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Table 4 Predictive factors of the 2-year PFS in univariate analysis

From: Dynamics in the expression of programmed death ligand 1 and cluster of differentiation 163 in the tumor microenvironment of uterine cervical cancer: a single-center retrospective study

Variables

Univariate analysis

HR

95% CI

p-value

Age

0.95

(0.91, 1.00)

0.03

FIGO stage

0.67

(0.34, 1.34)

0.26

Lymph node metastasis

 Negative

1.00

 Positive

2.13

(0.65, 6.91)

0.21

Distant metastasis

 Negative

1.00

 Positive

0.00

(0.00, ∞)

0.99

EBRT dose at the external os

1.04

(0.98, 1.11)

0.17

HDR-ICBT dose at the external os

1.01

(0.99, 1.03)

0.28

Chemotherapy

 0 mg/m2

1.00

 ≥ 100 mg/m2

1.01

(0.99, 1.02)

0.35

PD-1 expression levels

1.15

(0.72, 1.84)

0.56

PD-L1 expression levels

1.02

(1.00, 1.05)

0.09

CD8 expression levels

1.08

(0.95, 1.22)

0.24

CD68 expression levels

1.02

(0.99, 1.04)

0.26

CD163 expression levels

1.03

(1.00, 1.06)

0.09

FoxP3 expression levels

1.17

(0.65, 2.11)

0.61

HIF-1α expression levels

0.99

(0.96, 1.02)

0.52

  1. PFS Progression-free survival, FIGO International Federation of Gynecology and Obstetrics, EBRT external-beam radiation therapy, HDR-ICBT high-dose-rate intracavity brachytherapy, HR hazard ratio, CI confidence interval