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Table 4 Prognosis factors for decreased PFS by univariate analysis

From: Impact of fractionated stereotactic radiotherapy on activity of daily living and performance status in progressive/recurrent glioblastoma: a retrospective study

Variable

Hazard ratio [95% CI]

p-value

Male gender

0.85 [0.50; 1.47]

0.566

Initial brain surgery

0.48 [0.27; 0.86]

0.013

Motor deficiency

1.42 [0.68; 2.94]

0.350

Antiepileptic medication

1.17 [0.69; 1.98]

0.567

Headaches

0.86 [0.46; 1.61]

0.645

Age (years) > 60

0.67 [0.40; 1.13]

0.135

Steroids (mg)

1.81 [1.04; 3.16]

0.037

PTV (cc) *

1.14 [0.90; 1.44]

0.269

KPS (%) ≥ 90

1.01 [0.58; 1.73]

0.985

Time from RTCT to fSBReRT (months) < 12

0.60 [0.35; 1.01]

0.055

Number of recurrences before reirradiation ≥ 1

1.84 [0.98; 3.44]

0.056

Multifocality

1.18 [0.47; 2.99]

0.715

Brain topography

  

Cortical

1

 

Subcortical

1.58 [0.77; 3.26]

0.214

  1. CI, confidence interval; RTCT, concomitant adjuvant chemotherapy plus radiotherapy; fSRT, fractionated stereotactic RT
  2. *HR computed for an increase of 10 cc