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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. To evaluate clinical outcome after accelerated partial breast irradiation (APBI) in the elderly after high-dose-rate interstitial multi-catheter brachytherapy (HIBT).

    Authors: Caroline Genebes, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Ines Raoust, Tarik Ihrai, Adel Courdi, Jean-Marc Ferrero, Isabelle Peyrottes and Jean-Michel Hannoun-Levi
    Citation: Radiation Oncology 2014 9:115
    Content type: Research Published on:

  2. Concurrent chemotherapy and radiation therapy is the preferred standard of care for patients with anal cancer. Several studies have suggested a benefit of intensity-modulated radiation therapy (IMRT) compared ...

    Authors: Stefan Alexander Koerber, Alla Slynko, Matthias F Haefner, David Krug, Clara Schoneweg, Kerstin Kessel, Annette Kopp-Schneider, Klaus Herfarth, Juergen Debus and Florian Sterzing
    Citation: Radiation Oncology 2014 9:113
    Content type: Research Published on:

  3. Stereotactic body radiotherapy (SBRT) is a relatively new treatment for liver tumor. The outcomes of SBRT for liver tumor unfit for ablation and surgical resection were evaluated.

    Authors: Hideomi Yamashita, Hiroshi Onishi, Yasuo Matsumoto, Naoya Murakami, Yukinori Matsuo, Takuma Nomiya and Keiichi Nakagawa
    Citation: Radiation Oncology 2014 9:112
    Content type: Research Published on:

  4. To analyze the tumor control, survival outcomes, and toxicity after stereotactic radiosurgery (SRS) for skull base metastases from systemic cancer involving the anterior visual pathway.

    Authors: Giuseppe Minniti, Vincenzo Esposito, Enrico Clarke, Claudia Scaringi, Alessandro Bozzao, Teresa Falco, Vitaliana De Sanctis, Maurizio Maurizi Enrici, Maurizio Valeriani, Mattia Falchetto Osti and Riccardo Maurizi Enrici
    Citation: Radiation Oncology 2014 9:110
    Content type: Study protocol Published on:

  5. We assessed the robustness of passive scattering proton therapy (PSPT) plans for patients in a phase II trial of PSPT for stage III non-small cell lung cancer (NSCLC) by using the worst-case scenario method, a...

    Authors: Zhengfei Zhu, Wei Liu, Michael Gillin, Daniel R Gomez, Ritsuko Komaki, James D Cox, Radhe Mohan and Joe Y Chang
    Citation: Radiation Oncology 2014 9:108
    Content type: Research Published on:

  6. To assess the biochemical recurrence (BCR)-free rate in patients who underwent prostate low-dose-rate brachytherapy (LDR-brachytherapy), using two different definitions (Phoenix definition and PSA ≥ 0.2 ng/mL).

    Authors: Nobumichi Tanaka, Isao Asakawa, Emiko Katayama, Akihide Hirayama, Masatoshi Hasegawa, Noboru Konishi and Kiyohide Fujimoto
    Citation: Radiation Oncology 2014 9:107
    Content type: Research Published on:

  7. In the present study factors affecting survival and toxicity in cerebral metastasized patients treated with stereotactic radiosurgery (SRS) were analyzed with special focus on radiation necrosis.

    Authors: Lars Hendrik Schüttrumpf, Maximilian Niyazi, Silke Birgit Nachbichler, Farkhad Manapov, Nathalie Jansen, Axel Siefert and Claus Belka
    Citation: Radiation Oncology 2014 9:105
    Content type: Research Published on:

  8. The purpose of this study is to evaluate the possible predictors of thyroid disorders after neck radiotherapy, with a focus on radiation dose-volume factors.

    Authors: Zuleyha Akgun, Beste M Atasoy, Zeynep Ozen, Dilek Yavuz, Bahadir Gulluoglu, Meric Sengoz and Ufuk Abacioglu
    Citation: Radiation Oncology 2014 9:104
    Content type: Research Published on:

  9. To evaluate efficacy and toxicity after salvage brachytherapy (BT) in prostate local recurrence after radiation therapy.

