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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Granular cell or Abrikossoff’s tumors are usually benign however rare malignant forms concern 1 to 3% of cases reported. Pelvic locations are exceptional.

    Authors: C. Marchand Crety, C. Garbar, G. Madelis, F. Guillemin, P. Soibinet Oudot, J. C. Eymard and S. Servagi Vernat
    Citation: Radiation Oncology 2018 13:115
    Content type: Case report Published on:

  2. The goal of this study is to evaluate the status and future perspectives of clinical trials on positron emission tomography in prostate cancer for diagnostic or therapeutic as well as for surveillance purposes.

    Authors: Nikola Cihoric, Eugenia Vlaskou Badra, Alexandros Tsikkinis, Vikas Prasad, Stephanie Kroeze, Ivan Igrutinovic, Branislav Jeremic, Marcus Beck, Sebastian Zschaeck, Peter Wust and Pirus Ghadjar
    Citation: Radiation Oncology 2018 13:113
    Content type: Research Published on:

  3. In intensity modulated radiation therapy (IMRT) quality assurance (QA), evaluation of QA result using a pass/non-pass strategy under an acceptance criterion often suffers from lack of information on how good t...

    Authors: Dong-Su Kim, Siyong Kim, Seong-Hee Kang, Tae-Ho Kim, So-Hyun Park, Kyeong-Hyeon Kim, Min-Seok Cho, Dong-Seok Shin, Yu-Yun Noh, Jin-Beom Chung and Tae Suk Suh
    Citation: Radiation Oncology 2018 13:112
    Content type: Research Published on:

  4. We investigated the effectiveness of one education course to lower the severity of anxiety and depression symptoms among breast cancer (BC) patients during radiotherapy (RT).

    Authors: Zhensheng Li, Wenhui Geng, Junpu Yin and Jun Zhang
    Citation: Radiation Oncology 2018 13:111
    Content type: Research Published on:

  5. The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrenc...

    Authors: Barbara Zollner, Ute Ganswindt, Cornelius Maihöfer, Stefanie Corradini, Nathalie Lisa Albert, Christian Schichor, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2018 13:110
    Content type: Research Published on:

  7. The purpose of this study was to evaluate the impact of markerless on-board kilovoltage (kV) cone-beam computed tomography (CBCT)-based positioning uncertainty on determination of the planning target volume (P...

    Authors: Katsumi Hirose, Mariko Sato, Yoshiomi Hatayama, Hideo Kawaguchi, Fumio Komai, Makoto Sohma, Hideki Obara, Masashi Suzuki, Mitsuki Tanaka, Ichitaro Fujioka, Koji Ichise, Yoshihiro Takai and Masahiko Aoki
    Citation: Radiation Oncology 2018 13:106
    Content type: Research Published on:

  8. The use of intraprostatic gold fiducial markers (FMs) ensures highly accurate and precise image-guided radiation therapy for patients diagnosed with prostate cancer thanks to the ease of localising FMs on phot...

    Authors: Matteo Maspero, Peter R. Seevinck, Nicole J. W. Willems, Gonda G. Sikkes, Geja J. de Kogel, Hans C. J. de Boer, Jochem R. N. van der Voort van Zyp and Cornelis A. T. van den Berg
    Citation: Radiation Oncology 2018 13:105
    Content type: Research Published on:

  9. While breast radiotherapy typically includes regional nodal basins, the treatment of the internal mammary nodes (IMN) has been controversial due to concern for long-term cardiac toxicity. For high risk patient...

    Authors: Macklin H. Nguyen, Myra Lavilla, Janice N. Kim and L. Christine Fang
    Citation: Radiation Oncology 2018 13:103
    Content type: Research Published on:

  10. The existence of abscopal effects has been suggested already a long time ago, but only recently with the advent of immune checkpoint inhibition in clinical oncology and modern imaging techniques has it become ...

    Authors: Christian Britschgi, Oliver Riesterer, Irene A. Burger, Matthias Guckenberger and Alessandra Curioni-Fontecedro
    Citation: Radiation Oncology 2018 13:102
    Content type: Case report Published on:

  13. While intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour va...

    Authors: Michael P. Jones, Jarad Martin, Kerwyn Foo, Patrick Estoesta, Lois Holloway and Michael Jameson
    Citation: Radiation Oncology 2018 13:97
    Content type: Research Published on:

  15. IMRT provides higher dose conformation to the target and dose sparing to surrounding tissues than 3DCRT. Monte Carlo method in Medical Physics is not a novelty to approach dosimetric problems. A new PENELOPE b...

