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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. Radiation therapy is the standard radical treatment for nasopharyngeal carcinoma (NPC) but also causes transient as well as long-term complications. Patients who develop severe radiation-induced brainstem inju...

    Authors: Cheng-Yun Yao, Guo-Ren Zhou, Li-Jun Wang, Jian-Hua Xu, Jin-jun Ye, Lan-Fang Zhang, Xia He, Zhen-Zhang Chen and Sheng-Fu Huang
    Citation: Radiation Oncology 2018 13:194
  2. The SpaceOAR hydrogel is employed to limit rectal radiation dose during prostate radiotherapy. We identified a novel parameter – the product of angle θ and hydrogel volume – to quantify hydrogel placement. Thi...

    Authors: Mark E Hwang, Paul J Black, Carl D Elliston, Brian A Wolthuis, Deborah R Smith, Cheng-Chia Wu, Sven Wenske and Israel Deutsch
    Citation: Radiation Oncology 2018 13:192
  3. There is currently no worldwide consensus for the management of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). We evaluated the efficacy of stereotactic body radiotherapy (SBRT) as the ...

    Authors: Yongjie Shui, Wei Yu, Xiaoqiu Ren, Yinglu Guo, Jing Xu, Tao Ma, Bicheng Zhang, Jianjun Wu, Qinghai Li, Qiongge Hu, Li Shen, Xueli Bai, Tingbo Liang and Qichun Wei
    Citation: Radiation Oncology 2018 13:188
  4. Physicians and physicists are expected to contribute to patient safety and quality improvement (QI) in Radiation Oncology (RO), but prior studies suggest that training for this may be inadequate. RO and medica...

    Authors: Matthew B. Spraker, Matthew J. Nyflot, Kristi R. G. Hendrickson, Stephanie Terezakis, Shannon E. Fogh, Gabrielle M. Kane, Eric C. Ford and Jing Zeng
    Citation: Radiation Oncology 2018 13:186
  5. Prostate cancer (PCA) is the most-prevalent non-skin cancer in men worldwide. Nevertheless, the treatment of oligometastatic, especially lymph-node (ln) recurrent, PCA remains elusive. The aim of our study was...

    Authors: M. Oertel, S. Scobioala, K. Kroeger, A. Baehr, L. Stegger, U. Haverkamp, M. Schäfers and H.-T. Eich
    Citation: Radiation Oncology 2018 13:185
  6. The patterns of nodal relapse in submandibular gland carcinoma (SMGC) patients treated with postoperative radiotherapy (PORT) remain unclear. This study aims to investigate the nodal failure patterns and the u...

    Authors: Cheng-En Hsieh, Li-Yu Lee, Yung-Chih Chou, Kang-Hsing Fan, Ngan-Ming Tsang, Joseph Tung-Chieh Chang, Hung-Ming Wang, Shu-Hang Ng, Chun-Ta Liao, Tzu-Chen Yen, Ku-Hao Fang and Chien-Yu Lin
    Citation: Radiation Oncology 2018 13:184
  7. Concurrent chemoradiotherapy is considered curative intent treatment for patients with non-operative esophageal cancer. Radiation-induced heart damage receives much attention. We performed repeated four-dimens...

    Authors: Xue Wang, Jin-Zhi Wang, Jian-Bin Li, Ying-Jie Zhang, Feng-Xiang Li, Wei Wang, Yan-Luan Guo, Qian Shao, Min Xu, Xi-Jun Liu and Yue Wang
    Citation: Radiation Oncology 2018 13:181
  8. This study evaluated the effect of radiation dose rate in patients with hematolymphoid malignancies undergoing myeloablative conditioning with total body irradiation (TBI), for hematopoietic stem cell transpla...

    Authors: Dong-Yun Kim, Il Han Kim, Sung-Soo Yoon, Hyoung Jin Kang, Hee Young Shin and Hyun-Cheol Kang
    Citation: Radiation Oncology 2018 13:180
  9. We report prospectively captured clinical toxicity and patient reported outcomes in a single institutional cohort of patients treated for prostate cancer with proton beam therapy (PBT). This is the largest rep...

