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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. To establish a generalized equivalent uniform dose (gEUD) -based prescription method for Image Guided Brachytherapy (IGBT) that reproduces the Gyn GEC-ESTRO WG (GGE) prescription for cervix carcinoma patients ...

    Authors: William Shaw, William ID Rae and Markus L Alber

    Citation: Radiation Oncology 2013 8:266

    Content type: Research

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  2. N-stage is related to distant metastasis of nasopharyngeal carcinoma (NPC) patients. We performed this study to compare the efficacy of different chemotherapy sequences in advanced N-stage (N2 and N3) NPC pati...

    Authors: Xueming Sun, Lei Zeng, Chunyan Chen, Ying Huang, Fei Han, Weiwei Xiao, Shuai Liu and Taixiang Lu

    Citation: Radiation Oncology 2013 8:265

    Content type: Research

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  3. The standard clinical protocol of image-guided IMRT for prostate carcinoma introduces isocenter relocation to restore the conformity of the multi-leaf collimator (MLC) segments to the target as seen in the con...

    Authors: Kostyantyn Holubyev, Klaus Bratengeier, Mark Gainey, Bülent Polat and Michael Flentje

    Citation: Radiation Oncology 2013 8:263

    Content type: Research

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  4. Vascular abnormalities are the predominant histologic changes associated with radiation in nasopharyngeal carcinoma (NPC). This study examined if the duration after radiotherapy correlates with the progression...

    Authors: Tai Lin Huang, Hsuan Chih Hsu, Hui Chun Chen, Hsin Ching Lin, Chih Yen Chien, Fu Min Fang, Chih Cheng Huang, Hsueh Wen Chang, Wen Neng Chang, Chi Ren Huang, Nai Wen Tsai, Chia Te Kung, Hung Chen Wang, Wei Che Lin, Ben Chung Cheng, Yu Jih Su…

    Citation: Radiation Oncology 2013 8:261

    Content type: Research

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  5. The aim was to quantify severe transient and persisting late term effects in our single institution head neck cancer (HNC) cohort treated with curatively intended intensity modulated radiation therapy (IMRT). ...

    Authors: Gabriela Studer, Claudia Linsenmeier, Oliver Riesterer, Yousef Najafi, Michelle Brown, Bita Yousefi, Marius Bredell, Gerhard Huber, Stephan Schmid, Stephan Studer, Roger Zwahlen, Tamara Rordorf and Christoph Glanzmann

    Citation: Radiation Oncology 2013 8:259

    Content type: Research

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  6. To compare the short-term tumor response and long-term clinical outcome of two preoperative chemoradiotherapy (CRT) regimens for locally advanced rectal cancer.

    Authors: Sung Uk Lee, Dae Yong Kim, Sun Young Kim, Ji Yeon Baek, Hee Jin Chang, Min Ju Kim, Tae Hyun Kim, Ji Won Park and Jae Hwan Oh

    Citation: Radiation Oncology 2013 8:258

    Content type: Research

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  7. Erectile dysfunction after prostate radiation therapy remains an ongoing challenge and critical quality of life issue. Given the higher dose of radiation per fraction using stereotactic body radiation therapy ...

    Authors: Olusola Obayomi-Davies, Leonard N Chen, Aditi Bhagat, Henry C Wright, Sunghae Uhm, Joy S Kim, Thomas M Yung, Siyuan Lei, Gerald P Batipps, John Pahira, Kevin G McGeagh, Brian T Collins, Keith Kowalczyk, Gaurav Bandi, Deepak Kumar, Simeng Suy…

    Citation: Radiation Oncology 2013 8:256

    Content type: Research

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  8. To compare proton beam therapy (PBT) and intensity-modulated radiation therapy (IMRT) with conformal radiation therapy (CRT) in terms of their organ doses and ability to cause secondary cancer in normal organs.

    Authors: Hiroshi Fuji, Uwe Schneider, Yuji Ishida, Masahiro Konno, Haruo Yamashita, Yuki Kase, Shigeyuki Murayama, Tsuyoshi Onoe, Hirofumi Ogawa, Hideyuki Harada, Hirofumi Asakura and Tetsuo Nishimura

    Citation: Radiation Oncology 2013 8:255

    Content type: Research

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  9. Neoadjuvant stereotactic body radiotherapy (SBRT) has potential applicability in the management of borderline resectable and locally-advanced pancreatic adenocarcinoma. In this series, we report the pathologic...

