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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Planning for Volumetric Modulated Arc Therapy (VMAT) may be time consuming and its use is limited by available staff resources. Automated multicriterial treatment planning can eliminate this bottleneck. We com...

    Authors: Daniel Buergy, Abdul Wahab M. Sharfo, Ben J. M. Heijmen, Peter W. J. Voet, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr and Florian Stieler
    Citation: Radiation Oncology 2017 12:33
    Content type: Research Published on:

  2. To evaluate the efficacy and toxicity of helical tomotherapy (HT) in the management of spine chordomas when proton therapy is unavailable or non-feasible.

    Authors: Maxime Bobin, Christina Zacharatou, Paul Sargos, Véronique Brouste, Albert Lisbona, Marc-André Mahé, Georges Noël, Amandine Halley, Loïc Feuvret, Louis Gras, Stéphanie Hoppe, Bénédicte Henriques de Figueiredo and Guy Kantor
    Citation: Radiation Oncology 2017 12:32
    Content type: Research Published on:

  3. We report our experience of using helical tomotherapy (HT) to treat large and irregular shaped loco-regional advanced breast cancer target volumes embracing various organs at risk.

    Authors: M. N. Duma, C. Heinrich, C. Schönknecht, B. Chizzali, M. Mayinger, M. Devecka, S. Kampfer and S. E. Combs
    Citation: Radiation Oncology 2017 12:31
    Content type: Research Published on:

  4. A phase II trial was launched to evaluate if neoadjuvant stereotactic ablative radiotherapy (SABR) before surgery improves oncologic outcomes in patients with stage I non-small cell lung cancer (NSCLC). We rep...

    Authors: David A. Palma, Timothy K. Nguyen, Keith Kwan, Stewart Gaede, Mark Landis, Richard Malthaner, Dalilah Fortin, Alexander V. Louie, Eric Frechette, George B. Rodrigues, Brian Yaremko, Edward Yu, A. Rashid Dar, Ting-Yim Lee, Al Gratton, Andrew Warner…
    Citation: Radiation Oncology 2017 12:30
    Content type: Short report Published on:

  5. To report the effect of intraoperative electron beam radiotherapy (IOERT) and external beam radiotherapy (EBRT) in addition to surgery as well as to evaluate the role of resectable local recurrence for long-te...

    Authors: Sven Hager, Frank Makowiec, Karl Henne, Ulrich T. Hopt and Uwe A. Wittel
    Citation: Radiation Oncology 2017 12:29
    Content type: Research Published on:

  6. Multimodal treatment approaches have substantially improved the outcome of breast cancer patients in the last decades. Radiotherapy is an integral component of multimodal treatment concepts used in curative an...

    Authors: David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Marc D. Piroth, Marie-Luise Sautter-Bihl, Felix Sedlmayer, Rainer Souchon, Frederik Wenz and Rolf Sauer
    Citation: Radiation Oncology 2017 12:25
    Content type: Review Published on:

  7. Intraoperative radiotherapy differs from conventional, fractionated radiotherapy in several aspects that may influence its biological effect. The radiation quality influences the relative biologic effectivenes...

    Authors: Carsten Herskind, Lin Ma, Qi Liu, Bo Zhang, Frank Schneider, Marlon R. Veldwijk and Frederik Wenz
    Citation: Radiation Oncology 2017 12:24
    Content type: Review Published on:

  8. Intraoperative radiotherapy (IORT) refers to the delivery of a single radiation dose to a limited volume of tissue during a surgical procedure. A literature review was performed to analyze the role of IORT in ...

    Authors: Marco Krengli, Carla Pisani, Letizia Deantonio, Daniela Surico, Alessandro Volpe, Nicola Surico and Carlo Terrone
    Citation: Radiation Oncology 2017 12:18
    Content type: Review Published on:

  10. Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel chemotherapy re...

    Authors: Robert Krempien and Falk Roeder
    Citation: Radiation Oncology 2017 12:8
    Content type: Review Published on:

  11. The clinical effects of radiation dose-intensification in locally advanced non-small cell lung (NSCLCa) and other cancers are challenging to predict and are ideally studied in randomized trials. The purpose of...

