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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Accelerated partial breast irradiation (APBI) with balloon and strut adjusted volume implants (SAVI) show promising results with excellent tumor control and minimal toxicity. Knowing the factors that contribut...

    Authors: Zaker Rana, Nadim M. Nasr, Huaying Ji, Virginia Lorio, Stephanie Akbari, Molly Sebastian, Mami Martin and Robert L. Hong
    Citation: Radiation Oncology 2015 10:160
  2. Peritoneal carcinomatosis occurs in different cancer subtypes and is associated with a dismal prognosis. Some doubts remain whether the whole abdomen can be treated by regional hyperthermia, therefore we analy...

    Authors: Marcus Beck, Pirus Ghadjar, Mirko Weihrauch, Susen Burock, Volker Budach, Jacek Nadobny, Jalid Sehouli and Peter Wust
    Citation: Radiation Oncology 2015 10:157
  3. The efficacy of bevacizumab has not been determined for treatment-refractory meningiomas. We treated meningiomas with low-dose bevacizumab and compared the radiological responses of non-irradiated meningiomas ...

    Authors: Motomasa Furuse, Naosuke Nonoguchi, Shinji Kawabata, Tomo Miyata, Taichiro Toho, Toshihiko Kuroiwa and Shin-Ichi Miyatake
    Citation: Radiation Oncology 2015 10:156
  4. The risk of prostate cancer-specific mortality (PCSM) following a diagnosis of prostate cancer may improve after patients have survived a number of years after diagnosis. We sought to determine long-term condi...

    Authors: Vinayak Muralidhar, Brandon A. Mahal and Paul L. Nguyen
    Citation: Radiation Oncology 2015 10:155
  5. There is limited information available on the optimal Planning Target Volume (PTV) expansions and image guidance for post-prostatectomy intensity modulated radiotherapy (PP-IMRT). As the prostate bed does not ...

    Authors: Linda J. Bell, Jennifer Cox, Thomas Eade, Marianne Rinks, Alan Herschtal and Andrew Kneebone
    Citation: Radiation Oncology 2015 10:151
  6. To date, there are no reports of intraoperative radiotherapy (IORT) use with long-term follow up as a method of accelerated partial breast irradiation (APBI) in Asian countries. We initiated a prospective phas...

    Authors: Mariko Kawamura, Yoshiyuki Itoh, Masataka Sawaki, Toyone Kikumori, Nobuyuki Tsunoda, Takeshi Kamomae, Seiji Kubota, Tohru Okada, Rie Nakahara, Junji Ito, Hironori Hayashi and Shinji Naganawa
    Citation: Radiation Oncology 2015 10:150
  7. Miliary brain metastases are a rare condition but associated with an exceedingly poor prognosis. We present the case of a patient suffering from malignant melanoma with an acute progressively worsening of neur...

    Authors: Florian P. Reiter, Clemens Giessen-Jung, Mario M. Dorostkar, Birgit Ertl-Wagner, Gerald U. Denk, Suzette Heck, Christina T. Rieger, Hans W. Pfister and Mark op den Winkel
    Citation: Radiation Oncology 2015 10:148
  8. To investigate the meaning of lymphadenectomy (LNE) in women with endometrial cancer (EC) for clinical outcome and secondly to determine the impact of the method of adjuvant radiotherapy (RT) on survival as we...

    Authors: Robert Foerster, Robert Kluck, Nathalie Arians, Stefan Rieken, Harald Rief, Sebastian Adeberg, Tilman Bostel, Ingmar Schlampp, Juergen Debus and Katja Lindel
    Citation: Radiation Oncology 2015 10:147
  9. Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy...

    Authors: Claudia Blattmann, Susanne Oertel, Markus Thiemann, Anne Dittmar, Eva Roth, Andreas E. Kulozik, Volker Ehemann, Wilko Weichert, Peter E. Huber, Albrecht Stenzinger and Jürgen Debus
    Citation: Radiation Oncology 2015 10:146
  10. Bone metastases are an important clinical issue in women with breast cancer. Particularly, unstable spinal bone metastases (SBM) are a major cause of severe morbidity and reduced quality of life (QoL) due to f...

