Fig. 3From: Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challengesEach boxplot contains near-minimum (95%) or median (50%) values of all patients in the primary clinical target volume (CTV). Constant (D1.1, first row) and variable RBE-weighted dose (DRBE, third row) volume-histogram values were normalized to the respective prescription dose (Dpres). Dose-averaged linear energy transfer (LETd, second row) is displayed in absolute values. Abbreviations: DOSEopt: dose-only optimization, TEopt: track-end optimization, LETopt: dose-averaged linear energy transfer (LETd) optimization with dose threshold, DDopt: Dirty dose optimization, DRBEopt: variable RBE-weighted dose optimizationBack to article page