    Authors: Malolan S Rajagopalan, Dwight E Heron, Rodney E Wegner, Herbert J Zeh, Nathan Bahary, Alyssa M Krasinskas, Barry Lembersky, Randall Brand, A James Moser, Annette E Quinn and Steven A Burton

    Citation: Radiation Oncology 2013 8:254

    Content type: Research

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  10. Mucoepidermoid carcinoma of the maxillary sinus is a rare malignancy of the head and neck. The location of this tumour near vital structures and its large size at presentation makes surgical resection with neg...

    Authors: Horia Vulpe, Meredith Giuliani, David Goldstein, Bayardo Perez-Ordonez, Laura A Dawson and Andrew Hope

    Citation: Radiation Oncology 2013 8:251

    Content type: Case report

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  11. Recent studies using stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC) have reported high tumor response and local control. However, the optimal SBRT dose remains unknown, and it is stil...

    Authors: Won Il Jang, Mi-Sook Kim, Sun Hyun Bae, Chul Koo Cho, Hyung Jun Yoo, Young Seok Seo, Jin-Kyu Kang, So Young Kim, Dong Han Lee, Chul Ju Han, Jin Kim, Su Cheol Park, Sang Bum Kim, Eung-Ho Cho and Young Han Kim

    Citation: Radiation Oncology 2013 8:250

    Content type: Research

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  12. To investigate the clinical and dose–volumetric parameters that predict the risk of radiation-induced liver disease (RILD) for patients with small, unresectable hepatocellular carcinoma (HCC) treated with ster...

    Authors: Jinhong Jung, Sang Min Yoon, So Yeon Kim, Byungchul Cho, Jin-hong Park, Su Ssan Kim, Si Yeol Song, Sang-wook Lee, Seung Do Ahn, Eun Kyung Choi and Jong Hoon Kim

    Citation: Radiation Oncology 2013 8:249

    Content type: Research

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  13. Stereotactic ablative body radiotherapy (SABR) is an emerging treatment modality for primary renal cell carcinoma. To account for respiratory-induced target motion, an internal target volume (ITV) concept is o...

    Authors: Shankar Siva, Daniel Pham, Suki Gill, Mathias Bressel, Kim Dang, Thomas Devereux, Tomas Kron and Farshad Foroudi

    Citation: Radiation Oncology 2013 8:248

    Content type: Research

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  14. The aim of this work was to determine the technical feasibility and safety of extended-field radiotherapy (EF), performed by Helical TomoTherapy, in patients with positive pelvic and/or para-aortic nodes. Dosi...

    Authors: Sara Bresciani, Elisabetta Garibaldi, Gabriella Cattari, Angelo Maggio, Amalia Di Dia, Elena Delmastro, Domenico Gabriele, Michele Stasi and Pietro Gabriele

    Citation: Radiation Oncology 2013 8:247

    Content type: Research

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  15. To evaluate clinicopathological features, radiotherapeutic parameters, and their associations with responses to radiotherapy (RT) in patients with myeloid sarcoma (MS).

    Authors: Wan-Yu Chen, Chun-Wei Wang, Chin-Hao Chang, Heng-Hsiu Liu, Keng-Hsueh Lan, Jih-Luh Tang, Hwei-Fang Tien, Sung-Hsin Kuo and Ann-Lii Cheng

    Citation: Radiation Oncology 2013 8:245

    Content type: Research

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  16. Deformable image registration (DIR) is an attractive method for automatic propagation of regions of interest (ROIs) in adaptive lung radiotherapy. This study investigates DIR for automatic contour propagation ...

    Authors: Nicholas Hardcastle, Wouter van Elmpt, Dirk De Ruysscher, Karl Bzdusek and Wolfgang A Tomé

    Citation: Radiation Oncology 2013 8:243

    Content type: Research

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  17. This study aimed to compare the therapeutic outcomes and fatal carotid blow out syndrome (CBOS) incidence rates between two different stereotactic body radiotherapy (SBRT) protocols.

    Authors: Gozde Yazici, Tolga Yusuf Sanlı, Mustafa Cengiz, Deniz Yuce, Melis Gultekin, Pervin Hurmuz, Ferah Yıldız, Faruk Zorlu, Fadil Akyol, Murat Gurkaynak and Gokhan Ozyigit

    Citation: Radiation Oncology 2013 8:242

    Content type: Research

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  18. To assess the therapeutic outcome and failure pattern of three-dimensional conformal radiotherapy (3D-CRT)-based concurrent chemoradiotherapy (CCRT) for recurrence of esophageal squamous cell carcinoma (SCC) a...

