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Table 3 Recent and ongoing trials of NRT in RPLS

From: Neoadjuvant radiotherapy for resectable retroperitoneal sarcoma: a meta-analysis

Trial Name

Status

Primary Aims/Findings

Ref

Retroperitoneal SArcoma Registry: an International Prospective Initiative (RESAR) (NCT03838718)

Recruiting

(12/2030)a

To assess the survival after surgery for primary RPS resection

(Sarcoma subtype: primary RPS amenable to surgical resection)

NA

Proton or Photon RT for Retroperitoneal Sarcoma (NCT01659203)

Recruiting

(08/2025)a

To determine the maximum tolerated dose (MTD) of preoperative IG-IMRT with simultaneously integrated boost to the high-risk margin of retroperitoneal sarcoma

To determine the local control rate after the protocol treatment (IG-IMPT or IMRT MTD with simultaneously integrated boost to the high-risk margin) followed by surgical resection

(Sarcoma subtype: primary RPS)

NA

Neoadjuvant Irradiation of Retroperitoneal Soft Tissue Sarcoma With Ions Retro-Ion (Retro-Ion) (NCT04219202)

Recruiting

(05/2024)a

To evaluate the safety and feasibility of a hypofractionated, accelerated radiation approach based on the incidence of grade 3–5 NCI common terminology criteria for adverse events toxicity and/or termination of the planned therapy for any reason with neoadjuvant radiation with active beam guidance of the retroperitoneal sarcomas using protons or carbon ions before subsequent tumor resection

(Sarcoma subtype: RPS which is resectable or marginally resectable)

NA

Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis (NCT00091351)

Completed

(02/2006)b

Compare progression-free survival of patients with primary soft tissue sarcoma of the retroperitoneum or pelvis treated with surgery with vs without preoperative radiotherapy

(Sarcoma subtype: primary RPS)

NR

Preoperative Ultra-hypofractionated Radiotherapy Followed by Surgery for Retroperitoneal Sarcoma

(NCT05224934)

Recruiting

(12/2024)a

To investigate the feasibility and peri-operative complications of preoperative hypo-fractionated radiotherapy followed by surgery for retroperitoneal sarcoma

(Sarcoma subtype: primary RPS)

NA

  1. IG-IMRT image-guided intensity-modulated radiotherapy, IMRT intensity-modulated radiotherapy, NA not appliable, NR not reported, RPS retroperitoneal sarcoma
  2. aEstimated study completion date
  3. bActual study completion date