueß, Eren Celik, Christian Baues, Harald Treuer, Martin Kocher and Stefan Grau
    Citation: Radiation Oncology 2021 16:22
    Content type: Research Published on:

  13. Most previous studies focused on the minimum interval between surgery and radiotherapy in spinal metastases, leaving the maximum interval under-investigated. However, in real world, limited radiotherapist and ...

    Authors: Yining Gong, Hongqing Zhuang, Shan Chong, Qianyu Shi, Feng Wei, Zhongjun Liu, Hanqiang Ouyang, Xiaoguang Liu and Liang Jiang
    Citation: Radiation Oncology 2021 16:21
    Content type: Research Published on:

  15. To investigate maximum tolerated dose (MTD) of axitinib, a selective vascular endothelial growth factor receptor 1–3 inhibitor, in combination with radiotherapy (RT) for advanced hepatocellular carcinoma (HCC).

    Authors: Kai-Lin Yang, Mau-Shin Chi, Hui-Ling Ko, Yi-Ying Huang, Su-Chen Huang, Yu-Min Lin and Kwan-Hwa Chi
    Citation: Radiation Oncology 2021 16:18
    Content type: Research Published on:

  16. Patients with locally advanced rectal cancer generally have different response rates to preoperative neoadjuvant chemo-radiotherapy. This study investigated the value of the apparent diffusion coefficient (ADC...

    Authors: Mengjing Zhao, Lihao Zhao, Han Yang, Yuxia Duan and Gang Li
    Citation: Radiation Oncology 2021 16:17
    Content type: Research Published on:

  17. The watch-and-wait strategy offers a non-invasive therapeutic alternative for rectal cancer patients who have achieved a clinical complete response (cCR) after chemoradiotherapy. This study aimed to investigat...

    Authors: Qiao-xuan Wang, Rong Zhang, Wei-wei Xiao, Shu Zhang, Ming-biao Wei, Yong-heng Li, Hui Chang, Wei-hao Xie, Li-ren Li, Pei-rong Ding, Gong Chen, Zhi-fan Zeng, Wei-hu Wang, Xiang-bo Wan and Yuan-hong Gao
    Citation: Radiation Oncology 2021 16:16
    Content type: Research Published on:

  18. Stereotactic body radiotherapy (SBRT) is an emerging modality for hepatocellular carcinoma (HCC). However, there is scant information about its safety and effectiveness in the neoadjuvant setting prior to live...

    Authors: Ying-Fu Wang, Yang-Hong Dai, Chun-Shu Lin, Hao-Chih Chang, Po-Chien Shen, Jen-Fu Yang, Chih-Weim Hsiang, Cheng-Hsiang Lo and Wen-Yen Huang
    Citation: Radiation Oncology 2021 16:15
    Content type: Research Published on:

  19. Radiotherapy of gastric mucosa-associated lymphoid tissue (MALT) lymphoma should be delivered to the entire stomach with planning target volume (PTV) that accounts for variations in stomach volume, respiratory...

    Authors: Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Yumiko Kono, Yasuhiro Doi, Yoshiyuki Fukugawa, Takahiro Watakabe, Tadashi Matsumoto, Yudai Kai, Masato Maruyama and Natsuo Oya
    Citation: Radiation Oncology 2021 16:14
    Content type: Research Published on:

  20. Stereotactic ablative radiation therapy (SABR) is effective in treating inoperable stage I non-small cell lung cancer (NSCLC), but imaging assessment of response after SABR is difficult. This prospective study...

    Authors: Dae-Myoung Yang, David A. Palma, Keith Kwan, Alexander V. Louie, Richard Malthaner, Dalilah Fortin, George B. Rodrigues, Brian P. Yaremko, Joanna Laba, Stewart Gaede, Andrew Warner, Richard Inculet and Ting-Yim Lee
    Citation: Radiation Oncology 2021 16:11
    Content type: Research Published on:

  22. This study aimed to evaluate the predictive potential of contrast-enhanced computed tomography (CT)-based imaging biomarkers (IBMs) for the treatment outcomes of patients with oesophageal squamous cell carcino...

    Authors: Chengbing Zeng, Tiantian Zhai, Jianzhou Chen, Longjia Guo, Baotian Huang, Hong Guo, Guozhi Liu, Tingting Zhuang, Weitong Liu, Ting Luo, Yanxuan Wu, Guobo Peng, Derui Li and Chuangzhen Chen
    Citation: Radiation Oncology 2021 16:8
    Content type: Research Published on:

  23. In a palliative situation like metastatic spinal cord compression (MSCC), overall treatment time of radiotherapy should be as short as possible. This study compared 5 × 5 Gy in 1 week to 10 × 3 Gy in 2 weeks i...