    Authors: Yong Bao, ShiLiang Liu, QiChao Zhou, PeiQiang Cai, Simone Anfossi, QiaoQiao Li, YongHong Hu, MengZhong Liu, JianHua Fu, TieHua Rong, Qun Li and Hui Liu

    Citation: Radiation Oncology 2013 8:241

    Content type: Methodology

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  19. Treatment of pancreatic adenocarcinoma in the elderly is often complicated by comorbidities that preclude surgery, chemotherapy and/or conventional external beam radiation therapy (EBRT). Stereotactic body rad...

    Authors: Carolyn H Kim, Diane C Ling, Rodney E Wegner, John C Flickinger, Dwight E Heron, Herbert Zeh, Arthur J Moser and Steven A Burton

    Citation: Radiation Oncology 2013 8:240

    Content type: Research

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  20. Proton-beam radiotherapy (PBT) has been shown to be effective to hepatocellular carcinoma (HCC) as a nonsurgical local treatment option. However, HCC still remains as one of the most difficult cancers to be cu...

    Authors: Masato Abei, Toshiyuki Okumura, Kuniaki Fukuda, Takayuki Hashimoto, Masahiro Araki, Kazunori Ishige, Ichinosuke Hyodo, Ayae Kanemoto, Haruko Numajiri, Masashi Mizumoto, Takeji Sakae, Hideyuki Sakurai, Junko Zenkoh, Gerelchuluun Ariungerel, Yu Sogo, Atsuo Ito…

    Citation: Radiation Oncology 2013 8:239

    Content type: Research

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  21. To evaluate feasibility and preliminary outcomes associated with sequential whole abdomen irradiation (WAI) as consolidative treatment following comprehensive surgery and systemic chemotherapy for advanced end...

    Authors: Nathalie Rochet, Rachel S Kahn, Andrzej Niemierko, Thomas F Delaney and Anthony H Russell

    Citation: Radiation Oncology 2013 8:236

    Content type: Research

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  22. Patients with malignant melanoma may develop brain metastases during the course of the disease, requiring radiotherapeutic treatment. In patients with 1–3 brain metastases, radiosurgery has been established as...

    Authors: Henrik Hauswald, Gregor Habl, David Krug, Denise Kehle, Stephanie E Combs, Justo Lorenzo Bermejo, Jürgen Debus and Florian Sterzing

    Citation: Radiation Oncology 2013 8:234

    Content type: Study protocol

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  23. Langerhans Cell Histiocytosis (LCH) represents a rare benign disorder, previously designated as “Histiocytosis X”, “Type II Histiocytosis” or “Langerhans Cell Granulomatosis”. Clinical presentation includes os...

    Authors: Jan Kriz, Hans Theodor Eich, Frank Bruns, Reinhard Heyd, Ulrich Schäfer, Uwe Haverkamp, Jens Büntzel, Heinrich Seegenschmiedt and Oliver Micke

    Citation: Radiation Oncology 2013 8:233

    Content type: Research

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  24. To analyze dosimetric parameters of patients receiving adjuvant breast radiotherapy (RT) in the prone versus supine position.

    Authors: Marco Krengli, Laura Masini, Tina Caltavuturo, Carla Pisani, Giuseppina Apicella, Eleonora Negri, Letizia Deantonio, Marco Brambilla and Giuseppina Gambaro

    Citation: Radiation Oncology 2013 8:232

    Content type: Research

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  25. Semi-automated segmentation using deformable registration of selected atlas cases consisting of expert segmented patient images has been proposed to facilitate the delineation of lymph node regions for three-d...

    Authors: Carl Sjöberg, Martin Lundmark, Christoffer Granberg, Silvia Johansson, Anders Ahnesjö and Anders Montelius

    Citation: Radiation Oncology 2013 8:229

    Content type: Research

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  26. The delivery of a simultaneous integrated boost to the intra-prostatic tumour nodule may improve local control. The ability to deliver such treatments with hypofractionated SBRT was attempted using RapidArc (V...

    Authors: Alison Tree, Caroline Jones, Aslam Sohaib, Vincent Khoo and Nicholas van As

    Citation: Radiation Oncology 2013 8:228

    Content type: Research

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  27. Retrospective evaluation of the dental status of patients with oral cancer before radiotherapy, the extent of dental rehabilitation procedures, demographic and radiotherapy data as potential risk factors for d...

    Authors: Marcus Niewald, Jochen Fleckenstein, Kristina Mang, Henrik Holtmann, Wolfgang J Spitzer and Christian Rübe

    Citation: Radiation Oncology 2013 8:227

    Content type: Research

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  28. To investigate the feasibility of neoadjuvant chemotherapy and replanning intensity-modulated radiotherapy (IMRT) for intracranial invasion nasopharyngeal carcinoma (NPC).

