Table 3 Main radiotherapy results of included studies
From: Charged particle therapy for high-grade gliomas in adults: a systematic review
Studies (year) | Median age (range) | Median dose in Gy (RBE) | Fraction (Fx) | Gy (RBE)/Fx | OS% (year)/median OS | PFS% (year)/ median PFS |
|---|---|---|---|---|---|---|
Tsujii et al. [13] | AA:42.6 GBM:60.4 | Proton alone (GBM):66.8 Gy; Photon + Protonboost (AA):86.8 Gy | Proton alone:23 to 25Fx Photon:16 to 27FxProtonboost:15 to 17Fx | Proton alone:2.5 to 3.5 Gy Photon + Protonboost:1.8 Gy | mOS(AA/GBM/AA + GBM):25,13,20mo | – |
Fitzek et al. [15] | 51(21–68) | Photon + Protonboost:total dose 93.5CGE(92.05 to 94.2 CGE) | – | Photon:1.8 Gy; Protonboost: 1.92 CGE | OS%:78%(1y), 34% (2y), 18%(3y); mOS 20mo | – |
Mizoe et al. [27] | 53(18–78) | Photon 50 Gy + CIRTboost:16.8 to 24.8GyE (16.8,18.4,20,22.4,24.8) | Photon:25Fx + CIRTboost:8Fx | Photon:2 Gy; CIRTboost:2.1 to 3.1 GyE | mOS: AA 35mo; GBM 17mo; mOS:GBM(high-dose, middle-dose, low-dose):26mo,19mo, 7mo | mPFS: GBM (high-dose, middle-dose, low-dose): 4mo, 7mo, 14mo |
Mizumoto et al.[17] | 56(31–76) | Photon 50.4 Gy; after 6 h protonboost 46.2GyE | Photon:28 Fx; after 6 h protonboost:28 Fx | Photon:1.8 Gy; after 6 h proton:1.65GyE | OS%:78%(1y),43%(2y); mOS 21mo | PFS%(1,2y):36%,13% mPFS:9mo |
Adeberg et al. [14] | Photon:57.9 (21.6–77.9); Photon + Proton boost:57.9 (20.0–77.0) | Photon:50.0(50.0 to 50.4) Gy/25(25 to 28) Fx; Photon + Protonboost:50 Gy + 10GyE/5Fx | Photon:25–28Fx; Protonboost:5Fx | Photon:1.8–2 Gy; Proton boost:2GyE | mOS: Photon:20.9mo; Photon + protonboost:19.1mo | mPFS: Photon:7.2mo; Photon + protonboost:8.8mo |
Vora et al. [11] | 56 | Proton: 59.4 GyE (range 40–66 GyE) | 15–33Fx | – | mOS 18.3 mo OS%:39%(2y); mOS GBM 17mo | – |
Kong et al. (25) | 54.5(22–76) | Proton:60 GyE; Proton:50 GyE + CIRTboost:10 to12 GyE; Proton:60 GyE + CIRTboost: 9 to12GyE; Proton:34 GyE + CIRTboost:9 GyE | Proton:30Fx; Proton:25Fx + CIRTboost 4 to 5Fx; Proton 30 Fx + CIRTboost 3Fx; Proton:10 Fx + CIRT boost:3Fx | Proton 2 GyE; Proton, 2 GyE + CIRTboost 2–3GyE; Proton 2 GyE + CIRTboost 3–4 GyE; Proton 3–4 GyE + CIRTboost 3 GyE | OS%(1y,1.5y):87.8%,72.8%; OS%(1y,1.5y): AA 100%; GBM:77.4%, 61% | PFS%(1y,1.5y):74.2%,59.8%; PFS%(1y,1.5y): AA 100%; GBM:61.3%, 42.7% |
Brown et al. [12] | GBM: IMRT:53 (26,82); PT:54.5 (33,72) | PTV1a:50 Gy PTV2a:60 Gy | 25Fx | 2 Gy/2GyE | mOSa: IMRT 21.2mo Proton 24.5mo | mPFSa: IMRT 8.9mo Proton 6.6 mo |