    Authors: Alessandro Esposito, Sofia Silva, Jorge Oliveira, Joana Lencart and João Santos
    Citation: Radiation Oncology 2018 13:91
    Content type: Research Published on:

  16. 68Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative i....

    Authors: Sebastian Zschaeck, Fabian Lohaus, Marcus Beck, Gregor Habl, Stephanie Kroeze, Constantinos Zamboglou, Stefan Alexander Koerber, Jürgen Debus, Tobias Hölscher, Peter Wust, Ute Ganswindt, Alexander D. J. Baur, Klaus Zöphel, Nikola Cihoric, Matthias Guckenberger, Stephanie E. Combs…
    Citation: Radiation Oncology 2018 13:90
    Content type: Review Published on:

  17. With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor’s generally favorable outc...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs
    Citation: Radiation Oncology 2018 13:86
    Content type: Research Published on:

  18. L’Hermitte’s sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high.

    Authors: Hannah M. Laidley, David J. Noble, Gill C. Barnett, Julia R. Forman, Amy M. Bates, Richard J. Benson, Sarah J. Jefferies, Rajesh Jena and Neil G. Burnet
    Citation: Radiation Oncology 2018 13:84
    Content type: Research Published on:

  19. Previous studies reported that patients with preexisting radiological interstitial lung abnormalities (ILAs) were more susceptible to developing radiation pneumonitis (RP) after thoracic radiation therapy (TRT...

    Authors: Fangjuan Li, Ziyang Zhou, Ailu Wu, Yong Cai, Hongyu Wu, Ming Chen and Shixiong Liang
    Citation: Radiation Oncology 2018 13:82
    Content type: Research Published on:

  20. SBRT is standard therapy for early stage lung cancer. Toxicity in central tumors has been a concern. RTOG 0813 showed that central SBRT is safe and effective. We report our experience with central SBRT.

    Authors: Yasmin Korzets ceder, Eyal Fenig, Aron Popvtzer, Nir Peled, Mordechai R. Kramer, Milton Saute, Dima Bragilovsky, Tzippy Schochat and Aaron M. Allen
    Citation: Radiation Oncology 2018 13:77
    Content type: Research Published on:

  21. Oligo-recurrence has been considered to confer improved prognosis than other oligometastatic conditions, and stereotactic body radiation therapy (SBRT) is considered as an option of local therapy for lung or l...

    Authors: Masaki Nakamura, Naoki Hashimoto, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Ryo Nishikawa, Yoshiro Matsuo, Hiroki Kawaguchi and Hideki Nishimura
    Citation: Radiation Oncology 2018 13:75
    Content type: Research Published on:

  22. The aim of this prospective clinical quality assessment was to evaluate the short-term and long-term efficacy of low dose radiotherapy (RT) for calcaneodynia, achillodynia, painful gonarthrosis, painful bursit...

    Authors: Oliver Micke, Eyup Ugrak, Stefan Bartmann, Irenaeus A. Adamietz, Ulrich Schaefer, Rebecca Bueker, Klaus Kisters, M. Heinrich Seegenschmiedt, Khashayar Fakhrian and Ralph Muecke
    Citation: Radiation Oncology 2018 13:71
    Content type: Research Published on:

  23. Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictor...

    Authors: Chengbo Ren, Tianlong Ji, Tingting Liu, Jun Dang and Guang Li
    Citation: Radiation Oncology 2018 13:69
    Content type: Research Published on:

  24. Total skin electron beam therapy (TSEBT) is an effective treatment in mycosis fungoides. Total skin helical tomotherapy (TSHT) may be an alternative to TSEBT and may offer several dosimetric and treatment adva...

    Authors: Eric M. Schaff, Stephen A. Rosenberg, Stephanie J. Olson, Steven P. Howard and Kristin A. Bradley
    Citation: Radiation Oncology 2018 13:67
    Content type: Case report Published on:

  25. We hypothesized that dominant intraprostatic lesions (DILs) could be depictured by multimodal imaging techniques (MRI and/or PSMA PET/CT) in patients with primary prostate cancer (PCa) and investigated possibl...