    Authors: Dirk Rades, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Darejan Lomidze, Raquel Ciervide, Niels H. Hollaender and Steven E. Schild
    Citation: Radiation Oncology 2021 16:7
    Content type: Short report Published on:

  25. To investigate the potential benefit of cytoreductive radiotherapy (cRT) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving abiraterone.

    Authors: Yang Liu, Wen Long, Zitong Zhang, Lixin Mai, Sijuan Huang, Boji Liu, Wufei Cao, Jianhua Wu, Fangjian Zhou, Yonghong Li and Liru He
    Citation: Radiation Oncology 2021 16:5
    Content type: Research Published on:

  26. Metastasis directed treatment (MDT) is increasingly performed with the attempt to improve outcome in non-small cell lung cancer (NSCLC) patients receiving targeted- or immunotherapy (TT/IT). This study aimed t...

    Authors: Stephanie G. C. Kroeze, Jana Schaule, Corinna Fritz, David Kaul, Oliver Blanck, Klaus H. Kahl, Falk Roeder, Shankar Siva, Joost J. C. Verhoeff, Sonja Adebahr, Markus M. Schymalla, Markus Glatzer, Marcella Szuecs, Michael Geier, Georgios Skazikis, Irina Sackerer…
    Citation: Radiation Oncology 2021 16:4
    Content type: Research Published on:

  27. Particle radiotherapy has increasingly gained acceptance for locally advanced pancreatic cancers owing to superior tumor conformity and dosimetry compared to conventional photon radiotherapy. However, the clos...

    Authors: Dongha Lee, Shohei Komatsu, Kazuki Terashima, Hirochika Toyama, Yoshiro Matsuo, Daiki Takahashi, Masaki Suga, Naoko Nishimura, Kentaro Tai, Masahiro Kido, Yusuke Demizu, Sunao Tokumaru, Tomoaki Okimoto, Ryohei Sasaki and Takumi Fukumoto
    Citation: Radiation Oncology 2021 16:3
    Content type: Research Published on:

  28. The aim of this study was to evaluate the long-term treatment results of combined superselective intraarterial chemotherapy and radiation therapy for advanced maxillary sinus cancer (MSC) and the incidence of ...

    Authors: Yasuo Kosugi, Terufumi Kawamoto, Masaki Oshima, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Naoto Shikama and Keisuke Sasai
    Citation: Radiation Oncology 2021 16:2
    Content type: Research Published on:

  29. To evaluate factors associated with osteoradionecrosis of the jaw (ORNJ) in patients with head and neck squamous cell carcinoma (HNSCC), focusing on jaw-related dose–volume histogram (DVH) parameters.

    Authors: Hikaru Kubota, Daisuke Miyawaki, Naritoshi Mukumoto, Takeaki Ishihara, Megumi Matsumura, Takumi Hasegawa, Masaya Akashi, Naomi Kiyota, Hirotaka Shinomiya, Masanori Teshima, Ken-ichi Nibu and Ryohei Sasaki
    Citation: Radiation Oncology 2021 16:1
    Content type: Research Published on:

  30. Current guidelines for the treatment of anaplastic astrocytoma (AA) recommend maximal safe resection followed by radiotherapy and chemotherapy. Despite this multimodal treatment approach, patients have a limit...

    Authors: Helena C. W. Wahner, Malte Träger, Katja Bender, Leonille Schweizer, Julia Onken, Carolin Senger, Felix Ehret, Volker Budach and David Kaul
    Citation: Radiation Oncology 2020 15:282
    Content type: Research Published on:

  31. Current studies about percutaneous endoscopic gastrostomy (PEG) tube placement report equivalent patient outcomes with prophylactic PEG tubes (pPEGs) versus common nutritional support. Unreported was if omitti...

    Authors: Beat Bojaxhiu, Binaya K. Shrestha, Pascal Luterbacher, Olgun Elicin, Mohamed Shelan, Andrew J. S. Macpherson, Benjamin Heimgartner, Roland Giger, Daniel M. Aebersold and Kathrin Zaugg
    Citation: Radiation Oncology 2020 15:281
    Content type: Research Published on:

  32. Patients with locally advanced oropharynx squamous cell carcinoma have suboptimal outcomes with standard chemoradiation. Here, we evaluated toxicity and oncologic outcomes of dose escalation using radiosurgica...

