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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Lung cancer is frequently complicated by interstitial lung disease (ILD). Treatment protocols for lung cancer patients with ILD have not been established; surgery, chemotherapy, and radiotherapy can all cause ...

    Authors: Mio Nakajima, Naoyoshi Yamamoto, Kazuhiko Hayashi, Masataka Karube, Daniel K Ebner, Wataru Takahashi, Makoto Anzai, Kenji Tsushima, Yuji Tada, Koichiro Tatsumi, Tadaaiki Miyamoto, Hiroshi Tsuji, Takehiko Fujisawa and Tadashi Kamada
    Citation: Radiation Oncology 2017 12:144
    Content type: Research Published on:

  2. Imaging of bone metastasis response to therapy is a research priority. Stradwin is a new software-tool, with demonstrated sub-voxel accuracy in assessing cortical bone properties from routine CT. We applied th...

    Authors: D. Thurtle, G. M. Treece, T. Barrett and V. J. Gnanapragasam
    Citation: Radiation Oncology 2017 12:143
    Content type: Short report Published on:

  4. By the use of PSMA positron emission tomography (PET) detection of prostate cancer lesions with a high sensitivity and specificity combined with a favorable lesion to background contrast is feasible. Therefore...

    Authors: Sebastian Zschaeck, Peter Wust, Marcus Beck, Waldemar Wlodarczyk, David Kaul, Julian Rogasch, Volker Budach, Christian Furth and Pirus Ghadjar
    Citation: Radiation Oncology 2017 12:140
    Content type: Research Published on:

  5. Preoperative radiotherapy (RT) in combination with fluoropyrimidine-based chemotherapy (CT) is the standard of care in patients with locally advanced, T3-T4 N0–2, rectal cancer (LARC). Given the correlation be...

    Authors: Marco Lupattelli, Fabio Matrone, Maria Antonietta Gambacorta, Mattia Osti, Gabriella Macchia, Elisa Palazzari, Luca Nicosia, Federico Navarria, Giuditta Chiloiro, Vincenzo Valentini, Cynthia Aristei and Antonino De Paoli
    Citation: Radiation Oncology 2017 12:139
    Content type: Research Published on:

  6. For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionati...

    Authors: Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S. Merseburger…
    Citation: Radiation Oncology 2017 12:138
    Content type: Study protocol Published on:

  7. Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irr...

    Authors: Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He and Chaosu Hu
    Citation: Radiation Oncology 2017 12:137
    Content type: Research Published on:

  8. As irradiated brain volume at 12 Gy (V12) is a predictor for radionecrosis, the purpose of the study was to develop a model for Cyberknife (CK) plans that is able to predict the lowest achievable V12 at a give...

    Authors: Alexandra Hellerbach, Klaus Luyken, Mauritius Hoevels, Andreas Gierich, Daniel Rueß, Wolfgang W. Baus, Martin Kocher, Maximilian I. Ruge and Harald Treuer
    Citation: Radiation Oncology 2017 12:136
    Content type: Research Published on:

  10. Gamma Knife radiosurgery (GKRS) is an important part of the neurosurgical armamentarium in the treatment of acoustic neuromas. However, the treatment outcome related to the morphology of the tumor has not been...

    Authors: Szu-Yen Pan, Shih-An Liu, Ming-Hsi Sun, Hsi-Kai Tsou, Shinh-Dung Lee, Yen-Ju Chen, Jason Sheehan, Meei-Ling Sheu and Hung-Chuan Pan
    Citation: Radiation Oncology 2017 12:134
    Content type: Research Published on:

  11. Concurrent chemoradiation therapy (CCRT) followed by hepatic arterial infusional chemotherapy (HAIC) was reported to be effective for advanced hepatocellular carcinoma (HCC) with portal vein thrombosis. Howeve...

    Authors: Ja Kyung Kim, Jun Won Kim, Ik Jae Lee, Seung-Moon Joo, Kwang-Hun Lee, Eun-Suk Cho, Jeong-Sik Yu, Tae Joo Jeon, Yonsoo Kim, Jung Il Lee and Kwan Sik Lee
    Citation: Radiation Oncology 2017 12:133
    Content type: Research Published on:

  12. Though the vast majority of seminal trials for locally advanced esophageal cancer (EC) utilized three-dimensional conformal radiotherapy (3DCRT), the advanced and highly conformal technology known as intensity...