    Authors: Iván Henríquez, Gemma Sancho, Asunción Hervás, Benjamin Guix, Joan Pera, Cristina Gutierrez, Oscar Abuchaibe, Rafael Martínez-Monge, Alejandro Tormo and Alfredo Polo
    Citation: Radiation Oncology 2014 9:102
    Content type: Research Published on:

  10. We attempted to analyze the effects of an increase in the Child-Pugh (CP) score on the overall survival of patients with unresectable hepatocellular carcinoma (HCC) after radiotherapy (RT).

    Authors: Seok Hyun Son, Hong Seok Jang, In-Young Jo, Byung Ock Choi, Jeong Won Jang, Seung Kew Yoon and Chul Seung Kay
    Citation: Radiation Oncology 2014 9:101
    Content type: Research Published on:

  11. Chordomas are relatively rare lesions of the bones. About 30% occur in the sacrococcygeal region. Surgical resection is still the standard treatment. Due to the size, proximity to neurovascular structures and ...

    Authors: Matthias Uhl, Lutz Edler, Alexandra D Jensen, Gregor Habl, Jan Oelmann, Falk Röder, Oliver Jäckel, Jürgen Debus and Klaus Herfarth
    Citation: Radiation Oncology 2014 9:100
    Content type: Study protocol Published on:

  12. To assess the safety and usefulness of neutron brachytherapy (NBT) as an adjuvant in the treatment of patients with gastroesophageal junction adenocarcinoma (GEJAC) with external beam radiation (EBRT), with or...

    Authors: Qifeng Wang, Tao Li, Huiming Liu, Xitang Jia, Bo Liu, Xin Wan and Jinyi Lang
    Citation: Radiation Oncology 2014 9:99
    Content type: Research Published on:

  13. The objective of this study is to evaluate toxicity and cosmetic outcome in breast cancer patients treated with adjuvant hypo fractionated radiotherapy to the whole breast, and to identify the risk factors for...

    Authors: Patrizia Ciammella, Ala Podgornii, Maria Galeandro, Renato Micera, Dafne Ramundo, Tamara Palmieri, Elisabetta Cagni and Cinzia Iotti
    Citation: Radiation Oncology 2014 9:97
    Content type: Research Published on:

  14. Radiation therapy is one of the recommended treatment options for localized prostate cancer. In randomized trials, dose escalation was correlated with better biochemical control but also with higher rectal tox...

    Authors: Matthias Uhl, Klaus Herfarth, Michael J Eble, Michael Pinkawa, Baukelien van Triest, Robin Kalisvaart, Damien C Weber, Raymond Miralbell, Danny Y Song and Theodore L DeWeese
    Citation: Radiation Oncology 2014 9:96
    Content type: Research Published on:

  15. Long-term survival is rare in patients with glioblastoma (GBM). We set out to determine prognostic factors for patients with favorable and poor prognosis in regard of tumor localization to the subventricular z...

    Authors: Sebastian Adeberg, Tilman Bostel, Laila König, Thomas Welzel, Juergen Debus and Stephanie E Combs
    Citation: Radiation Oncology 2014 9:95
    Content type: Research Published on:

  16. High cure rates for Hodgkin’s lymphoma must be balanced with long-term treatment-related toxicity. Here we report an intensity-modulated radiation therapy (IMRT) technique that achieves adequate target coverag...

    Authors: Khinh Ranh Voong, Kelli McSpadden, Chelsea C Pinnix, Ferial Shihadeh, Valerie Reed, Mohammad R Salehpour, Isidora Arzu, He Wang, David Hodgson, John Garcia, Michalis Aristophanous and Bouthaina S Dabaja
    Citation: Radiation Oncology 2014 9:94
    Content type: Research Published on:

  18. Osteoradionecrosis (ORN) is a critical complication after carbon ion (C-ion) or photon radiotherapy (RT) for head and neck tumors. However, the risk factors for ORN after C-ion RT remain unclear. Therefore, th...

    Authors: Go Sasahara, Masashi Koto, Hiroaki Ikawa, Azusa Hasegawa, Ryo Takagi, Yoshitaka Okamoto and Tadashi Kamada
    Citation: Radiation Oncology 2014 9:92
    Content type: Research Published on:

  19. Data in the literature suggest the existence of oligometastatic disease, a state in which metastases are limited in number and site. Different kinds of local therapies have been used for the treatment of limit...

