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Clinical Radiation Oncology

Section edited by Stephanie Combs, Pirus Ghadjar, Matthias Guckenberger, Daniel Habermehl, Silke Nachbichler, Maximilian Niyazi, and Falk Roeder

The Clinical Radiation Oncology section aims to provide a platform for clinical research in radiation oncology. Research includes innovative early phase and later stage clinical trials, technical approaches, review articles on “burning” clinical questions, invited key reviews, RT planning studies, multimodal therapy, data mining from retrospective cohorts in a hypothesis-generating manner, interconnection between imaging and improved target delineation, and intensity modulation/high precision techniques. The section addresses current, timely and cutting- edge research and reviews about clinically relevant issues in radiation oncology, while offering a fast review process.

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  1. The COVID-19 pandemic has stripped many medical students worldwide of their right to quality education. In response, we developed hybrid courses involving aspects of both online and in-person teaching for radi...

    Authors: Tae Hyung Kim, Jin Sung Kim, Hong In Yoon, Joongyo Lee, Jason Joon Bock Lee, Hwa Kyung Byun, Yeona Cho, Yong Bae Kim, Ik Jae Lee, Kyung Hwan Kim and Jee Suk Chang

    Citation: Radiation Oncology 2021 16:204

    Content type: Research

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  2. To study the performance of a proposed deep learning-based autocontouring system in delineating organs at risk (OARs) in breast radiotherapy with a group of experts.

    Authors: Hwa Kyung Byun, Jee Suk Chang, Min Seo Choi, Jaehee Chun, Jinhong Jung, Chiyoung Jeong, Jin Sung Kim, Yongjin Chang, Seung Yeun Chung, Seungryul Lee and Yong Bae Kim

    Citation: Radiation Oncology 2021 16:203

    Content type: Research

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  3. To develop a nomogram model for predicting local progress-free survival (LPFS) in esophageal squamous cell carcinoma (ESCC) patients treated with concurrent chemo-radiotherapy (CCRT).

    Authors: He-San Luo, Ying-Ying Chen, Wei-Zhen Huang, Sheng-Xi Wu, Shao-Fu Huang, Hong-Yao Xu, Ren-Liang Xue, Ze-Sen Du, Xu-Yuan Li, Lian-Xin Lin and He-Cheng Huang

    Citation: Radiation Oncology 2021 16:201

    Content type: Research

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  4. Second head and neck neuroendocrine carcinoma (NEC) after radical radiotherapy for nasopharyngeal carcinoma (NPC) treatment is rarely reported. The prognosis of second cancer is poor, and our research focuses ...

    Authors: Ying-peng Peng, Qiao-dan Liu, Yu-jing Lin, Shun-li Peng, Rong Wang, Xi-wei Xu, Wei Wei, Gui-hua Zhong, Yu-ling Zhou, Ya-qin Zhang, Ye Liu, Si-yang Wang, Hai-yu Hong and Zhi-gang Liu

    Citation: Radiation Oncology 2021 16:198

    Content type: Research

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  5. Approximately one third of cancer patients will develop spinal metastases, that can be associated with back pain, neurological symptoms and deterioration in performance status. Stereotactic radiosurgery (SRS) ...

    Authors: Niccolò Giaj-Levra, Vanessa Figlia, Francesco Cuccia, Rosario Mazzola, Luca Nicosia, Francesco Ricchetti, Michele Rigo, Giorgio Attinà, Claudio Vitale, Gianluisa Sicignano, Antonio De Simone, Stefania Naccarato, Ruggero Ruggieri and Filippo Alongi

    Citation: Radiation Oncology 2021 16:197

    Content type: Research

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  6. Adjuvant therapy is a promising treatment to improve the prognosis of cancer patients, however, the evidence base driving recommendations for adjuvant radiotherapy (ART) or chemotherapy (ACT) in retroperitonea...

    Authors: Xiangji Li, Tong Wu, Mengmeng Xiao, Shanshan Wu, Li Min and Chenghua Luo

    Citation: Radiation Oncology 2021 16:196

    Content type: Research

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  7. Whether adjuvant chemotherapy (AC) after concurrent chemoradiotherapy (CCRT) could provide benefit to esophageal squamous cell carcinoma (ESCC) patients is controversial. Therefore, we decided to investigate t...

