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Table 5 Association between acute toxicity at each SRT session and clinical and dosimetric characteristics

From: Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients

 

SRT1 (n = 184)

SRT2 (n = 184)

SRT3 (n = 61)

U

M

U

M

U

M

Patient characteristics

Age

0.44

0.38

0.01

0.87

0.43

1

WHO grade

0.99

0.76

0.07

0.73

0.01

1

KPS score

0.11

0.31

0.15

0.85

 < 0.01

1

DS-GPA

0.99

 

0.34

 

0.04

 

RPA

0.06

 

0.62

 

0.05

 

Symptoms pre-SRT

0.3

0.46

0.04

0.45

0.29

1

Corticosteroid use pre-SRT

0.78

0.85

 < 0.01

0.07

0.12

1

Immunotherapy

0.27

0.32

0.36

0.37

0.29

1

Targeted therapy

0.78

0.74

0.62

0.06

0.67

1

BM characteristics

Number of BMs

0.18

0.89

0.09

0.1

0.66

1

Surgery

0.35

 

1

 

0.6

 

GTV

0.07

0.13

0.30

0.67

0.05

1

Local recurrence

/

 

0.96

 

0.17

 
  1. BM brain metastasis, DS-GPA Diagnosis-Specific Graded Prognostic Assessment, GTV gross tumor volume, KPS Karnofsky Performance Score, M multivariate analysis, RPA recursive partitioning analysis, SRT stereotactic radiotherapy, U univariate analysis
  2. Bold values indicate significant values
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Radiation Oncology

ISSN: 1748-717X

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