Table 6 Dosimetry comparison study
From: Charged particle therapy for high-grade gliomas in adults: a systematic review
Authors (year) | Tumor histology | Patient number | Technique types | Target prescription dose and a fraction (Gy/RBE/CGE) | Comparative parameters of treatment plans | Evaluation parameters for OARs | Conclusions |
|---|---|---|---|---|---|---|---|
Rosenschöld et al. [19] | High-grade glioma | 15 | Dosimetry comparison between IMRT, VMAT and IMPT | IMRT/VAMT (PTV:60.0 Gy/30Fx) IMPT(PTV:60GyE/30Fx) | PTV dose conformity: Absorbed dose standard deviation for PTV | Dmax, Dmin, and Dmean evaluated for the normal brain (hippocampus, eyes, optic chiasm, fiber objects, brainstem) | The IMPT produced the most conform plans among other techniques |
Adeberg et al. [18] | High-grade glioma | 12 | Dosimetry comparison between 3D-CRT, VMAT and IMPT | IMPT (Median dose of 60.0 GyE (range 56.0–60.0GyE)/30Fx) IMRT/VAMT(PTV:60.0 Gy/30Fx) | CTV coverage: V90%, V95%, V100%, Dmax, Dmean, Dmin, HI, IC, ID | Dmax and Dmean evaluated for the normal brain (Chiasm, Optic nerve, Brainstem, Lens, Pituitary gland axis, Hippocampus, SVZ, Whole brain) | IMPT can serve as a valuable alternative to photon therapy for HGG |
Holm et al. [20] | High-grade glioma | 5 | Dosimetry comparison between IMRT, VMAT and IMPT | Standard IMRT plan: (PTVboost:60.0 Gy/30Fx); Dose escalation plan: Dmean to PTVboost (77.1 Gy for IMRT, 79.2 Gy for VMAT and 85.1GyE for IMPT); Dmax (81.3 Gy, 86.9 Gy and 89.3 GyE, respectively) | Dose-escalation plan: PTVboost (Dmax,Dmean Gy/GyE); ODV; R30 | Dmean evaluated for the normal brain (Temporal lobe, Spinal cord, Optic nerve, Lens, Hippocampus, Eyes, Cochlea, Brainstem, Chiasm) | IMPT being the most favorable technique among others |