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Table 4 Summary of previous reports comparing the outcomes of adjuvant treatment with surgery or CRT after noncurative ESD for SESCC

From: Chemoradiation versus surgery for superficial esophageal squamous cell carcinoma after noncurative endoscopic submucosal dissection: comparison of long-term oncologic outcomes

Authors (reference)

Year

n (CRT/Esophagectomy)

Median follow-up periods (CRT/Esophagectomy)

Basic chemotherapy regimen (5-FU/CDDP)

Irradiation field

DFS rate (CRT/Esophagectomy)

Tanaka et al. [9]

2019

52 (33/19)

NR

700/70

Standard ENI*

(% [at 3 years]) (87.4/100)***

Ikeda et al. [13]

2015

26 (11/15)

43 m/47 m

700/70

NR

(% [at 3 years]) (69**/86)***

Koterazawa et al. [22]

2018

59 (31/28)

41 m/45 m

700/70

Standard ENI*

NR***

Current study

 

60 (34/26)

46 m/56 m

1000/75

Short ENI

(% [at 4 years]) (65/73)***

  1. CRT, chemoradiation; m, months; ENI, elective nodal irradiation; NR, not reported; DFS, disease-free survival
  2. *Japan Clinical Oncology Group Study JCOG0508 protocol (11)
  3. **Including CRT and RT
  4. ***No significant difference between the two groups