    Authors: Matthias Felix Haefner, Kristin Lang, Vivek Verma, Stefan Alexander Koerber, Lorenz Uhlmann, Juergen Debus and Florian Sterzing
    Citation: Radiation Oncology 2017 12:131
    Content type: Research Published on:

  13. We sought to identify spatial/dosimetric patterns of failure for oral cavity cancer patients receiving post-operative IMRT (PO-IMRT).

    Authors: Abdallah S. R. Mohamed, Andrew J. Wong, Clifton D. Fuller, Mona Kamal, Gary B. Gunn, Jack Phan, William H. Morrison, Beth M. Beadle, Heath Skinner, Stephen Y. Lai, Sean R. Quinlan-Davidson, Abdelaziz M. Belal, Ahmed G. El-Gowily, Steven J. Frank, David I. Rosenthal and Adam S. Garden
    Citation: Radiation Oncology 2017 12:129
    Content type: Research Published on:

  14. To cover the microscopic tumor spread in squamous cell carcinoma of the esophagus (SCC), longitudinal margins of 3–4 cm are used for radiotherapy (RT) protocols. However, smaller margins of 2–3 cm might be rea...

    Authors: S Münch, M Oechsner, SE Combs and D Habermehl
    Citation: Radiation Oncology 2017 12:128
    Content type: Research Published on:

  15. Cranial irradiation is associated with long-term cognitive changes. Cerebral microbleeds (CMBs) have been identified on susceptibility-weighted MRI (SWI) in patients who have received prior cranial radiation, ...

    Authors: Michael Wahl, Mekhail Anwar, Christopher P. Hess, Susan M Chang and Janine M. Lupo
    Citation: Radiation Oncology 2017 12:126
    Content type: Research Published on:

  16. Postoperative adjuvant radiation therapy (ART) in T3 and R1 prostate cancer as well as salvage radiation therapy (SRT) in case of postoperative biochemical failure (BF) are established treatments. Dose-intensi...

    Authors: Marcus Beck, Peter Wust, Tomasz Barelkowski, David Kaul, Alexander-Henry Thieme, Sascha Wecker, Waldemar Wlodarczyk, Volker Budach and Pirus Ghadjar
    Citation: Radiation Oncology 2017 12:125
    Content type: Research Published on:

  17. The eighth tumor, node, metastasis (TNM) staging system (8-TNM) for non-small cell lung cancer (NSCLC) was newly released in 2015. This system had limitation because most patients included in the analysis were...

    Authors: Hoon Sik Choi, Bae Kwon Jeong, Hojin Jeong, Yun Hee Lee, In Bong Ha, Jin Ho Song and Ki Mun Kang
    Citation: Radiation Oncology 2017 12:122
    Content type: Research Published on:

  18. This work aims to assess the feasibility of selectively sparing the hippocampus during prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC).

    Authors: Lei Zhao, Yan Shen, Jin-Dong Guo, Heng-Le Gu, Wen Yu, Jia-Ming Wang, Chang-Xing LV, Jun Liu, Xu-Wei Cai and Xiao-Long Fu
    Citation: Radiation Oncology 2017 12:118
    Content type: Research Published on:

  19. To evaluate the efficacy and toxicity of stereotactic body radiotherapy (SBRT) in the treatment of advanced hepatocellular carcinoma (HCC).

    Authors: Eleni Gkika, Michael Schultheiss, Dominik Bettinger, Lars Maruschke, Hannes Philipp Neeff, Michaela Schulenburg, Sonja Adebahr, Simon Kirste, Ursula Nestle, Robert Thimme, Anca-Ligia Grosu and Thomas Baptist Brunner
    Citation: Radiation Oncology 2017 12:116
    Content type: Research Published on:

  20. This retrospective analysis aimed to analyse the stability of spinal bone metastases in colorectal cancer (CRC) patients following radiotherapy (RT) by use of a validated score and to assess prognostic factors...

    Authors: Tilman Bostel, Robert Förster, Ingmar Schlampp, Tania Sprave, Thomas Bruckner, Nils Henrik Nicolay, Stefan Ezechiel Welte, Jürgen Debus and Harald Rief
    Citation: Radiation Oncology 2017 12:115
    Content type: Research Published on:

  21. Today intensity modulated radiation therapy (IMRT) can be considered the standard of care in patients with head and neck tumors. IMRT treatment plans are proven to reduce acute treatment related side effects b...

