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Table 2 Uni- and multivariate analysis

From: Stereotactic radiosurgery for the treatment of brainstem metastases: a multicenter retrospective study

  Univariate analysis Multivariate analysis
  Freedom from local progression
BED 35.7 Gy10 0.13 HR 0.455 (95%CI 0.140–1.479); p = 0.19
GTV volume ≤ 0.4 0.041 HR 3.77 (95%CI 0.945–15.061); p = 0.06
PTV margin 0.59
BM site
(base = midbrain)
0.09 Pons: HR 0.202 (95%CI 0.048–0.845); p = 0.02
M. Oblongata: HR 0.627 (95%CI 0.150–2.619); p = 0.52
Primary histology 0.74
Previous WBRT 0.85
Concurrent targeted therapy 0.03 HR 0.169 (95%CI 0.021–1.348); p = 0.09
Single- versus multifraction 0.51
  Overall survival
BED 35.7 Gy10 0.06 HR 0.887 (95%CI 0.534–1.473); p = 0.64
GTV volume ≤ 0.4 0.45
PTV margin 0.17
Primary histology 0.17  
BM site 0.16
Previous WBRT 0.01 HR 1.59 (95%CI 0.827–3.080); p = 0.16
Concurrent targeted therapy 0.01 HR 0.466 (95%CI 0.270–0.804); p = 0.006
Single-versus multifraction 0.03 HR 1.61 (95%CI 0.972–2.696); p = 0.06
  Cancer-specific survival
BED 35.7 Gy10 0.26
GTV volume ≤ 0.4 0.33
PTV margin 0.23
BM site
(base = midbrain)
0.06 Pons: HR 0.587 (95%CI 0.338–1.019); p = 0.06
M. oblongata: HR 1.026 (95%CI 0.505–2.082); p = 0.94
Primary histology 0.23  
Previous WBRT 0.03 HR 2.055 (95%CI 1.023–4.128); p = 0.04
Concurrent targeted therapy 0.03 HR 0.573 (95%CI 0.331–0.992); p = 0.04
Single- versus multifraction 0.11
  Neurological Death
BED 35.7 Gy10 0.75
GTV volume ≤ 0.4 0.75
PTV margin 0.54
Primary histology 0.23  
BM site
(base = midbrain)
0.15 Pons: HR 0.431 (95%CI 0.179–1.037); p = 0.06
M. Oblongata: HR 0.631 (95%CI 0.172–2.308); p = 0.48
Previous WBRT 0.00 HR 3.381 (95%CI 1.287–8.879); p = 0.01
Concurrent targeted therapy 0.13 0.530 (95%CI 0.197–1.427); p = 0.21
Single- versus multifraction 0.74
  1. BED: biological effective dose; HR: hazard ratio; CI: confidence interval; GTV: gross tumor volume; PTV: planning target volume; BM: brainstem; WBRT: whole-brain radiotherapy
  2. Italics values indicate a significant correlation