    Authors: Ao Liu, Yalin Wang, Xin Wang, Liqiong Zhu, Yu Nie and Minghuan Li

    Citation: Radiation Oncology 2021 16:195

    Content type: Research

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  8. Systemic response to local anticancer treatment is a phenomenon called ‘abscopal effect’. The immune system is thought to play a pivotal role in its occurrence. To date, several cases have been reported, parti...

    Authors: Oliver Vilinovszki, Nicolaus Andratschke, Martin Huellner, Alessandra Curioni-Fontecedro and Stephanie G. C. Kroeze

    Citation: Radiation Oncology 2021 16:194

    Content type: Case report

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  9. To determine the most appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with maxillary sinus cancer (MSC).

    Authors: Yasuo Kosugi, Michimasa Suzuki, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Yoichi Muramoto, Terufumi Kawamoto, Masaki Oshima, Naoto Shikama and Keisuke Sasai

    Citation: Radiation Oncology 2021 16:190

    Content type: Research

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  10. MR-guided online adaptive stereotactic body radiation therapy (SBRT) for prostate cancer aims to reduce toxicity by full compensation of interfractional uncertainties. However, the process of online adaptation...

    Authors: J. Schaule, M. Chamberlain, L. Wilke, M. Baumgartl, J. Krayenbühl, M. Zamburlini, M. Mayinger, N. Andratschke, S. Tanadini-Lang and M. Guckenberger

    Citation: Radiation Oncology 2021 16:189

    Content type: Research

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  11. To develop a risk model based on dosimetric metrics to predict local recurrence in nasopharyngeal carcinoma (NPC) patients treated with intensive modulated radiation therapy (IMRT).

    Authors: Wenjun Liao, Jinlan He, Zijian Liu, Maolang Tian, Jiangping Yang, Jiaqi Han and Jianghong Xiao

    Citation: Radiation Oncology 2021 16:186

    Content type: Research

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  12. To investigate the relationship between radiotherapy (RT) and the risk of cerebrovascular mortality (CVM) in head and neck cancer (HNC) survivors aged ≥ 65 years.

    Authors: Qing-Song He, Zhen-Ping Wang, Zhao-Jun Li, Ping Zhou, Chen-Lu Lian, San-Gang Wu and Si-Fang Chen

    Citation: Radiation Oncology 2021 16:185

    Content type: Research

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  13. The role of postoperative radiotherapy (PORT) in cardiovascular-pulmonary disease mortality in patients with stage IIIA-N2 resected non-small cell lung cancer (NSCLC) remains uncertain. The purpose of this pop...

    Authors: Xia Wang, Jiaqi Song, Jie Long, Zhimin Zeng and Anwen Liu

    Citation: Radiation Oncology 2021 16:184

    Content type: Research

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  14. Hybrid magnetic resonance (MR)-guided linear accelerators represent a new horizon in the field of radiation oncology. By harnessing the favorable combination of on-board MR-imaging with the possibility to dail...

    Authors: Francesco Cuccia, Filippo Alongi, Claus Belka, Luca Boldrini, Juliane Hörner-Rieber, Helen McNair, Michele Rigo, Maartje Schoenmakers, Maximilian Niyazi, Judith Slagter, Claudio Votta and Stefanie Corradini

    Citation: Radiation Oncology 2021 16:183

    Content type: Review

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  15. In patients with stage III melanoma, the use of adjuvant radiation therapy (RT) after lymph node dissection (LND) may be currently considered in selected high-risk patients to improve tumor control. Melanomas ...

    Authors: Adam R. Wolfe, Priyanka Chablani, Michael R. Siedow, Eric D. Miller, Steve Walston, Kari L. Kendra, Evan Wuthrick and Terence M. Williams

    Citation: Radiation Oncology 2021 16:181

    Content type: Research

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  16. To report preliminary data on treatment outcome and compliance to dose-intensified organ sparing SBRT for prostate cancer using a novel electromagnetic transmitter-based tracking system (RayPilot® System) to a...