    Authors: Pierina Navarria, Anna Maria Ascolese, Stefano Tomatis, Luca Cozzi, Fiorenza De Rose, Pietro Mancosu, Filippo Alongi, Elena Clerici, Francesca Lobefalo, Angelo Tozzi, Giacomo Reggiori, Antonella Fogliata and Marta Scorsetti
    Citation: Radiation Oncology 2014 9:91
    Content type: Research Published on:

  20. Anaplastic thyroid cancer (ATC) is an aggressive malignant tumour with a poor prognosis. The median overall survival is described in the literature to be just 6 months, however, in series of selected patients ...

    Authors: Anne-Katrin Dumke, Tanja Pelz and Dirk Vordermark
    Citation: Radiation Oncology 2014 9:90
    Content type: Research Published on:

  21. Radiotherapy for the treatment of cancer is undergoing an evolution, shifting to the use of heavier ion species. For a plethora of malignancies, current radiotherapy using photons or protons yields marginal be...

    Authors: Cody D Schlaff, Andra Krauze, Arnaud Belard, John J O’Connell and Kevin A Camphausen
    Citation: Radiation Oncology 2014 9:88
    Content type: Review Published on:

  24. To evaluate toxicity and outcome of intensity modulated radiotherapy (IMRT) with simultaneous integrated boost (SIB) to the positive lymph nodes in patients with loco-regional advanced cervical cancer (LRACC).

    Authors: Nikola Cihoric, Coya Tapia, Kamilla Krüger, Daniel M Aebersold, Bernd Klaeser and Kristina Lössl
    Citation: Radiation Oncology 2014 9:83
    Content type: Research Published on:

  25. This clinical study compared four different cases of extensive scalp malignancies treated by intensity-modulated radiation therapy. The merits of coplanar and non-coplanar Step-and-shoot total scalp irradiatio...

    Authors: Christian Ostheimer, Martin Janich, Patrick Hübsch, Reinhard Gerlach and Dirk Vordermark
    Citation: Radiation Oncology 2014 9:82
    Content type: Research Published on:

  27. It was our purpose to analyze long-term clinical outcome and to identify prognostic factors after Linac-based fractionated stereotactic radiotherapy (Linac-based FSRT) and stereotactic radiosurgery (SRS) in pa...

    Authors: David Kaul, Volker Budach, Reinhard Wurm, Arne Gruen, Lukas Graaf, Piet Habbel and Harun Badakhshi
    Citation: Radiation Oncology 2014 9:78
    Content type: Research Published on:

  28. To analyze the feasibility of active breath control (ABC), the lung tumor reproducibility and the rationale for single-breath-hold cone beam CT (CBCT)-guided hypofraction radiotherapy.

    Authors: Renming Zhong, Jin Wang, Lin Zhou, Feng Xu, Li Liu, Jidan Zhou, Xiaoqin Jiang, Nianyong Chen, Sen Bai and You Lu
    Citation: Radiation Oncology 2014 9:77
    Content type: Research Published on:

  29. To explore the volume and localization of the internal gross target volume defined using the seroma and/or surgical clips based on the four-dimensional computed tomography (4DCT) during free-breathing.

    Authors: Yun Ding, Jianbin Li, Wei Wang, Suzhen Wang, Jinzhi Wang, Zhifang Ma, Qian Shao and Min Xu
    Citation: Radiation Oncology 2014 9:76
    Content type: Research Published on:

  30. A retrospective analysis is performed to determine if pre-treatment [18 F]-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG PET/CT) image derived parameters can predict radiation pneu...

    Authors: Richard Castillo, Ngoc Pham, Sobiya Ansari, Dmitriy Meshkov, Sarah Castillo, Min Li, Adenike Olanrewaju, Brian Hobbs, Edward Castillo and Thomas Guerrero
    Citation: Radiation Oncology 2014 9:74
    Content type: Research Published on:

  31. This study was designed to evaluate the efficacy and toxicities of concomitant boost intensity-modulated radiation therapy (IMRT) along with capecitabine and oxaliplatin, followed by a cycle of Xelox, in neoad...

