Table 1 Features of the clinical dataset

Patient characteristics

Histopathologic diagnosis

 Glioblastoma, WHO grade 4

N = 33

 Anaplastic astrocytoma, IDH wildtype, TERT promotor mutation (Glioblastoma, WHO grade 4 equivalent according to the current WHO classification)

N = 4

IDH mutational status

 IDH WT

N = 28

 IDH mutational status unknown

N = 9

MGMT promotor methylation status

 Methylated

N = 21

 Unmethylated

N = 16

Sex

 Male

N = 20

 Female

N = 17

Age at the time of irradiation

 Median

62 years

 Range

30–76 years

Neurosurgical treatment prior to irradiation

 Stereotactical biopsy only

N = 27

 Neurosurgical resection

N = 10

Radiotherapy dosage

 30 × 2 Gy

N = 32

 29 × 2 Gy (due to discontinuation)

N = 1

 33 × 1.8 Gy

N = 2

 12 × 1.8 Gy/2,1 SIB (due to discontinuation)

N = 1

 10 × 3 Gy plus 1 × 4 Gy

N = 1

Chemotherapy concomitant to radiotherapy

 Temozolomide (EORTC26981/22981-NCIC CE3 protocol)

N = 34

 Temozolomide and lomustine (NOA-09 protocol)

N = 1

 No concomitant chemotherapy

N = 2

PET characteristics

PET acquisition protocol

 Intravenous bolus

180 MBq

 Scan duration

40 min

 Dynamic frames

16

OSEM-2D

 Iterations

6

 Subsets

16

 Voxel spacing

2.035 × 2.035 × 2.425 mm³

 Reconstruction matrix

128 × 128 × 63

OSEM-3D

 Iterations

4

 Subsets

21

 Voxel spacing

1.018 × 1.018 × 2.027 mm³

 Reconstruction matrix

336 × 336 × 109

 Post-reconstruction filter

Gaussian (5 mm)