    Authors: Raffaella Lucchini, Denis Panizza, Riccardo Ray Colciago, Veronica Vernier, Martina Camilla Daniotti, Valeria Faccenda and Stefano Arcangeli

    Citation: Radiation Oncology 2021 16:180

    Content type: Research

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  17. The purpose of the study was to assess the uterus motions and bladder volume changes of fractional movements in cervical sites throughout the external beam radiotherapy (EBRT) treatment.

    Authors: Xu Li, Lizhen Wang, Zhen Cui, Yukun Li, Pei Liu, Yungang Wang, Jinhong Zhu, Jianmin Zhu, Yong Yin and Zhenjiang Li

    Citation: Radiation Oncology 2021 16:179

    Content type: Research

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    The Correction to this article has been published in Radiation Oncology 2021 16:200

  18. There is limited evidence concerning radiotherapy for painful lymph node metastases (PLM). We evaluated the effectiveness of radiotherapy for PLM using the International Consensus Endpoint in a subgroup analys...

    Authors: Kohsei Yamaguchi, Tetsuo Saito, Ryo Toya, Etsushi Tomitaka, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Takahiro Watakabe, Hirohito Otsuka and Natsuo Oya

    Citation: Radiation Oncology 2021 16:178

    Content type: Research

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  19. The SWORD trial is the first multicenter, single arm, phase II study assessing the safety and efficacy of a PD-1 inhibitor (Sintilimab), stereotactic body radiotherapy (SBRT) and granulocyte–macrophage colony ...

    Authors: Jianjiao Ni, Yue Zhou, Lin Wu, Xinghao Ai, Xiaorong Dong, Qian Chu, Chengbo Han, Xiaofei Wang and Zhengfei Zhu

    Citation: Radiation Oncology 2021 16:177

    Content type: Research

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  20. The aim of this study was to compare the pattern of intra-patient spread of lymph-node (LN)-metastases within the mediastinum as assessed by 18F-FDG PET/CT and systematic endobronchial ultrasound-guided transbron...

    Authors: Maja Guberina, Kaid Darwiche, Hubertus Hautzel, Christoph Pöttgen, Nika Guberina, Thomas Gauler, Till Ploenes, Lale Umutlu, Dirk Theegarten, Clemens Aigner, Wilfried E. E. Eberhardt, Martin Metzenmacher, Marcel Wiesweg, Rüdiger Karpf-Wissel, Martin Schuler, Ken Herrmann…

    Citation: Radiation Oncology 2021 16:176

    Content type: Research

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  21. Proton beam therapy is a well-established treatment option for patients with uveal melanoma (UM). The treatment procedure, in general, includes placing radiopaque clips to ensure exact eye-positioning during r...

    Authors: Johannes Gollrad, Christopher Rabsahl, Aline-Isabel Riechardt, Jens Heufelder, Andrea Stroux, Ute Goerling, Antonia Joussen, Volker Budach and Dirk Boehmer

    Citation: Radiation Oncology 2021 16:174

    Content type: Research

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  22. This study aimed to investigate the effect of abdominal compression on tumour motion and target volume and to determine suitable planning target volume (PTV) margins for patients treated with lung stereotactic...

    Authors: Yuanjun Qi, Jianbin Li, Yingjie Zhang, Qian Shao, Xijun Liu, Fengxiang Li, Jinzhi Wang, Zhenxiang Li and Wei Wang

    Citation: Radiation Oncology 2021 16:173

    Content type: Research

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  23. To investigate risk factors for developing radiation-associated facial lymphedema (FL) in nasopharyngeal carcinoma (NPC) patients after concurrent chemoradiation (CCRT).

    Authors: Donghyun Kim, Jiho Nam, Wontaek Kim, Dahl Park, Jihyeon Joo, Hosang Jeon and Yongkan Ki

    Citation: Radiation Oncology 2021 16:172

    Content type: Research

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  24. Stereotactic Body Radiotherapy (SBRT) has shown effectiveness in treating bone metastases to alleviate pain. The benefit of SBRT may be further harnessed especially when radiating disease from primary malignan...