    Authors: Ji Zhu, Fangqi Liu, Weilie Gu, Peng Lian, Weiqi Sheng, Junyan Xu, Gang Cai, Debing Shi, Sanjun Cai and Zhen Zhang
    Citation: Radiation Oncology 2014 9:70
    Content type: Research Published on:

  32. The Spinal Instability Neoplastic Score (SINS) categorizes tumor related spinal instability. It has the potential to streamline the referral of patients with established or potential spinal instability to a sp...

    Authors: Charles G Fisher, Rowan Schouten, Anne L Versteeg, Stefano Boriani, Peter Pal Varga, Laurence D Rhines, Norio Kawahara, Daryl Fourney, Lorna Weir, Jeremy J Reynolds, Arjun Sahgal, Michael G Fehlings and Ziya L Gokaslan
    Citation: Radiation Oncology 2014 9:69
    Content type: Research Published on:

  33. The purpose of this study was to evaluate the efficacy and feasibility of carbon ion radiotherapy (CIRT) for oligo-recurrent lung tumors from colorectal cancer (CRC).

    Authors: Wataru Takahashi, Mio Nakajima, Naoyoshi Yamamoto, Shigeru Yamada, Hideomi Yamashita, Keiichi Nakagawa, Hiroshi Tsuji and Tadashi Kamada
    Citation: Radiation Oncology 2014 9:68
    Content type: Research Published on:

  34. The purpose was to determine whether a brachytherapy boost improves outcomes in patients with advanced nasopharyngeal carcinoma treated with standard chemo-radiotherapy.

    Authors: Eduardo Rosenblatt, May Abdel-Wahab, Mahmoud El-Gantiry, Inas Elattar, Jean Marc Bourque, M’hamed Afiane, Nouredine Benjaafar, Shahid Abubaker, Yaowalak Chansilpa, Bhadrasain Vikram and Peter Levendag
    Citation: Radiation Oncology 2014 9:67
    Content type: Research Published on:

  36. In breast conserving radiotherapy differences of target volume delineations between observers do occur. We evaluated whether delineations based on co-registered computed tomography (CT) and magnetic resonance ...

    Authors: Mirjam Mast, Emile Coerkamp, Mark Heijenbrok, Astrid Scholten, Wim Jansen, Erik Kouwenhoven, Jasper Nijkamp, Stephanie de Waard, Anna Petoukhova and Henk Struikmans
    Citation: Radiation Oncology 2014 9:65
    Content type: Research Published on:

  37. Since there is high local failure and poor survival for unresectable esophageal squamous cell carcinoma (ESCC), the necessity of elective node irradiation is controversial. The purpose of this study was to inv...

    Authors: Xiaoli Zhang, Minghuan LI, Xue Meng, Li Kong, Yan Zhang, Guangsheng Wei, Xiqin Zhang, Fang Shi, Man Hu, Guoli Zhang and Jinming Yu
    Citation: Radiation Oncology 2014 9:64
    Content type: Research Published on:

  38. Accurate tumor bed delineation after breast-conserving surgery is important. However, consistency among observers on standard postoperative radiotherapy planning CT is low and volumes can be large due to serom...

    Authors: Mariska D den Hartogh, Marielle EP Philippens, Iris E van Dam, Catharina E Kleynen, Robbert JHA Tersteeg, Ruud M Pijnappel, Alexis NTJ Kotte, Helena M Verkooijen, Maurice AAJ van den Bosch, Marco van Vulpen, Bram van Asselen and HJG Desirée van den Bongard
    Citation: Radiation Oncology 2014 9:63
    Content type: Research Published on:

  39. The aim of this study was to evaluate the clinical efficacy of submandibular gland transfer for the prevention of xerostomia after radiotherapy for nasopharyngeal carcinoma.

