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Table 3 TIL levels depending on patient age

From: Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy

Variable

HR

Mean age (SD)

p

CD3 + TILs (intraepithelial)

 ≤ 20/HPF (n = 5)

79 (11)

 
 

21–100/HPF (n = 34)

74 (7)

 
 

 > 100/HPF (n = 24)

76 (8)

0.42a

CD3 + TILs (stromal)

21–100/HPF (10)

76 (8)

 
 

 > 100/HPF (53)

74 (7)

0.31b

CD4 + TILs (intraepithelial)

 ≤ 20/HPF (n = 42)

74 (7)

 
 

21–100/HPF (20)

75 (8)

 
 

 > 100/HPF (n = 1)

92

0.21a

CD4 + TILs (stromal)

 ≤ 20/HPF (n = 19)

73 (8)

 
 

21–100/HPF (n = 30)

75 (8)

 
 

 > 100/HPF (n = 14)

75 (7)

0.50a

CD8 + TILs (intraepithelial)

 ≤ 20/HPF (n = 15)

73 (8)

 
 

21–100/HPF (n = 33)

74 (7)

 
 

 > 100/HPF (n = 15)

76 (8)

0.41a

CD8 + TILs (stromal)

21–100/HPF (n = 30)

72 (7)

 
 

 > 100/HPF (n = 33)

76 (8)

 < 0.05b

  1. a Kruskal–Wallis test
  2. b Mann–Whitney-U test
  3. Mean age depending on the levels of TILs intraepithelial and stromal. Mean age including standard deviation is shown. Groups were compared using Mann–Whitney-U tests (for 2 groups) or Kruskal–Wallis tests (for 3 groups)