Table 5 Acute toxicity (greater than grade 2) according to the Common Terminology Criteria for Adverse Events version 5.0.
Toxicity | Neoadjuvant RCT n (%) | Other therapies n (%) | ||
|---|---|---|---|---|
Grade 3 | Grade 4 | Grade 3 | Grade 4 | |
Hematological | ||||
Anemia | 4 (17.4) | 0 (0) | 9 (9.8) | 1 (1.1) |
Leukopenia | 3 (13) | 3 (13) | 2 (2.2) | 3 (3.3) |
Lymphocytopenia | 7 (30) | 1 (4.3) | 7 (7.6) | 1 (1.1) |
Neutropenia | 0 (0) | 9 (39.1) | 1 (1.1) | 6 (6.5) |
Thrombocytopenia | 3 (13) | 1 (4.3) | 1 (1.1) | 1 (1.1) |
Overall hematological | 12 (52.2%) (Grade 3 + 4) | 17 (18.5%) (Grade 3 + 4) | ||
Fatigue | 3 (13) | 0 (0) | 4 (4.3) | 0 (0) |
Gastrointestinal | ||||
Nausea | 1 (4.3) | 0 (0) | 5 (5.4) | 0 (0) |
Dysgeusia | 0 (0) | 0 (0) | 1 (1.1) | 0 (0) |
Dysphagia | 0 (0) | 0 (0) | 1 (1.1) | 0 (0) |
Dermatological | ||||
Erythema | 0 (0) | 0 (0) | 3 (3.3) | 0 (0) |
Radiodermatitis | 2 (8.7) | 0 (0) | 2 (2.2) | 0 (0) |
Hyperpigmentation | 0 (0) | 0 (0) | 3 (3.3) | 0 (0) |
Epitheliolysis | 0 (0) | 0 (0) | 2 (2.2) | 0 (0) |
Lymphedema | 0 (0) | 0 (0) | 3 (3.3) | 0 (0) |
Inflammation | ||||
Mucositis | 1 (4.3) | 0 (0) | 1 (1.1) | 1 (1.1) |
Stomatitis | 2 (8.7) | 0 (0) | 0 (0) | 0 (0) |
Neurological | ||||
Psychosis | 0 (0) | 0 (0) | 1 (1.1) | 0 (0) |
Wound complication | 6 (26.1) | 0 (0) | 10 (10.9) | 5 (5.4) |
Other | 1 (4.3) | 0 (0) | 1 (1.1) | 1 (0) |