Prognostic value of baseline 18F-FDG PET/CT in patients with esophageal squamous cell carcinoma treated with definitive (chemo)radiotherapy

Table 2 Univariate Cox regression analysis in patients with ESCC

Parameters	OS			PFS
Parameters	HR	95% CI	p value	HR	95% CI	p value
Clinical parameters
Age (years)	0.986	0.958–1.016	0.361	0.985	0.956–1.015	0.328
Sex
Male	1			1
Female	0.821	0.255–2.642	0.741	0.763	0.238–2.451	0.650
Histologic differentiation grade			0.964		0.988
Poor	1			1
Moderate	0.956	0.648–1.412	0.822	0.977	0.581–1.643	0.931
Well	1.025	0.701–1.499	0.898	0.935	0.383–2.287	0.884
Tumor location			0.006		0.011
Upper	1			1
Middle	1.450	0.804–2.616	0.217	1.333	0.739–2.402	0.340
Lower	2.892	1.491–5.612	0.002	2.654	1.375–5.122	0.004
Clinical T stage			0.165		0.082
T1	1			1
T2	1.027	0.417–2.528	0.954	1.006	0.409–2.476	0.989
T3	2.050	0.851–4.939	0.109	2.163	0.894–5.236	0.087
T4	1.611	0.691–3.759	0.270	1.857	0.792–4.353	0.154
Clinical N stage			0.824		0.896
N1	1			1
N2	1.027	0.580–1.820	0.927	0.901	0.506–1.602	0.722
N3	1.252	0.588–2.665	0.560	1.034	0.487–2.196	0.930
AJCC Stage
I–III	1			1
IV	1.310	0.801–2.142	0.283	1.366	0.835–2.235	0.214
Chemotherapy
Yes	1			1
No	1.267	0.644–2.493	0.492	1.294	0.658–2.544	0.456
PET parameters
SUV_Tumor	1.043	0.999–1.089	0.055	1.054	1.009–1.101	0.019
MTV (cm³)	1.022	1.011–1.033	< 0.001	1.02	1.01–1.031	< 0.001
TLG (g)	1.002	1.001–1.004	< 0.001	1.002	1.001–1.003	< 0.001
SUV_LN	1.025	0.993–1.057	0.129	1.025	0.993–1.057	0.121
PLNS number	1.063	0.993–1.138	0.081	1.037	0.968–1.110	0.304
SD_max(LN-T)(m⁻¹)	6.516	2.427–17.499	< 0.001	4.972	1.798–13.746	0.002

OS, overall survival; PFS, progression-free survival; HR, hazard ratio; CI, confidence interval; SUV_Tumor, SUV_max of primary tumor; MTV, metabolic tumor volume; TLG, total lesion glycolysis; SUV_LN, SUV_max of lymph node; PLNS, PET positive lymph nodes; SD_max(LN-T), the shortest distance between the farthest PET positive lymph node and the primary tumor in three-dimensional space after the standardization of the patient BSA
Values in bold indicate a significant result (p < 0.1)

ISSN: 1748-717X