Treatment plan comparison for irradiation of multiple brain metastases with hippocampal avoidance whole brain radiotherapy and simultaneous integrated boost using the Varian Halcyon and the Elekta Synergy platforms

Kraft, Johannes; Weick, Stefan; Breuer, Kathrin; Lutyj, Paul; Bratengeier, Klaus; Exner, Florian; Richter, Anne; Tamihardja, Jörg; Lisowski, Dominik; Polat, Bülent; Flentje, Michael

doi:10.1186/s13014-022-02156-6

Table 2 Study Protocol specifications and requirements for target structures and organs at risk

From: Treatment plan comparison for irradiation of multiple brain metastases with hippocampal avoidance whole brain radiotherapy and simultaneous integrated boost using the Varian Halcyon and the Elekta Synergy platforms

Structure (target/OAR)	Parameter and required value per protocol	Minor deviation per study protocol	Major deviation per study protocol	Halcyon (Eclipse)	Synergy (Pinnacle)	p-value	Number of major deviations (n)		Number of minor deviations (n)
Structure (target/OAR)	Parameter and required value per protocol	Minor deviation per study protocol	Major deviation per study protocol	Halcyon (Eclipse)	Synergy (Pinnacle)	p-value	H⁺	S^#	H⁺	S^#
PTVwholebrain	D98% ≥ 25 Gy	24 Gy ≤ D98% < 25 Gy	D98% < 24 Gy	26.25 ± 0.23	26.18 ± 0.51	0.71	0	0	0	0
	Dmean ≤ 35 Gy	35 Gy < Dmean ≤ 37 Gy	Dmean > 37 Gy	30.27 ± 0.89	31.43 ± 1.02	< 0.01	0	0	0	0
	Dmax	*	*	53.53 ± 0.85	54.67 ± 1.14	0.01	*	*	*	*
PTVmetastases	D98% ≥ 48.4 Gy	47.4 Gy ≤ D98% < 48.4 Gy	D98% < 47.4 Gy	50.76 ± 0.50	50.59 ± 0.46	0.07	0	0	0	0
	D2% ≤ 63.7 Gy	63.7 Gy < D2% ≤ 66.3 Gy	D2% > 66.3 Gy	53.59 ± 0.80	54.09 ± 0.33	0.07	0	0	0	0
	Dmean	*	*	52.28 ± 0.58	52.44 ± 0.26	0.25	*	*	*	*
	Dmax	*	*	54.96 ± 0.95	55.48 ± 0.54	0.09	*	*	*	*
GTVmetastases	Dmean	*	*	52.54 ± 0.71	52.74 ± 0.23	0.30	*	*	*	*
	Dmax	*	*	54.93 ± 0.99	55.45 ± 0.54	0.09	*	*	*	*
Hippocampus	D98% ≤ 9 Gy	9 Gy < D98% ≤ 10 Gy	D98% > 10 Gy	7.92 ± 0.51	8.04 ± 0.38	0.58	0	0	1	0
	D2% ≤ 17 Gy	17 Gy < D2% ≤ 18 Gy	D2% > 18 Gy	17.82 ± 8.84	18.77 ± 9.56	0.13	2	3	0	1
Optical nerves	D2% ≤ 33 Gy	33 Gy < D2% ≤ 35 Gy	D2% > 35 Gy	29.52 ± 7.41	28.62 ± 7.63	0.13	0	0	0	0
Chiasm	D2% ≤ 33 Gy	33 Gy < D2% ≤ 35 Gy	D2% > 35 Gy	30.20 ± 5.20	31.36 ± 5.67	0.15	1	1	0	1
Lenses	D2% ≤ 7 Gy	7 Gy < D2% ≤ 10 Gy	D2% > 10 Gy	5.65 ± 1.48	5.57 ± 0.71	0.91	0	0	1	0
Inner ear	D2% ≤ 33 Gy	33 Gy < D2% ≤ 35 Gy	D2% > 35 Gy	31.37 ± 6.60	32.59 ± 6.03	0.23	2	2	0	2
Eyes	D2% ≤ 33 Gy	33 Gy < D2% ≤ 35 Gy	D2% > 35 Gy	20.80 ± 4.35	18.16 ± 5.97	0.03	0	0	0	0
Brain stem	D2% ≤ 33 Gy	33 Gy < D2% ≤ 35 Gy	D2% > 35 Gy	34.02 ± 3.50	32.16 ± 3.38	0.01	3	2	1	1

Median values ± standard deviation (SD) for Halcyon (Eclipse) and Synergy (Pinnacle). Number of major and minor protocol deviations for H+ Halcyon (Eclipse) and S# Synergy (Pinnacle). *missing study protocol specifications

Back to article page

ISSN: 1748-717X

Contact us

General enquiries: journalsubmissions@springernature.com

Radiation Oncology

Contact us