    Authors: John P. Christodouleas, Matthew D. Hall, Marjorie A. van der Pas, Wensheng Guo, Timothy E. Schultheiss and Peter Gabriel
    Citation: Radiation Oncology 2017 12:19
    Content type: Research Published on:

  12. In the breast cancer, the decision whether to administer adjuvant therapy is increasingly influenced by the Ki-67 proliferation index. In the present retrospective study, we investigated if this index could pr...

    Authors: Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Haruna Nishimaki and Shinobu Masuda
    Citation: Radiation Oncology 2017 12:16
    Content type: Research Published on:

  13. The effect of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)-guided dose-painting intensity-modulated radiation therapy (IMRT) in locoregionally advanced nasopharyngeal carci...

    Authors: Feng Liu, Xu-ping Xi, Hui Wang, Ya-qian Han, Feng Xiao, Ying Hu, Qian He, Lin Zhang, Qin Xiao, Lin Liu, Le Luo, Yun Li, Yi Mo and Hong-zhi Ma
    Citation: Radiation Oncology 2017 12:15
    Content type: Research Published on:

  14. Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radi...

    Authors: Matthew J. Boyer, Michael A. Papagikos, Rex Kiteley, Zeljko Vujaskovic, Jackie Wu and W. Robert Lee
    Citation: Radiation Oncology 2017 12:14
    Content type: Research Published on:

  15. Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-rela...

    Authors: Gregory Vlacich, Mark J. Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr and Anthony J. Cmelak
    Citation: Radiation Oncology 2017 12:13
    Content type: Research Published on:

  16. To assess feasibility and safety of conventionally fractionated radiotherapy (cfRT) in patients with hepatocellular carcinoma (HCC).

    Authors: Evelyn Herrmann, Diana Naehrig, Manfred Sassowsky, Martin Bigler, Jeroen Buijsen, Ilja Ciernik, Daniel Zwahlen, Alessandra Franzetti Pellanda, Andreas Meister, Peter Brauchli, Simona Berardi, Erika Kuettel, Jean-François Dufour and Daniel M. Aebersold
    Citation: Radiation Oncology 2017 12:12
    Content type: Research Published on:

  17. Dose escalation of SBRT for locally advanced pancreatic cancer patients had been reported in several studies in one or three fractions, and phase I protocol was developed to investigate the maximum tolerated d...

    Authors: Shui-Wang Qing, Xiao-Ping Ju, Yang-Sen Cao and Huo-Jun Zhang
    Citation: Radiation Oncology 2017 12:6
    Content type: Study protocol Published on:

  18. To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT).

    Authors: Akram Saad, Jeffrey Goldstein, Yaacov R. Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss and Zvi Symon
    Citation: Radiation Oncology 2017 12:5
    Content type: Research Published on:

  19. Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) have poor prognosis despite several multimodal approaches. Recently, low-dose fractionated radiotherapy concurrent to the induction chemothe...

    Authors: Maria Vittoria Mattoli, Mariangela Massaccesi, Alessandra Castelluccia, Valentina Scolozzi, Giovanna Mantini and Maria Lucia Calcagni
    Citation: Radiation Oncology 2017 12:4
    Content type: Research Published on:

  20. To investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy.

    Authors: Nina-Sophie Hegemann, Anne Schlesinger-Raab, Ute Ganswindt, Claudia Hörl, Stephanie E. Combs, Dieter Hölzel, Jürgen E. Gschwend, Christian Stief, Claus Belka and Jutta Engel
    Citation: Radiation Oncology 2017 12:2
    Content type: Research Published on:

  21. Image guided radiotherapy (IGRT) is an essential pre-requisite for delivering high precision radiotherapy. We compared daily variation detected by two non-ionizing imaging modalities (surface imaging and trans...

    Authors: Marco Krengli, Gianfranco Loi, Carla Pisani, Debora Beldì, Giuseppina Apicella, Valentina Amisano and Marco Brambilla
    Citation: Radiation Oncology 2016 11:159
    Content type: Research Published on:

  22. Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of per...

