Proposed prognostic subgroups and facilitated clinical decision-making for additional locoregional radiotherapy in de novo metastatic nasopharyngeal carcinoma: a retrospective study based on recursive partitioning analysis

Table 2 Univariable and multivariable analyses of the training group

Characteristics	Univariate analysis		Multivariate analysis
Characteristics	HR (95% CI)	P	HR (95% CI)	P
Age (years)	1.486 (1.075–2.056)	0.017	1.018 (1.003–1.034)	0.018
≤ 52
> 52
Gender	1.065 (0.705–1.607)	0.765
Male
Female
Family history of NPC	0.979 (0.515–1.861)	0.949
No
Yes
Smoking history	1.193 (0.863–1.647)	0.285
No
Yes
Tumor stage	1.284 (0.823–2.002)	0.270
T1-T2
T3–T4
Node stage	1.519 (0.986–2.341)	0.058
N0-N1
N2-N3
EBV DNA copies/ml	2.252 (1.626–3.119)	< 0.001	1.559 (1.104–2.202)	0.012
< 62,000
≥ 62,000
No. of involved organs	2.705 (1.919–3.813)	< 0.001
Single
Multiple
No. of involved lesions	3.227 (2.325–4.480)	< 0.001	2.302 (1.621–3.268)	< 0.001
≤ 4
> 4
Liver involvement	2.826 (2.023–3.948)	< 0.001	2.055 (1.441–2.931)	< 0.001
No
Yes
Bone involvement	1.245 (0.874–1.773)	0.225
No
Yes
Lung involvement
No	0.683 (0.455–1.024)	0.065
Yes
Distant lymph node involvement	1.733 (1.153–2.605)	0.008
Yes
No
Tumor Response to PCT	2.115 (1.523–2.935)	< 0.001	1.558 (1.110–2.187)	0.010
PR/CR
SD/PD

NPC nasopharyngeal carcinoma, PCT palliative chemotherapy, IMRT intensity-modulated radiotherapy, EBV Epstein–Barr virus, No. Number, CR complete response, PR partial response, PD disease progression, SD stable disease
Bold values were considered statistically significant

ISSN: 1748-717X