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Table 5 Acute toxicity (greater than grade 2) according to the Common Terminology Criteria for Adverse Events version 5.0.

From: The role of neoadjuvant radiochemotherapy in the management of localized high-grade soft tissue sarcoma

Toxicity Neoadjuvant RCT n (%) Other therapies n (%)
  Grade 3 Grade 4 Grade 3 Grade 4
Hematological
 Anemia 4 (17.4) 0 (0) 9 (9.8) 1 (1.1)
 Leukopenia 3 (13) 3 (13) 2 (2.2) 3 (3.3)
 Lymphocytopenia 7 (30) 1 (4.3) 7 (7.6) 1 (1.1)
 Neutropenia 0 (0) 9 (39.1) 1 (1.1) 6 (6.5)
 Thrombocytopenia 3 (13) 1 (4.3) 1 (1.1) 1 (1.1)
 Overall hematological 12 (52.2%)
(Grade 3 + 4)
17 (18.5%)
(Grade 3 + 4)
Fatigue 3 (13) 0 (0) 4 (4.3) 0 (0)
Gastrointestinal
 Nausea 1 (4.3) 0 (0) 5 (5.4) 0 (0)
 Dysgeusia 0 (0) 0 (0) 1 (1.1) 0 (0)
 Dysphagia 0 (0) 0 (0) 1 (1.1) 0 (0)
Dermatological
 Erythema 0 (0) 0 (0) 3 (3.3) 0 (0)
 Radiodermatitis 2 (8.7) 0 (0) 2 (2.2) 0 (0)
 Hyperpigmentation 0 (0) 0 (0) 3 (3.3) 0 (0)
 Epitheliolysis 0 (0) 0 (0) 2 (2.2) 0 (0)
 Lymphedema 0 (0) 0 (0) 3 (3.3) 0 (0)
Inflammation
 Mucositis 1 (4.3) 0 (0) 1 (1.1) 1 (1.1)
 Stomatitis 2 (8.7) 0 (0) 0 (0) 0 (0)
Neurological
 Psychosis 0 (0) 0 (0) 1 (1.1) 0 (0)
 Wound complication 6 (26.1) 0 (0) 10 (10.9) 5 (5.4)
 Other 1 (4.3) 0 (0) 1 (1.1) 1 (0)
  1. No grade 5 toxicity was observed