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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. The accurate definition of organs at risk (OARs) is required to fully exploit the benefits of intensity-modulated radiotherapy (IMRT) for head and neck cancer. However, manual delineation is time-consuming and...

    Authors: David Thomson, Chris Boylan, Tom Liptrot, Adam Aitkenhead, Lip Lee, Beng Yap, Andrew Sykes, Carl Rowbottom and Nicholas Slevin
    Citation: Radiation Oncology 2014 9:173
  2. The rate of radiation pneumonitis (RP) for patients receiving chemoradiotherapy has been various across studies. Whether it is related to different chemotherapy schedules used in combination with radiation the...

    Authors: Jun Dang, Guang Li, Shuang Zang, Shuo Zhang and Lei Yao
    Citation: Radiation Oncology 2014 9:172
  3. Prostate-specific antigen (PSA) nadir + 2 ng/mL, also known as the Phoenix definition, is the definition most commonly used to establish biochemical failure (BF) after external beam radiotherapy for prostate canc...

    Authors: Kamran A Ahmed, Brian J Davis, Lance A Mynderse, Jeffrey M Slezak, Eric J Bergstralh, Torrence M Wilson and C Richard Choo
    Citation: Radiation Oncology 2014 9:171
  4. To report the dosimetric results and impact of volumetric arc therapy (VMAT) on temporary alopecia and hair-loss related quality of life (QOL) in whole brain radiotherapy (WBRT).

    Authors: Annemieke De Puysseleyr, Joris Van De Velde, Bruno Speleers, Tom Vercauteren, Anneleen Goedgebeur, Tom Van Hoof, Tom Boterberg, Wilfried De Neve, Carlos De Wagter and Piet Ost
    Citation: Radiation Oncology 2014 9:170
  5. Hepatocellular carcinoma is a primary tumor of the liver and involves different treatment modalities according to the tumor stage. After local therapies, the tumor evaluation is based on the mRECIST criteria, ...

    Authors: Matheus Alvarez, Diana Rodrigues de Pina, Fernando Gomes Romeiro, Sérgio Barbosa Duarte and José Arruda Ricardo de Miranda
    Citation: Radiation Oncology 2014 9:166
  6. Prospective evaluation of accelerated hypofractionated radiotherapy (RT) in breast cancer patients treated with 41.6 Gy in 13 fractions plus boost delivered five times a week.

    Authors: Stefan Janssen, Christoph Glanzmann, Stephanie Lang, Sarah Verlaan, Tino Streller, Doris Wisler, Claudia Linsenmeier and Gabriela Studer
    Citation: Radiation Oncology 2014 9:165
  7. This study was designed to evaluate the dosimetric feasibility of definitive stereotactic body radiation therapy (SBRT) for the treatment of medically inoperable early stage endometrial cancer.

    Authors: Ryan Jones, Quan Chen, Ryan Best, Bruce Libby, Edwin F Crandley and Timothy N Showalter
    Citation: Radiation Oncology 2014 9:164
  8. Obstructive voiding symptoms (OVS) are common following prostate cancer treatment with radiation therapy. The risk of urinary retention (UR) following hypofractionated radiotherapy has yet to be fully elucidat...

    Authors: W Tristram Arscott, Leonard N Chen, Nathan Wilson, Aditi Bhagat, Joy S Kim, Rudy A Moures, Thomas M Yung, Siyuan Lei, Brian T Collins, Keith Kowalczyk, Simeng Suy, Anatoly Dritschilo, John H Lynch and Sean P Collins
    Citation: Radiation Oncology 2014 9:163
  9. The significance of definitive radiotherapy for sinonasal mucosal melanoma (SMM) is sill controvertial. T his study was to evaluate the role of high-dose proton beam therapy (PBT) in patients with SMM.

    Authors: Hiroshi Fuji, Shusuke Yoshikawa, Masako Kasami, Shigeyuki Murayama, Tetsuro Onitsuka, Hiroya Kashiwagi and Yoshio Kiyohara
    Citation: Radiation Oncology 2014 9:162
  10. This clinical study was designed to prospectively evaluate the acute and moderately-late cardiac and lung toxicities of intensity modulated radiation therapy delivered by helical tomotherapy (IMRT-HT) for loco...