    Authors: J. Roesch, C. Panje, F. Sterzing, F. Mantel, U. Nestle, N. Andratschke and M. Guckenberger
    Citation: Radiation Oncology 2016 11:157
    Content type: Research Published on:

  23. Clinical target volumes (CTV) for radiotherapy (RT) in esophageal cancer (EC) are based on standard expansions of primary tumor volume. Data is needed to define regions at highest risk for occult disease, base...

    Authors: Brandon Garcia, Karyn A. Goodman, Lajhem Cambridge, Mark Dunphy and Abraham J. Wu
    Citation: Radiation Oncology 2016 11:156
    Content type: Research Published on:

  24. To report our initial clinical experience with the novel surface imaging system Catalyst™ (C-RAD AB, Sweden) in connection with an Elekta Synergy linear accelerator for daily patient positioning in patients un...

    Authors: F. Walter, P. Freislederer, C. Belka, C. Heinz, M. Söhn and F. Roeder
    Citation: Radiation Oncology 2016 11:154
    Content type: Research Published on:

  25. Radiation therapy-related dysphagia is worsened by xerostomia. The submandibular glands (SMG) produce saliva rich in lubricating mucins, and sparing the SMG has been shown to reduce xerostomia. The goal of thi...

    Authors: Michael F. Gensheimer, Matthew Nyflot, George E. Laramore, Jay J. Liao and Upendra Parvathaneni
    Citation: Radiation Oncology 2016 11:151
    Content type: Research Published on:

  26. In carbon ion radiotherapy (CIR) for esophageal cancer, organ and target motion is a major challenge for treatment planning due to potential range deviations. This study intends to analyze the impact of intraf...

    Authors: M. F. Haefner, F. Sterzing, D. Krug, S. A. Koerber, O. Jaekel, J. Debus and M. M. Haertig
    Citation: Radiation Oncology 2016 11:150
    Content type: Research Published on:

  27. To investigate second cancer risk (SCR) comparing volumetric modulated arc therapy (VMAT) and 3D conformal radiotherapy (3DCRT) with different high dose fractionation schemes.

    Authors: Daniel R. Zwahlen, Laura I. Bischoff, Günther Gruber, Marcin Sumila and Uwe Schneider
    Citation: Radiation Oncology 2016 11:149
    Content type: Research Published on:

  28. Radiomics or computer – extracted texture features have been shown to achieve superior performance than multiparametric MRI (mpMRI) signal intensities alone in targeting prostate cancer (PCa) lesions. Radiomic...

    Authors: Rakesh Shiradkar, Tarun K Podder, Ahmad Algohary, Satish Viswanath, Rodney J. Ellis and Anant Madabhushi
    Citation: Radiation Oncology 2016 11:148
    Content type: Research Published on:

  29. To determine whether dose/volume specific endpoints (DVSE) or Area under the rectal DVH curve (rAUC) better predict acute gastrointestinal (GI) toxicity in prostate cancer patients treated with IMRT in the era...

    Authors: Céline Mirjolet, Paul M. Walker, Mélanie Gauthier, Cécile Dalban, Suzanne Naudy, Frédéric Mazoyer, Etienne Martin, Philippe Maingon and Gilles Créhange
    Citation: Radiation Oncology 2016 11:145
    Content type: Research Published on:

  30. To explore the role of apparent diffusion coefficient (ADC) histogram shape related parameters in early assessment of treatment response during the concurrent chemo-radiotherapy (CCRT) course of advanced cervi...

    Authors: Jie Meng, Lijing Zhu, Li Zhu, Huanhuan Wang, Song Liu, Jing Yan, Baorui Liu, Yue Guan, Yun Ge, Jian He, Zhengyang Zhou and Xiaofeng Yang
    Citation: Radiation Oncology 2016 11:141
    Content type: Research Published on:

  31. After focused high dose radiotherapy of brain metastases, differentiation between tumor recurrence and radiation-induced lesions by conventional MRI is challenging. This study investigates the usefulness of dy...