    Authors: Robert Foerster, Thomas Bruckner, Tilman Bostel, Ingmar Schlampp, Juergen Debus and Harald Rief
    Citation: Radiation Oncology 2015 10:144
  11. With the development of more conformal and precise radiation techniques such as Intensity-Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy (SBRT) and Image-Guided Radiotherapy (IGRT), patients wit...

    Authors: Daniel Habermehl, Patrick Naumann, Rolf Bendl, Uwe Oelfke, Simeon Nill, Jürgen Debus and Stephanie E. Combs
    Citation: Radiation Oncology 2015 10:143
  12. To evaluate the prognostic factors affecting survival in esophageal squamous cell Carcinoma (ESCC) patients with pathologic T0 (ypT0) underwent preoperative radiotherapy.

    Authors: Qifeng Wang, Shufei Yu, Zefen Xiao, Xiao Liu, Wencheng Zhang, Xun Zhang, Jie He, Kelin Sun, Ting Xu, Qinfu Feng, Zongmei Zhou, Lvhua Wang and Weibo Yin
    Citation: Radiation Oncology 2015 10:142
  13. Adjuvant radiotherapy (RT) for left-sided breast cancer increases cardiac morbidity and mortality. For the heart, no safe radiation threshold has been established. Troponin T is a sensitive marker of myocardia...

    Authors: Tanja Skyttä, Suvi Tuohinen, Eeva Boman, Vesa Virtanen, Pekka Raatikainen and Pirkko-Liisa Kellokumpu-Lehtinen
    Citation: Radiation Oncology 2015 10:141
  14. To report our results with postoperative or definitive radiation therapy in head and neck sarcomas.

    Authors: Claudia Andrä, Josefine Rauch, Minglun Li, Ute Ganswindt, Claus Belka, Ladan Saleh-Ebrahimi, Hendrik Ballhausen, Silke Birgit Nachbichler and Falk Roeder
    Citation: Radiation Oncology 2015 10:140
  15. This study aimed for a collaborative evaluation of variability in the target volumes for glioblastoma, determined and contoured by different radiotherapy (RT) facilities in Korea.

    Authors: Chan Woo Wee, Wonmo Sung, Hyun-Cheol Kang, Kwan Ho Cho, Tae Jin Han, Bae-Kwon Jeong, Jae-Uk Jeong, Haeyoung Kim, In Ah Kim, Jin Hee Kim, Sung Hwan Kim, Suzy Kim, Dong Soo Lee, Me Yeon Lee, Do Hoon Lim, Hye Li Park…
    Citation: Radiation Oncology 2015 10:137
  16. To evaluate the effect of two different alpha-1 adrenoceptor antagonists on lower urinary tract symptoms in patients who underwent LDR-brachytherapy.

    Authors: Nobumichi Tanaka, Kazumasa Torimoto, Isao Asakawa, Makito Miyake, Satoshi Anai, Akihide Hirayama, Masatoshi Hasegawa, Noboru Konishi and Kiyohide Fujimoto
    Citation: Radiation Oncology 2014 9:302
  17. Radiation dermatitis is common in patients treated with combined radiotherapy and chemotherapy for head and neck malignancies. Its timely and adequate management is of uttermost importance for both oncological...

    Authors: Pierfrancesco Franco, Ilenia Potenza, Francesco Moretto, Mattia Segantin, Mario Grosso, Antonello Lombardo, Daniela Taricco, Patrizia Vallario, Andrea Riccardo Filippi, Monica Rampino and Umberto Ricardi
    Citation: Radiation Oncology 2014 9:297
  18. Performing intensity-modulated radiotherapy (IMRT) on head and neck cancer patients (HNCPs) requires robust training and experience. Thus, in 2011, the Head and Neck Cancer Working Group (HNCWG) of the Italian...

    Authors: Anna Merlotti, Daniela Alterio, Riccardo Vigna-Taglianti, Alessandro Muraglia, Luciana Lastrucci, Roberto Manzo, Giuseppina Gambaro, Orietta Caspiani, Francesco Miccichè, Francesco Deodato, Stefano Pergolizzi, Pierfrancesco Franco, Renzo Corvò, Elvio G Russi and Giuseppe Sanguineti
    Citation: Radiation Oncology 2014 9:264
  19. A 67-year old man with a history of papillary thyroid cancer (PTC) presented with metastatic disease to the left colon in the form of a 6.1x1.0 cm bleeding, ulcerated mass. Radiopaque surgical clips were used ...