    Authors: Howard J. Lee Jr, Meghan W. Macomber, Matthew B. Spraker, Stephen R. Bowen, Daniel S. Hippe, Angela Fung, Kenneth J. Russell, George E. Laramore, Ramesh Rengan, Jay Liao, Smith Apisarnthanarax and Jing Zeng
    Citation: Radiation Oncology 2018 13:179
  10. To compare the efficacies and toxicities of intensity-modulated radiotherapy (IMRT) with three-dimensional conformal radiotherapy (3D-CRT) or conventional two-dimensional radiotherapy (2D-RT) for definitive tr...

    Authors: Yanzhu Lin, Kai Chen, Zhiyuan Lu, Lei Zhao, Yalan Tao, Yi Ouyang and Xinping Cao
    Citation: Radiation Oncology 2018 13:177
  11. To analyze the clinical outcome of elderly women with early breast cancer who underwent accelerated partial breast irradiation (APBI) based on a post-operative single fraction of multicatheter interstitial hig...

    Authors: Rémy Kinj, Marie-Eve Chand, Jocelyn Gal, Mathieu Gautier, Lucile Montagné, Daniel Lam Cham Kee and Jean Michel Hannoun-Lévi
    Citation: Radiation Oncology 2018 13:174
  12. To evaluate clinical outcomes of simultaneous integrated boost (SIB) - intensity modulated radiotherapy (RT) in patients with non metastatic anal cancer compared to those of a set of patients treated with 3-di...

    Authors: Pierfrancesco Franco, Berardino De Bari, Francesca Arcadipane, Alexis Lepinoy, Manuela Ceccarelli, Gabriella Furfaro, Massimiliano Mistrangelo, Paola Cassoni, Martina Valgiusti, Alessandro Passardi, Andrea Casadei Gardini, Elisabetta Trino, Stefania Martini, Giuseppe Carlo Iorio, Andrea Evangelista, Umberto Ricardi…
    Citation: Radiation Oncology 2018 13:172
  13. To investigate the treatment failure pattern and factors influencing locoregional recurrence of esophageal squamous cell carcinoma (ESCC) and examine patient survival with re-irradiation (re-RT) after primary ...

    Authors: Liang Hong, Yun-xia Huang, Qing-yang Zhuang, Xue-qing Zhang, Li-rui Tang, Kai-xin Du, Xiao-yi Lin, Bu-hong Zheng, Shao-li Cai, Jun-xin Wu and Jin-luan Li
    Citation: Radiation Oncology 2018 13:171
  14. The cranial border of the target volume (TV) in rectal cancer patients treated with neoadjuvant chemoradiation (nCRT) is mostly defined at the level of L5/S1. However, current studies have shown that relapse c...

    Authors: Hendrik Dapper, Markus Oechsner, Stefan Münch, Kai Borm, Jan Peeken, Michael Mayinger, Stephanie E. Combs and Daniel Habermehl
    Citation: Radiation Oncology 2018 13:169
  15. Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the cent...

    Authors: Jackson M. May, Mark R. Waddle, Daniel H. Miller, William C. Stross, Tasneem A. Kaleem, Byron C. May, Robert C. Miller, Liuyan Jiang, Gerald W. Strong, Daniel M. Trifiletti, Kaisorn L. Chaichana, Ronald Reimer, Han W. Tun and Jennifer L. Peterson
    Citation: Radiation Oncology 2018 13:167
  16. Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with localized prostate cancer. Promising results in terms of disease control and toxicity have been reported with 4 to 5...

    Authors: Thomas Zilli, Marta Scorsetti, Daniel Zwahlen, Ciro Franzese, Robert Förster, Niccolò Giaj-Levra, Nikolaos Koutsouvelis, Aurelie Bertaut, Michel Zimmermann, Giuseppe Roberto D’Agostino, Filippo Alongi, Matthias Guckenberger and Raymond Miralbell
    Citation: Radiation Oncology 2018 13:166

    The Correction to this article has been published in Radiation Oncology 2018 13:182

  17. Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validit...