    Authors: Jean-Michel Caudrelier, Joanne Meng, Bernd Esche, Laval Grimard, Terrence Ruddy and Kayvan Amjadi
    Citation: Radiation Oncology 2014 9:161
  11. Weight loss is a common problem in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) treated with radiotherapy (RT). The aims of the present study were to determine if treated volume (TV), as ...

    Authors: Sandra Ottosson, Karin Söderström, Elisabeth Kjellén, Per Nilsson, Björn Zackrisson and Göran Laurell
    Citation: Radiation Oncology 2014 9:160
  12. Due to the Total Mesorectal Excision (TME) surgery made a good local control,the role of radiotherapy in the treatment of pT3N0 rectal cancer is debated and whether this group of patiens were overtreated has b...

    Authors: Jun-xin Wu, Yu Wang, Na Chen, Lu-chuan Chen, Peng-gang Bai and Jian-ji Pan
    Citation: Radiation Oncology 2014 9:159
  13. Ototoxicity is a known side effect of combined radiation therapy and cisplatin chemotherapy for the treatment of medulloblastoma. The delivery of an involved field boost by intensity modulated radiation therap...

    Authors: Wilson Albieri Vieira, Eduardo Weltman, Michael Jenwei Chen, Nasjla Saba da Silva, Andrea Maria Cappellano, Liliane Desgualdo Pereira, Maria Ines Rabelo Gonçalves, Robson Ferrigno, Rodrigo Morais Hanriot, Wladimir Nadalin, Vicente Odone Filho and Antonio Sergio Petrilli
    Citation: Radiation Oncology 2014 9:158
  14. Ameloblastoma is a benign but locally aggressive tumor of odontogenic epithelial tissue. Reports of radiotherapy treatment modalities are limited in the literature.

    Authors: Timur Koca, Hamit Başaran, Deniz Arslan, Duygu Sezen, Zümrüt Arda Çerkeşli, Özlem Kılınç, Sibel Karaca, Cumhur İbrahim Başsorgun, Hilmi Önder Okay and Münir Demirci
    Citation: Radiation Oncology 2014 9:157
  15. The purpose of this study was to compare the surface dose of 7-field IMRT (7 F-IMRT), tangential beam IMRT (TB-IMRT), and tangential beam 3D-CRT (3D-CRT) of breast cancer patients receiving adjuvant radiothera...

    Authors: Volker Rudat, Alaa Nour, Abdul Aziz Alaradi, Adel Mohamed and Saleh Altuwaijri
    Citation: Radiation Oncology 2014 9:156
  16. Since the results from the randomized TARGIT A trial were published, intraoperative radiotherapy (IORT) is used more often. IORT can be provided as accelerated partial breast irradiation (APBI) or as a boost. ...

    Authors: Elena Sperk, Daniela Astor, Anke Keller, Grit Welzel, Axel Gerhardt, Benjamin Tuschy, Marc Sütterlin and Frederik Wenz
    Citation: Radiation Oncology 2014 9:154
  17. Although the efficacy of prophylactic or therapeutic whole brain radiotherapy (WBRT) for brain metastases (BM) from small cell lung cancer (SCLC) is well established, the role of stereotactic radiosurgery (SRS...

    Authors: Shoji Yomo and Motohiro Hayashi
    Citation: Radiation Oncology 2014 9:152
  18. The aim of this trial was to compare the effects of resistance training versus passive physical therapy on quality of life (QoL), fatigue, and emotional distress outcomes during radiation therapy in patients w...

    Authors: Harald Rief, Michael Akbar, Monika Keller, Georg Omlor, Thomas Welzel, Thomas Bruckner, Stefan Rieken, Matthias F Häfner, Ingmar Schlampp, Alexandros Gioules and Jürgen Debus
    Citation: Radiation Oncology 2014 9:151
  19. Urinary incontinence (UI) following prostate radiotherapy is a rare toxicity that adversely affects a patient’s quality of life. This study sought to evaluate the incidence of UI following stereotactic body ra...