    Authors: Alexander Romagna, Marcus Unterrainer, Christine Schmid-Tannwald, Matthias Brendel, Jörg-Christian Tonn, Silke Birgit Nachbichler, Alexander Muacevic, Peter Bartenstein, Friedrich-Wilhelm Kreth and Nathalie Lisa Albert
    Citation: Radiation Oncology 2016 11:139
    Content type: Research Published on:

  32. To explore the areas at highest risk for postoperative pancreatic cancer local recurrence according to the spatial location of local failures, with the aim to provide a precise target volume for pancreatic can...

    Authors: Wei Yu, Wei Hu, Yongjie Shui, Xiaoyang Zhu, Chao Li, Xiaoqiu Ren, Xueli Bai, Risheng Yu, Li Shen, Tingbo Liang, Lei Zheng and Qichun Wei
    Citation: Radiation Oncology 2016 11:138
    Content type: Research Published on:

  34. Soft tissue sarcomas are uncommon tumours of mesenchymal origin, most commonly arising in the extremities. Treatment includes surgical resection in combination with radiotherapy. Resection margins are of param...

    Authors: Fien Hoefkens, Charlotte Dehandschutter, Johan Somville, Paul Meijnders and Dirk Van Gestel
    Citation: Radiation Oncology 2016 11:136
    Content type: Review Published on:

  36. Especially elderly and frail patients have a limited ability to compensate for side effects of a radical treatment of head and neck malignancies. Limiting the target volume to the macroscopic disease, without ...

    Authors: Christoph Straube, Steffi U. Pigorsch, Hagen Scherb, Jan J. Wilkens, Henning Bier and Stephanie E. Combs
    Citation: Radiation Oncology 2016 11:133
    Content type: Research Published on:

  37. The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surg...

    Authors: Naomi E. Verstegen, Alexander P. W. M. Maat, Frank J. Lagerwaard, Marinus A. Paul, Michel I Versteegh, Joris J. Joosten, Willem Lastdrager, Egbert F. Smit, Ben J. Slotman, Joost J. M. E. Nuyttens and Suresh Senan
    Citation: Radiation Oncology 2016 11:131
    Content type: Research Published on:

  38. This study examines patient reported outcome measures of women undergoing hyperbaric oxygen treatment (HBOT) after breast-conserving therapy.

    Authors: David N. Teguh, René Bol Raap, Henk Struikmans, Cees Verhoef, Linetta B. Koppert, Arne Koole, Yadi Huang and Rob A. van Hulst
    Citation: Radiation Oncology 2016 11:130
    Content type: Research Published on:

  39. There is a lack of data on quality of life in long-term survivors of nasopharyngeal carcinoma (NPC) who have been treated with intensity-modulated radiation therapy (IMRT). We characterized long-term disease-s...

    Authors: Alan Kiang, Vivian K. Weinberg, Ka Ho Nicholas Cheung, Erin Shugard, Josephine Chen, Jeanne M. Quivey and Sue S. Yom
    Citation: Radiation Oncology 2016 11:127
    Content type: Research Published on:

  40. The use of involved field radiotherapy (IFRT) has generated concern about the increasing incidence of elective nodal failure (ENF) in contrast to elective nodal irradiation (ENI). This meta-analysis aimed to p...

    Authors: Ruijian Li, Liang Yu, Sixiang Lin, Lina Wang, Xin Dong, Lingxia Yu, Weiyi Li and Baosheng Li
    Citation: Radiation Oncology 2016 11:124
    Content type: Review Published on:

  41. Radiation is an effective treatment against nasopharyngeal carcinoma (NPC). However, radioresistance-induced locoregional recurrence remains as a major cause of treatment failure. Therefore, radiosensitivity i...

    Authors: Siwei Li, Taowen Liu, Wenfa Mo, Qiaoyan Hou, Yingqiong Zhou, Meilian Liu, Zhoukai He, Zhengchun Liu, Qiuqiu Chen, Hua Wang, Xiang Guo, Weixiong Xia, Musheng Zeng and Haiyun Zhao
    Citation: Radiation Oncology 2016 11:121
    Content type: Research Published on:

  42. To report toxicity and early clinical outcomes of hypofractionated simultaneous integrated boost (SIB) approach with Volumetric Modulated Arc Therapy (VMAT) as adjuvant treatment after breast-conserving surgery.