    Authors: Xiaoshuang Niu, Xi Chang, Yunsheng Gao, Chaosu Hu and Lin Kong

    Citation: Radiation Oncology 2013 8:226

    Content type: Research

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  29. Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Tumor control and survival have improved with the use of radiotherapy (RT) plus concomitant and adjuvant chemotherapy, but the pro...

    Authors: Patrizia Ciammella, Ala Podgornii, Maria Galeandro, Nunziata D’Abbiero, Anna Pisanello, Andrea Botti, Elisabetta Cagni, Mauro Iori and Cinzia Iotti

    Citation: Radiation Oncology 2013 8:222

    Content type: Study protocol

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  30. The aim of this study was to assess the management of cervical necrosis (CN) following radiotherapy (RT) and the impact of smoking status. This rare complication mimics a neoplastic recurrence, and causes conc...

    Authors: Ziad Simon Fawaz, Maroie Barkati, Marie-Claude Beauchemin, Philippe Sauthier, Philippe Gauthier and Thu Van Nguyen

    Citation: Radiation Oncology 2013 8:220

    Content type: Research

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  31. In combined proton-carbon fixed-nozzle treatment facilities with raster scanning delivery, the scattering of proton pencil beams caused by nozzle elements and the relatively large nozzle-to-isocenter distance ...

    Authors: Urszula Jelen, Marta E Bubula, Filippo Ammazzalorso, Rita Engenhart-Cabillic, Uli Weber and Andrea Wittig

    Citation: Radiation Oncology 2013 8:218

    Content type: Research

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  32. The optimal timing of chemoradiotherapy in limited-stage small-cell lung cancer (LS-SCLC) hasn’t been established, although evidence from studies supported that patients can benefit from early radiation therap...

    Authors: Bing Xia, Jia-Zhou Wang, Qi Liu, Jing-Yi Cheng, Zheng-Fei Zhu and Xiao-Long Fu

    Citation: Radiation Oncology 2013 8:216

    Content type: Research

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  33. The co-incidence of synchronous intraepithelial neoplasia and early stage invasive lung cancer is not a rare phenomenon. The need for curative treatment and the invasive potential of squamous cell pulmonary ca...

    Authors: Feras Oskan, Christine Kornhuber, Grit Krause and Dirk Vordermark

    Citation: Radiation Oncology 2013 8:213

    Content type: Case report

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  34. Chloroquine (CLQ), an antimalarial drug, has a lysosomotropic effect associated with increased radiationsensibility, which is mediated by the leakage of hydrolytic enzymes, increased apoptosis, autophagy and i...

    Authors: Luis L Rojas-Puentes, Marcelino Gonzalez-Pinedo, Alejando Crismatt, Alette Ortega-Gomez, Carlos Gamboa-Vignolle, Rodrigo Nuñez-Gomez, Yusmiren Dorantes-Gallareta, Claudia Arce-Salinas and Oscar Arrieta

    Citation: Radiation Oncology 2013 8:209

    Content type: Research

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  35. The goal of this study was to assess a possible dosimetric advantage of intensity modulated radiotherapy (IMRT) of upper abdominal malignancies compared to three-dimensional conformal radiotherapy (3DCRT), and...

    Authors: Alaa Ahmad Nour, Aziz Alaradi, Adel Mohamed, Saleh Altuwaijri and Volker Rudat

    Citation: Radiation Oncology 2013 8:207

    Content type: Research

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  36. The α/β ratio for prostate cancer is postulated being in the range of 0.8 to 2.2 Gy, giving rise to the hypothesis that there may be a therapeutic advantage to hypofractionation. To do so, we carried out a random...

    Authors: Darius Norkus, Agata Karklelyte, Benedikt Engels, Harijati Versmessen, Romas Griskevicius, Mark De Ridder, Guy Storme, Eduardas Aleknavicius, Ernestas Janulionis and Konstantinas Povilas Valuckas

    Citation: Radiation Oncology 2013 8:206

    Content type: Research

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  37. Survival of patients with brain metastasis particularly from historically more radio-resistant malignancies remains dismal. A phase I study of concurrent bortezomib and whole brain radiotherapy was conducted t...

    Authors: Christopher D Lao, Judah Friedman, Christina I Tsien, Daniel P Normolle, Christopher Chapman, Yue Cao, Oliver Lee, Matt Schipper, Catherine Van Poznak, Daniel Hamstra, Theodore Lawrence, James Hayman and Bruce G Redman

    Citation: Radiation Oncology 2013 8:204

    Content type: Research

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  38. Accelerated hypofractionated radiotherapy can shorten total treatment time and overcome the accelerated repopulation of tumour cells during radiotherapy. This therapeutic approach has demonstrated good efficac...

