Skip to main content

Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

Page 22 of 27

  1. Due to substantial improvement in diagnosis and treatment of oral cavity cancer, a better understanding of the patient care needs to be revised. We reviewed literature related to OCC and discussed current gene...

    Authors: Francesca De Felice, Daniela Musio, Valentina Terenzi, Valentino Valentini, Andrea Cassoni, Mario Tombolini, Marco De Vincentiis and Vincenzo Tombolini
    Citation: Radiation Oncology 2014 9:263
    Content type: Review Published on:

  2. Retrospective, monocentric analysis of localized superior sulcus non-small cell cancer (SS-NSCLC), article management.

    Authors: Pierre Truntzer, Delphine N Antoni, Nicola Santelmo, Catherine Schumacher, Pierre-Emmanuel Falcoz, Elisabeth Quoix, Jean-Pierre Steib, Gilbert Massard and Georges Noël
    Citation: Radiation Oncology 2014 9:259
    Content type: Case report Published on:

  3. The prognostic factors of thoracic esophageal squamous carcinoma with cervical lymph nodal metastasis (CLNM) have not been specifically investigated. This study was performed to analyze the efficacy and progno...

    Authors: Peng Zhang, Mian Xi, Lei Zhao, Qiao-Qiao Li, Li-Ru He, Shi-Liang Liu, Jing-Xian Shen and Meng-Zhong Liu
    Citation: Radiation Oncology 2014 9:256
    Content type: Research Published on:

  4. Saliva from submandibular glands (SMG) is necessary to minimize xerostomia. It is unclear whether SMG can be safely spared in patients undergoing bilateral neck radiotherapy for locally advanced oropharyngeal ...

    Authors: Michael F Gensheimer, Jay J Liao, Adam S Garden, George E Laramore and Upendra Parvathaneni
    Citation: Radiation Oncology 2014 9:255
    Content type: Research Published on:

  5. Stereotactic ablative body radiotherapy (SABR) has been proposed as a definitive treatment for patients with inoperable primary renal cell carcinoma. However, there is little documentation detailing the radiob...

    Authors: Price Jackson, Farshad Foroudi, Daniel Pham, Michael S Hofman, Nicholas Hardcastle, Jason Callahan, Tomas Kron and Shankar Siva
    Citation: Radiation Oncology 2014 9:253
    Content type: Short report Published on:

  6. The phase III 22071–26071 trial was designed to evaluate the addition of panitumumab to adjuvant chemotherapy plus intensity modulated radiotherapy (IMRT) in locally advanced resected squamous cell head and ne...

    Authors: Alysa Fairchild, Johannes A Langendijk, Sandra Nuyts, Christopher Scrase, Milan Tomsej, Danny Schuring, Akos Gulyban, Sunita Ghosh, Damien C Weber and Wilfried Budach
    Citation: Radiation Oncology 2014 9:248
    Content type: Research Published on:

  7. Cigarette smoking is a common risk factor for developing nasopharyngeal carcinoma. However, the relationship between smoking and clinical outcomes remains uncertain.

    Authors: Shan-Shan Guo, Pei-Yu Huang, Qiu-Yan Chen, Huai Liu, Lin-Quan Tang, Lu Zhang, Li-Ting Liu, Ka-Jia Cao, Ling Guo, Hao-Yuan Mo, Xiang Guo, Ming-Huang Hong and Hai-Qiang Mai
    Citation: Radiation Oncology 2014 9:246
    Content type: Research Published on:

  8. The optimal clinical context for initiation of salvage androgen deprivation therapy (SADT) following the biochemical recurrence of localized prostate cancer remains controversial. We chose to investigate if di...

    Authors: Corey C Foster, William C Jackson, Benjamin C Foster, Skyler B Johnson, Felix Y Feng and Daniel A Hamstra
    Citation: Radiation Oncology 2014 9:245
    Content type: Research Published on:

  9. To evaluate the technical feasibility and toxicity of TomoDirect in breast cancer patients who received radiotherapy after breast-conserving surgery.

    Authors: Hyo Chun Lee, Sung Hwan Kim, Young Jin Suh, Mi Joo Chung, Dae Gyu Kang, Hyun Joo Choi and Jong Hoon Lee
    Citation: Radiation Oncology 2014 9:244
    Content type: Research Published on:

  10. Patients with large prostate volumes have been shown to have higher rates of genitourinary and gastrointestinal toxicities after conventional radiation therapy for prostate cancer. The efficacy and toxicity of...