    Authors: Eric K. Nguyen, Kimmen Quan, Sameer Parpia, Stephan Tran and Anand Swaminath

    Citation: Radiation Oncology 2021 16:170

    Content type: Study protocol

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  25. To evaluate the influence of target dose heterogeneity on normal tissue dose sparing for peripheral lung tumor stereotactic body radiation therapy (SBRT).

    Authors: Zhigong Wei, Xingchen Peng, Yan Wang, Lianlian Yang, Ling He, Zheran Liu, Jingjing Wang, Xiaoli Mu, Ruidan Li and Jianghong Xiao

    Citation: Radiation Oncology 2021 16:167

    Content type: Research

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  26. Most anterior visual pathway meningiomas (AVPM) are benign and slow-growing, but these tumors may affect visual functions, including visual acuity (VA) and visual field (VF). Due to location, most are treated ...

    Authors: Leor Zach, Amir Agami, Orit Furman, Moshe Attia, Zvi Cohen, Iris Ben-Bassat Mizrachi, Guy Tam, Zion Zibly, Ouzi Nissim, Roberto Spiegelmann and Ruth Huna-Baron

    Citation: Radiation Oncology 2021 16:166

    Content type: Research

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  27. Multifocal manifestation of high-grade glioma is a rare disease with very unfavourable prognosis. The pathogenesis of multifocal glioma and pathophysiological differences to unifocal glioma are not fully under...

    Authors: Daniel Felix Fleischmann, Rudolph Schön, Stefanie Corradini, Raphael Bodensohn, Indrawati Hadi, Jan Hofmaier, Robert Forbrig, Niklas Thon, Mario Dorostkar, Claus Belka and Maximilian Niyazi

    Citation: Radiation Oncology 2021 16:165

    Content type: Research

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  28. The benefit and the risk profile of Gamma Knife radiosurgery (GKRS) for intracerebral cavernoma remains incompletely defined in part due to the natural history of low incidence of bleeding and spontaneous regr...

    Authors: Chiung-Chyi Shen, Ming Hsi Sun, Meng-Yin Yang, Weir-Chiang You, Meei-Ling Sheu, Yen-Ju Chen, Ying Ju Chen, Jason Sheehan and Hung-Chuan Pan

    Citation: Radiation Oncology 2021 16:164

    Content type: Research

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  29. Advances in multi-modality treatment of locally advanced rectal cancer (LARC) have resulted in low local recurrence rates, but around 30% of patients will still die from distant metastatic disease. In parallel...

    Authors: Catherine R. Hanna, Sean M. O’Cathail, Janet S. Graham, Mark Saunders, Leslie Samuel, Mark Harrison, Lynsey Devlin, Joanne Edwards, Daniel R. Gaya, Caroline A. Kelly, Liz-Anne Lewsley, Noori Maka, Paula Morrison, Louise Dinnett, Susan Dillon, Jacqueline Gourlay…

    Citation: Radiation Oncology 2021 16:163

    Content type: Study protocol

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  30. Gastric bleeding negatively impacts the quality of life of patients with unresectable advanced gastric cancer and is frequently lethal. We investigated the efficacy of RT for palliation of gastric bleeding fro...

    Authors: Joongyo Lee, Hwa Kyung Byun, Woong Sub Koom, Yong Chan Lee and Jinsil Seong

    Citation: Radiation Oncology 2021 16:161

    Content type: Research

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  31. Disruption of the tumor-brain barrier in meningioma is a crucial factor in peritumoral brain edema (PTBE). We previously reported the possible effect of osteoporosis on the integrity of the arachnoid trabecula...

    Authors: Sang Mook Kang, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Yu Deok Won, Young Soo Kim and Myung-Hoon Han

    Citation: Radiation Oncology 2021 16:160

    Content type: Research

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  32. Patients with low-grade gliomas (LGGs) harboring O6-methylguanine-DNA methyltransferase promoter nonmethylation (MGMT-non-pM) have a particularly short survival and are great resistance to chemotherapy. The objec...