    Authors: Georgia K. B. Halkett, Charles Adam Wigley, Samar M Aoun, Maurizio Portaluri, Francesco Tramacere, Lorenzo Livi, Beatrice Detti, Stefano Arcangeli, Jo-Asmund Lund, Are Kristensen, Nathalie McFadden, Arne Grun, Sean Bydder, Irina Sackerer, Elfriede Greimel and Nigel Spry
    Citation: Radiation Oncology 2018 13:162
  18. The reporting of adverse effects is an integral aspect of a hospital quality improvement (QI) program with the goal of improving care for current and future patients. We report the results of our experience tr...

    Authors: Varun Chowdhry, Pamela Jangro, Saveli Goldberg, Nolan Gagne, Shelley Chabot, Gary Proulx and Cocav Rauwerdink
    Citation: Radiation Oncology 2018 13:161
  19. To assess the effect of radiochemotherapy (RCT) on proposed tumour hypoxia marker transverse relaxation time (T2*) and to analyse the relation between T2* and 18F-misonidazole PET/CT (FMISO-PET) and 18F-fluorodeo...

    Authors: Nicole Wiedenmann, Hatice Bunea, Hans C. Rischke, Andrei Bunea, Liette Majerus, Lars Bielak, Alexey Protopopov, Ute Ludwig, Martin Büchert, Christian Stoykow, Nils H. Nicolay, Wolfgang A. Weber, Michael Mix, Philipp T. Meyer, Jürgen Hennig, Michael Bock…
    Citation: Radiation Oncology 2018 13:159

    The Correction to this article has been published in Radiation Oncology 2018 13:183

  20. Radiotherapy is one of the standard treatments for cutaneous lymphoma and Total Skin Electrons Beam Irradiation (TSEBI) is generally used to treat diffuse cutaneous lymphoma and some cases of localized disease...

    Authors: Michela Buglione, Luigi Spiazzi, Mauro Urpis, Liliana Baushi, Rossella Avitabile, Nadia Pasinetti, Paolo Borghetti, Luca Triggiani, Sara Pedretti, Federica Saiani, Alfredo Fiume, Diana Greco, Stefano Ciccarelli, Alessia Polonini, Renzo Moretti and Stefano Maria Magrini
    Citation: Radiation Oncology 2018 13:158
  21. A recent Japanese study suggested prophylactic cranial irradiation (PCI) failed to improve survival of extensive-stage small-cell lung cancer (SCLC). However, previous studies showed that PCI was beneficial in...

    Authors: Wei Ge, Huilin Xu, Yafei Yan and Dedong Cao
    Citation: Radiation Oncology 2018 13:155
  22. This study aimed to analyse the frequency and clinical relevance of sacral insufficiency fractures (SIFs) after high-dose carbon-ion based irradiation of sacral chordomas.

    Authors: Tilman Bostel, Nils Henrik Nicolay, Thomas Welzel, Thomas Bruckner, Matthias Mattke, Sati Akbaba, Tanja Sprave, Jürgen Debus and Matthias Uhl
    Citation: Radiation Oncology 2018 13:154
  23. In this pooled 2-center series LINAC radiosurgery (SRS) has been applied as a treatment option for a subset of refractory trigeminal neuralgia (TN) patients. This study approached to retrospectively assess the...

    Authors: Ali Rashid, Bogdan Pintea, Thomas M. Kinfe, Gunnar Surber, Klaus Hamm and Jan P. Boström
    Citation: Radiation Oncology 2018 13:153
  24. In an oligometastatic setting, metastasis-directed treatment could render patients disease free, possibly for a protracted interval. Stereotactic ablative radiotherapy (SABR) is one of the treatment modalities...

