Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients

Table 6 Association between cumulative acute toxicity and clinical and dosimetric characteristics

		p value univariate	p value multivariate
Patient’s history and tumor characteristics	Sex	0.51	0.14
	Hypertension	0.68	0.25
	Kidney disease	0.54
	Cholesterol	1
	Tobacco	0.52	0.22
	Alcohol	0.12	0.21
	Diabetes	0.25	0.99
	Primary tumor	0.24
Patient’s worst/all characteristics	Worst DS-GPA	0.49	0.10
	Worst RPA	0.67	0.20
	Corticosteroid therapy before SRT	< 0.001	0.03
	Immunotherapy all time	0.2	0.06
	Targeted therapy all time	0.63	0.53
	BMV grade	0.04	0.13
	Surgery	0.30	0.39
	Local reirradiation	0.45	0.28
	Symptoms pre-SRT at any session	< 0.001	0.21
Dosimetric characteristics	Number of SRT sessions	0.01	0.35
	Number of SRT sessions > 3	0.04
	Total number of BMs	0.08	0.67
	BMs > 5	0.28
	BMs > 10	0.59
	Total GTV	0.61	0.15
	V_12Gy	0.52
	V_14Gy	0.58
	V_21Gy	0.64
	V_23Gy	0.6
	V_40Gy	0.51

BM brain metastasis, BMV brain metastasis velocity, DS-GPA Diagnosis-Specific Graded Prognostic Assessment, GTV gross tumor volume, KPS Karnofsky Performance Score, RPA Recursive Partitioning Analysis, SRT stereotactic radiotherapy
Bold values indicate significant values

ISSN: 1748-717X