    Authors: Constantinos Zamboglou, Christina Marie Klein, Benedikt Thomann, Thomas Franz Fassbender, Hans C. Rischke, Simon Kirste, Karl Henne, Natalja Volegova-Neher, Michael Bock, Mathias Langer, Philipp T. Meyer, Dimos Baltas and Anca L. Grosu
    Citation: Radiation Oncology 2018 13:65
    Content type: Research Published on:

  26. To determine if reduced dose delivery uncertainty is associated with daily image-guidance (IG) and Prostate Specific Antigen Relapse Free Survival (PRFS) in intensity-modulated radiotherapy (IMRT) of high-risk...

    Authors: Per Munck af Rosenschold, Michael J. Zelefsky, Aditya P. Apte, Andrew Jackson, Jung Hun Oh, Elliot Shulman, Neil Desai, Margie Hunt, Pirus Ghadjar, Ellen Yorke and Joseph O. Deasy
    Citation: Radiation Oncology 2018 13:64
    Content type: Research Published on:

  27. Lung stereotactic ablative radiotherapy (SABR) is associated with low morbidity, however there is an increased risk of treatment-related toxicity in tumors directly abutting or invading the proximal bronchial ...

    Authors: Donna H. Murrell, Joanna M. Laba, Abigail Erickson, Barbara Millman, David A. Palma and Alexander V. Louie
    Citation: Radiation Oncology 2018 13:57
    Content type: Research Published on:

  28. Meningiomas of the skull base account for 25–30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantia...

    Authors: Rami A. El Shafie, Maja Czech, Kerstin A. Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus and Stephanie E. Combs
    Citation: Radiation Oncology 2018 13:54
    Content type: Research Published on:

  29. 68Ga-PSMA-PET-imaging has proven to be a highly sensitive and specific diagnostic element for patients with prostate cancer (PC). Does the standard clinical target volume (CTV) cover the majority of 68Ga-PSMA-PET...

    Authors: K. Schiller, M. Devecka, T. Maurer, M. Eiber, J. Gschwend, M. Schwaiger, S. E. Combs and G. Habl
    Citation: Radiation Oncology 2018 13:36
    Content type: Research Published on:

  30. The purpose of this study was to evaluate the prognostic impact of Positron Emission Tomography Response Criteria in Solid Tumors (PERCIST) and Response Evaluation Criteria in Solid Tumors (RECIST) and of pre-...

    Authors: Cory Pierson, Taras Grinchak, Casey Sokolovic, Brandi Holland, Teresa Parent, Mark Bowling, Hyder Arastu, Paul Walker and Andrew Ju
    Citation: Radiation Oncology 2018 13:34
    Content type: Research Published on:

  31. Concurrent chemoradiotherapy is a standard modality for locally advanced esophageal squamous cell carcinoma (ESCC) patients. Cisplatin combined with 5-fluorouracil continuous infusion (PF) remains the standard...

    Authors: Yun Chen, Zhengfei Zhu, Weixin Zhao, Ling Li, Jinjun Ye, Chaoyang Wu, Huarong Tang, Qin Lin, Jiancheng Li, Yi Xia, Yunhai Li, Jialiang Zhou and Kuaile Zhao
    Citation: Radiation Oncology 2018 13:33
    Content type: Study protocol Published on:

  32. We hypothesized that hippocampal-sparing radiotherapy via volumetric modulated arc therapy (VMAT) could preserve the neurocognitive function (NCF) of patients with primary brain tumors treated with radiotherapy.

    Authors: Kyung Su Kim, Chan Woo Wee, Jin-Yong Seok, Joo Wan Hong, Jin-Beom Chung, Keun-Yong Eom, Jae-Sung Kim, Chae-Yong Kim, Young Ho Park, Yu Jung Kim and In Ah Kim
    Citation: Radiation Oncology 2018 13:29
    Content type: Research Published on:

  33. Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors occurring in various anatomic regions. Although diagnostic criteria and treatment management are not established, current treatment op...

    Authors: Simon Kirste, Gian Kayser, Anne Zipfel, Anca-Ligia Grosu and Thomas Brunner
    Citation: Radiation Oncology 2018 13:28
    Content type: Case report Published on:

  34. We evaluated dynamic changes in 18F–borono-L-phenylalanine (18F–BPA) uptake in unresectable, advanced, or recurrent squamous cell carcinoma of the head and neck (SCC) and malignant melanoma (MM) during boron neut...