    Authors: Xiangmin Zhang, Folin Liu, Xiaolin Lan, Lijiang Yu, Wei Wu, Xiuhong Wu, Fufu Xiao and Shaojin Li
    Citation: Radiation Oncology 2014 9:62
    Content type: Research Published on:

  40. The aim of this study was to investigate the peripheral doses resulting from volumetric modulated arc therapy (VMAT) and intensity modulated radiotherapy (IMRT) techniques in cervical cancer radiotherapy.

    Authors: Ming X Jia, Xu Zhang, Ce Yin, Ge Feng, Na Li, Song Gao and Da W Liu
    Citation: Radiation Oncology 2014 9:61
    Content type: Research Published on:

  42. Identifying those patients who have a higher chance to be cured with fewer side effects by particle beam therapy than by state-of-the-art photon therapy is essential to guarantee a fair and sufficient access t...

    Authors: Armin Lühr, Steffen Löck, Klaus Roth, Stephan Helmbrecht, Annika Jakobi, Jørgen B Petersen, Uwe Just, Mechthild Krause, Wolfgang Enghardt and Michael Baumann
    Citation: Radiation Oncology 2014 9:59
    Content type: Methodology Published on:

  43. To estimate the risk of radiation induced second cancers after radiotherapy using deep-inspiration breath-hold (DI) technique with three-dimensional conformal (3DCRT) and volumetric arc therapy (VMAT) for pati...

    Authors: Uwe Schneider, Marcin Sumila, Judith Robotka, Damien Weber and Günther Gruber
    Citation: Radiation Oncology 2014 9:58
    Content type: Research Published on:

  44. The long-term aim of developing a laser based acceleration of protons and ions towards clinical application requires not only substantial technological progress, but also the radiobiological characterization o...

    Authors: Kerstin Brüchner, Elke Beyreuther, Michael Baumann, Mechthild Krause, Melanie Oppelt and Jörg Pawelke
    Citation: Radiation Oncology 2014 9:57
    Content type: Research Published on:

  45. To compare the treatment outcomes of intensity-modulated radiotherapy with simultaneous integrated boost (IMRT-SIB) alone to concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carci...

    Authors: Junlin Yi, Xiaodong Huang, Li Gao, Jingwei Luo, Shiping Zhang, Kai Wang, Yuan Qu, Jianping Xiao and Guozhen Xu
    Citation: Radiation Oncology 2014 9:56
    Content type: Research Published on:

  47. To analyze the clinical and dosimetric risk factors of acute esophagitis (AE) in non-small-cell lung cancer (NSCLC) patients treated with concomitant chemoradiotherapy.

    Authors: ZiCheng Zhang, Jin Xu, Tao Zhou, Yan Yi, HongSheng Li, HongFu Sun, Wei Huang, DongQing Wang, BaoSheng Li and GuoGuang Ying
    Citation: Radiation Oncology 2014 9:54
    Content type: Research Published on:

  48. Stereotactic body radiation therapy (SBRT) delivers high doses of radiation to the prostate while minimizing radiation to adjacent normal tissues. Large fraction sizes may increase the risk of functional decre...

    Authors: Onita Bhattasali, Leonard N Chen, Jennifer Woo, Jee-Won Park, Joy S Kim, Rudy Moures, Thomas Yung, Siyuan Lei, Brian T Collins, Keith Kowalczyk, Simeng Suy, Anatoly Dritschilo, John H Lynch and Sean P Collins
    Citation: Radiation Oncology 2014 9:52
    Content type: Research Published on:

  49. The purpose of this study is to evaluate the clinical impact of using deformable registration in tumor volume definition between separately acquired PET/CT and planning CT images.

    Authors: Dominique Fortin, Parminder S Basran, Tanya Berrang, David Peterson and Elaine S Wai
    Citation: Radiation Oncology 2014 9:50
    Content type: Research Published on:

  50. Gastroesophageal cancers (such as esophageal, gastric and gastroesophageal-junction -GEJ- lesions) are worldwide a leading cause of death being relatively rare but highly aggressive. In the past years, a clear...

    Authors: Francesco Cellini, Alessio G Morganti, Francesco M Di Matteo, Gian Carlo Mattiucci and Vincenzo Valentini
    Citation: Radiation Oncology 2014 9:45
    Content type: Review Published on:
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Radiation Oncology

ISSN: 1748-717X

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