Fig. 4

Two patients from the high-risk (A) and low-risk group (B). From the series CT images, there were discernible distinction observed in tumor and pulmonary status between the two cases. High-risk patient had heterogeneous primary lung tumor and chronic obstructive pneumonia (A-1), while low-risk patient had relatively homogeneous primary lung tumor and better pulmonary condition (B-1). Significant tumor remission was achieved in low-risk patient without obvious radiation pneumonitis after CCRT (B-2), while high-risk patient had stable disease and developed Grade 2 radiation pneumonitis in bilateral lungs (A-2). The GLZLM matrices for tumor, GLRLM matrices along + x axis for lungs, and histograms of HU values for tumor (A-3, B-3) were displayed. It was found that the short homogeneous runs and the non-uniformity of the grey-levels (CT value) were emphasized for high-risk patient compared to those of low-risk patient