    Authors: Kilian Schiller, Hanno Martin Specht, Bernhard Haller, Daniela Hallqvist, Michal Devecka, Aaron Becker von Rose, Stephanie Elisabeth Combs and Steffi Pigorsch
    Citation: Radiation Oncology 2017 12:113
    Content type: Research Published on:

  22. The aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arte...

    Authors: Yuichiro Hayashi, Kenji Mitsudo, Kaname Sakuma, Masaki Iida, Toshinori Iwai, Hideyuki Nakashima, Yoshiyuki Okamoto, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Izumi Koike, Masaharu Hata and Iwai Tohnai
    Citation: Radiation Oncology 2017 12:112
    Content type: Research Published on:

  23. Stereotactic ablative radiotherapy (SABR) is a safe and effective modality in patients with liver cancer who are ineligible for other local therapies. However SABR is not current standard of practice and requi...

    Authors: Adam Mutsaers, Jeffrey Greenspoon, Cindy Walker-Dilks and Anand Swaminath
    Citation: Radiation Oncology 2017 12:110
    Content type: Review Published on:

  24. Idelalisib is approved for the treatment of relapsed chronic lymphocytic leukemia together with Rituximab and for monotherapy of follicular B-cell non-Hodgkin’s lymphoma and small lymphocytic lymphoma. It is a...

    Authors: Thomas Gryc, Florian Putz, Nicole Goerig, Sonia Ziegler, Rainer Fietkau, Luitpold V. Distel and Barbara Schuster
    Citation: Radiation Oncology 2017 12:109
    Content type: Research Published on:

  25. Many patients with brain metastases from non-small cell lung cancer have limited survival, while others survive for several years, depending on patterns of spread, EGFR and ALK alterations, among others. The p...

    Authors: Carsten Nieder, Mandy Hintz, Oliver Oehlke, Angelika Bilger and Anca L. Grosu
    Citation: Radiation Oncology 2017 12:107
    Content type: Research Published on:

  26. In limited metastatic burden of disease, stereotactic body radiotherapy (SBRT) has been shown to achieve high local control rates. It has been hypothesized that SBRT may translate to a better quality of life b...

    Authors: Rosanna Yeung, Jeremy Hamm, Mitchell Liu and Devin Schellenberg
    Citation: Radiation Oncology 2017 12:105
    Content type: Research Published on:

  27. To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast ir...

    Authors: Seung Hyuck Jeon, Kyung Hwan Shin, So-Yeon Park, Jung-in Kim, Jong Min Park, Jin Ho Kim, Eui Kyu Chie and Hong-Gyun Wu
    Citation: Radiation Oncology 2017 12:103
    Content type: Research Published on:

  28. The aim was to evaluate the geometric and corresponding dosimetric differences between two delineation strategies for head and neck tumors neighboring air cavities.

    Authors: Olgun Elicin, Dario Terribilini, Mohamed Shelan, Werner Volken, Etienne Mathier, Alan Dal Pra, Daniel M. Aebersold, Michael K. Fix and Peter Manser
    Citation: Radiation Oncology 2017 12:102
    Content type: Research Published on:

  29. To report grade ≥2 overall late rectal and urinary toxicities in patients (pts) with prostate cancer treated by intensity-modulated radiotherapy (IMRT) at 3 dose-levels. Identify predictors of radiation toxici...

    Authors: Maria Jolnerovski, Julia Salleron, Véronique Beckendorf, Didier Peiffert, Anne-Sophie Baumann, Valérie Bernier, Sandrine Huger, Vincent Marchesi and Ciprian Chira
    Citation: Radiation Oncology 2017 12:99
    Content type: Research Published on:

  30. The aim of this study was to evaluate the long-term prognostic significance of rising PSA levels, particularly focussing on overall survival.

    Authors: Carla Freiberger, Vanessa Berneking, Thomas-Alexander Vögeli, Ruth Kirschner-Hermanns, Michael J. Eble and Michael Pinkawa
    Citation: Radiation Oncology 2017 12:98
    Content type: Research Published on:

  31. To investigate the effects of postoperative radiotherapy (PORT) on the survival of patients with resected stage IIIA-N2 non-small cell lung cancer (NSCLC).