    Authors: Carole Mercier, Piet Dirix, Paul Meijnders, Peter Vermeulen, Steven Van Laere, Hilde Debois, Philippe Huget and Dirk Verellen
    Citation: Radiation Oncology 2018 13:152
  25. The aim of the present study was to assess the efficacy of adjuvant chemotherapy (AC) in patients with esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiotherapy (CRT).

    Authors: Mingqiu Chen, Minmin Shen, Yu Lin, Pingping Liu, Xiaohong Liu, Xiqing Li, Anchuan Li, Rongqiang Yang, Wei Ni, Xin Zhou, Lurong Zhang, Benhua Xu, Jianhua Lin, Junqiang Chen and Ye Tian
    Citation: Radiation Oncology 2018 13:150
  26. In the era of intensity-modulated radiotherapy (IMRT), the role of additional concurrent chemotherapy (CC) to radiotherapy (RT) after induction chemotherapy (IC) compared to IC followed by RT alone remains unc...

    Authors: Linger Liu, Zhenghua Fei, Mengfeng Chen, Lihao Zhao, Huafang Su, Dianna Gu, Baochai Lin, Xiaona Cai, Lihuai Lu, Mengdan Gao, Xuxue Ye, Xiance Jin and Congying Xie
    Citation: Radiation Oncology 2018 13:148
  27. We aimed to evaluate the toxicity, loco-regional control (LRC) and overall survival (OS) associated with accelerated intensity-modulated radiotherapy (IMRT) for locally advanced lung cancer.

    Authors: Nicolas Jaksic, Enrique Chajon, Julien Bellec, Romain Corre, Charles Ricordel, Bertrand de Latour, Hervé Lena, Ulrike Schick, Renaud de Crevoisier and Joël Castelli
    Citation: Radiation Oncology 2018 13:147
  28. For 2018, the American Cancer Society estimated that there would be approximately 1.7 million new diagnoses of cancer and about 609,640 cancer-related deaths in the United States. By 2030 these numbers are ant...

    Authors: Paul Russell Roberts, Ashesh B. Jani, Satyaseelan Packianathan, Ashley Albert, Rahul Bhandari and Srinivasan Vijayakumar
    Citation: Radiation Oncology 2018 13:146
  29. We sought to determine the role of abdominal reirradiation for patients presenting with recurrent or new primary gastrointestinal (GI) malignancies. At our institution, we have established a hyperfractionated,...

    Authors: Andrew Hunt, Prajnan Das, Bruce D. Minsky, Eugene J. Koay, Sunil Krishnan, Joseph M. Herman, Cullen Taniguchi, Albert Koong, Grace L. Smith and Emma B. Holliday
    Citation: Radiation Oncology 2018 13:143
  30. Development of primary lung cancer in donor lung post-lung transplantation is very rare, with few described cases. The safety of stereotactic ablative radiotherapy (SABR) for early-stage lung cancer arising fr...

    Authors: Hanbo Chen, Jussi Tikkanen, R. Gabriel Boldt and Alexander V. Louie
    Citation: Radiation Oncology 2018 13:142
  31. To compare the efficacy of ipsilateral lower neck sparing irradiation (ILNSI) versus ipsilateral lower neck prophylactic irradiation (ILNPI) for unilateral or bilateral neck node-negative nasopharyngeal cancer...

    Authors: Cheng-Long Huang, Cheng Xu, Yuan Zhang, Guan-Qun Zhou, Yan-Ping Mao, Qing Liu, Ying Sun, Jun Ma and Ling-Long Tang
    Citation: Radiation Oncology 2018 13:141
  32. The purpose of this retrospective analysis is to analyze clinical outcome, visual acuity and enucleation rates after linear accelerator-based stereotactic fractionated photon radiotherapy for primary uveal mel...

    Authors: Sati Akbaba, Robert Foerster, Nils Henrik Nicolay, Nathalie Arians, Tilman Bostel, Juergen Debus and Henrik Hauswald
    Citation: Radiation Oncology 2018 13:140
  33. While neoadjuvant chemoradiation therapy (nCRT) with subsequent surgery is the treatment of choice for patients with locally advanced or node-positive squamous cell carcinoma of the esophagus (SCC) suitable fo...

