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Table 3 Main case series and outcomes for PCNSL

From: The role of whole-brain radiotherapy (WBRT) in primary central nervous system lymphoma: is it an alternative to ASCT for consolidation following HD-methotrexate based induction in low-income settings?

Cohort

Period

N

2-year OS (%)

5-year OS (%)

Krogh-Jensen et al. [26] (Denmark)

1971–1990

48

38

26

Villano et al. [46] (SEER, USA)

2000–2008

3100

42.6

31.2

Shiels et al. [41] (SEER, USA)

1992–2011

4158

HIV (9.0)

Non-HIV (26.2)

HC-FMUSP (2022) (Brazil)

2000–2021

47

60.2

45.5

Zeremski et al. [47] (Germany)

2000–2015

86

CT (20)

RL (66)

65

37.9

40

23

  1. OS overall survival, CT clinical trial, RL “real-life” settings