    Authors: Shenhai Wei, Mian Xie, Jintao Tian, Xiaoping Song, Bingqun Wu and Limin Liu
    Citation: Radiation Oncology 2017 12:96
    Content type: Research Published on:

  32. Currently, there is no standard option for local salvage treatment for local prostate cancer recurrence after radiotherapy. Our objective was to investigate the feasibility and efficiency of Robotic Stereotact...

    Authors: Thomas Leroy, Thomas Lacornerie, Emilie Bogart, Philippe Nickers, Eric Lartigau and David Pasquier
    Citation: Radiation Oncology 2017 12:95
    Content type: Research Published on:

  33. This study aimed to highlight the type of tumor thrombus and identify the prognostic factors influencing the long-term survival outcomes in patients with hepatocellular carcinoma (HCC) having a tumor thrombus....

    Authors: Xiang-quan Kong, Ya-ping Dong, Jun-xin Wu, Jun-yan He, Yu-yin Le, Kai-xin Du, Qing-qin Peng and Jin-luan Li
    Citation: Radiation Oncology 2017 12:92
    Content type: Research Published on:

  34. Carbon-ion radiotherapy (CIRT) is a promising treatment for locally advanced non-small-cell lung cancer, especially for patients with inoperable lung cancer. Although the incidence of CIRT-induced radiation pn...

    Authors: Kazuhiko Hayashi, Naoyoshi Yamamoto, Masataka Karube, Mio Nakajima, Naruhiro Matsufuji, Hiroshi Tsuji, Kazuhiko Ogawa and Tadashi Kamada
    Citation: Radiation Oncology 2017 12:91
    Content type: Research Published on:

  35. Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole bre...

    Authors: Pieter Deseyne, Bruno Speleers, Wilfried De Neve, Bert Boute, Leen Paelinck, Tom Van Hoof, Joris Van de Velde, Annick Van Greveling, Chris Monten, Giselle Post, Herman Depypere and Liv Veldeman
    Citation: Radiation Oncology 2017 12:89
    Content type: Research Published on:

  37. To assess toxicity and clinical outcome, in breast cancer patients treated with external beam partial breast irradiation (PBI) consisting of 35 Gy in 7 daily fractions (5 Gy/fraction).

    Authors: Marco Trovo, Michele Avanzo, Lorenzo Vinante, Carlo Furlan, Francesco Fiorica, Tiziana Perin, Loredana Militello, Simon Spazzapan, Massimiliano Berretta, Rajesh Jena, Joseph Stancanello, Erica Piccoli, Mario Mileto, Elvia Micheli, Mario Roncadin and Samuele Massarut
    Citation: Radiation Oncology 2017 12:86
    Content type: Research Published on:

  38. This review aims to provide a comprehensive overview of the literature and elucidate open questions for future clinical trials concerning diagnostics and treatment modalities for cervical cancer of unknown pri...

    Authors: Jens Müller von der Grün, Aykut Tahtali, Shahram Ghanaati, Claus Rödel and Panagiotis Balermpas
    Citation: Radiation Oncology 2017 12:82
    Content type: Review Published on:

  39. Type-C dose algorithms provide more accurate dosimetry for lung SBRT treatment planning. However, because current dosimetric protocols were developed based on conventional algorithms, its applicability for the...

    Authors: Christina Zhou, Nathan Bennion, Rongtao Ma, Xiaoying Liang, Shuo Wang, Kristina Zvolanek, Megan Hyun, Xiaobo Li, Sumin Zhou, Weining Zhen, Chi Lin, Andrew Wahl and Dandan Zheng
    Citation: Radiation Oncology 2017 12:80
    Content type: Research Published on:

  40. Glioblastoma is usually diagnosed around the age of 60–70 years. Patients older than 65 years are frequently described as “elderly”. Several trials with monotherapy have established treatment regimens that off...

    Authors: Christoph Straube, Hagen Scherb, Jens Gempt, Stefanie Bette, Claus Zimmer, Friederike Schmidt-Graf, Jürgen Schlegel, Bernhard Meyer and Stephanie E. Combs
    Citation: Radiation Oncology 2017 12:77
    Content type: Research Published on:

  41. Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a contraindication for chemotherapy. Pre-clinical evidence suggest...