    Authors: Stefan Münch, Steffi U. Pigorsch, Michal Devečka, Hendrik Dapper, Wilko Weichert, Helmut Friess, Rickmer Braren, Stephanie E. Combs and Daniel Habermehl
    Citation: Radiation Oncology 2018 13:139
  34. Until 50% of patients with renal cancer or melanoma, develop brain metastases during the course of their disease. Stereotactic radiotherapy has become a standard of care for patients with a limited number of b...

    Authors: Paul Lesueur, Justine Lequesne, Victor Barraux, William Kao, Julien Geffrelot, Jean-Michel Grellard, Jean-Louis Habrand, Evelyne Emery, Brigitte Marie, Juliette Thariat and Dinu Stefan
    Citation: Radiation Oncology 2018 13:138
  35. This study evaluated the safety and efficacy of repeat SBRT for local recurrence of stage I non-small-cell lung cancer (NSCLC) and solitary lung metastasis.

    Authors: Yasutaka Ogawa, Yuta Shibamoto, Chisa Hashizume, Takuhito Kondo, Hiromitsu Iwata, Natsuo Tomita and Hiroyuki Ogino
    Citation: Radiation Oncology 2018 13:136
  36. To evaluate the clinical outcomes of patients treated with 3D conformal Hypo-fractionated, deep Inspiratory breath-hold (DIBH), Partial breast radiotherapy, termed “HIP.” HIP was implemented to merge the schedule...

    Authors: Roman O. Kowalchuk, Kara D. Romano, Daniel M. Trifiletti, Sunil W. Dutta, Timothy N. Showalter and Monica M. Morris
    Citation: Radiation Oncology 2018 13:135
  37. The effect of radiotherapy, in particular the application of different multi-fraction schedules in the management of unstable spinal bone metastases (SBM), is incompletely understood. This study aims to compar...

    Authors: Tanja Sprave, Katharina Hees, Thomas Bruckner, Robert Foerster, Tilman Bostel, Ingmar Schlampp, Rami El Shafie, Nils Henrik Nicolay, Juergen Debus and Harald Rief
    Citation: Radiation Oncology 2018 13:134
  38. Melanoma brain metastases (MBM) often cause morbidity and mortality for stage IV melanoma patients. An ongoing randomised phase III trial (NCT01503827 – WBRT-Mel) evaluates the role of adjuvant whole brain rad...

    Authors: Geoffrey Martinage, Angela M. Hong, Mike Fay, Thanuja Thachil, Daniel Roos, Narelle Williams, Serigne Lo and Gerald Fogarty
    Citation: Radiation Oncology 2018 13:132
  39. Gene expression of specific therapeutic targets in non-malignant lung tissue might play an important role in optimizing targeted therapies. This study aims to identify different expression patterns of fifteen ...

    Authors: Kobe Reynders, Els Wauters, Matthieu Moisse, Herbert Decaluwé, Paul De Leyn, Stéphanie Peeters, Maarten Lambrecht, Kristiaan Nackaerts, Christophe Dooms, Wim Janssens, Johan Vansteenkiste, Diether Lambrechts and Dirk De Ruysscher
    Citation: Radiation Oncology 2018 13:131
  40. To investigate the incidence of radiation esophagitis (RE) and tumor local control using esophagus sparing technique in locally advanced non-small cell lung cancer (LANSCLC) treated by simultaneous integrated ...

    Authors: Li Ma, Bo Qiu, QiWen Li, Li Chen, Bin Wang, YongHong Hu, MengZhong Liu, Li Zhang, Yan Huang, XiaoWu Deng, YunFei Xia, MaoSheng Lin and Hui Liu
    Citation: Radiation Oncology 2018 13:130
  41. Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. The American Brachytherapy Society has published guidelines for high dose rate (HDR) BT with recommended d...