    Authors: Fiorenza De Rose, Antonella Fogliata, Davide Franceschini, Piera Navarria, Elisa Villa, Cristina Iftode, Giuseppe D’Agostino, Luca Cozzi, Francesca Lobefalo, Pietro Mancosu, Stefano Tomatis and Marta Scorsetti
    Citation: Radiation Oncology 2016 11:120
    Content type: Research Published on:

  43. Recurrent or metastatic lung cancer is difficult to manage. This retrospective study aimed to assess the efficacy of repeated iodine-125 seed implantations combined with external beam radiotherapy (EBRT) for l...

    Authors: Wei Li, Gang Dan, Jianqing Jiang, Yifeng Zheng, Xiushan Zheng and Dan Deng
    Citation: Radiation Oncology 2016 11:119
    Content type: Research Published on:

  44. The purpose of this study is to investigate the potential to reduce exposure of the contralateral hippocampus in radiotherapy for glioblastoma using volumetric modulated arc therapy (VMAT).

    Authors: Jan Hofmaier, Steffi Kantz, Matthias Söhn, Oliver S. Dohm, Stefan Bächle, Markus Alber, Katia Parodi, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2016 11:118
    Content type: Research Published on:

  45. Radiotherapy (RT) in combination with androgen deprivation therapy (ADT) for prostate cancer (PCa) carries a risk of gastrointestinal (GI) and genitourinary toxicity, which might affect the quality of life (Qo...

    Authors: Joen Sveistrup, Ole Steen Mortensen, Jakob B Bjørner, Svend Aage Engelholm, Per Munck af Rosenschöld and Peter Meidahl Petersen
    Citation: Radiation Oncology 2016 11:117
    Content type: Research Published on:

  46. Radiotherapy (RT) is frequently used in the treatment of head and neck cancer, but different side-effects are frequently reported, including a higher frequency of radiation-related caries, what may be conseque...

    Authors: Eduardo Rodrigues Fregnani, Cláudia Joffily Parahyba, Karina Morais-Faria, Felipe Paiva Fonseca, Pedro Augusto Mendes Ramos, Fábio Yone de Moraes, Karina Gondim Moutinho da Conceição Vasconcelos, Gisela Menegussi, Alan Roger Santos-Silva and Thais B. Brandão
    Citation: Radiation Oncology 2016 11:116
    Content type: Research Published on:

  48. After local excision of early rectal cancer, revision radical resection is recommended for patients with high-risk pathologic stage T1 (pT1) or pT2 cancer, but the revision procedure has high morbidity rates. ...

    Authors: Jae-Uk Jeong, Taek-Keun Nam, Hyeong-Rok Kim, Hyun-Jeong Shim, Yong-Hyub Kim, Mee Sun Yoon, Ju-Young Song, Sung-Ja Ahn and Woong-Ki Chung
    Citation: Radiation Oncology 2016 11:114
    Content type: Research Published on:

  49. Although parotid-sparing IMRT decreased the dose distribution of parotid, parotid region recurrence has been reported. Prophylactic irradiation in parotid area would be necessary in patients with high risk of ...

    Authors: Hong-zhi Wang, Cai-neng Cao, Jing-wei Luo, Jun-lin Yi, Xiao-dong Huang, Shi-ping Zhang, Kai Wang, Yuan Qu, Jian-ping Xiao, Su-yan Li, Li Gao and Guo-zhen Xu
    Citation: Radiation Oncology 2016 11:113
    Content type: Research Published on:

  50. Two large, recently published observational studies demonstate a clear down-trend in the use of radiotherapy (RT) over the last 15 years, both in the setting of follicular and diffuse large B-cell lymphoma. Th...

    Authors: Michel Zimmermann, Christoph Oehler, Ulrich Mey, Pirus Ghadjar and Daniel Rudolf Zwahlen
    Citation: Radiation Oncology 2016 11:110
    Content type: Review Published on:
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Radiation Oncology

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