    Authors: Einsley Janowski, Leonard N Chen, Joy S Kim, Siyuan Lei, Simeng Suy, Brian Collins, John Lynch, Anatoly Dritschilo and Sean Collins
    Citation: Radiation Oncology 2014 9:241
    Content type: Research Published on:

  11. The aim of this study was to report the outcome of primary or metastatic lung cancer patients undergoing volumetric modulated arc therapy for stereotactic body radiation therapy (VMAT-SBRT).

    Authors: Hideomi Yamashita, Akihiro Haga, Wataru Takahashi, Ryousuke Takenaka, Toshikazu Imae, Shigeharu Takenaka and Keiichi Nakagawa
    Citation: Radiation Oncology 2014 9:243
    Content type: Research Published on:

  12. To evaluate PTV margins for hypofractionated IGRT of prostate comparing kV/kV imaging or CBCT.

    Authors: Christoph Oehler, Stephanie Lang, Peter Dimmerling, Christian Bolesch, Stephan Kloeck, Alessandra Tini, Christoph Glanzmann, Yousef Najafi, Gabriela Studer and Daniel R Zwahlen
    Citation: Radiation Oncology 2014 9:229
    Content type: Research Published on:

  15. We treated a 54-year-old Japanese female with a recurrent radiation-induced osteosarcoma arising from left occipital skull, by reactor-based boron neutron capture therapy (BNCT). Her tumor grew rapidly with su...

    Authors: Gen Futamura, Shinji Kawabata, Hiroyuki Siba, Toshihiko Kuroiwa, Minoru Suzuki, Natsuko Kondo, Koji Ono, Yoshinori Sakurai, Minoru Tanaka, Tomoki Todo and Shin-Ichi Miyatake
    Citation: Radiation Oncology 2014 9:237
    Content type: Case report Published on:

  16. A brainstorming and consensus meeting organized by the German Cancer Aid focused on modern treatment of prostate cancer and promising innovative techniques and research areas. Besides optimization of screening...

    Authors: Stephanie E Combs, Jürgen Debus, Günter Feick, Boris Hadaschik, Markus Hohenfellner, Roland Schüle, Jens-Peter Zacharias and Malte Schwardt
    Citation: Radiation Oncology 2014 9:224
    Content type: Research Published on:

  17. The standard treatment choice for cancer metastasis has been systemic management, including cytotoxic chemotherapy, hormonal manipulation, and targeted therapy. Emerging evidence has shown an oligometastatic s...

    Authors: Fang Huang, Gang Wu and Kunyu Yang
    Citation: Radiation Oncology 2014 9:230
    Content type: Review Published on:

  18. Increased caseload has been associated with better patient outcomes in many areas of health care, including high-risk surgery and cancer treatment. However, such a positive volume vs. outcome relationship has ...

    Authors: Moon-Sing Lee, Shiang-Jiun Tsai, Ching-Chih Lee, Yu-Chieh Su, Wen-Yen Chiou, Hon-Yi Lin and Shih-Kai Hung
    Citation: Radiation Oncology 2014 9:234
    Content type: Research Published on:

  19. A retrospective study to compare the failure patterns and effects of elective nodal irradiation (ENI) or involved field irradiation (IFI) for cervical and upper thoracic esophageal squamous cell carcinoma (SCC...

    Authors: Mina Liu, Kuaile Zhao, Yun Chen and Guo-Liang Jiang
    Citation: Radiation Oncology 2014 9:232
    Content type: Research Published on:

  20. Preoperative chemoradiotherapy is usually not indicated for cT2N0 rectal cancer. Abdominoperineal resection is the standard treatment for distal rectal tumors. The aim of the study was to evaluate the actual s...

    Authors: Nir Wasserberg, Yulia Kundel, Ofer Purim, Andrei Keidar, Hanoch Kashtan, Eran Sadot, Eyal Fenig and Baruch Brenner
    Citation: Radiation Oncology 2014 9:233
    Content type: Research Published on:

  21. Treatment options for patients with recurrent disease after radical prostatectomy include salvage radiotherapy of the prostatic bed and/or androgen deprivation therapy. To establish an effective treatment stra...

    Authors: Makito Miyake, Nobumichi Tanaka, Isao Asakawa, Yosuke Morizawa, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Tatsuo Yoneda, Masatoshi Hasegawa, Noboru Konishi and Kiyohide Fujimoto
    Citation: Radiation Oncology 2014 9:208
    Content type: Research Published on:

  22. A single-institutional prospective study of optimal hypofractionated conformal radiotherapy for large brain metastases with high risk factors was performed based on the risk prediction of radiation-related com...