    Authors: Kara D. Romano, Colin Hill, Daniel M. Trifiletti, M. Sean Peach, Bethany J. Horton, Neil Shah, Dylan Campbell, Bruce Libby and Timothy N. Showalter
    Citation: Radiation Oncology 2018 13:129
  42. Intra-fraction motion represents a crucial issue in the era of precise radiotherapy in several settings, including breast irradiation. To date, only few data exist on real-time measured intra-fraction motion i...

    Authors: D. Reitz, G. Carl, S. Schönecker, M. Pazos, P. Freislederer, M. Niyazi, U. Ganswindt, F. Alongi, M. Reiner, C. Belka and S. Corradini
    Citation: Radiation Oncology 2018 13:128
  43. Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer.

    Authors: Yeon Joo Kim, Su Ssan Kim, Si Yeol Song and Eun Kyung Choi
    Citation: Radiation Oncology 2018 13:127
  44. Heart-sparing techniques are time and resource intensive, although not all patients require the use of these strategies. This study evaluates the performance of different distance metrics in predicting the nee...

    Authors: Lucas C. Mendez, Alexander V. Louie, Carolina Moreno, Matt Wronski, Andrew Warner, Eric Leung, Roberto Sakuraba, Juliana K. Helito, Ana Rezende, Icaro T. Carvalho and Eduardo Weltman
    Citation: Radiation Oncology 2018 13:124
  45. Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group “Personali...

    Authors: Cornelius Maihoefer, Lars Schüttrumpf, Corinna Macht, Ulrike Pflugradt, Julia Hess, Ludmila Schneider, Christine Woischke, Axel Walch, Philipp Baumeister, Thomas Kirchner, Horst Zitzelsberger, Claus Belka and Ute Ganswindt
    Citation: Radiation Oncology 2018 13:123
  46. The benefits of proton therapy in the treatment of patients with Hodgkin lymphoma (HL) are controversially discussed. Therefore we compared intensitiy modulated proton therapy (IMPT) with intensity modulated r...

    Authors: Christian Baues, Simone Marnitz, Andreas Engert, Wolfgang Baus, Karolina Jablonska, Antonella Fogliata, Andrés Vásquez-Torres, Marta Scorsetti and Luca Cozzi
    Citation: Radiation Oncology 2018 13:122
  47. Carbon-ion radiotherapy (C-ion RT) provides better dose distribution in cancer treatment compared to photons. Additionally, carbon-ion beams provide a higher biological effectiveness, and thus a higher tumor c...

    Authors: Noriyuki Okonogi, Mai Fukahori, Masaru Wakatsuki, Yu Ohkubo, Shingo Kato, Yuhei Miyasaka, Hiroshi Tsuji, Takashi Nakano and Tadashi Kamada
    Citation: Radiation Oncology 2018 13:119
  48. The purpose was to retrospectively evaluate the effect of intensity-modulated radiotherapy (IMRT) on gastrointestinal (GI) toxicities and outcomes compared to three-dimensional conformal radiotherapy (3DCRT) f...

    Authors: Yoko Goto, Akira Nakamura, Ryo Ashida, Katsuyuki Sakanaka, Satoshi Itasaka, Keiko Shibuya, Shigemi Matsumoto, Masashi Kanai, Hiroyoshi Isoda, Toshihiko Masui, Yuzo Kodama, Kyoichi Takaori, Masahiro Hiraoka and Takashi Mizowaki
    Citation: Radiation Oncology 2018 13:118
  49. Deep inspiration breath hold (DIBH) can be performed using different breathing maneuvers, such as DIBH with a thoracic breathing maneuver (T-DIBH) and DIBH with an abdominal breathing maneuver (A-DIBH). Dosime...

    Authors: Feng Zhao, Jiayan Shen, Zhongjie Lu, Yongbiao Luo, Guorong Yao, Luyi Bu, Jia Ge, Xin Yang, Lihua Ning and Senxiang Yan
    Citation: Radiation Oncology 2018 13:116

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