    Authors: Takahiro Morita, Hiroaki Kurihara, Kenta Hiroi, Natsuki Honda, Hiroshi Igaki, Jun Hatazawa, Yasuaki Arai and Jun Itami
    Citation: Radiation Oncology 2018 13:4
    Content type: Research Published on:

  35. Malignant melanoma brain metastases (MBM) are the third most common cause for brain metastases (BM). Historically Whole-brain radiotherapy (WBRT) was considered the goldstandard of treatment even though melano...

    Authors: Harun Badakhshi, Fidelis Engeling, Volker Budach, Pirus Ghadjar, Sebastian Zschaeck and David Kaul
    Citation: Radiation Oncology 2018 13:3
    Content type: Research Published on:

  36. Radiation pneumonitis (RP) is the most common subacute side effect after concurrent chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer. Several clinical and dose-volume (DV) parameters are...

    Authors: Mohammed Alharbi, Stefan Janssen, Heiko Golpon, Michael Bremer and Christoph Henkenberens
    Citation: Radiation Oncology 2017 12:165
    Content type: Research Published on:

  37. Stereotactic body radiotherapy (SBRT) is an emerging modality for definitive treatment of Hepatocellular carcinoma (HCC).

    Authors: Assaf Moore, Michal Cohen-Naftaly, Anna Tobar, Yulia Kundel, Ofer Benjaminov, Marius Braun, Assaf Issachar, Eytan Mor, Michal Sarfaty, Dimitri Bragilovski, Ran Ben Hur, Noa Gordon, Salomon M. Stemmer and Aaron M. Allen
    Citation: Radiation Oncology 2017 12:163
    Content type: Research Published on:

  38. Local treatment options for patients with in-field non-small cell lung cancer (NSCLC) recurrence following conventionally fractionated external beam radiation therapy (CF-EBRT) are limited. Stereotactic body r...

    Authors: Michael C. Repka, Nima Aghdam, Shaan K. Kataria, Lloyd Campbell, Simeng Suy, Sean P. Collins, Eric Anderson, Jonathan W. Lischalk and Brian T. Collins
    Citation: Radiation Oncology 2017 12:162
    Content type: Research Published on:

  39. The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of...

    Authors: Yasuki Uchida, Takuya Tsugawa, Sachiko Tanaka-Mizuno, Kazuo Noma, Ken Aoki, Wataru Shigemori, Hiroaki Nakagawa, Daisuke Kinose, Masafumi Yamaguchi, Makoto Osawa, Emiko Ogawa and Yasutaka Nakano
    Citation: Radiation Oncology 2017 12:160
    Content type: Research Published on:

  40. Predicting recurrence after stereotactic body radiotherapy (SBRT) in non-small cell lung cancer (NSCLC) patients is problematic, but critical for the decision of following treatment. This study aims to investi...

    Authors: Qian Li, Jongphil Kim, Yoganand Balagurunathan, Jin Qi, Ying Liu, Kujtim Latifi, Eduardo G. Moros, Matthew B. Schabath, Zhaoxiang Ye, Robert J. Gillies and Thomas J. Dilling
    Citation: Radiation Oncology 2017 12:158
    Content type: Research Published on:

  41. The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment.

    Authors: Katrien De Wolf, Sylvie Rottey, Karim Vermaelen, Karel Decaestecker, Nora Sundahl, Lizzy De Lobel, Els Goetghebeur, Gert De Meerleer, Nicolaas Lumen, Valérie Fonteyne, Daan De Maeseneer and Piet Ost
    Citation: Radiation Oncology 2017 12:157
    Content type: Research Published on:

  42. The aim of this retrospective study was to compare volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with three-dimensional conformal radiotherapy ...

    Authors: Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Kae Okuma, Osamu Abe, Toshiaki Watanabe and Keiichi Nakagawa
    Citation: Radiation Oncology 2017 12:156
    Content type: Research Published on:

  43. Since the discovery of X-rays at the end of the 19th century, medical imageology has progressed for 100 years, and medical imaging has become an important auxiliary tool for clinical diagnosis. With the launch of...