    Authors: Hiroshi K Inoue, Hiro Sato, Yoshiyuki Suzuki, Jun-ichi Saitoh, Shin-ei Noda, Ken-ichi Seto, Kota Torikai, Hideyuki Sakurai and Takashi Nakano
    Citation: Radiation Oncology 2014 9:231
    Content type: Research Published on:

  23. Hypoxia and increased glycolytic activity of tumors are associated with poor prognosis. The purpose of this study was to investigate differences in radiotherapy (RT) dose painting based on the uptake of 2-deox...

    Authors: Malene Martini Clausen, Anders Elias Hansen, Michael Lundemann, Christian Hollensen, Tobias Pommer, Per Munck af Rosenschöld, Annemarie Thuri Kristensen, Andreas Kjær, Fintan J McEvoy and Svend Aage Engelholm
    Citation: Radiation Oncology 2014 9:228
    Content type: Research Published on:

  24. Radiotherapy for long bone metastases (RTLB) can be complicated by fractures, which considerably increase morbidity and mortality. The aim of this study was to analyze the risk factors for impending fractures ...

    Authors: Zuzana Tatar, Martin Soubrier, Anne Françoise Dillies, Pierre Verrelle, Stéphane Boisgard and Michel Lapeyre
    Citation: Radiation Oncology 2014 9:227
    Content type: Research Published on:

  25. Interstitial brachytherapy (ISBT) is an optional treatment for locally advanced gynecological tumours for which conventional intracavitary brachytherapy (ICBT) would result in suboptimal dose coverage. However...

    Authors: Takahiro Oike, Tatsuya Ohno, Shin-ei Noda, Hiroki Kiyohara, Ken Ando, Kei Shibuya, Tomoaki Tamaki, Yosuke Takakusagi, Hiro Sato and Takashi Nakano
    Citation: Radiation Oncology 2014 9:222
    Content type: Research Published on:

  26. Dang and colleagues recently reported in the journal that tumor response to definitive chemoradiation, as assessed using the RECIST criteria, and the risk of radiation pneumonitis were positively correlated in...

    Authors: Michael P MacManus, David Ball and Rodney J Hicks
    Citation: Radiation Oncology 2014 9:217
    Content type: Letter to the Editor Published on:

  27. Yomo and Hayashi reported results of stereotactic radiosurgery alone for brainmetastases from small cell lung cancer. This strategy aims to avoid theneurocognitive effects of whole-brain radiation therapy. How...

    Authors: Eric Ojerholm, Michelle Alonso-Basanta and Charles B Simone II
    Citation: Radiation Oncology 2014 9:218
    Content type: Letter to the Editor Published on:

  28. To evaluate efficacy and toxicity of hypofractionated intensity-modulated simultaneous integrated boost (IMRT-SIB) and image-guided (IGRT) radiotherapy in the treatment of high-risk prostate cancer patients.

    Authors: Maurizio Valeriani, Alessia Carnevale, Mattia Falchetto Osti, Vitaliana DE Sanctis, Linda Agolli and Riccardo Maurizi Enrici
    Citation: Radiation Oncology 2014 9:214
    Content type: Research Published on:

  29. To retrospectively review the efficacy and organ preservation experience for muscle-invasive bladder cancer by trimodality therapy at our institution.

    Authors: Cheng-Yen Lee, Kai-Lin Yang, Hui-Ling Ko, Rong-Yau Huang, Pei-Pin Tsai, Ming-Tsun Chen, Yi-Chia Lin, Thomas I-Sheng Hwang, Guang-Dar Juang and Kwan-Hwa Chi
    Citation: Radiation Oncology 2014 9:213
    Content type: Research Published on:

  31. The role of prophylactic cranial irradiation (PCI) on small cell lung cancer (SCLC) has been established based on the two-stage system of limited versus extensive disease and the treatment modality of chemorad...

    Authors: Hui Zhu, Yongmin Bi, Anqin Han, Jingyu Luo, Minghuan Li, Fang Shi, Li Kong and Jinming Yu
    Citation: Radiation Oncology 2014 9:216
    Content type: Research Published on:

  32. Addition of whole-brain irradiation (WBI) to radiosurgery for treatment of few cerebral metastases is controversial. This study aimed to create an instrument that estimates the probability of developing new ce...

    Authors: Stefan Huttenlocher, Liesa Dziggel, Dagmar Hornung, Oliver Blanck, Steven E Schild and Dirk Rades
    Citation: Radiation Oncology 2014 9:215
    Content type: Research Published on:

  33. Lung cancer continues to be one of the most prevalent malignancies worldwide and is the leading cause of death in both men and women. Presently, local control rates are quite poor. Improvements in imaging and ...

