Table 2 The Probit analyses based on subgroups between BED10 and 3-years local control
From: Dose–effect relationship of stereotactic body radiotherapy in non-small cell lung cancer patients
Parameter | Nominal dose BED10 (GyBED10) | Peripheral dose BED10 (GyBED10) | Central dose BED10 (GyBED10) | Average dose BED10 (GyBED10) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
s (p) | ED90 (95% CI) | P | s (p) | ED90 (95% CI) | P | s (p) | ED90 (95% CI) | P | s (p) | ED90 (95% CI) | P | |
Country | ||||||||||||
United States | 9 (831) | 143.0 (–, –) | 0.331 | 8 (766) | 182.1 (–, –) | 0.653 | 8 (766) | 166.0 (–, –) | 0.318 | 7 (701) | 176.7 (–, –) | 0.280 |
Japan | 7 (701) | 122.5 (–, –) | 0.069 | 7 (701) | 100.2 (89.7, 123.6) | 0.002 | 7 (701) | 144.0 (117.2, 227.6) | 0.007 | 7 (701) | 121.8 (103.5, 171.0) | 0.004 |
Study design | ||||||||||||
Prospective | 13 (1058) | 148.5 (–, –) | 0.118 | 12 (993) | 125.1 (104.1, 176.9) | 0.003 | 12 (993) | 200.0 (157.1, 394.0) | 0.010 | 11 (928) | 167.0 (132.5, 310.1) | 0.011 |
Retrospective | 9 (803) | 148.0 (–, –) | 0.105 | 9 (803) | 153.1 (–, –) | 0.301 | 9 (803) | 218.2 (–, –) | 0.136 | 9 (803) | 184.6 (–, –) | 0.178 |
Treatment era | ||||||||||||
Before 2010 | 9 (695) | 185.5 (–, –) | 0.665 | 9 (695) | 127.3 (–, –) | 0.100 | 9 (695) | 190.1 (–, –) | 0.083 | 9 (695) | 157.8 (–, –) | 0.084 |
After 2005 | 12 (1100) | 146.2 (–, –) | 0.439 | 11 (1035) | 235.3 (–, –) | 0.792 | 11 (1035) | 181.9 (–, –) | 0.465 | 10 (970) | 182.3 (–, –) | 0.350 |
Operable or not | ||||||||||||
Both | 6 (665) | 118.4 (–, –) | 0.064 | 6 (665) | 98.8 (88.2, 116.3) | 0.001 | 5 (600) | 145.9 (117.5, 227.1) | 0.007 | 5 (600) | 123.3 (103.5, 174.1) | 0.005 |
Inoperable | 12 (784) | 120.5 (–, –) | 0.237 | 12 (784) | 121.2 (–, –) | 0.097 | 12 (784) | 165.3 (–, –) | 0.125 | 12 (784) | 144.4 (–, –) | 0.152 |
Proportion of male patients | ||||||||||||
≥ 50% | 11 (907) | 86.1 (–, –) | 0.061 | 11 (907) | 9.2 (–, –) | 0.397 | 11 (907) | –67.9 (–, –) | 0.439 | 11 (907) | –30.7 (–, –) | 0.435 |
< 50% | 8 (729) | 126.1 (114.2, 144.4) | 0.002 | 7 (664) | 115.9 (100.6–133.6) | 0.0001 | 7 (664) | 173.7 (146.2, 219.3) | 0.001 | 6 (599) | 149.3 (124.0, 186.1) | 0.001 |
Median age | ||||||||||||
> 75 | 10 (1015) | 68.4 (–6622.2, 100.4) | 0.048 | 9 (950) | –63.3 (–, –) | 0.451 | 10 (1015) | –221.2 (–, –) | 0.478 | 9 (950) | –116.4 (–, –) | 0.441 |
≤ 75 | 10 (636) | 110.3 (82.9, 120.4) | 0.002 | 10 (636) | 110.3 (82.9, 120.4) | 0.002 | 9 (571) | 123.5 (− 452.0, 161.7) | 0.034 | 9 (571) | 116.0 (–, –) | 0.051 |
Immobilization | ||||||||||||
SBF | 6 (457) | − 294.5 (–, –) | 0.945 | 6 (457) | 291.9 (–, –) | 0.851 | 6 (457) | 246.5 (–, –) | 0.459 | 6 (457) | 221.8 (–, –) | 0.580 |