    Authors: Prashant Vempati, Aditya N. Halthore, Sewit Teckie, Zaker Rana, Emile Gogineni, Jeffrey Antone, Honglai Zhang, Mihaela Marrero, Kristin Beadle, Douglas K. Frank, Mohamed Aziz, Doru Paul and Maged Ghaly
    Citation: Radiation Oncology 2020 15:278
    Content type: Research Published on:

  33. Local hypofractionated stereotactic radiotherapy (HFSRT) of the resection cavity is emerging as the standard of care in the treatment of patients with a limited number of brain metastases as it warrants less n...

    Authors: Sophia Scharl, Kerstin A. Kessel, Christian Diehl, Jens Gempt, Bernhard Meyer, Claus Zimmer, Christoph Straube and Stephanie E. Combs
    Citation: Radiation Oncology 2020 15:276
    Content type: Research Published on:

  34. This long-term retrospective analysis aimed to investigate the outcome and toxicity profile of stereotactic brachytherapy (SBT) in selected low-grade gliomas WHO grade II (LGGII) in a large patient series.

    Authors: Juliana Watson, Alexander Romagna, Hendrik Ballhausen, Maximilian Niyazi, Stefanie Lietke, Sebastian Siller, Claus Belka, Niklas Thon and Silke Birgit Nachbichler
    Citation: Radiation Oncology 2020 15:275
    Content type: Research Published on:

  35. Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been ...

    Authors: Daniel Rueß, Vera Weyer, Juman Tutunji, Stefan Grau, Martin Kocher, Mauritius Hoevels, Harald Treuer, Christian Baues and Maximilian I. Ruge
    Citation: Radiation Oncology 2020 15:274
    Content type: Research Published on:

  36. To investigate predictors of cognitive decline after whole brain radiotherapy (WBRT) for brain metastases.

    Authors: Matthew Chan, David Ferguson, Elaine Ni Mhurchu, Ren Yuan, Lovedeep Gondara, Michael McKenzie, Robert Olson, Brian Thiessen, Nafisha Lalani, Roy Ma and Alan Nichol
    Citation: Radiation Oncology 2020 15:271
    Content type: Research Published on:

  37. To recommend a cranial border for level IIb in delineating clinical target volumes (CTV) for nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy and to help reach a consensus on ...

    Authors: Lijun Wang, Shengfu Huang, Lanfang Zhang, Xia He and Yatian Liu
    Citation: Radiation Oncology 2020 15:270
    Content type: Research Published on:

  38. Metastatic epidural spinal cord compression (MESCC) is a devastating complication of advanced malignancy, which can result in neurologic complications and significant deterioration in overall function and qual...

    Authors: Elysia K. Donovan, Jeffrey Greenspoon, Kara L. Schnarr, Timothy J. Whelan, James R. Wright, Crystal Hann, Anthony Whitton, Tom Chow, Sameer Parpia and Anand Swaminath
    Citation: Radiation Oncology 2020 15:267
    Content type: Study protocol Published on:

  39. Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR). This study aims to analyze patt...

    Authors: Lucas Basler, Robert Poel, Christina Schröder, Alessandra Bolsi, Antony Lomax, Stephanie Tanadini-Lang, Matthias Guckenberger and Damien C. Weber
    Citation: Radiation Oncology 2020 15:266
    Content type: Research Published on:

  40. Our institute initiated carbon ion radiotherapy research for patients with stage I breast cancer in April 2013. The purpose of this article is to evaluate the treatment outcome of cases treated outside clinica...

    Authors: Kumiko Karasawa, Tokuhiko Omatsu, Shintaro Shiba, Daisuke Irie, Masaru Wakatsuki and Shigekazu Fukuda
    Citation: Radiation Oncology 2020 15:265
    Content type: Research Published on:

  41. It is important to understand how elderly patients with locally advanced pancreatic carcinoma (LAPC) should be treated, since the number of elderly cancer patients will increase. However, the optimal treatment...

    Authors: Takahiro Iwai, Michio Yoshimura, Ryo Ashida, Yoko Goto, Takahiro Kishi, Satoshi Itasaka, Keiko Shibuya, Masashi Kanai, Toshihiko Masui, Akihisa Fukuda, Hiroyoshi Isoda, Masahiro Hiraoka and Takashi Mizowaki
    Citation: Radiation Oncology 2020 15:264
    Content type: Research Published on:

  42. The spine represents the site which is most frequently affected by bone metastases in patients with systemic cancer. Of all local treatment options, combined kyphoplasty and intraoperative radiotherapy (Kypho-...