    Authors: Alvin Szeto, Lee Chin, Patrick Whelan, Jennifer Wilson and Justin Lee
    Citation: Radiation Oncology 2014 9:298
  20. Recurrence rates following radiotherapy for prostate cancer in the post-operative adjuvant or salvage setting remain substantial. Previous work from our institution demonstrated that published prostate bed CTV...

    Authors: Jennifer Croke, Jillian Maclean, Balazs Nyiri, Yan Li, Kyle Malone, Leonard Avruch, Cathleen Kayser and Shawn Malone
    Citation: Radiation Oncology 2014 9:303
  21. Management of spinal neoplasms has relied on open surgery and external beam radiotherapy (EBRT). Although primary spinal tumors are rare, their treatment remains a pervasive problem. This analysis sought to ev...

    Authors: Qianqian Cao, Hao Wang, Na Meng, Yuliang Jiang, Ping Jiang, Yang Gao, Suqing Tian, Chen Liu, Ruijie Yang, Junjie Wang and Kaixian Zhang
    Citation: Radiation Oncology 2014 9:301
  22. The aim of this study was to assess if FDG-PET could guide dose prescription heterogeneity and decrease arbitrary location of hotspots in SBRT.

    Authors: Bénédicte Henriques de Figueiredo, Mikael Antoine, Renaud Trouette, Philippe Lagarde, Adeline Petit, Frédéric Lamare, Mathieu Hatt and Philippe Fernandez
    Citation: Radiation Oncology 2014 9:300
  23. We investigated whether routine elective irradiation of a clinically negative inguinal node (IGN) is necessary for patients with locally advanced distal rectal cancer and anal canal invasion (ACI).

    Authors: Seung-Gu Yeo, Hyeon Woo Lim, Dae Yong Kim, Tae Hyun Kim, Sun Young Kim, Ji Yeon Baek, Hee Jin Chang, Ji Won Park and Jae Hwan Oh
    Citation: Radiation Oncology 2014 9:296
  24. The aim of the present analysis was to evaluate the recurrence pattern in patients with recurrent malignant glioma after re-irradiation in combination with bevacizumab as there is limited data on how to optima...

    Authors: Maximilian Niyazi, Nathalie Lisa Jansen, Maya Rottler, Ute Ganswindt and Claus Belka
    Citation: Radiation Oncology 2014 9:299
  25. Intermediate- to-high-risk prostate cancer can locally invade seminal vesicle (SV). It is recommended that anatomic proximal 1-cm to 2-cm SV be included in the clinical target volume (CTV) for definitive radio...

    Authors: Xin Qi, Xian-Shu Gao, Junichi Asaumi, Min Zhang, Hong-Zhen Li, Ming-Wei Ma, Bo Zhao, Fei-Yu Li and Dian Wang
    Citation: Radiation Oncology 2014 9:288
  26. The neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response and may predict the clinical outcome in some cancers, such as head and neck cancer and gastric cancer. ...

    Authors: Lijun Shen, Hui Zhang, Liping Liang, Guichao Li, Ming Fan, Yongxin Wu, Ji Zhu and Zhen Zhang
    Citation: Radiation Oncology 2014 9:295
  27. The impact of thoracic three-dimensional radiotherapy on the prognosis for stage IV non-small-cell lung cancer is unclear. This study is to investigate survival outcomes and prognosis in patients with stage IV...

    Authors: ShengFa Su, YinXiang Hu, WeiWei Ouyang, Zhu Ma, Bing Lu, QingSong Li, HuiQin Li, ZhiYong Wang and Yu Wang
    Citation: Radiation Oncology 2014 9:290
  28. The aim of this study was to retrospectively observe and analyze the long-term treatment outcomes of a total of 140 esophageal cancer patients who were treated with californium-252 (252Cf) neutron brachytherapy (...

    Authors: Kai Ma, Qifeng Wang, Tao Li, Huiming Liu, Bo Liu, Xitang Jia, Shufeng Li, Junyuan Lang and Mingzhi Zhang
    Citation: Radiation Oncology 2014 9:294
  29. PET/CT scans acquired in the radiotherapy treatment position are typically performed without compensating for respiratory motion. The purpose of this study was to investigate geographic miss of lung tumours du...