    Authors: Arya Amini, Norman Yeh, Laurie E Gaspar, Brian Kavanagh and Sana D Karam
    Citation: Radiation Oncology 2014 9:210
    Content type: Review Published on:

  34. There are already numerous reports about high local control rates in patients with craniopharyngioma but there are only few studies with follow up times of more than 10 years. This study is an analysis of long...

    Authors: Semi B Harrabi, Sebastian Adeberg, Thomas Welzel, Stefan Rieken, Daniel Habermehl, Jürgen Debus and Stephanie E Combs
    Citation: Radiation Oncology 2014 9:203
    Content type: Research Published on:

  35. Standard treatment strategies for embryonal central nervous system (CNS) tumors have not yet been established. We treated these tumors using an original chemoradiation therapy protocol; the clinical outcomes a...

    Authors: Kazumasa Odagiri, Motoko Omura, Masaharu Hata, Noriko Aida, Tetsu Niwa, Hiroaki Goto, Susumu Ito, Masanori Adachi, Haruyasu Yoshida, Hiroko Yuki and Tomio Inoue
    Citation: Radiation Oncology 2014 9:201
    Content type: Research Published on:

  36. Prostate volume can affect whether patients qualify for brachytherapy (desired size ≥20 mL and ≤60 mL) and/or active surveillance (desired PSA density ≤0.15 for very low risk disease). This study examines vari...

    Authors: Yonina R Murciano-Goroff, Luciant D Wolfsberger, Arti Parekh, Fiona M Fennessy, Kemal Tuncali, Peter F Orio III, Thomas R Niedermayr, W Warren Suh, Phillip M Devlin, Clare Mary C Tempany, Emily H Neubauer Sugar, Desmond A O’Farrell, Graeme Steele, Michael O’Leary, Ivan Buzurovic, Antonio L Damato…
    Citation: Radiation Oncology 2014 9:200
    Content type: Research Published on:

  37. To evaluate feasibility and outcome of our institutional SIB-IMRT schedule in patients with anal cancer and to selectively review the literature on different SIB-IMRT schedules.

    Authors: Stefan Janssen, Christoph Glanzmann, Peter Bauerfeind, Sonja Stieb, Gabriela Studer, Michelle Brown and Oliver Riesterer
    Citation: Radiation Oncology 2014 9:199
    Content type: Research Published on:

  38. An observational multi-institutional study has been conducted aimed to evaluate the inter-observer variability in clinical target volume (CTV) delineation among different radiation oncologists in radiotherapy ...

    Authors: Luciana Caravatta, Gabriella Macchia, Gian Carlo Mattiucci, Aldo Sainato, Nunzia LV Cernusco, Giovanna Mantello, Monica Di Tommaso, Marianna Trignani, Antonino De Paoli, Gianni Boz, Maria L Friso, Vincenzo Fusco, Marta Di Nicola, Alessio G Morganti and Domenico Genovesi
    Citation: Radiation Oncology 2014 9:198
    Content type: Research Published on:

  39. Since lymph nodes volumes are generally four times the volume of the primary PTV, the advantage of using tight margins around the primary PTV is not clear. Therefore treatment margins of T2-T4 laryngeal carcin...

    Authors: Cornelia AJM Vugts, Chris HJ Terhaard, Marielle EP Philippens, Frank A Pameijer, Nicolien Kasperts and Cornelis PJ Raaijmakers
    Citation: Radiation Oncology 2014 9:195
    Content type: Research Published on:

  40. The aim of this retrospective study was to evaluate the stability of spinal metastases in gynecologic cancer patients (pts) on the basis of a validated scoring system after radiotherapy (RT), to define prognos...

    Authors: Robert Foerster, Daniel Habermehl, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Thomas Welzel, Juergen Debus and Harald Rief
    Citation: Radiation Oncology 2014 9:194
    Content type: Research Published on:

  42. To report our experience with increased dose intensity-modulated radiation and concurrent systemic chemotherapy as definitive treatment of locally advanced esophageal cancer.

    Authors: Falk Roeder, Nils H Nicolay, Tam Nguyen, Ladan Saleh-Ebrahimi, Vasilis Askoxylakis, Tilman Bostel, Felix Zwicker, Juergen Debus, Carmen Timke and Peter E Huber
    Citation: Radiation Oncology 2014 9:191
    Content type: Research Published on:

  43. Stage III unresectable non-small cell lung cancer (NSCLC) is preferably treated with concurrent schedules of chemoradiotherapy, but none is clearly superior Gemcitabine is a radiosensitizing cytotoxic drug tha...