BodyFix | 2 (201) | 125.3(115.9, 211.6) | 0.025 | 2 (201) | 108.0 (94.0, 153.1) | 0.003 | 2 (201) | 125.3 (115.9, 211.6) | 0.025 | 2 (201) | 115.1 (104.6, 153.0) | 0.005 |
VP | 5 (453) | 208.2 (–, –) | 0.405 | 5 (453) | 204.8 (–, –) | 0.316 | 5 (453) | 541.0 (–, –) | 0.567 | 5 (453) | 349.2 (–, –) | 0.472 |
AC | 4 (348) | 105.8 (–, –) | 0.096 | 4 (348) | 88.7 (–, –) | 0.170 | 4 (348) | 44.7 (–, –) | 0.753 | 4 (348) | 82.9 (–, –) | 0.396 |
CT scan | ||||||||||||
4D-CT | 13 (1432) | 146.4 (–, –) | 0.075 | 11 (949) | 60.9 (–, –) | 0.689 | 12 1367) | 216.4 (–, –) | 0.130 | 10 (884) | 248.3 (–, –) | 0.737 |
PTV margin | ||||||||||||
≥ 5 mm | 16 (1351) | 43.3 (–, –) | 0.211 | 15 (1286) | − 949.9 (–, –) | 0.911 | 16 (1351) | − 250.9 (–, –) | 0.571 | 15 (1286) | − 188.9 (–, –) | 0.604 |
< 5 mm | 5 (445) | 103.8 (–, –) | 0.066 | 5 (445) | 103.8 (–, –) | 0.066 | 5 (445) | 91.3 (–, –) | 0.097 | 5 (445) | 102.9 (–, –) | 0.080 |
Fractions | ||||||||||||
3 | 10 (779) | 166.5 (146.2, 216.0) | 0.008* | 10 (779) | 166.5 (146.2, 216.0) | 0.008* | 10 (779) | 250.9 (231.6, 275.8) | < 0.0001* | 10 (779) | 207.3 (189.6, 232.7) | 0.0002* |
4 | 7 (662) | 100.3 (–, –) | 0.264 | 7 (662) | 93.1 (87.8, 105.3) | 0.001 | 6 (597) | 97.4 (–, –) | 0.283 | 6 (597) | 106.3 (–, –) | 0.140 |
5 | 4 (311) | 122.6 (–, –) | 0.243 | 4 (311) | 113.9 (–, 1) | 0.075 | 4 (311) | 171.2 (–, –) | 0.476 | 4 (311) | 162.0 (–, –) | 0.458 |
Interval time | ||||||||||||
≤ 48 h | 13 (1156) | 64.7 (–, –) | 0.604 | 12 (1091) | 178.1 (–, –) | 0.662 | 12 (1088) | 22.4 (–, –) | 0.605 | 11 (1023) | 26.8 (–, –) | 0.745 |
> 48 h | 4 (290) | 134.7 (124.6, 158.2) | 0.001 | 4 (290) | 127.0 (108.8, 167.1) | 0.001 | 4 (290) | 184.7 (156.5, 246.5) | 0.001 | 4 (290) | 166.0 (137.5, 240.2) | 0.002 |
Treatment equipment | ||||||||||||
LA | 20 (1686) | − 624.4 (–, –) | 0.948 | 19 (1621) | 157.0 (–, –) | 0.202 | 19 (1621) | 336.3 (–, –) | 0.440 | 18 (1556) | 253.9 (–, –) | 0.416 |
Tissue heterogeneity correction | ||||||||||||
Yes | 12 (998) | 116.0 (106.8, 131.3) | 0.002 | 12 (998) | 102.5 (92.9, 115.3) | < 0.0001 | 12 (998) | 142.4 (118.8, 177.0) | 0.001 | 12 (998) | 125.1 (105.9, 153.1) | 0.001 |
No | 4 (428) | 148.3 (–, –) | 0.063 | 3 (363) | 131.4 (–, –) | 0.053 | 4 (428) | 195.8 (122.4, 368.5) | 0.020 | 3 (363) | 160.4 (–, –) | 0.053 |
Median follow-up time (months) | ||||||||||||
< 36 months | 13 (1045) | 120.8 (–, –) | 0.367 | 12 (980) | 103.3 (–, –) | 0.741 | 13 (1045) | 139.2 (–, –) | 0.501 | 12 (980) | 158.8 (–, –) | 0.606 |
≥ 36 months | 9 (816) | 146.7 (-, –) | 0.118 | 9 (816) | 134.6 (102.2, 310.7) | 0.025 | 8 (751) | 206.8 (161.5, 342.2) | 0.006 | 8 (751) | 178.3 (137.9, 350.0) | 0.014 |
6 | 10 | 10 | 8 | |||||||||