    Authors: Jason Callahan, Tomas Kron, Shankar Siva, Nathalie Simoens, Amanda Edgar, Sarah Everitt, Michal E Schneider and Rodney J Hicks
    Citation: Radiation Oncology 2014 9:291
  30. This study was conducted to assess the prognostic value of the number of negative lymph nodes (NLNs) in breast cancer patients with four or more positive lymph nodes after postmastectomy radiotherapy (PMRT).

    Authors: San-Gang Wu, Jia-Yuan Sun, Juan Zhou, Feng-Yan Li, Hao Zhou, Qin Lin, Huan-Xin Lin, Yong Bao and Zhen-Yu He
    Citation: Radiation Oncology 2014 9:284
  31. A handful of studies have reported outcomes with CyberKnife radiosurgery (CKRS) for the treatment of trigeminal neuralgia. However, the follow-up has been short with no minimum follow-up required and have incl...

    Authors: Sana D Karam, Alexander Tai, James W Snider, Shilpa Bhatia, Edward J Bedrick, Abdul Rashid, Ann Jay, Christopher Kalhorn, Nathan Nair, K William Harter, Sean P Collins and Walter Jean
    Citation: Radiation Oncology 2014 9:257
  32. To investigate a prognostic role of gross tumor volume (GTV) changes on survival outcomes following concurrent chemoradiotherapy (CCRT) in stage III non-small-cell lung cancer (NSCLC) patients.

    Authors: Tae Ryool Koo, Sung Ho Moon, Yu Jin Lim, Ja Young Kim, Yeonjoo Kim, Tae Hyun Kim, Kwan Ho Cho, Ji-Youn Han, Young Joo Lee, Tak Yun, Heung Tae Kim and Jin Soo Lee
    Citation: Radiation Oncology 2014 9:283
  33. To assess the impact of incremental modifications of treatment planning and delivery technique, as well as patient anatomical factors, on late gastrointestinal toxicity using data from the TROG 03.04 RADAR pro...

    Authors: Noorazrul Yahya, Martin A Ebert, Max Bulsara, Annette Haworth, Rachel Kearvell, Kerwyn Foo, Angel Kennedy, Sharon Richardson, Michele Krawiec, David J Joseph and Jim W Denham
    Citation: Radiation Oncology 2014 9:282
  34. The purpose of this study was to evaluate the brachial plexus (BP) dose of postmastectomy radiotherapy (PMRT) to the ipsilateral supraclavicular (ISCL) area, and report the characteristics of radiation-induced...

    Authors: San-Gang Wu, Si-Juan Huang, Juan Zhou, Jia-Yuan Sun, Han Guo, Feng-Yan Li, Qin Lin, Huan-Xin Lin and Zhen-Yu He
    Citation: Radiation Oncology 2014 9:292
  35. Proctitis after radiation therapy for prostate cancer remains an ongoing clinical challenge and critical quality of life issue. SBRT could minimize rectal toxicity by reducing the volume of rectum receiving hi...

    Authors: Daniel Y Joh, Leonard N Chen, Gerald Porter, Aditi Bhagat, Sumit Sood, Joy S Kim, Rudy Moures, Thomas Yung, Siyuan Lei, Brian T Collins, Andrew W Ju, Simeng Suy, John Carroll, John H Lynch, Anatoly Dritschilo and Sean P Collins
    Citation: Radiation Oncology 2014 9:277
  36. Limiting radiation dose to the larynx can diminish effects of laryngeal dysfunction. However, no clear guidelines exist for defining the larynx and its substructures consistently on cross-sectional imaging. Th...

    Authors: Mehee Choi, Tamer Refaat, Malisa S Lester, Ian Bacchus, Alfred W Rademaker and Bharat B Mittal
    Citation: Radiation Oncology 2014 9:285
  37. To evaluate the feasibility and efficacy of simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) in patients with limited-disease small-cell lung cancer (LD-SCLC).

    Authors: Dan Han, Qin Qin, Shaoyu Hao, Wei Huang, Yumei Wei, Zicheng Zhang, Zhongtang Wang and Baosheng Li
    Citation: Radiation Oncology 2014 9:280
  38. This study was conducted to investigate the local effects and toxicity of accelerated hyperfractionated intensity-modulated radiotherapy for recurrent/unresectable rectal cancer in patients with previous pelvi...