    Authors: Frederic Bludau, Laura Winter, Grit Welzel, Udo Obertacke, Frank Schneider, Frederik Wenz, Arne Mathias Ruder and Frank A. Giordano
    Citation: Radiation Oncology 2020 15:263
    Content type: Short report Published on:

  44. Transoral surgery (TOS), particularly transoral robotic surgery (TORS) has become the preferred modality in the United States for the treatment of early stage oropharyngeal cancer, largely due to assumptions o...

    Authors: Eric J. Di Gravio, Pencilla Lang, Hugh Andrew Jinwook Kim, Tricia Chinnery, Neil Mundi, S. Danielle MacNeil, Adrian Mendez, John Yoo, Kevin Fung, Joe S. Mymryk, John W. Barrett, Nancy Read, Varagur Venkatesan, Sara Kuruvilla, Lucas C. Mendez, Eric Winquist…
    Citation: Radiation Oncology 2020 15:261
    Content type: Research Published on:

  45. The gross tumor volume (GTV) could be an independent prognostic factor for unresectable locally advanced non-small cell lung cancer (LANSCLC). We aimed to develop and validate a novel integrated GTV-TNM strati...

    Authors: Nai-Bin Chen, Qi-Wen Li, Zheng-Fei Zhu, Yi-Ming Wang, Zhangkai J. Cheng, Zhou-Guang Hui, Su-Ping Guo, Hao-Qiang He, Bin Wang, Xiao-Yan Huang, Ji-Bin Li, Jin-Yu Guo, Nan Hu, Xin-Lei Ai, Yin Zhou, Da-Quan Wang…
    Citation: Radiation Oncology 2020 15:260
    Content type: Research Published on:

  46. There is considerable evidence that platelets contribute to cancer growth and metastatic dissemination. In recent studies, altered mean platelet volume (MPV) has been associated with prognosis in different typ...

    Authors: Daniela Delago, Olivia Knittelfelder, Gabriele Jakse, Katarzyna Lukasiak, Sabine Reinisch, Wilfried Renner, Heidi Stranzl-Lawatsch, Richard Partl and Tanja Langsenlehner
    Citation: Radiation Oncology 2020 15:259
    Content type: Research Published on:

  47. This study investigates daily breast geometry and delivered dose to prone-positioned patients undergoing tangential whole breast radiation therapy (WBRT) on an O-ring linear accelerator with 6X flattening filt...

    Authors: Suk W. Yoon, Neil K. Taunk, Gary M. Freedman, Emily Hubley, Shannon O’Reilly, Boon- Keng K. Teo, Shibu Anamalayil, Lei Dong, Christopher Kennedy, Wei Zou, James M. Metz and Taoran Li
    Citation: Radiation Oncology 2020 15:258
    Content type: Research Published on:

  48. This study aimed to contrast four different irradiation methods for pediatric medulloblastoma tumors in a dosimetric comparison regarding planning target volume (PTV) coverage and sparing of organs at risk (OA...

    Authors: Gerhard Pollul, Tilman Bostel, Sascha Grossmann, Sati Akbaba, Heiko Karle, Marcus Stockinger and Heinz Schmidberger
    Citation: Radiation Oncology 2020 15:256
    Content type: Research Published on:

  49. Recent advances in radiotherapy techniques have allowed ablative doses to be safely delivered to inoperable liver tumors. In this setting, proton beam radiotherapy (PBT) provides the means to escalate radiatio...

    Authors: Jacob S. Parzen, William Hartsell, John Chang, Smith Apisarnthanarax, Jason Molitoris, Michael Durci, Henry Tsai, James Urbanic, Jonathan Ashman, Carlos Vargas, Craig Stevens and Peyman Kabolizadeh
    Citation: Radiation Oncology 2020 15:255
    Content type: Research Published on:

  50. We read the article entitled “Patterns of brain metastasis immediately before prophylactic cranial irradiation (PCI): implications for PCI optimization in limited-stage small cell lung cancer” with great inter...

    Authors: Lukas Käsmann, Chukwuka Eze, Julian Taugner and Farkhad Manapov
    Citation: Radiation Oncology 2020 15:252
    Content type: Letter to the Editor Published on:
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Radiation Oncology

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