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Table 2 Multivariate analysis of LRFS, RRFS, LRRFS, DMFS, PFS and OS

From: PET/CT standardized uptake value and EGFR expression predicts treatment failure in nasopharyngeal carcinoma

Variables

Multivariate analysis

P

HR (95%CI)

Test for LRFS

T-stage

T1-T2 vs. T3-T4

0.055

2.975(0.974–9.084)

EGFR

Negative vs. positive

0.147

1.074(0.684–12.536)

SUVmax-T

0.005

1.060(1.018–1.103)

Test for RRFS

N-stage

N0-N1 vs. N2-N3

0.023

12.950(1.423–111.833)

SUVmax-T

0.526

1.028(0.943–1.120)

SUVmax-N

0.025

1.110(1.013–1.216)

Test for LRRFS

T-stage

T1-T2 vs. T3-T4

0.503

1.310(0.594–2.892)

N-stage

N0-N1 vs. N2-N3

0.007

3.392(1.389–8.280)

EGFR

Negative vs. positive

0.046

3.409(1.019–11.402)

SUVmax-T

0.023

1.076(1.010–1.147)

SUVmax-N

0.901

1.004(0.937–1.077)

Test for DMFS

T-stage

T1-T2 vs. T3-T4

0.045

2.303(1.020–5.198)

N-stage

N0-N1 vs. N2-N3

0.002

24.741(3.349–182.792)

EGFR

Negative vs. positive

0.041

4.497(1.067–18.960)

SUVmax-N

0.521

1.021(0.957–1.090)

Test for PFS

T-stage

T1-T2 vs. T3-T4

0.113

1.603(0.895–2.871)

N-stage

N0-N1 vs. N2-N3

 < 0.001

4.060(2.060–8.004)

EGFR

Negative vs. positive

0.004

3.851(1.524–9.730)

SUVmax-T

0.073

1.046(0.996–1.099)

SUVmax-N

0.588

1.014(0.964–1.067)

Test for OS

Age

 < 50 vs. ≥ 50

0.034

2.484(1.070–5.768)

T-stage

T1-T2 vs. T3-T4

0.229

1.817(0.687–4.806)

N-stage

N0-N1 vs. N2-N3

0.009

4.513(1.460–13.951)

EGFR

Negative vs. positive

0.099

3.446(0.793–14.972)

SUVmax-T

0.361

1.036(0.960–1.119)

SUVmax-N

0.227

1.049(0.971–1.133)

  1. SUVmax-T Standardized uptake value of the primary tumor, SUV max-N The highest standardized uptake value of neck lymph nodes, DMFS Distant metastasis-free survival, LRFS Local recurrence‐free, survival; RRFS Regional recurrence-free survival, LRRFS Locoregional relapse-free survival, DMFS Distant metastasis-free survival, PFS Progression-free survival, OS Overall survival