Table 4 Univariate Cox regression analysis. HR > 1 indicates a greater risk for the group > 70y; HR < 1 indicates a smaller risk for the group > 70y
Parameter | OS HR [95% CI] | p-value | PFS HR [95% CI] | p-value |
|---|---|---|---|---|
Treatment Regimen (nCRT vs. dRCT) | 0.399 [0.203; 0.785] | 0.008 | 0.477 [0.252; 0.902] | 0.023 |
Age > 70 y vs. \(\le\) 70 y) | 0.850 [0.433; 1.666] | 0.636 | 0.891 [0.493; 1.610] | 0.701 |
Sex | ||||
(Female > 70 y vs. \(\le\) 70 y) | 0.782 [0.205; 2.982] | 0.719 | 0.605 [0.168; 2.173] | 0.441 |
(Male > 70 y vs. \(\le\) 70 y) | 0.773 [0.340; 1.759] | 0.539 | 1.032 [0.511; 2.083] | 0.931 |
ECOG (2–3 vs. 0–1) | 3.825 [1.738; 8.416] | < 0.001 | 3.096 [1.460; 6.565] | 0.003 |
T-stage (> 70 y vs. \(\le\) 70 y) | ||||
T3 | 0.958 [0.429; 2.140] | 0.917 | 0.973 [0.496; 1.908] | 0.936 |
Grading (> 70 y vs. \(\le\) 70 y) | ||||
G2 | 0.379 [0.133; 1.081] | 0.070 | 0.487 [0.204; 1.164] | 0.105 |
G3 | 2.328 [0.819; 6.619] | 0.113 | 2.585 [1.025; 6.520] | 0.044 |
Histology (\(>\) 70 y vs. \(\le\) 70 y) | ||||
SCC | 0.462 [0.174; 1.227] | 0.121 | 0.454 [0.172; 1.193] | 0.109 |
AC | 1.968 [0.625; 6.197] | 0.248 | 1.495 [0.632; 3.536] | 0.360 |