    Authors: Yanwei Liu, Yanong Li, Peng Wang, Li Chen, Jin Feng and Xiaoguang Qiu

    Citation: Radiation Oncology 2021 16:157

    Content type: Research

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  33. To investigate the treatment outcomes of passive scattering proton beam therapy using stereotactic ablative radiotherapy (SABR) or hypofractionated radiation therapy (RT) for inoperable patients or those who r...

    Authors: Unurjargal Bayasgalan, Sung Ho Moon, Jong Hwi Jeong, Tae Hyun Kim, Kwan Ho Cho and Yang-Gun Suh

    Citation: Radiation Oncology 2021 16:155

    Content type: Research

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  34. Common symptoms of oesophageal cancer are dysphagia, pain, and bleeding. These symptoms can be relieved with palliative radiotherapy. The aim of this study was to analyse the outcome of two different palliativ...

    Authors: Halla Sif Ólafsdóttir, Fredrik Klevebro, Nelson Ndegwa and Gabriella Alexandersson von Döbeln

    Citation: Radiation Oncology 2021 16:153

    Content type: Research

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  35. Treatment-related white blood cell (WBC) toxicity has been associated with an inferior prognosis in different malignancies, including anal cancer. The aim of the present study was to investigate predictors of ...

    Authors: Martin P. Nilsson, Anders Johnsson and Jonas Scherman

    Citation: Radiation Oncology 2021 16:152

    Content type: Research

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  36. Meningiomas express the somatostatin receptor (SSTR), which normal bone and brain lack. PET imaging with SSTR ligands such as 68 Ga-DOTATATE have been recently shown to aid in the imaging and identification of me...

    Authors: Emily S. Kowalski, Rahul Khairnar, Anton A. Gryaznov, Vivek Kesari, Antony Koroulakis, Prashant Raghavan, Wengen Chen, Graeme Woodworth and Mark Mishra

    Citation: Radiation Oncology 2021 16:151

    Content type: Research

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  37. The purpose of this study was to analyze the treatment efficacy and safety of stereotactic ablative body radiotherapy (SABR) boost for cervical cancer patients not amenable to brachytherapy.

    Authors: Tae Hoon Lee, Changhoon Song, In Ah Kim, Jae-Sung Kim, Yong Beom Kim, Kidong Kim, Jae Hong No, Dong Hoon Suh, Jin-Beom Chung and Keun-Yong Eom

    Citation: Radiation Oncology 2021 16:148

    Content type: Research

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  38. Image guidance in radiation oncology has resulted in significant improvements in the accuracy and precision of radiation therapy (RT). Recently, the resolution and quality of cone beam computed tomography (CBC...

    Authors: Whitney Sumner, Sangwoo S. Kim, Lucas Vitzthum, Kevin Moore, Todd Atwood, James Murphy, Sayuri Miyauchi, Joseph A. Califano, Loren K. Mell, Arno J. Mundt and Andrew B. Sharabi

    Citation: Radiation Oncology 2021 16:147

    Content type: Research

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  39. Radiochemotherapy (RCT) has been shown to induce changes in immune cell homeostasis which might affect antitumor immune responses. In the present study, we aimed to compare the composition and kinetics of majo...

    Authors: Minli Niu, Stephanie E. Combs, Annett Linge, Mechthild Krause, Michael Baumann, Fabian Lohaus, Nadja Ebert, Ingeborg Tinhofer, Volker Budach, Jens von der Grün, Franz Rödel, Anca-Ligia Grosu and Gabriele Multhoff

    Citation: Radiation Oncology 2021 16:141

    Content type: Research

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  40. The risk for radiation necrosis is lower in fractionated stereotactic radiotherapy (SRT) than in conventional radiotherapy, and 13-fraction SRT is our method of choice for the treatment of brain metastases ≥ a...

    Authors: Megumi Uto, Kengo Ogura, Tomohiro Katagiri, Keiichi Takehana and Takashi Mizowaki

    Citation: Radiation Oncology 2021 16:140

    Content type: Research

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  41. The study aims to analyze the clinical characteristics of head and neck mucosal melanoma (MMHN) and the effects of multiple treatment modalities on distant metastasis, recurrence and survival rates to provide ...