    Authors: Qiang Lin, Yue-E Liu, Xiao-Cang Ren, Na Wang, Xue-Ji Chen, Dong-Ying Wang, Jie Zong, Yu Peng, Zhi-Jun Guo and Jing Hu

    Citation: Radiation Oncology 2013 8:201

    Content type: Research

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  39. The objective of this retrospective analysis is to systematically assess osseous lesions on the basis of a validated scoring system in terms of stability and fractures prior to and following radiotherapy in 33...

    Authors: Harald Rief, Marc Bischof, Thomas Bruckner, Thomas Welzel, Vasileios Askoxylakis, Stefan Rieken, Katja Lindel, Stephanie Combs and Jürgen Debus

    Citation: Radiation Oncology 2013 8:200

    Content type: Research

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  40. The role of adjuvant radiotherapy (RT) for patients with stage III thymoma after complete resection is not definite. Some authors have advocated postoperative RT after complete tumor resection, but some others...

    Authors: Chengcheng Fan, Qinfu Feng, Yidong Chen, Yirui Zhai, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Hongxing Zhang, Jian Li, Zhouguang Hui, Jun Liang, Jima Lv, Yousheng Mao, Luhua Wang and Jie He

    Citation: Radiation Oncology 2013 8:199

    Content type: Research

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  41. Increasing the radiotherapy dose can result in improved local control for non-small-cell lung cancer (NSCLC) and can thereby improve survival. Accelerated hypofractionated radiotherapy can expose tumors to a h...

    Authors: Yue-E Liu, Qiang Lin, Fan-Jie Meng, Xue-Ji Chen, Xiao-Cang Ren, Bin Cao, Na Wang, Jie Zong, Yu Peng, Ya-Jun Ku and Yan Chen

    Citation: Radiation Oncology 2013 8:198

    Content type: Research

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  42. Treating prostate cancer with SBRT could potentially minimize radiation proctitis by reducing high-dose rectal irradiation. In addition, it offers the potential radiobiologic benefits of hypofractionation. Thi...

    Authors: Sumit Sood, Andrew W Ju, Honkung Wang, Siyuan Lei, Sunghae Uhm, Guowei Zhang, Simeng Suy, John Carroll, John Lynch, Anatoly Dritschilo and Sean P Collins

    Citation: Radiation Oncology 2013 8:197

    Content type: Research

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  43. Radiologic response of brain tumors is traditionally assessed according to the Macdonald criteria 10 weeks from the start of therapy. Because glioblastoma (GB) responds in days rather than weeks after boron ne...

    Authors: Ryo Hiramatsu, Shinji Kawabata, Motomasa Furuse, Shin-Ichi Miyatake and Toshihiko Kuroiwa

    Citation: Radiation Oncology 2013 8:192

    Content type: Research

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  44. The Montpellier cancer institute phase II trial started in 2004 and evaluated the feasibility of intraoperative radiotherapy (IORT) technique given as a sole radiation treatment for patients with an excellent ...

    Authors: Claire Lemanski, David Azria, Sophie Gourgou-Bourgade, Norbert Ailleres, Aurelie Pastant, Philippe Rouanet, Pascal Fenoglietto, Jean-Bernard Dubois and Marian Gutowski

    Citation: Radiation Oncology 2013 8:191

    Content type: Study protocol

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  45. The prognosis of prostate cancer patients with lymph node metastases so small they can only be visualized by new imaging techniques as MR lymphography (MRL) is unknown. The purpose of this study was to investi...

    Authors: Hanneke JM Meijer, Oscar A Debats, Emile NJTh van Lin, Johannes Alfred Witjes, Johannes HAM Kaanders and Jelle O Barentsz

    Citation: Radiation Oncology 2013 8:190

    Content type: Research

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  46. The vascular endothelial cells are important targets of radiotherapy, which may be involved in the pathogenesis of radiation pneumonitis (RP). This study investigated the variations of circulating endothelial ...

    Authors: Yunfang Liu, Tingyi Xia, Wenjun Zhang, Yongjie Zhong, Luhua Zhang, Xuan Wang and Huiming Yu

    Citation: Radiation Oncology 2013 8:189

    Content type: Research

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  47. Increasing use of IMRT to treat breast and prostate cancers at high risk of regional nodal spread relies on accurate contouring of targets and organs at risk, which is subject to significant inter- and intra-o...

    Authors: Vikram M Velker, George B Rodrigues, Robert Dinniwell, Jeremiah Hwee and Alexander V Louie

    Citation: Radiation Oncology 2013 8:188

    Content type: Research

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