    Authors: Leonard N Chen, Simeng Suy, Hongkun Wang, Aditi Bhagat, Jennifer A Woo, Rudy A Moures, Joy S Kim, Thomas M Yung, Siyuan Lei, Brian T Collins, Keith Kowalczyk, Anatoly Dritschilo, John H Lynch and Sean P Collins
    Citation: Radiation Oncology 2014 9:148
  20. To evaluate the efficacy of three-dimensional radiotherapy for non-small cell lung cancer (NSCLC) patients with bone metastases.

    Authors: Wei-Wei Ouyang, Sheng-Fa Su, Zhu Ma, Yin-Xiang Hu, Bing Lu, Qing-Song Li, Yi-Chao Geng and Hui-Qin Li
    Citation: Radiation Oncology 2014 9:147
  21. The best method of identifying regions within pancreatic tumours that might benefit from an increased radiotherapy dose is not known. We investigated the utility of pre-treatment FDG-PET in predicting the spat...

    Authors: James M Wilson, Somnath Mukherjee, Kwun-Ye Chu, Thomas B Brunner, Mike Partridge and Maria Hawkins
    Citation: Radiation Oncology 2014 9:146
  22. The customer of a new system for clinical use in radiation oncology must consider many options in order to find the optimal combination of software tools. Many commercial systems are available and each system ...

    Authors: Hilke Vorwerk, Klemens Zink, Daniela Michaela Wagner and Rita Engenhart-Cabillic
    Citation: Radiation Oncology 2014 9:145
  23. Brain metastases are common in patients with melanoma, and optimal management is not well defined. As melanoma has traditionally been thought of as “radioresistant,” the role of whole brain radiation therapy (...

    Authors: Michael A Dyer, Nils D Arvold, Yu-Hui Chen, Nancy E Pinnell, Timur Mitin, Eudocia Q Lee, F Stephen Hodi, Nageatte Ibrahim, Stephanie E Weiss, Paul J Kelly, Scott R Floyd, Anand Mahadevan and Brian M Alexander
    Citation: Radiation Oncology 2014 9:143
  24. To assess clinical outcomes of high-dose rate interstitial brachytherapy (HIB) in localized penile carcinoma.

    Authors: Yohann Rouscoff, Alexander Tuan Falk, Matthieu Durand, Jocelyn Gal, Marie-Eve Chand, Mathieu Gautier, Alexandre Marsaud, Daniel Chevallier, Jean Amiel and Jean-Michel Hannoun-Levi
    Citation: Radiation Oncology 2014 9:142
  25. Type II (papillary serous and clear cell) endometrial carcinoma (EC) is a rare subgroup and is considered to have an unfavorable prognosis. The purpose of this retrospective analysis was to elucidate the meani...

    Authors: Robert Foerster, Robert Kluck, Harald Rief, Stefan Rieken, Juergen Debus and Katja Lindel
    Citation: Radiation Oncology 2014 9:141
  26. The goal of this review is to summarize the rationale for and feasibility of hippocampal sparing techniques during brain irradiation. Radiotherapy is the most effective non-surgical treatment of brain tumors a...

    Authors: Tomas Kazda, Radim Jancalek, Petr Pospisil, Ondrej Sevela, Tomas Prochazka, Miroslav Vrzal, Petr Burkon, Marek Slavik, Ludmila Hynkova, Pavel Slampa and Nadia N Laack
    Citation: Radiation Oncology 2014 9:139
  27. Stereotactic body radiotherapy (SBRT) for non-small cell lung cancer (NSCLC) is primarily a treatment option for medically inoperable patients, who are often elderly. However, few studies report the effects of...

    Authors: Shinya Hayashi, Hidekazu Tanaka, Yuuichi Kajiura, Yasushi Ohno and Hiroaki Hoshi
    Citation: Radiation Oncology 2014 9:138
  28. The aim of this study was to evaluate dysphagia in patients with head and neck cancer (HNC) undergoing three-dimensional conformal radiation therapy using objective and subjective tools simultaneously and to a...