    Authors: Gang Cai, Ji Zhu, Weigang Hu and Zhen Zhang
    Citation: Radiation Oncology 2014 9:278
  39. There are various subgroups of patients with metastatic prostate cancer: polymetastatic, oligometastatic, or oligo-recurrent cancers whose progression follows different courses and for whom there are different...

    Authors: Antonio José Conde Moreno, Carlos Ferrer Albiach, Rodrigo Muelas Soria, Verónica González Vidal, Raquel García Gómez and María Albert Antequera
    Citation: Radiation Oncology 2014 9:258

    The Erratum to this article has been published in Radiation Oncology 2015 10:154

  40. Radiation delivery for malignant brain tumors is gradually becoming more precise. Particularly the possibilities of sparing adjacent normal structures such as the hippocampus are increasing. To determine its r...

    Authors: Raphael Bodensohn, Matthias Söhn, Ute Ganswindt, Gabriele Schupp, Silke B Nachbichler, Oliver Schnell, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2014 9:276
  41. In the last few years, hypofractionated external beam radiotherapy has gained increasing popularity for prostate cancer treatment, since sufficient evidence exists that prostate cancer has a low α/β ratio, low...

    Authors: Nina-Sophie Hegemann, Matthias Guckenberger, Claus Belka, Ute Ganswindt, Farkhad Manapov and Minglun Li
    Citation: Radiation Oncology 2014 9:275
  42. To evaluate the clinical features, treatment results, prognostic factors and late toxicities of nasopharyngeal carcinoma in children and adolescents.

    Authors: Weixin Liu, Yuan Tang, Li Gao, Xiaodong Huang, Jingwei Luo, Shiping Zhang, Kai Wang, Yuan Qu, Jianping Xiao, Guozhen Xu and Junlin Yi
    Citation: Radiation Oncology 2014 9:274
  43. Consensus-based approaches provide an alternative to evidence-based decision making, especially in situations where high-level evidence is limited. Our aim was to demonstrate a novel source of information, obj...

    Authors: Paul Martin Putora, Cedric M Panje, Alexandros Papachristofilou, Alan Dal Pra, Thomas Hundsberger and Ludwig Plasswilm
    Citation: Radiation Oncology 2014 9:270
  44. Radiation to the neck has long been associated with an elevated risk of hypothyroidism development. The goal of the present work is to define dosimetric predictors of hypothyroidism in oropharyngeal cancer (OP...

    Authors: Arthur Chyan, Josephine Chen, Erin Shugard, Louise Lambert, Jeanne M Quivey and Sue S Yom
    Citation: Radiation Oncology 2014 9:269
  45. An important issue in palliative radiation oncology is the whether whole-brain radiotherapy should be added to radiosurgery when treating a limited number of brain metastases. To optimize personalized treatmen...

    Authors: Dirk Rades, Stefan Huttenlocher, Dagmar Hornung, Oliver Blanck, Steven E Schild and Dorothea Fischer
    Citation: Radiation Oncology 2014 9:267
  46. The aim of this study was to analyse the reasons for not starting or for early of radiotherapy at the Radiation Oncology Department.

    Authors: Meritxell Arenas, Sebastià Sabater, Marina Gascón, Ivan Henríquez, M José Bueno, Àngels Rius, Àngels Rovirosa, David Gómez, Anna Lafuerza, Albert Biete and Jordi Colomer
    Citation: Radiation Oncology 2014 9:260
  47. POEMS syndrome is a paraneoplastic syndrome caused by an underlying plasma cell proliferative disease. In this study, we examined the treatment outcomes and role of radiotherapy in the management of POEMS synd...

    Authors: Yang-Gun Suh, Young-Suk Kim, Chang-Ok Suh, Yu Ri Kim, June-Won Cheong, Jin Seok Kim and Jaeho Cho
    Citation: Radiation Oncology 2014 9:265
  48. To determine prostate displacement during extreme hypofractionated volume modulated arc radiotherapy (VMAT) using pre- and post-treatment orthogonal images with three implanted gold seed fiducial markers.

    Authors: Adam Gladwish, Geordi Pang, Patrick Cheung, Laura D’Alimonte, Andrea Deabreu and Andrew Loblaw
    Citation: Radiation Oncology 2014 9:262

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