    Authors: Bojiang Chen, Rui Zhang, Yuncui Gan, Lan Yang and Weimin Li
    Citation: Radiation Oncology 2017 12:154
    Content type: Review Published on:

  44. Stereotactic body radiotherapy (SBRT) for vertebral metastases has emerged as a promising technique, offering high rates of symptom relief and local control combined with low risk of toxicity. Nonetheless, loc...

    Authors: Johannes Roesch, John B.C. Cho, Daniel K. Fahim, Peter C. Gerszten, John C. Flickinger, Inga S. Grills, Maha Jawad, Ronald Kersh, Daniel Letourneau, Frederick Mantel, Arjun Sahgal, John H. Shin, Brian Winey and Matthias Guckenberger
    Citation: Radiation Oncology 2017 12:153
    Content type: Research Published on:

  45. Efficacy of stereotactic body radiotherapy (SBRT) in stage I non–small-cell lung cancer (NSCLC) has almost been established. In Japan, the protocol of 48 Gy in 4 fractions over 4 days has been most often emplo...

    Authors: Akifumi Miyakawa, Yuta Shibamoto, Fumiya Baba, Yoshihiko Manabe, Taro Murai, Chikao Sugie, Takeshi Yanagi and Taiki Takaoka
    Citation: Radiation Oncology 2017 12:152
    Content type: Research Published on:

  46. Given the potential for older patients to experience exaggerated toxicity and symptoms, this study was performed to characterize patient reported outcomes in older patients following definitive radiation thera...

    Authors: Salman A. Eraj, Mona K. Jomaa, Crosby D. Rock, Abdallah S. R. Mohamed, Blaine D. Smith, Joshua B. Smith, Theodora Browne, Luke C. Cooksey, Bowman Williams, Brandi Temple, Kathryn E. Preston, Jeremy M. Aymard, Neil D. Gross, Randal S. Weber, Amy C. Hessel, Renata Ferrarotto…
    Citation: Radiation Oncology 2017 12:150
    Content type: Research Published on:

    The Correction to this article has been published in Radiation Oncology 2017 12:186

  47. The aim of this study is to investigate the effect of tumor characteristics and parameters of treatment response in predicting biochemical disease-free survival (BFS) for patients with intermediate or high ris...

    Authors: Fady B. Geara, Muhammad Bulbul, Raja B. Khauli, Therese Y. Andraos, Mirna Abboud, Abdelatif Al Mousa, Nasim Sarhan, Ahmed Salem, Hamza Ghatasheh, Anoud Alnsour, Zeina Ayoub, Ibrahim Abu Gheida, Maya Charafeddine, Mohammed Shahait, Ali Shamseddine, Rami Abu Gheida…
    Citation: Radiation Oncology 2017 12:149
    Content type: Research Published on:

  48. Hypoxic cancer cells are thought to be radioresistant and could impact local recurrence after radiotherapy (RT). One of the major hypoxic imaging modalities is [18F]fluoromisonidazole positron emission tomography...

    Authors: Yukiko Nishikawa, Koichi Yasuda, Shozo Okamoto, Yoichi M. Ito, Rikiya Onimaru, Tohru Shiga, Kazuhiko Tsuchiya, Shiro Watanabe, Wataru Takeuchi, Yuji Kuge, Hao Peng, Nagara Tamaki and Hiroki Shirato
    Citation: Radiation Oncology 2017 12:148
    Content type: Research Published on:

  49. To compare target volume delineation of anal cancer using positron emission tomography (PET) and magnetic resonance imaging (MRI) with respect to inter-observer and inter-modality variability.

    Authors: Espen Rusten, Bernt Louni Rekstad, Christine Undseth, Ghazwan Al-Haidari, Bettina Hanekamp, Eivor Hernes, Taran Paulsen Hellebust, Eirik Malinen and Marianne Grønlie Guren
    Citation: Radiation Oncology 2017 12:147
    Content type: Research Published on:

  50. Neoadjuvant chemoradiotherapy following surgery has recently become a standard therapy. The purpose of the present study was to determine the effectiveness and toxicity of re-irradiation for oligo-recurrence i...

    Authors: Keiichi Jingu, Yuzuru Niibe, Hideomi Yamashita, Kuniaki Katsui, Toshihiko Matsumoto, Tomohiro Nishina and Atsuro Terahara
    Citation: Radiation Oncology 2017 12:146
    Content type: Research Published on:
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Radiation Oncology

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