    Authors: Eda Yirmibeşoğlu Erkal, Doğu Canoğlu, Ahmet Kaya, Görkem Aksu, Binnaz Sarper, Gür Akansel, Tülay Meydancı and Haldun Şükrü Erkal
    Citation: Radiation Oncology 2014 9:137
  29. To evaluate outcome in patients with glottic cancer treated with intensity-modulated radiotherapy (IMRT) and to show effectiveness of partial laryngeal- and/or carotid artery sparing in low to intermediate ris...

    Authors: Stefan Janssen, Christoph Glanzmann, Gerhard Huber and Gabriela Studer
    Citation: Radiation Oncology 2014 9:136
  30. To assess the outcome of prostate cancer (PCa) patients diagnosed with oligometastatic disease at recurrence and treated with stereotactic body radiotherapy (SBRT).

    Authors: Karel Decaestecker, Gert De Meerleer, Bieke Lambert, Louke Delrue, Valérie Fonteyne, Tom Claeys, Filip De Vos, Wouter Huysse, Arne Hautekiet, Gaethan Maes and Piet Ost
    Citation: Radiation Oncology 2014 9:135
  31. Radiotherapy (RT) is a risk factor for accelerated carotid artery atherosclerotic disease in subjects with head and neck cancer. However, the risk factors of RT-induced carotid artery remodeling are not establ...

    Authors: Eduardo B Pereira, Tiago Gemignani, Andrei C Sposito, José R Matos-Souza and Wilson Nadruz Jr
    Citation: Radiation Oncology 2014 9:134
  32. To evaluate the local response according to stability after radiotherapy (RT) with a special focus on quality-of-life (QoL), fatigue, pain and emotional distress in patients with unstable spinal bone metastases.

    Authors: Harald Rief, Maximiliane Heinhold, Thomas Bruckner, Ingmar Schlampp, Robert Förster, Thomas Welzel, Tilman Bostel, Jürgen Debus and Stefan Rieken
    Citation: Radiation Oncology 2014 9:133
  33. Large brain metastases (BM) remain a significant cause of morbidity and death for cancer patients despite current advances in multimodality therapies. The goal of the present study was to evaluate the efficacy...

    Authors: Shoji Yomo and Motohiro Hayashi
    Citation: Radiation Oncology 2014 9:132
  34. To analyze patterns of failure in patients with glioblastoma multiforme (GBM) treated with limited-margin radiation therapy and concurrent temozolomide. We hypothesize that patients treated with margins in acc...

    Authors: Brian J Gebhardt, Michael C Dobelbower, William H Ennis, Asim K Bag, James M Markert and John B Fiveash
    Citation: Radiation Oncology 2014 9:130
  35. To investigate added morbidity associated with the addition of pelvic elective nodal irradiation (ENI) to hypofractionated radiotherapy to the prostate.

    Authors: Andrew M McDonald, Christopher B Baker, Richard A Popple, Kiran Shekar, Eddy S Yang, Rojymon Jacob, Rex Cardan, Robert Y Kim and John B Fiveash
    Citation: Radiation Oncology 2014 9:129
  36. Re-irradiation has been shown to be a valid option with proven efficacy for recurrent high-grade glioma patients. Overall, up to now it is unclear which patients might be optimal candidates for a second course...

    Authors: Maximilian Niyazi, Maya Flieger, Ute Ganswindt, Stephanie E Combs and Claus Belka
    Citation: Radiation Oncology 2014 9:128
  37. To assess the feasibility and benefit of integrating four-dimensional (4D) Positron Emission Tomography (PET) – computed tomography (CT) for liver stereotactic body radiation therapy (SBRT) planning.

    Authors: Olivier Riou, Benjamin Serrano, David Azria, Benoit Paulmier, Remy Villeneuve, Pascal Fenoglietto, Antonella Artenie, Cécile Ortholan, Marc Faraggi and Juliette Thariat
    Citation: Radiation Oncology 2014 9:127
  38. The study evaluates frequency of and indications for disease-related radiotherapy in the palliative breast cancer (BC) situation and analyzes in which phase of the palliative disease course radiotherapy was ap...