    Authors: Caspar M. van Leeuwen, Arlene L. Oei, Kenneth W. T. K. Chin, Johannes Crezee, Arjan Bel, Anneke M. Westermann, Marrije R. Buist, Nicolaas A. P. Franken, Lukas J. A. Stalpers and H. Petra Kok
    Citation: Radiation Oncology 2017 12:75
    Content type: Research Published on:

  42. In patients with head-neck cancer treated with IMRT, immobility of the upper part of the body during radiation is maintained by means of customised immobilisation devices.

    Authors: Massimiliano Contesini, Monica Guberti, Roberta Saccani, Luca Braglia, Cinzia Iotti, Andrea Botti, Emilio Abbati and Marina Iemmi
    Citation: Radiation Oncology 2017 12:72
    Content type: Research Published on:

  43. This is the first known study examining renal function following stereotactic body radiotherapy (SBRT) for pancreatic head adenocarcinoma.

    Authors: Vivek Verma, Abhijeet R. Bhirud, Kyle A. Denniston, Nathan R. Bennion and Chi Lin
    Citation: Radiation Oncology 2017 12:71
    Content type: Research Published on:

  44. Twelve years ago, a randomized trial demonstrated that a radiosurgery boost added to whole-brain radiotherapy (WBRT) improved intracerebral control (IC) in patients with one to three cerebral metastases. Overa...

    Authors: Dirk Rades, Stefan Janssen, Amira Bajrovic, Mai Trong Khoa, Theo Veninga and Steven E. Schild
    Citation: Radiation Oncology 2017 12:69
    Content type: Research Published on:

  45. The management of solely intracanalicular acoustic neurinoma (iAN) includes observation, microsurgical resection and radiation therapy. Treatment goals are long-term tumor control, hearing preservation and con...

    Authors: Daniel Rueß, Lea Pöhlmann, Stefan Grau, Christina Hamisch, Alexandra Hellerbach, Harald Treuer, Martin Kocher and Maximilian I. Ruge
    Citation: Radiation Oncology 2017 12:68
    Content type: Research Published on:

  46. We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma.

    Authors: J. Khalifa, F. Tensaouti, A. Lusque, B. Plas, J.-A. Lotterie, A. Benouaich-Amiel, E. Uro-Coste, V. Lubrano and E. Cohen-Jonathan Moyal
    Citation: Radiation Oncology 2017 12:67
    Content type: Research Published on:

  47. For stereotactic body radiation therapy (SBRT) of liver tumors, tumor motion induced by respiration must be taken into account in planning and treatment. We evaluated whether liver tumor motion at the planning...

    Authors: Yoshinobu Shimohigashi, Ryo Toya, Tetsuo Saito, Osamu Ikeda, Masato Maruyama, Keisuke Yonemura, Yuji Nakaguchi, Yudai Kai, Yasuyuki Yamashita, Natsuo Oya and Fujio Araki
    Citation: Radiation Oncology 2017 12:61
    Content type: Research Published on:

  48. To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the ...

    Authors: Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien, Chun-Nan Chu, Hsiu-Ting Hsu, Ji-An Liang, Ying-Jun Lin and An-Cheng Shiau
    Citation: Radiation Oncology 2017 12:55
    Content type: Research Published on:

  49. Patients with locally advanced colon cancer (LACC) have a relatively poor prognosis despite radical resection and adjuvant chemotherapy. This study investigated the treatment efficacy and toxicity of neoadjuva...

    Authors: Chun-Ming Huang, Ming-Yii Huang, Cheng-Jen Ma, Yung –Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Chih-Jen Huang and Jaw-Yuan Wang
    Citation: Radiation Oncology 2017 12:48
    Content type: Research Published on:

  50. A phase II study was performed to investigate the safety and efficacy of weekly doses of combined paclitaxel and 5-fluorouracil (5-FU) with concurrent radiation therapy, followed by 2 cycles of consolidation c...

    Authors: Yi Xia, Yun-hai Li, Yun Chen, Jun-hua Zhang, Qi Liu, Jia-ying Deng, Ta-shan Ai, Han-ting Zhu, Jian-hong Fan, Harun Badakhshi and Kuai-le Zhao
    Citation: Radiation Oncology 2017 12:47
    Content type: Research Published on:
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Radiation Oncology

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