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Table 5 Survival analyses when functional imaging incorporated in radiation therapy planning

From: Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review

Study name

Citation

N (patients)

Intervention

Median OS (months)

Median PFS (months)

12 Mths OS %

12 Mths PFS %

Piroth

[34,35,36,37]

22

F18-FET & 72 Gy/30 fractions boost

14.8 (95% CI 12.7–16.0)

7.8 (95% CI 5.1–10.5)

63.6

25.4

Laouiti

[38]

12

F18-FET & 72 Gy/30 fractions boost

  

38.4

28.6

Miwa

[39]

51

F18-FET & 68 Gy/8 fractions boost

20

13

71.2

52.6

Munck Af Rosenschold

[40, 41]

190

F18-FET

15 (range 2.04–48.0)

6 (range 2.04–48.0)

  

Lundemann

[42,43,44]

15

F18-FET

20.74 (range 9.53–25.12)

11.7 (range 4.06–17.91)

  

Poulsen

[45, 46]

146

F18-FET

16.5

6.5

  

Vigil

[52, 53]

50

C11-MET & boost

20

6.7

  

Brinkmann

[59, 61, 61]

75

F18-FDOPA & 76 Gy/30 fractions boost

16

8.7

  

Kim

[66, 68, 86]

25

DW & DCE & 75 Gy/30 fractions boost

20 (95% CI 14-NA )

 

90 (95% CI 0.8–1.0)

 

Zhang

[71]

100

DTT

17.6 (range 6–42)

 

76

66

Stupp et al.

[9]

573

Historical control

14.6 (95% CI 13.2–16.8)

6.9 (95% CI 5.8–8.2)

61.1

26.9

Analysis all

 

686

Functional imaging

16.88

7.44

70.86

55.05

Analysis boost

 

235

Functional imaging & boost

18.52

9.31

73.05

42.17

  1. Bold indicate that it is different type of data than the data directly above
  2. N Number of, OS Overall survival, PFS Progression free survival, Mths Months, NA Non applicable, Analyses formula = (n1(f1) + n2(f2 )+... n5(f5))/n total
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Radiation Oncology

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