    Authors: Kirsten Steinauer, Markus Wolfram Gross, Dorothy Jane Huang, Serenella Eppenberger-Castori and Uwe Güth
    Citation: Radiation Oncology 2014 9:126
  39. To establish guidelines for the selenium supplementation in radiotherapy we assessed the benefits and risks of selenium supplementation in radiotherapy. Clinical studies on the use of selenium in radiotherapy ...

    Authors: Irma M Puspitasari, Rizky Abdulah, Chiho Yamazaki, Satomi Kameo, Takashi Nakano and Hiroshi Koyama
    Citation: Radiation Oncology 2014 9:125
  40. Intensity-modulated radiotherapy (IMRT) credentialing for a EORTC study was performed using an anthropomorphic head phantom from the Radiological Physics Center (RPC; RPCPH). Institutions were retrospectively req...

    Authors: Damien C Weber, Veronique Vallet, Andrea Molineu, Christos Melidis, Vanda Teglas, Suzanne Naudy, Raphael Moeckli, David S Followill and Coen W Hurkmans
    Citation: Radiation Oncology 2014 9:123
  41. Clinically node negative HNSCC patients have a risk ranging between 18 and 45% of occult metastases, making prophylactic irradiation mandatory. Selective irradiation of nodal target volume based on internation...

    Authors: Jean-François Daisne, Johanne Installé, Benoît Bihin, Marc Laloux, Thierry Vander Borght, Isabelle Mathieu and Georges Lawson
    Citation: Radiation Oncology 2014 9:121
  42. To evaluate the safety and efficacy of Cyberknife stereotactic body radiation therapy (SBRT) and its effect on survival in patients with unresectable huge hepatocellular carcinoma (HCC) unsuitable of other sta...

    Authors: Jenny Y Que, Li-Ching Lin, Kuei-Li Lin, Chia-Hui Lin, Yu-Wei Lin and Ching-Chieh Yang
    Citation: Radiation Oncology 2014 9:120
  43. To evaluate the role of RapidArc (RA) for stereotactic radiosurgery (SRS) of benign brain lesions in comparison to GammaKnife (GK) based technique.

    Authors: Ufuk Abacioglu, Zeynep Ozen, Meltem Yilmaz, Alptekin Arifoglu, Basri Gunhan, Namik Kayalilar, Selcuk Peker, Meric Sengoz, Salih Gurdalli and Luca Cozzi
    Citation: Radiation Oncology 2014 9:119
  44. We prospectively assessed the utility of intensity-modulated radiation therapy (IMRT) with urethral dose reduction and a small margin between the clinical target volume (CTV) and the planning target volume (PT...

    Authors: Shinichi Shimizu, Kentaro Nishioka, Ryusuke Suzuki, Nobuo Shinohara, Satoru Maruyama, Takashige Abe, Rumiko Kinoshita, Norio Katoh, Rikiya Onimaru and Hiroki Shirato
    Citation: Radiation Oncology 2014 9:118
  45. Whole brain radiotherapy (WBRT) plus sequential focal radiation boost is a commonly used therapeutic strategy for patients with brain metastases. However, recent reports on WBRT plus simultaneous in-field boos...

    Authors: Lin Zhou, Jia Liu, Jianxin Xue, Yong Xu, Youling Gong, Lei Deng, Shichao Wang, Renming Zhong, Zhenyu Ding and You Lu
    Citation: Radiation Oncology 2014 9:117
  46. This prospective randomized study aimed to evaluate the role of WBRT + SRS compared to SRS alone and to WBRT alone in improvement of overall survival, brain local control and neurologic manifestations.

    Authors: Mahmoud M El Gantery, HodaM Abd El Baky, Hesham A El Hossieny, Mohamed Mahmoud and Osama Youssef
    Citation: Radiation Oncology 2014 9:116

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