    Authors: Qing-Qing Xu, Yan-Zhen Lai, Zi-Lu Huang, Zi-Yi Zeng, Ya-Ni Zhang, Rui-Yao Ou, Wen-Min Wu, Lei Chen and Li-Xia Lu

    Citation: Radiation Oncology 2021 16:138

    Content type: Research

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  42. Neoadjuvant chemoradiotherapy (nCRT) followed by surgery is a currently widely used strategy for locally advanced esophageal cancer (EC). However, the conventional imaging methods have certain deficiencies in ...

    Authors: Xin Xu, Zhi-Yong Sun, Hua-Wei Wu, Chen-Peng Zhang, Bin Hu, Ling Rong, Hai-Yan Chen, Hua-Ying Xie, Yu-Ming Wang, Hai-Ping Lin, Yong-Rui Bai, Qing Ye and Xiu-Mei Ma

    Citation: Radiation Oncology 2021 16:132

    Content type: Research

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  43. Symptomatic radiation pneumonitis (RP) may be a serious complication after thoracic radiation therapy (RT) for non-small cell lung cancer (NSCLC). This prospective observational study sought to evaluate the ut...

    Authors: Weronika Maria Szejniuk, Martin Skovmos Nielsen, Zsuzsanna Takács-Szabó, Jacek Pawlowski, Sahar Sulaiman Al-Saadi, Panagiotis Maidas, Martin Bøgsted, Tine McCulloch, Jens Brøndum Frøkjær, Ursula Gerda Falkmer and Oluf Dimitri Røe

    Citation: Radiation Oncology 2021 16:131

    Content type: Research

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  44. Tooth extraction post radiotherapy is one of the most important risk factors of osteoradionecrosis of the jawbones. The objective of this study was to determine the predictors of osteoradionecrosis (ORN) which...

    Authors: Szu Ching Khoo, Syed Nabil, Azizah Ahmad Fauzi, Siti Salmiah Mohd Yunus, Wei Cheong Ngeow and Roszalina Ramli

    Citation: Radiation Oncology 2021 16:130

    Content type: Research

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  45. To map anatomic patterns of para-aortic lymph node (PALN) recurrence in cervical cancer patients and validate currently available guidelines on PA clinical target volumes (CTV).

    Authors: Bong Kyung Bae, Shin-Hyung Park, Shin Young Jeong, Gun Oh Chong, Mi Young Kim and Jae-Chul Kim

    Citation: Radiation Oncology 2021 16:128

    Content type: Research

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  46. Historically, IBD has been thought to increase the underlying risk of radiation related toxicity in the treatment of prostate cancer. In the modern era, contemporary radiation planning and delivery may mitigat...

    Authors: Jonathan W. Lischalk, Seth Blacksburg, Christopher Mendez, Michael Repka, Astrid Sanchez, Todd Carpenter, Matthew Witten, Jules E. Garbus, Andrew Evans, Sean P. Collins, Aaron Katz and Jonathan Haas

    Citation: Radiation Oncology 2021 16:126

    Content type: Research

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  47. The aim of this work was to investigate the outcome of metastasis-directed radiotherapy (MDT) in prostate cancer patients with bone metastases following current ESTRO/EORTC subclassifications for oligometastat...

    Authors: Paul Rogowski, Christian Trapp, Rieke von Bestenbostel, Nina-Sophie Schmidt-Hegemann, Run Shi, Harun Ilhan, Alexander Kretschmer, Christian Stief, Ute Ganswindt, Claus Belka and Minglun Li

    Citation: Radiation Oncology 2021 16:125

    Content type: Research

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  48. Adjuvant hysterectomy following chemoradiation for bulky, early stage cervical cancer has been shown to decrease local relapse rate. The objective of this study is to compare complications and recurrences betw...

    Authors: Heather Miller, Koji Matsuo, Lynda D. Roman, Annie A. Yessaian, Huyen Q. Pham, Marianne Hom, Antonio Castaneda, Anthony Pham, Omar Ragab, Laila Muderspach, Marcia Ciccone and Laurie L. Brunette

    Citation: Radiation Oncology 2021 16:123

    Content type: Research

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    The Correction to this article has been published in Radiation Oncology 2021 16:162

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