    Authors: Gerald SMA Kerner, Leon FA van Dullemen, Erwin M Wiegman, Joachim Widder, Edwin Blokzijl, Ellen M Driever, John WG van Putten, Jeroen JW Liesker, Tineke EJ Renkema, Remge M Pieterman, Marc JF Mertens, Thijo JN Hiltermann and Harry JM Groen
    Citation: Radiation Oncology 2014 9:190
    Content type: Research Published on:

  44. To evaluate the feasibility and educational value of high-fidelity, interprofessional team-based simulation in radiation oncology.

    Authors: Meredith Giuliani, Caitlin Gillan, Olive Wong, Nicole Harnett, Emily Milne, Doug Moseley, Robert Thompson, Pamela Catton and Jean-Pierre Bissonnette
    Citation: Radiation Oncology 2014 9:189
    Content type: Research Published on:

  45. Locoregional tumor failure (LRF) after definitive chemoradiation for patients with stage III NSCLC remains unacceptably high. This analysis sought to further define where LRF occurs relative to radiation dose ...

    Authors: Raj S Rajpara, Eduard Schreibmann, Tim Fox, Liza J Stapleford, Jonathan J Beitler, Walter J Curran and Kristin A Higgins
    Citation: Radiation Oncology 2014 9:187
    Content type: Research Published on:

  46. There is a trend towards hypofractionated stereotactic radiotherapy (RT) in prostate cancer to apply high single doses in a few fractions. Using the Cyberknife® robotic system multiple non-coplanar fields are ...

    Authors: Marcin Sumila, Andreas Mack, Uwe Schneider, Fabrizio Storelli, Jürgen Curschmann and Günther Gruber
    Citation: Radiation Oncology 2014 9:186
    Content type: Case report Published on:

  47. A study was undertaken to analyze the efficacy and feasibility of particle beam radiation therapy (PBRT) using carbon ions and protons for the treatment of patients with oligometastatic lung tumors.

    Authors: Nor Shazrina Sulaiman, Osamu Fujii, Yusuke Demizu, Kazuki Terashima, Yasue Niwa, Takashi Akagi, Takashi Daimon, Masao Murakami, Ryohei Sasaki and Nobukazu Fuwa
    Citation: Radiation Oncology 2014 9:183
    Content type: Research Published on:

  48. This research paper presents a valid treatment strategy for recurrent glioblastoma multiforme (GBM) using hypofractionated stereotactic radiotherapy by intensity modulated radiation therapy (HS-IMRT) planned w...

    Authors: Kazuhiro Miwa, Masayuki Matsuo, Shin-ichi Ogawa, Jun Shinoda, Kazutoshi Yokoyama, Jitsuhiro Yamada, Hirohito Yano and Toru Iwama
    Citation: Radiation Oncology 2014 9:181
    Content type: Research Published on:

  49. In a previous study we demonstrated that, based on 11C/18 F-choline positron emission tomography-computerized-tomography as a diagnostic tool, salvage lymph node dissection (LND) plus adjuvant radiotherapy (ART) ...

    Authors: Cordula A Jilg, Anja Leifert, Daniel Schnell, Simon Kirste, Natalia Volegova-Neher, Daniel Schlager, Gesche Wieser, Karl Henne, Wolfgang Schultze-Seemann, Anca-L Grosu and Hans Christian Rischke
    Citation: Radiation Oncology 2014 9:178
    Content type: Research Published on:

  50. The aim of the present analysis was to assess the feasibility, toxicity, and the tumor control of reirradiation as a salvage treatment for progressive pediatric non-pontine high-grade gliomas (HGG).

    Authors: Klaus Müller, Heike Scheithauer, Sophie Pietschmann, Marion Hoffmann, Jochen Rössler, Norbert Graf, Brigitta G Baumert, Hans Christiansen, Rolf-Dieter Kortmann, Christof M Kramm and André O von Bueren
    Citation: Radiation Oncology 2014 9:177
    Content type: Research Published on:
Submit manuscript

Follow

Annual Journal Metrics

  • 2022 Citation Impact
    3.6 - 2-year Impact Factor
    3.8 - 5-year Impact Factor
    1.370 - SNIP (Source Normalized Impact per Paper)
    1.037 - SJR (SCImago Journal Rank)

    2023 Speed
    16 days submission to first editorial decision for all manuscripts (Median)
    132 days submission to accept (Median)

    2023 Usage 
    1,958,690 downloads
    605 Altmetric mentions

Radiation Oncology

ISSN: 1748-717X

Contact us